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Intrafractional relationship changes between an external breathing signal and fiducial marker positions in pancreatic cancer patients.

Abstract：

BACKGROUND AND PURPOSE:The purpose of this study of pancreatic cancer patients treated with respiratory-guided stereotactic body radiotherapy (SBRT) on a standard linac was to investigate (a) the intrafractional relationship change (IRC) between a breathing signal and the tumor position, (b) the impact of IRC on the delivered dose, and (c) potential IRC predictors. MATERIALS AND METHODS:We retrospectively investigated 10 pancreatic cancer patients with 2-4 implanted fiducial markers in the tumor treated with SBRT. Fluoroscopic images were acquired before and after treatment delivery simultaneously with the abdominal breathing motion. We quantified the IRC as the change in fiducial location for a given breathing amplitude in the left-right (LR), anterior-posterior (AP), and superior-inferior (SI) directions from before to after treatment delivery. The treatment plans were re-calculated after changing the isocenter coordinates according to the IRCs. Four treatment- or patient-related factors were investigated as potential predictors for IRC using linear models. RESULTS:The average (±1 SD) absolute IRCs in the LR, AP, and SI directions were 1.2 ± 1.2 mm, 0.7 ± 0.7 mm, and 1.1 ± 0.8 mm, respectively. The average 3D IRC was 2.0 ± 1.3 mm (range: 0.4-5.3 mm) for a median treatment delivery time of 8.5 min (range: 5.7-19.9 min; n = 31 fractions). The dose coverage of the internal target volume (ITV) decreased by more than 3% points in three of 31 fractions. In those cases, the 3D IRC had been larger than 4.3 mm. The 3D IRC was found to correlate with changes in the minimum breathing amplitude during treatment delivery. CONCLUSION:On average, 2 mm of treatment delivery accuracy was lost due to IRC. Periodical intrafractional imaging is needed to safely deliver respiratory-guided SBRT.

journal_name

J Appl Clin Med Phys

journal_title

Journal of applied clinical medical physics

authors

Pettersson N,Oderinde OM,Murphy J,Simpson D,Cerviño LI

doi

10.1002/acm2.12841

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

153-161

issue

issn

1526-9914

journal_volume

pub_type

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Intrafractional relationship changes between an external breathing signal and fiducial marker positions in pancreatic cancer patients.