Clonazepam add-on therapy for drug-resistant epilepsy.

Abstract:

BACKGROUND:This is an updated version of the original Cochrane Review published in 2018, Issue 5. Epilepsy affects over 70 million people worldwide, and nearly a quarter of patients with seizures have drug-resistant epilepsy. People with drug-resistant epilepsy have increased risks of premature death, injuries, psychosocial dysfunction, and a reduced quality of life. OBJECTIVES:To assess the efficacy and tolerability of clonazepam when used as an add-on therapy for adults and children with drug-resistant focal onset or generalised onset epileptic seizures, when compared with placebo or another antiepileptic agent. SEARCH METHODS:For the latest update we searched the following databases on 4 June 2019: Cochrane Register of Studies (CRS Web), MEDLINE (Ovid) 1946 to 3 June, 2019. The Cochrane Register of Studies (CRS Web) includes the Cochrane Epilepsy Group Specialized Register, the Cochrane Central Register of Controlled Trials (CENTRAL), and randomised or quasi-randomised, controlled trials from Embase, ClinicalTrials.gov and the World Health Organization International Clinical Trials Registry Platform (ICTRP). SELECTION CRITERIA:Double-blind randomised controlled studies of add-on clonazepam in people with resistant focal or generalised onset seizures, with a minimum treatment period of eight weeks. The studies could be of parallel or cross-over design. DATA COLLECTION AND ANALYSIS:Two review authors independently selected studies for inclusion, extracted relevant data, and assessed trial quality. We contacted study authors for additional information. MAIN RESULTS:We found no double-blind randomised controlled trials which met the inclusion criteria. AUTHORS' CONCLUSIONS:There is no evidence from double-blind randomised controlled trials for or against the use of clonazepam as an add-on therapy for adults and children with drug-resistant focal or generalised onset epileptic seizures. Since the last version of this review no new studies have been found.

authors

Song L,Liu F,Liu Y,Zhang R,Ji H,Jia Y

doi

10.1002/14651858.CD012253.pub3

subject

Has Abstract

pub_date

2020-04-20 00:00:00

pages

CD012253

issn

1469-493X

journal_volume

4

pub_type

杂志文章
  • Interventions for treating recurrent stress urinary incontinence after failed minimally invasive synthetic midurethral tape surgery in women.

    abstract:BACKGROUND:Surgery is a common treatment modality for stress urinary incontinence (SUI), usually offered to women for whom conservative treatments have failed. Midurethral tapes have superseded colposuspension because cure rates are comparable and recovery time is reduced. However, some women will not be cured after mi...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章

    doi:10.1002/14651858.CD009407.pub3

    authors: Bakali E,Johnson E,Buckley BS,Hilton P,Walker B,Tincello DG

    更新日期:2019-09-04 00:00:00

  • Methods of consumer involvement in developing healthcare policy and research, clinical practice guidelines and patient information material.

    abstract:BACKGROUND:The importance of consumer involvement in health care is widely recognised. Consumers can be involved in developing healthcare policy and research, clinical practice guidelines and patient information material, through consultations to elicit their views or through collaborative processes. Consultations can ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD004563.pub2

    authors: Nilsen ES,Myrhaug HT,Johansen M,Oliver S,Oxman AD

    更新日期:2006-07-19 00:00:00

  • Unconditional cash transfers for assistance in humanitarian disasters: effect on use of health services and health outcomes in low- and middle-income countries.

    abstract:BACKGROUND:Unconditional cash transfers (UCTs) are a common social protection intervention that increases income, a key social determinant of health, in disaster contexts in low- and middle-income countries (LMICs). OBJECTIVES:To assess the effects of UCTs in improving health services use, health outcomes, social dete...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD011247.pub2

    authors: Pega F,Liu SY,Walter S,Lhachimi SK

    更新日期:2015-09-11 00:00:00

  • Dietary advice for illness-related malnutrition in adults.

    abstract:BACKGROUND:Illness-related malnutrition has been reported in 10% to 55% of ill people in hospital and the community in areas of food sufficiency. Dietary advice encouraging the use of energy- and nutrient-rich foods rather than oral nutritional supplements has been suggested for managing illness-related malnutrition. ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD002008.pub3

    authors: Baldwin C,Weekes CE

    更新日期:2008-01-23 00:00:00

  • WITHDRAWN. Combined chemotherapy and radiotherapy (without surgery) compared with radiotherapy alone in localized carcinoma of the esophagus.

    abstract:BACKGROUND:Esophageal carcinoma can be managed primarily with either a surgical or non-surgical radiotherapeutic approach. Combination chemotherapy (CT) and radiotherapy (RT) has been incorporated into clinical practice and applied increasingly, especially in North America. OBJECTIVES:To evaluate combined CT and RT (C...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD002092.pub3

    authors: Wong RK,Malthaner R

    更新日期:2010-01-20 00:00:00

  • Sports and games for post-traumatic stress disorder (PTSD).

    abstract:BACKGROUND:Traumatic experiences evoke emotions such as fear, anxiety and distress and may encourage avoidance of similar situations in the future. For a proportion of those exposed to a traumatic event, this emotional reaction becomes uncontrollable and can develop into Post Traumatic Stress Disorder (PTSD) (Breslau 2...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD007171.pub2

    authors: Lawrence S,De Silva M,Henley R

    更新日期:2010-01-20 00:00:00

  • Virtual reality for stroke rehabilitation.

    abstract:BACKGROUND:Virtual reality and interactive video gaming have emerged as new treatment approaches in stroke rehabilitation. In particular, commercial gaming consoles are being rapidly adopted in clinical settings; however, there is currently little information about their effectiveness. OBJECTIVES:To evaluate the effec...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD008349.pub2

    authors: Laver KE,George S,Thomas S,Deutsch JE,Crotty M

    更新日期:2011-09-07 00:00:00

  • Enteral lactoferrin supplementation for prevention of sepsis and necrotizing enterocolitis in preterm infants.

    abstract:BACKGROUND:Lactoferrin, a normal component of human colostrum and milk, can enhance host defenses and may be effective for prevention of sepsis and necrotizing enterocolitis (NEC) in preterm neonates. OBJECTIVES:Primary objective 1. To assess the safety and effectiveness of lactoferrin supplementation to enteral feeds...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD007137.pub5

    authors: Pammi M,Suresh G

    更新日期:2017-06-28 00:00:00

  • Edaravone for acute intracerebral haemorrhage.

    abstract:BACKGROUND:Intracerebral haemorrhage (ICH) causes significant morbidity and mortality. Prognosis for ICH patients is poor. Edaravone may be safe and effective in reducing the risk of early death and improving long-term functional outcomes in survivors. OBJECTIVES:To assess the safety and efficacy of edaravone for acut...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD007755.pub2

    authors: Yang J,Liu M,Zhou J,Zhang S,Lin S,Zhao H

    更新日期:2011-02-16 00:00:00

  • Absorbable staples for uterine incision at caesarean section.

    abstract:BACKGROUND:Staples can be placed during the making of an incision, with the aim of decreasing blood loss from the cut edges. OBJECTIVES:The objective of this review was to assess the effects of using a stapler with absorbable staples to extend the uterine incision at lower segment caesarean section. SEARCH STRATEGY:W...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD000005

    authors: Wilkinson C,Enkin MW

    更新日期:2000-01-01 00:00:00

  • Topical antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving mechanical ventilation.

    abstract:BACKGROUND:Patients treated with mechanical ventilation in intensive care units (ICUs) have a high risk of developing respiratory tract infections (RTIs). Ventilator-associated pneumonia (VAP) has been estimated to affect 5% to 40% of patients treated with mechanical ventilation for at least 48 hours. The attributable ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD000022.pub4

    authors: Minozzi S,Pifferi S,Brazzi L,Pecoraro V,Montrucchio G,D'Amico R

    更新日期:2021-01-22 00:00:00

  • Vitamin supplementation for preventing miscarriage.

    abstract:BACKGROUND:Miscarriage is a common complication of pregnancy that can be caused by a wide range of factors. Poor dietary intake of vitamins has been associated with an increased risk of miscarriage, therefore supplementing women with vitamins either prior to or in early pregnancy may help prevent miscarriage. OBJECTIV...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD004073.pub3

    authors: Rumbold A,Middleton P,Pan N,Crowther CA

    更新日期:2011-01-19 00:00:00

  • Non-steroidal anti-inflammatory drugs versus corticosteroids for controlling inflammation after uncomplicated cataract surgery.

    abstract:BACKGROUND:Cataract is a leading cause of blindness worldwide. Cataract surgery is commonly performed but can result in postoperative inflammation of the eye. Inadequately controlled inflammation increases the risk of complications. Non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids are used to prevent ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD010516.pub2

    authors: Juthani VV,Clearfield E,Chuck RS

    更新日期:2017-07-03 00:00:00

  • Screening programmes for the early detection and prevention of oral cancer.

    abstract:BACKGROUND:Oral cancer is an important global healthcare problem, its incidence is increasing and late-stage presentation is common. Screening programmes have been introduced for a number of major cancers and have proved effective in their early detection. Given the high morbidity and mortality rates associated with or...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD004150.pub3

    authors: Brocklehurst P,Kujan O,Glenny AM,Oliver R,Sloan P,Ogden G,Shepherd S

    更新日期:2010-11-10 00:00:00

  • Ketamine as an adjuvant to opioids for cancer pain.

    abstract:BACKGROUND:This is an update of a review first published in 2003 and updated in 2012.Ketamine is a commonly used anaesthetic agent, and in subanaesthetic doses is also given as an adjuvant to opioids for the treatment of refractory cancer pain, when opioids alone or in combination with appropriate adjuvant analgesics p...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD003351.pub3

    authors: Bell RF,Eccleston C,Kalso EA

    更新日期:2017-06-28 00:00:00

  • Inhaled steroids for acute asthma following emergency department discharge.

    abstract:BACKGROUND:Patients with acute asthma treated in the emergency department (ED) are frequently treated with inhaled beta(2)-agonists and systemic corticosteroids after discharge. The use of inhaled corticosteroids (ICS) following discharge may also be beneficial in improving patient outcomes after acute asthma. OBJECTI...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD002316.pub2

    authors: Edmonds ML,Milan SJ,Brenner BE,Camargo CA Jr,Rowe BH

    更新日期:2012-12-12 00:00:00

  • Therapeutic ultrasound for postpartum perineal pain and dyspareunia.

    abstract:BACKGROUND:Proponents of therapeutic ultrasound suggest it can decrease pain by resolution of inflammation processes and reducing the pressure on pain sensitive structures by haematoma and oedema. OBJECTIVES:The objective of this review was to assess the effects of therapeutic ultrasound for treating acute perineal pa...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD000495

    authors: Hay-Smith EJ

    更新日期:2000-01-01 00:00:00

  • Intra-articular corticosteroid for knee osteoarthritis.

    abstract:BACKGROUND:Knee osteoarthritis is a leading cause of chronic pain, disability, and decreased quality of life. Despite the long-standing use of intra-articular corticosteroids, there is an ongoing debate about their benefits and safety. This is an update of a Cochrane review first published in 2005. OBJECTIVES:To deter...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD005328.pub3

    authors: Jüni P,Hari R,Rutjes AW,Fischer R,Silletta MG,Reichenbach S,da Costa BR

    更新日期:2015-10-22 00:00:00

  • Removal of nail polish and finger rings to prevent surgical infection.

    abstract:BACKGROUND:Surgical wound infections may be caused by the transfer of bacteria from the hands of surgical teams to patients during operations. Surgical scrubbing prior to surgery reduces the number of bacteria on the skin, but wearing rings and nail polish on the fingers may reduce the efficacy of scrubbing, as bacteri...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD003325.pub2

    authors: Arrowsmith VA,Taylor R

    更新日期:2012-05-16 00:00:00

  • Intravenous or intramuscular parecoxib for acute postoperative pain in adults.

    abstract:BACKGROUND:Parecoxib was the first COX-2 available for parenteral administration, and may, given intravenously or intramuscularly, offer advantages over oral medication when patients have nausea and vomiting or are unable to swallow, such as in the immediate postoperative period. OBJECTIVES:Assess the efficacy of sing...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD004771.pub4

    authors: Lloyd R,Derry S,Moore RA,McQuay HJ

    更新日期:2009-04-15 00:00:00

  • Single dose oral etoricoxib for acute postoperative pain in adults.

    abstract:BACKGROUND:Etoricoxib is a selective cyclo-oxygenase-2 (COX-2) inhibitor prescribed for the relief of chronic pain in osteoarthritis and rheumatoid arthritis, and acute pain. The drug is believed to be associated with fewer upper gastrointestinal adverse effects than conventional non-steroidal anti-inflammatory drugs (...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD004309.pub2

    authors: Clarke R,Derry S,Moore RA,McQuay HJ

    更新日期:2009-04-15 00:00:00

  • Home or foster home care versus institutional long-term care for functionally dependent older people.

    abstract:BACKGROUND:Changing population demographics have led to an increasing number of functionally dependent older people who require care and medical treatment. In many countries, government policy aims to shift resources into the community from institutional care settings with the expectation that this will reduce costs an...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD009844.pub2

    authors: Young C,Hall AM,Gonçalves-Bradley DC,Quinn TJ,Hooft L,van Munster BC,Stott DJ

    更新日期:2017-04-03 00:00:00

  • Linezolid versus vancomycin for skin and soft tissue infections.

    abstract:BACKGROUND:The morbidity and treatment costs associated with skin and soft tissue infections (SSTIs) are high. Linezolid and vancomycin are antibiotics that are commonly used in treating skin and soft-tissue infections, specifically those infections due to methicillin-resistant Staphylococcus aureus (MRSA). OBJECTIVES...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD008056.pub2

    authors: Yue J,Dong BR,Yang M,Chen X,Wu T,Liu GJ

    更新日期:2013-07-12 00:00:00

  • Continuous support for women during childbirth.

    abstract:BACKGROUND:Historically, women have generally been attended and supported by other women during labour. However, in hospitals worldwide, continuous support during labour has often become the exception rather than the routine. OBJECTIVES:The primary objective was to assess the effects, on women and their babies, of con...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章

    doi:10.1002/14651858.CD003766.pub6

    authors: Bohren MA,Hofmeyr GJ,Sakala C,Fukuzawa RK,Cuthbert A

    更新日期:2017-07-06 00:00:00

  • Lobeline for smoking cessation.

    abstract:BACKGROUND:Lobeline is a partial nicotine agonist, which has been used in a variety of commercially available preparations to help stop smoking. OBJECTIVES:The objective of this review was to assess the effects of lobeline on long term smoking cessation. SEARCH METHODS:We searched the Cochrane Tobacco Addiction Group...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD000124.pub2

    authors: Stead LF,Hughes JR

    更新日期:2012-02-15 00:00:00

  • Lay-led and peer support interventions for adolescents with asthma.

    abstract:BACKGROUND:Adolescents with asthma are at high risk of poor adherence with treatment. This may be compounded by activities that worsen asthma, in particular smoking. Additional support above and beyond routine care has the potential to encourage good self-management. We wanted to find out whether sessions led by their ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD012331.pub2

    authors: Kew KM,Carr R,Crossingham I

    更新日期:2017-04-19 00:00:00

  • Mobility management to prevent, reduce, or delay driving a car in teenagers.

    abstract:BACKGROUND:Rates of injury and death caused by car crashes with teenage drivers remain high in most high-income countries. In addition to injury and death, car use includes other non-traffic risks; these may be health-related, such as physical inactivity or respiratory disease caused by air pollution, or have global si...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章

    doi:10.1002/14651858.CD009438.pub2

    authors: Ward A,Lewis SR,Weiss H

    更新日期:2020-08-16 00:00:00

  • Prescription of prosthetic ankle-foot mechanisms after lower limb amputation.

    abstract:BACKGROUND:A correct prosthetic prescription can be derived from adapting the functional benefits of a prosthesis to the functional needs of the prosthetic user. For adequate matching, the functional abilities of the amputees are of value, as well as the technical and functional aspects of the various prosthetic ankle-...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD003978.pub2

    authors: Hofstad C,Linde H,Limbeek J,Postema K

    更新日期:2004-01-01 00:00:00

  • Cisapride treatment for gastro-oesophageal reflux in children.

    abstract:BACKGROUND:Gastro-oesophageal reflux (GOR) is an extremely common and usually self-limiting condition in infants. When treatment is required, Cisapride, a pro-kinetic agent, has been commonly prescribed for the symptomatic management of GOR. There have been recent reports of possibly serious adverse events, e.g. an inc...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD002300

    authors: Augood C,MacLennan S,Gilbert R,Logan S

    更新日期:2003-01-01 00:00:00

  • Fluticasone versus HFA-beclomethasone dipropionate for chronic asthma in adults and children.

    abstract:BACKGROUND:The relative efficacy of fluticasone (FP) and beclomethasone (BDP) propelled with CFCs has been well established. The potency of HFA-BDP is thought to have been improved with new propellant and some studies suggest that it may equipotent at half the dose of CFC propelled-BDP. There is a need to revisit this ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD005309.pub2

    authors: Lasserson TJ,Cates CJ,Jones AB,Steele EH,White J

    更新日期:2005-10-19 00:00:00