A potential new mechanism for pregnancy loss: considering the role of LINE-1 retrotransposons in early spontaneous miscarriage.

abstract：BACKGROUND:hCG is a wonder. Firstly, because hCG is such an extreme molecule. hCG is the most acidic glycoprotein containing the highest proportion of sugars. Secondly, hCG exists in 5 common forms. Finally, it has so many functions ranging from control of human pregnancy to human cancer. This review examines these mol...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Cole LA

更新日期：2012-03-28 00:00:00

abstract：:Endometrial carcinoma is the most common neoplasm of the female genital tract, accounting for nearly one half of all gynecologic cancers in the Western world. Although intensive research on pathological phenomena of endometrial cancer is currently going on, but exact cause and biological aspects of this disease are no...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Park DW,Choi KC,MacCalman CD,Leung PC

更新日期：2009-08-05 00:00:00

abstract：BACKGROUND:Polo-like kinase 1 (Plk1), as a characteristic regulator in meiosis, organizes multiple biological events of cell division. Although Plk1 has been implicated in various functions in somatic cell mitotic processes, considerably less is known regarding its function during the transition from metaphase I (MI) t...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Zhang Z,Chen C,Ma L,Yu Q,Li S,Abbasi B,Yang J,Rui R,Ju S

更新日期：2017-08-29 00:00:00

abstract：BACKGROUND:Age at menarche is the reflection of cumulative pre-adolescent exposure of girls to either adverse environment such as food insecurity or affluent living conditions. Food insecurity could result in inadequate nutrient intake and stress, both of which are hypothesized to have opposing effects on the timing of...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Belachew T,Hadley C,Lindstrom D,Getachew Y,Duchateau L,Kolsteren P

更新日期：2011-09-13 00:00:00

abstract：:Macaques are menstruating nonhuman primates that provide important animal models for studies of hormonal regulation in the uterus. In women and macaques the decline of progesterone (P) at the end of the cycle triggers endometrial expression of a variety of matrix metalloproteinase (MMP) enzymes that participate in tis...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Slayden OD,Brenner RM

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:In animals, low levels of vitamin D are associated with estrus cycle disturbances, but there are virtually no human data. We examined the association of 25-hydroxyvitamin D (25(OH)D) (a biomarker for vitamin D status) with menstrual cycle characteristics. METHODS:Women aged 35-44 were randomly selected from...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Jukic AM,Steiner AZ,Baird DD

更新日期：2015-03-11 00:00:00

abstract：BACKGROUND:The World Health Organization (WHO) international body mass index (BMI) cut-off points defining pre-pregnancy BMI categories in the Institute of Medicine (IOM) guidelines are not directly applicable to Asians. We aimed to define the optimal gestational weight gain (GWG) for the Korean population based on Asi...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Choi SK,Lee G,Kim YH,Park IY,Ko HS,Shin JC

更新日期：2017-08-22 00:00:00

abstract：BACKGROUND:Dehydroepinadrosterone (DHEA) supplementation improves pregnancy chances in women with diminished ovarian reserve (DOR), by possibly reducing aneuploidy. Since a large majority of spontaneous miscarriages are associated with aneuploidy, one can speculate that DHEA supplementation may also reduce miscarriage ...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Gleicher N,Ryan E,Weghofer A,Blanco-Mejia S,Barad DH

更新日期：2009-10-07 00:00:00

abstract：BACKGROUND:Nomegestrol acetate (NOMAC), a synthetic progestogen derived from 19-nor-progesterone, recently completed clinical trials for use with 17beta-estradiol in a new monophasic combined oral contraceptive. In this review, published as well as previously unpublished preclinical studies that detail the effects of N...

journal_title：Reproductive biology and endocrinology : RB&E

authors： van Diepen HA

更新日期：2012-10-08 00:00:00

abstract：:Cloning by nuclear transfer using mammalian somatic cells has enormous potential application. However, somatic cloning has been inefficient in all species in which live clones have been produced. High abortion and fetal mortality rates are commonly observed. These developmental defects have been attributed to incomple...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Tian XC,Kubota C,Enright B,Yang X

更新日期：2003-11-13 00:00:00

abstract：BACKGROUND:High levels of dopamine (DA) were described in human ovary and recently evidence for DA receptors in granulosa and luteal cells has been provided, as well. However, neither the full repertoire of ovarian receptors for DA, nor their specific role, is established. Human granulosa cells (GCs) derived from women...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Rey-Ares V,Lazarov N,Berg D,Berg U,Kunz L,Mayerhofer A

更新日期：2007-10-25 00:00:00

abstract：BACKGROUND:Density gradient is the preferred technique for sperm processing for ART. However, no study has examined sperm quality using different processing media simultaneously and under identical conditions. Therefore, we evaluated semen quality following sperm preparation by three commonly used commercially availabl...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Malvezzi H,Sharma R,Agarwal A,Abuzenadah AM,Abu-Elmagd M

更新日期：2014-12-02 00:00:00

abstract：BACKGROUND:Human uterine leiomyoma (fibroids; LYO) are the most common benign neoplasms in reproductive-aged women. Dysregulated extracellular matrix and irregular LYO reversion-inducing cysteine-rich protein with Kazal motifs (RECK) expression are thought to be mediated by aberrant microRNA (miR) expression. The relat...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Guan Y,Guo L,Zukerberg L,Rueda BR,Styer AK

更新日期：2016-08-17 00:00:00

abstract：BACKGROUND:Ovarian follicle growth and maturation requires extensive communication between follicular somatic cells and oocytes. Recently, intercellular cell communication was described involving cell-secreted vesicles called exosomes (50-150 nm), which contain miRNAs and protein, and have been identified in ovarian fo...

journal_title：Reproductive biology and endocrinology : RB&E

authors： da Silveira JC,Carnevale EM,Winger QA,Bouma GJ

更新日期：2014-05-26 00:00:00

abstract：BACKGROUND:Nucleotide-binding oligomerization domain (NACHT), leucine rich repeat (LRR) and pyrin domain (PYD) 7 containing protein, NLRP7, is a member of the NLR family which serves as innate immune sensors. Mutations and genetic variants of NLRP7 have been found in women with infertility associated conditions, such a...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Huang JY,Yu PH,Li YC,Kuo PL

更新日期：2017-08-15 00:00:00

abstract：BACKGROUND:Patients hoping to preserve their fertility receive conservative treatment with high-dose medroxyprogesterone acetate (MPA) for well-differentiated endometrioid adenocarcinoma (EC) or atypical endometrial hyperplasia (AEH) . Such treatment generally involves frequent intrauterine operations, including dilati...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Inoue O,Hamatani T,Susumu N,Yamagami W,Ogawa S,Takemoto T,Hirasawa A,Banno K,Kuji N,Tanaka M,Aoki D

更新日期：2016-01-15 00:00:00

abstract：BACKGROUND:Spermatozoa are extremely vulnerable to oxidative stress caused by the unbalance between concentrations of reactive oxygen species and antioxidant scavenging systems present inside the male reproductive tract. In spite of a large number of clinical studies that claimed the beneficial effects of antioxidant o...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Talevi R,Barbato V,Fiorentino I,Braun S,Longobardi S,Gualtieri R

更新日期：2013-08-16 00:00:00

abstract：BACKGROUND:Pregnancy-associated plasma protein-A2 (PAPP-A2) is consistently upregulated in the placentae of pregnancies complicated by preeclampsia and fetal growth restriction. The causes and significance of this upregulation remain unknown, but it has been hypothesized that it is a compensatory response to improve pl...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Christians JK,Lennie KI,Huicochea Munoz MF,Binning N

更新日期：2018-06-12 00:00:00

abstract：:Transient receptor potential cation channel, subfamily V, member 6 (TRPV6) is an epithelial Ca2+ channel protein expressed in calcium absorbing organs. In the present study, we investigated the expression and regulation of uterine and placental TRPV6 during gestation in rodents. Uterine TRPV6 peaked at pregnancy day (...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Lee BM,Lee GS,Jung EM,Choi KC,Jeung EB

更新日期：2009-05-21 00:00:00

abstract：BACKGROUND:Spontaneous abortion is one of the most common complications in early pregnancy. A preventive test to identify women who will experience a miscarriage, even before first symptoms occur, is not established. Activation of maternal immunological tolerance seems to be essential for early fetal development and va...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Freis A,Schlegel J,Daniel V,Jauckus J,Strowitzki T,Germeyer A

更新日期：2018-09-28 00:00:00

abstract：BACKGROUND:Endocrine mechanisms governing canine reproductive function remain still obscure. Progesterone (P4) of luteal origin is required for maintenance of pregnancy. Corpora lutea (CL) are gonadotrop-independent during the first third of dioestrus; afterwards prolactin (PRL) is the primary luteotropic factor. Inter...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Kowalewski MP,Michel E,Gram A,Boos A,Guscetti F,Hoffmann B,Aslan S,Reichler I

更新日期：2011-08-03 00:00:00

abstract：BACKGROUND:Septate uterus, one of the most common forms of congenital uterine malformations, negatively affects female reproductive health. METHODS:In a retrospective cohort study, we evaluated the reproductive outcome after hysteroscopic septoplasty in 64 women with septate uterus and primary or secondary infertility...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Nouri K,Ott J,Huber JC,Fischer EM,Stögbauer L,Tempfer CB

更新日期：2010-05-21 00:00:00

abstract：BACKGROUND:Considering that clinical trial studies are limited in polycystic ovary syndrome (PCOS) patients, and there is no consensus on an optimum endometrial preparation protocol for frozen embryo transfer (FET), the present study was designed as a randomized clinical trial to compare the reproductive outcomes follo...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Hosseini-Najarkolaei A,Moini A,Kashani L,Farid Mojtahedi M,Hosseini-Najarkolaee E,Salehi E

更新日期：2020-11-20 00:00:00

abstract：:The adaptive immune system of placental mammals has evolved to tolerate the fetus. Rejection of the fetus by adaptive immune responses is therefore a rare event, with abortion being caused more frequently by inflammation in the placenta. This review will cover recent aspects of immune privilege and the innate immune s...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Kanellopoulos-Langevin C,Caucheteux SM,Verbeke P,Ojcius DM

更新日期：2003-12-02 00:00:00

abstract：BACKGROUND:New anticancer treatments have increased survival rates for cancer patients, but often at the cost of sterility. Several strategies are currently available for preserving fertility. However, the chances of achieving a pregnancy with one technique are still limited. A combination of methods is therefore recom...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Dittrich R,Lotz L,Mueller A,Hoffmann I,Wachter DL,Amann KU,Beckmann MW,Hildebrandt T

更新日期：2013-03-05 00:00:00

abstract：BACKGROUND:To examine the effects of IVF, ICSI and FET, as well as in vitro culture, on the safety of offspring, this study was conducted from the perspective of genetic imprinting to investigate whether assisted reproductive technology would influence the parental and maternal imprinting genes. METHODS:Eighteen foetu...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Ji M,Wang X,Wu W,Guan Y,Liu J,Wang J,Liu W,Shen C

更新日期：2018-07-05 00:00:00

abstract：BACKGROUND:hCG is a term referring to 4 independent molecules, each produced by separate cells and each having completely separate functions. These are hCG produced by villous syncytiotrophoblast cells, hyperglycosylated hCG produced by cytotrophoblast cells, free beta-subunit made by multiple primary non-trophoblastic...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Cole LA

更新日期：2010-08-24 00:00:00

abstract：BACKGROUND:The synthesis of sex steroids is controlled by several enzymes such as17α-hydroxylase cytochrome P450 (P450c17) catalyzing androgen synthesis and aromatase cytochrome P450 (P450arom) catalyzing estrogen synthesis, both of which must complex with the redox partner NADPH-cytochrome P450 oxidoreductase (CPR) fo...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Dos Santos AC,Conley AJ,de Oliveira MF,Oliveira GB,Viana DC,Assis Neto AC

更新日期：2017-04-24 00:00:00

abstract：BACKGROUND:The placenta is an essential organ that provides nutrients and oxygen to the developing fetus and removes toxic waste products from the fetal circulation. Maintaining placental blood osmotic pressure and blood flow is crucial for viable offspring. The renin-angiotensin system (RAS) in the placenta is a key p...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Vaswani K,Chan HW,Verma P,Dekker Nitert M,Peiris HN,Wood-Bradley RJ,Armitage JA,Rice GE,Mitchell MD

更新日期：2015-08-12 00:00:00

abstract：BACKGROUND:Polycystic ovary syndrome (PCOS) has been recognized as a metabolic disorder, manifested by abdominal obesity, insulin resistance, dyslipidemia and hypertension. Pigment epithelium-derived factor (PEDF), a member of the serine protease inhibitor family, is a pleiotropic protein known for its antiangiogenic, ...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Lecke SB,Morsch D,Spritzer PM

更新日期：2013-08-14 00:00:00