Abstract:
BACKGROUND:Astragaloside IV (AS-IV) was reported to play a role in improving diabetic nephropathy (DN), however, the underlying mechanisms still remain unclear. The aim of the present study is to investigate whether AS-IV ameliorates DN via the regulation of endothelial nitric oxide synthase (eNOS). METHODS:DN model was induced in Sprague-Dawley (SD) male rats by intraperitoneal injection of 65 mg/kg streptozotocin (STZ). Rats in the AS-IV treatment group were orally gavaged with 5 mg/kg/day or 10 mg/kg/day AS-IV for eight consecutive weeks. Body weight, blood glucose, blood urea nitrogen (BUN), Serum creatinine (Scr), proteinuria and Glycosylated hemoglobin (HbA1c) levels were measured. Hematoxylin-Eosin (HE) and Periodic Acid-Schiff (PAS) staining were used to detect the renal pathology. The apoptosis status of glomerular cells was measured by TUNEL assay. The phosphorylation and acetylation of eNOS were detected by western blot. The effects of AS-IV on high-glucose (HG)-induced apoptosis and eNOS activity were also investigated in human renal glomerular endothelial cells (HRGECs) in vitro. RESULTS:Treatment with AS-IV apparently reduced DN symptoms in diabetic rats, as evidenced by reduced BUN, Scr, proteinuria, HbA1c levels and expanding mesangial matrix. AS-IV treatment also promoted the synthesis of nitric oxide (NO) in serum and renal tissues and ameliorated the phosphorylation of eNOS at Ser 1177 with decreased eNOS acetylation. Moreover, HG-induced dysfunction of HRGECs including increased cell permeability and apoptosis, impaired eNOS phosphorylation at Ser 1177, and decreased NO production, were all reversed by AS-IV treatment. CONCLUSIONS:These novel findings suggest that AS-IV ameliorates functional abnormalities of DN through inhibiting acetylation of eNOS and activating its phosphorylation at Ser 1177. AS-IV could be served as a potential therapeutic drug for DN.
journal_name
BMC Complement Altern Medjournal_title
BMC complementary and alternative medicineauthors
Fan Y,Fan H,Zhu B,Zhou Y,Liu Q,Li Pdoi
10.1186/s12906-019-2728-9subject
Has Abstractpub_date
2019-12-05 00:00:00pages
355issue
1issn
1472-6882pii
10.1186/s12906-019-2728-9journal_volume
19pub_type
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journal_title:BMC complementary and alternative medicine
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abstract:BACKGROUND:Morus alba, a medicinal plant in Asia, has been used traditionally to treat diabetes mellitus and hypoglycemia. However, the effects of M. alba extract (MAE) on atopic dermatitis have not been verified scientifically. We investigated the effects of MAE on atopic dermatitis through in vitro and in vivo experi...
journal_title:BMC complementary and alternative medicine
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更新日期:2014-10-07 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
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更新日期:2013-09-05 00:00:00
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journal_title:BMC complementary and alternative medicine
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pub_type: 杂志文章
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更新日期:2014-06-30 00:00:00
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pub_type: 杂志文章
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更新日期:2016-08-31 00:00:00
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journal_title:BMC complementary and alternative medicine
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更新日期:2018-06-07 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12906-015-0698-0
更新日期:2015-06-25 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2017-07-03 00:00:00
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更新日期:2015-08-29 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2013-11-07 00:00:00
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journal_title:BMC complementary and alternative medicine
pub_type: 杂志文章
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更新日期:2016-07-26 00:00:00
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pub_type: 杂志文章
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更新日期:2017-01-19 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2018-06-15 00:00:00