A mathematical model for pattern of change in beta-cell reserve and factors affecting residual reserve within the first 2 years of type 1 diabetes.

Abstract:

:The aim of this study was to investigate the effects of age, duration of diabetes, sex and ICA (Islet cell cytoplasmic antibody) on beta-cell reserves and to develop a model within the first 2 years of Type 1 diabetes. Beta-cell reserve is evaluated as fasting (FCp) and 1 mg i.v. glucagon stimulated C-peptide (SCp) levels in 58 Type 1 diabetics and in 12 normoglycemic subjects. Patients were divided into 3 groups according to duration of diabetes: Group I (2.5+/-0.3 weeks), Group II (13.4+/-1.2 months) and Group III (24.2+/-1.8 months). FCp/SCp level in nmol/l (mean+/-SE) were as follows. Group I: 0.21+/-0.02/0.38+/-0.04, Group II: 0.15+/-0.01/0.27+/-0.02, Group III: 0.07+/-0.01/0.11+/-0.02, CONTROL GROUP: 0.42+/-0.09/1.29+/-0.13. The scatter plots of C-peptide levels vs time in all the diabetic patients fitted in to a 4th-order polynomial regression (R: 0.96-0.98). Age was strongly correlated with FCp (rs: 0.46, p<0.05) and ICA positivity affected Cp-levels negatively (p>0.05). In conclusion, as the duration of diabetes increases, response time to glucagon prolongs and amplitude of it shortens. Duration of diabetes of less than 2 weeks, feminity, puberty and ICA positivity affect beta-cell reserve negatively, conversely, masculinity, post-puberty, older age and ICA negativity affect the reserve positively. The dynamics of C-peptide response to glucagon follow a mathematical model and Type 1 diabetes causes a decrease not only in the amplitude of the response but also in the duration of the response.

journal_name

J Endocrinol Invest

authors

Altuntas Y

doi

10.1007/BF03344073

keywords:

subject

Has Abstract

pub_date

2002-12-01 00:00:00

pages

987-92

issue

11

eissn

0391-4097

issn

1720-8386

pii

5790

journal_volume

25

pub_type

杂志文章
  • Hyperthyroidism due to familial pituitary resistance to thyroid hormone: successful control with 3, 5, 3' triiodothyroacetic associated to propranolol.

    abstract::We herein describe a family with thyroid hormone resistance. Thyroid hormones and basal TSH were elevated. Pituitary tumor or abnormality in thyroid hormone binding proteins were ruled out by appropriate tests. Mother and sister of the propositus presented similar abnormal hormonal features but no hyperthyroidism. Ini...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03347890

    authors: Aguilar Diosdado M,Escobar-Jimenez L,Fernandez Soto ML,Garcia Curiel A,Escobar-Jimenez F

    更新日期:1991-09-01 00:00:00

  • Achieving HbA1c targets in clinical trials and in the real world: a systematic review and meta-analysis.

    abstract:PURPOSE:To review the proportion of diabetic patients reaching recommended therapeutic goals, as reported in intervention trials and observational studies, and to analyse the factors associated with success or failure in achieving these targets. METHODS:A systematic review and meta-analysis through a Medline and Embas...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s40618-014-0069-6

    authors: Mannucci E,Monami M,Dicembrini I,Piselli A,Porta M

    更新日期:2014-05-01 00:00:00

  • Exercise-induced endocrine pathologies.

    abstract::There has been a substantial increase in women practicing sports over the past 30 yr. While exercise provides many health benefits, there appears to be a unique set of risks associated with intense exercise for the female athlete. The female athlete triad encompasses these risks, including amenorrhea, osteoporosis and...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.1007/BF03345238

    authors: Warren MP,Goodman LR

    更新日期:2003-09-01 00:00:00

  • Is serum C-reactive protein concentration correlated with HbA1c and insulin resistance in Type 2 diabetic men with or without coronary heart disease?

    abstract:BACKGROUND AND AIMS:C-reactive protein (CRP) is an inflammatory marker that predicts coronary heart disease (CHD) risk. Diabetes mellitus (DM) counts as a CHD risk equivalent. We aimed to compare serum high sensitivity CRP (hs-CRP) levels in Type 2 diabetic (T2DM) men without CHD, non-diabetic CHD patients and T2DM pat...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03345357

    authors: Bahceci M,Tuzcu A,Ogun C,Canoruc N,Iltimur K,Aslan C

    更新日期:2005-02-01 00:00:00

  • Decreased peak bone mass is associated with a 3-bp deletion/insertion of the CYP19 intron 4 polymorphism: preliminary data from the GOOS study.

    abstract::Finding that estrogen plays an important role in bone homeostasis in men prompted research on relationship of polymorphism at the CYP19 gene and the bone mass. Therefore, influence of 3-bp deletion/insertion polymorphism of CYP19 (TTTA)7 allele on the peak bone mass attainment in males was studied. Fifty-eight unrelat...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03346329

    authors: Kastelan D,Grubic Z,Kraljevic I,Duric K,Kardum I,Dusek T,Stingl K,Giljevic Z,Kerhin-Brkljacic V,Suchanek E,Korsic M

    更新日期:2007-06-01 00:00:00

  • Thyroid function evaluation by different commercially available free thyroid hormone measurement kits in term pregnant women and their newborns.

    abstract::Evaluation of thyroid status by measurement of free thyroid hormone concentrations seems particularly helpful in conditions with altered serum binding proteins. In pregnancy, a condition of increased thyroxine binding globulin, serum free thyroxine (FT4) and free triiodothyronine (FT3) concentrations have been reporte...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03350244

    authors: Roti E,Gardini E,Minelli R,Bianconi L,Flisi M

    更新日期:1991-01-01 00:00:00

  • GH replacement therapy and second neoplasms in adult survivors of childhood cancer: a retrospective study from a single institution.

    abstract:PURPOSE:Growth hormone deficiency (GHD) is the most common endocrine late effect observed in childhood cancer survivors (CCS) previously submitted to cranial irradiation. Radiation therapy can also increase the risk of second neoplasms (SNs). Since in previous studies GH replacement therapy was associated with increase...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-014-0179-1

    authors: Brignardello E,Felicetti F,Castiglione A,Fortunati N,Matarazzo P,Biasin E,Sacerdote C,Ricardi U,Fagioli F,Corrias A,Arvat E

    更新日期:2015-02-01 00:00:00

  • A rapid procedure for the quantitation of natriuretic peptide RNAs by competitive RT-PCR in congenital heart defects.

    abstract::We report an original application of quantitative reverse transcription-polymerase chain reaction (Q.RT-PCR) for the evaluation of atrial natriuretic factor (ANF), brain natriuretic peptide (BNP) and beta-actin mRNA in small atrial samples (10-15 mg). A fixed amount of total RNA was simultaneously reverse transcribed ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03343655

    authors: Iascone MR,Vittorini S,Collavoli A,Cupelli A,Kraft G,Biagini A,Clerico A

    更新日期:1999-12-01 00:00:00

  • Human medullary thyroid carcinoma in tissue culture; secretion of calcitonin and carcinoembryonic antigen.

    abstract::Monolayer cultures of medullary thyroid carcinoma (MTC) cells were prepared from 5 patients with familial and 4 with sporadic MTC. Basal calcitonin (CT) release decreased rapidly during 17 days in culture. Addition of extra calcium (2 mmol/l) or dibutyryl cyclic AMP (dBcAMP, 3 mmol/l) increased CT release in all inves...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03347169

    authors: Oosterom R,Verleun T,Bruining HA,Hackeng WH,Lamberts SW

    更新日期:1987-04-01 00:00:00

  • Effects of whole-body vibration exercise on the endocrine system of healthy men.

    abstract::Whole-body vibration is reported to increase muscle performance, bone mineral density and stimulate the secretion of lipolytic and protein anabolic hormones, such as GH and testosterone, that might be used for the treatment of obesity. To date, as no controlled trial has examined the effects of vibration exercise on t...

    journal_title:Journal of endocrinological investigation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF03351056

    authors: Di Loreto C,Ranchelli A,Lucidi P,Murdolo G,Parlanti N,De Cicco A,Tsarpela O,Annino G,Bosco C,Santeusanio F,Bolli GB,De Feo P

    更新日期:2004-04-01 00:00:00

  • CDY1 analysis in infertile patients with DAZ deletions.

    abstract::The DAZ (deleted in azoospermia) gene family is considered the major AZFc ("azoospermia factor" c) candidate responsible for male infertility. However, other genes have been recently mapped to this region and they could contribute to the AZFc phenotype. In particular, the testis-specific CDY1 (chromadomain protein 1) ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03343814

    authors: Ferlin A,Moro E,Rossi A,Foresta C

    更新日期:2001-02-01 00:00:00

  • Beyond waist circumference in an adult male population of Southern Italy: Is there any role for subscapular skinfold thickness in the relationship between insulin-like growth factor-I system and metabolic parameters?

    abstract:BACKGROUND:Apart from waist circumference, other adiposity measures, such as subscapular skin fold (SST), arouse growing interest due to their relationship to metabolic complications and cardiovascular risk. The IGF-I system is deregulated in obese subjects in proportion to their degree of visceral adiposity. AIM:To e...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.3275/8511

    authors: Savastano S,Barbato A,Di Somma C,Guida B,Pizza G,Barrea L,Avallone S,Schiano di Cola M,Strazzullo P,Colao A

    更新日期:2012-11-01 00:00:00

  • Adult subjects with Prader-Willi syndrome show more low-grade systemic inflammation than matched obese subjects.

    abstract:AIM:Adult subjects with Prader-Willi syndrome (PWS) may show several conditions that are associated with an activation of innate immunity such as obesity, deficient GH secretion or hypogonadism. Our aim was to study whether obese adult PWS subjects show an additional low-grade systemic inflammation (LGSI) in relation t...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03345585

    authors: Caixàs A,Giménez-Palop O,Broch M,Vilardell C,Megía A,Simón I,Giménez-Pérez G,Mauricio D,Vendrell J,Richart C,González-Clemente JM

    更新日期:2008-02-01 00:00:00

  • The triglycerides and glucose index is associated with cardiovascular risk factors in metabolically obese normal-weight subjects.

    abstract:PURPOSE:The aim of this study was to determine whether the triglycerides and glucose (TyG) index is associated with the presence of metabolically obese normal-weight (MONW) phenotype and related cardiovascular risk factors. METHODS:Apparently healthy men and non-pregnant women aged 20-65 years were enrolled in a popul...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-020-01184-x

    authors: Morales-Gurrola G,Simental-Mendía LE,Castellanos-Juárez FX,Salas-Pacheco JM,Guerrero-Romero F

    更新日期:2020-07-01 00:00:00

  • Comparison of histopathological features and prognosis of classical and follicular variant papillary thyroid carcinoma.

    abstract:PURPOSE:To compare the histopathological features and the outcomes of the follicular variant and classical variant of papillary thyroid carcinoma. MATERIAL AND THE METHODS:Demographic data, histopathological features (tumor size, thyroid capsule invasion, extrathyroidal extension, vascular invasion and multicentricity...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-015-0376-6

    authors: Tunca F,Sormaz IC,Iscan Y,Senyurek YG,Terzioglu T

    更新日期:2015-12-01 00:00:00

  • Thyroid, hemostasis and thrombosis.

    abstract::The aim of this paper is to briefly review some practical aspects of the relationship between thyroid function and several disorders of the hemostatic system in terms of bleeding and thrombosis. Thrombocytopenia, acquired hemophilia, hypercoagulability, cardioembolism and other biochemical coagulative and fibrinolytic...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.1007/BF03345311

    authors: Marongiu F,Cauli C,Mariotti S

    更新日期:2004-12-01 00:00:00

  • P53 mutations in thyroid carcinoma: tidings from an old foe.

    abstract::The underlying mechanism leading to carcinogenesis involves genomic instability, likely related to aneuploidy. While p53 as a "guardian of the genome" is an appealing candidate as an initiator of genomic instability, its mutations or deletions usually occur late in the course of tumor progression. P53 may, however, be...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.1007/BF03343889

    authors: Farid NR

    更新日期:2001-07-01 00:00:00

  • Structure-function correlations of growth hormone or/and prolactin-producing pituitary adenomas: an in vitro study with the reverse hemolytic plaque assay.

    abstract::The purpose of this study was to detect in vitro growth hormone (GH) and prolactin (PRL) secretion from adenomas clinically associated with GH or PRL hypersecretion. The reverse hemolytic plaque assay (RHPA) was applied in order to reveal possible differences among various morphologic adenoma types, and to examine the...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03343628

    authors: Thodou E,Kontogeorgos G,Kyrodimou E,Salla H,Ramyar L,Vamvassakis E,Piaditis G,Anagnostopoulos N,Tzanis S,Levedis A,Rologis D,Asa SL

    更新日期:1999-10-01 00:00:00

  • Role of serotoninergic receptors in gonadotropin secretion in male rats.

    abstract::Experimental data concerning the role of serotonin (5-HT) in the control of gonadotropins secretion remain controversial: different receptors subtypes should mediate the serotoninergic action. In the present work we analyzed in prepubertal and adult male rats the FSH and LH responses after administration of the follow...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03347993

    authors: Pinilla L,Tena-Sempere M,Aguilar E

    更新日期:1997-07-01 00:00:00

  • Radioiodine therapy of metastatic lesions of differentiated thyroid cancer.

    abstract::Seventy years after the first successful radioiodine treatment of metastatic differentiated thyroid cancer (DTC), radioiodine (131I) therapy for this type of tumor is still without alternative. During the last decade, some key issues such as individual dosimetry, and preparation of 131I therapy by recombinant human TS...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:

    authors: Luster M,Hänscheid H,Freudenberg LS,Verburg FA

    更新日期:2012-01-01 00:00:00

  • Therapeutic effects of obeticholic acid (OCA) treatment in a bleomycin-induced pulmonary fibrosis rat model.

    abstract:PURPOSE:We recently demonstrated a protective effect of the farnesoid X receptor agonist obeticholic acid (OCA) in rat models of bleomycin-induced pulmonary fibrosis (PF). Aim of the present study was to investigate whether the positive effects of OCA treatment are apparent also on ongoing bleomycin-induced PF, i.e., a...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-018-0913-1

    authors: Comeglio P,Filippi S,Sarchielli E,Morelli A,Cellai I,Corno C,Pini A,Adorini L,Vannelli GB,Maggi M,Vignozzi L

    更新日期:2019-03-01 00:00:00

  • Prolactin secretion in idiopathic hypogonadotropic hypogonadism during pulsatile luteinizing hormone-releasing hormone long-term administration.

    abstract::Recent data seem to suggest that LHRH may be involved in the modulation of PRL secretion. We studied the PRL pattern in 9 males (age range 18-38 yr) with idiopathic hypogonadotropic hypogonadism (IHH) before and during long-term pulsatile LHRH therapy (120-160 ng/kg bw every 120 min sc) in order to evaluate variations...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03350751

    authors: Giusti M,Traverso L,Cavagnaro P,Torre R,Durante R,Giordano G

    更新日期:1989-09-01 00:00:00

  • Four year treatment with a long acting somatostatin analogue in a patient with Verner-Morrison syndrome.

    abstract::The case is described of a woman with a Verner-Morrison syndrome of extreme severity, caused by an occult VIPoma. Administration of SMS 201-995 (Sandoz) (SMS) at the dose of 150 and subsequently of 250 micrograms daily, decreased plasma levels of vasoactive intestinal polypeptide (VIP) from about 500 to 100 pg/ml (hig...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03347894

    authors: Brunani A,Crespi C,De Martin M,Dubini A,Piolini M,Cavagnini F

    更新日期:1991-09-01 00:00:00

  • Effects of PCSK9 inhibitors on LDL cholesterol, cardiovascular morbidity and all-cause mortality: a systematic review and meta-analysis of randomized controlled trials.

    abstract:BACKGROUND AND AIMS:Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors determine a wide reduction of LDL cholesterol, greater than other lipid-lowering agents. The present meta-analysis is aimed at the assessment of PCSK9 inhibitors effect on LDL Cholesterol, cardiovascular morbidity and all-cause mortali...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,meta分析

    doi:10.1007/s40618-019-01019-4

    authors: Dicembrini I,Giannini S,Ragghianti B,Mannucci E,Monami M

    更新日期:2019-09-01 00:00:00

  • Expression and ligand binding of bombesin receptors in pulmonary and intestinal carcinoids.

    abstract:INTRODUCTION:Carcinoids are mainly found in the gastrointestinal (65%) and bronchopulmonary tract (25%). These neuroendocrine tumors secrete a wide range of bioactive peptides, including gastrin releasing peptide and neuromedin B, the mammalian analogs of bombesin. The purpose of this study was to investigate the quant...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.3275/7332

    authors: Kuiper P,Verspaget HW,Biemond I,de Jonge-Muller ES,van Eeden S,van Velthuysen ML,Taal BG,Lamers CB

    更新日期:2011-10-01 00:00:00

  • Resistance to somatostatin analogs in acromegaly: an evolving concept?

    abstract::The aim of acromegaly treatment is to control the disease by suppressing GH hyperactivity and reducing the size or impeding the growth of the pituitary GH secreting mass. Over recent years, many studies have emphasized the role of SS analogs in the treatment of acromegaly. In fact, SS analogs have been demonstrated to...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.1007/BF03349183

    authors: Gola M,Bonadonna S,Mazziotti G,Amato G,Giustina A

    更新日期:2006-01-01 00:00:00

  • Effect of exposure to the altitude of 300 meters below sea-level on testosterone, luteinizing hormone, follicle-stimulating hormone and prolactin in man.

    abstract::Serum testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH) and prolactin (PRL) responses to exposure to sea-level altitude (LA) were examined in 13 eugonadal males, age 21-22 yr, 3 and 5 days after residing at LA and on the second day of return to basal altitude 90 days later. After 3 days at the...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03350195

    authors: Ajlouni KM,Sliman NA,Najdawi A,Abu-Hajir MM,Arnaout MA

    更新日期:1988-09-01 00:00:00

  • Lack of effect of the dopamine D1 antagonist, NNC 01-0687, on unstimulated and stimulated release of anterior pituitary hormones in males.

    abstract::Dopamine in humans inhibits the secretion of luteinizing hormone (LH), follicular stimulating hormone (FSH), thyroid stimulating hormone (TSH) and prolactin (PRL), and is a stimulator of growth hormone (GH) secretion. Dopamine-D1 receptor stimulation with fenoldopam increases basal PRL levels, suppresses TSH, and incr...

    journal_title:Journal of endocrinological investigation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF03350331

    authors: Grodum E,Andersen M,Hangaard J,Koldkjaer O,Hagen C

    更新日期:1998-05-01 00:00:00

  • Correction to: EStradiol and PRogesterone in In vitro ferTilization (ESPRIT): a multicenter study evaluating third‑ versus second‑generation estradiol and progesterone immunoassays.

    abstract::The article "EStradiol and PRogesterone in In vitro ferTilization (ESPRIT): a multicenter study evaluating third‑ versus second‑generation estradiol and progesterone immunoassays. ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s40618-020-01295-5

    authors: Polyzos NP,Anckaert E,Drakopoulos P,Tournaye H,Schiettecatte J,Donner H,Bobba G,Miles G,Verhagen-Kamerbeek WDJ,Bosch E

    更新日期:2020-09-01 00:00:00

  • False-positive diagnosis of adrenal pheochromocytoma on iodine-123-MIBG scan.

    abstract::1-123 metaiodobenzylguanidine (1-123 MIBG) scintigraphy is known for its high specificity in detecting pheochromocytoma and other tumors of neural crest origin. In this rare case report, we describe a definite adrenocortical adenoma that demonstrated false-positive uptake at I-123 MIBG scintigraphy and a remarkable ac...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348046

    authors: Letizia C,De Toma G,Massa R,Corsi A,Caliumi C,Subioli S,D'Erasmo E

    更新日期:1998-12-01 00:00:00