Abstract:
BACKGROUND:This study was undertaken with the objective of comparing efficacy and safety for two different regimens using misoprostol for induction of labour. METHODS:The study was set in two different hospitals in the region of Zeeland, Denmark, and designed as a prospective cohort study. Nulliparous women with unripe cervix, eligible for vaginal delivery and medical induction of labour were included. Exclusion criteria were a previous uterine scar, suspicion of growth restriction of the fetus and prelabour rupture of membranes. One department used 25 mcg oral misoprostol tablets and the other department used 200 mcg slow-release misoprostol vaginal insert, for induction of labour. Primary outcomes were predefined as frequency of cesarean section, tachysystole and delivery within 24 h. Secondary outcomes were: time from induction to delivery, use of additional methods for induction, postpartum hemorrhage, anal sphincter rupture, epidural, pyrexia (rectal temperature > 38.5 °C), prolonged rupture of membranes, and use of tocolysis. RESULTS:No significant differences in women achieving vaginal delivery was found. However, a significantly increased risk of tachysystole for the vaginal administration route was observed; 28.4% compared with 2.3%. There were no events of serious neonatal asphyxia. Half of the women induced with vaginal insert delivered within 24 h, compared with 16.8% of the women induced with oral misoprostol. CONCLUSIONS:Induction with vaginal slow-release misoprostol leads to quicker delivery with an increased risk of tachysystole but with similar perinatal outcomes and rates of cesarean sections. Low-dose oral misoprostol appears to be safe, however it leads to an increased use of secondary methods and a tendency of more intrapartum pyrexia. TRIAL REGISTRATION:Clinicaltrials.gov ID: NCT02693587 on February 262,016. EudraCT number 2020-000366-42 on 23 January 2020, retrospectively registered.
journal_name
BMC Pregnancy Childbirthjournal_title
BMC pregnancy and childbirthauthors
Eriksson A,Jeppesen S,Krebs Ldoi
10.1186/s12884-020-2770-0subject
Has Abstractpub_date
2020-02-07 00:00:00pages
79issue
1issn
1471-2393pii
10.1186/s12884-020-2770-0journal_volume
20pub_type
杂志文章abstract:BACKGROUND:Access factors associated with maternal death are important to understand because they are considered to be an essential measure of women's health and indicative of the performance of health care systems in any community globally. This study aimed to analyse the access risk factors linked to maternal deaths ...
journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章
doi:10.1186/s12884-018-1717-1
更新日期:2018-04-16 00:00:00
abstract:BACKGROUND:To investigate the effect of different delivery modes and related obstetric factors on the short-term strength of the pelvic floor muscle after delivery in Chinese primipara. METHODS:A total of 4769 healthy Chinese primiparas at postpartum 6-8 weeks were interviewed. According to the difference of delivery ...
journal_title:BMC pregnancy and childbirth
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journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章,随机对照试验
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更新日期:2009-01-05 00:00:00
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journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章,评审
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journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章,随机对照试验
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abstract:BACKGROUND:Postpartum depression (PPD) is a mood disorder that affects 10-20 percent of women, and can begin any time during first year after delivery lasting for months. Social support may decrease risk of depression during pregnancy for women. However, literature shows that the amount of social support received durin...
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journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章,多中心研究,随机对照试验
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abstract::Following publication of the original article [1], we have been notified that there is a missing conflict of interest. ...
journal_title:BMC pregnancy and childbirth
pub_type: 已发布勘误
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更新日期:2020-04-17 00:00:00
abstract:BACKGROUND:Although a number of antenatal and intrapartum interventions have shown some evidence of impact on stillbirth incidence, much confusion surrounds ideal strategies for delivering these interventions within health systems, particularly in low-/middle-income countries where 98% of the world's stillbirths occur....
journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章,meta分析,评审
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journal_title:BMC pregnancy and childbirth
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journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章,随机对照试验
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更新日期:2008-05-30 00:00:00
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journal_title:BMC pregnancy and childbirth
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更新日期:2020-05-20 00:00:00
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journal_title:BMC pregnancy and childbirth
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doi:10.1186/s12884-017-1551-x
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abstract:BACKGROUND:A Melbourne (Australia) university affiliated, tertiary obstetric hospital provides lay and professional education about influenza vaccine in pregnancy annually each March, early in the local influenza season. Responding to a 2011 survey of new mothers' opinions, the hospital made influenza vaccine freely av...
journal_title:BMC pregnancy and childbirth
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doi:10.1186/s12884-015-0486-3
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journal_title:BMC pregnancy and childbirth
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更新日期:2020-09-23 00:00:00
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journal_title:BMC pregnancy and childbirth
pub_type: 临床试验,杂志文章
doi:10.1186/s12884-015-0515-2
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abstract:BACKGROUND:Postpartum hemorrhage remains the leading cause of maternal morbidity and mortality worldwide. Few population-based studies have examined the epidemiology of massive transfusion for postpartum hemorrhage. The aim of this study was to determine the incidence, management, and outcomes of women with postpartum ...
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pub_type: 杂志文章
doi:10.1186/s12884-017-1384-7
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abstract:BACKGROUND:In high-income countries, the incidence of severe postpartum hemorrhage (PPH) has increased. This has important public health relevance because severe PPH is a leading cause of major maternal morbidity. However, few studies have identified risk factors for severe PPH within a contemporary obstetric cohort. ...
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journal_title:BMC pregnancy and childbirth
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更新日期:2008-02-25 00:00:00
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journal_title:BMC pregnancy and childbirth
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更新日期:2019-01-14 00:00:00
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journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章,评审
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更新日期:2016-02-29 00:00:00
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journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2018-11-01 00:00:00
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journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章
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更新日期:2018-05-31 00:00:00
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journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章
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更新日期:2017-12-20 00:00:00
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journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章
doi:10.1186/s12884-020-03112-6
更新日期:2020-07-29 00:00:00
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journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章,随机对照试验
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更新日期:2013-09-05 00:00:00