当前位置： SCI文献检索 > RESPIRATORY RESEARCH期刊下所有文献 > Determination of rheology and surface tension of airway surface liquid: a review of clinical relevance and measurement techniques.

Determination of rheology and surface tension of airway surface liquid: a review of clinical relevance and measurement techniques.

Abstract：

:By airway surface liquid, we mean a thin fluid continuum consisting of the airway lining layer and the alveolar lining layer, which not only serves as a protective barrier against foreign particles but also contributes to maintaining normal respiratory mechanics. In recent years, measurements of the rheological properties of airway surface liquid have attracted considerable clinical attention due to new advances in microrheology instruments and methods. This article reviews the clinical relevance of measurements of airway surface liquid viscoelasticity and surface tension from four main aspects: maintaining the stability of the airways and alveoli, preventing ventilator-induced lung injury, optimizing surfactant replacement therapy for respiratory syndrome distress, and characterizing the barrier properties of airway mucus to improve drug and gene delivery. Primary measuring techniques and methods suitable for determining the viscoelasticity and surface tension of airway surface liquid are then introduced with respect to principles, advantages and limitations. Cone and plate viscometers and particle tracking microrheometers are the most commonly used instruments for measuring the bulk viscosity and microviscosity of airway surface liquid, respectively, and pendant drop methods are particularly suitable for the measurement of airway surface liquid surface tension in vitro. Currently, in vivo and in situ measurements of the viscoelasticity and surface tension of the airway surface liquid in humans still presents many challenges.

journal_name

Respir Res

journal_title

Respiratory research

authors

Chen Z,Zhong M,Luo Y,Deng L,Hu Z,Song Y

doi

10.1186/s12931-019-1229-1

subject

Has Abstract

pub_date

2019-12-04 00:00:00

pages

274

issue

1

eissn

1465-9921

issn

1465-993X

pii

10.1186/s12931-019-1229-1

journal_volume

20

pub_type

杂志文章,评审

相关文献

RESPIRATORY RESEARCH文献大全
  • Analysis of comorbid factors that increase the COPD assessment test scores.

    abstract：BACKGROUND:The chronic obstructive pulmonary disease (COPD) Assessment Test (CAT) is a concise health status measure for COPD. COPD patients have a variety of comorbidities, but little is known about their impact on quality of life. This study was designed to investigate comorbid factors that may contribute to high CAT...

    journal_title：Respiratory research

    pub_type： 临床试验,杂志文章

    doi：10.1186/1465-9921-15-13

    authors： Miyazaki M,Nakamura H,Chubachi S,Sasaki M,Haraguchi M,Yoshida S,Tsuduki K,Shirahata T,Takahashi S,Minematsu N,Koh H,Nakamura M,Sakamaki F,Terashima T,Sayama K,Jones PW,Asano K,Betsuyaku T,Keio COPD Comorbidity Researc

    更新日期：2014-02-06 00:00:00

  • Clinical outcomes stratified by baseline functional class after initial combination therapy for pulmonary arterial hypertension.

    abstract：BACKGROUND:Initial combination therapy with ambrisentan and tadalafil reduced the risk of clinical failure events for treatment-naïve participants with pulmonary arterial hypertension (PAH) as compared to monotherapy. Previous studies in PAH have demonstrated greater treatment benefits in more symptomatic participants....

    journal_title：Respiratory research

    pub_type： 杂志文章,随机对照试验

    doi：10.1186/s12931-019-1180-1

    authors： White RJ,Vonk-Noordegraaf A,Rosenkranz S,Oudiz RJ,McLaughlin VV,Hoeper MM,Grünig E,Ghofrani HA,Chakinala MM,Barberà JA,Blair C,Langley J,Frost AE

    更新日期：2019-09-12 00:00:00

  • Network analysis of quantitative proteomics on asthmatic bronchi: effects of inhaled glucocorticoid treatment.

    abstract：BACKGROUND:Proteomic studies of respiratory disorders have the potential to identify protein biomarkers for diagnosis and disease monitoring. Utilisation of sensitive quantitative proteomic methods creates opportunities to determine individual patient proteomes. The aim of the current study was to determine if quantita...

    journal_title：Respiratory research

    pub_type： 杂志文章,随机对照试验

    doi：10.1186/1465-9921-12-124

    authors： O'Neil SE,Sitkauskiene B,Babusyte A,Krisiukeniene A,Stravinskaite-Bieksiene K,Sakalauskas R,Sihlbom C,Ekerljung L,Carlsohn E,Lötvall J

    更新日期：2011-09-22 00:00:00

  • Decreased expression of the NF-κB family member RelB in lung fibroblasts from Smokers with and without COPD potentiates cigarette smoke-induced COX-2 expression.

    abstract：BACKGROUND:Heightened inflammation, including expression of COX-2, is associated with COPD pathogenesis. RelB is an NF-κB family member that attenuates COX-2 in response to cigarette smoke by a mechanism that may involve the miRNA miR-146a. There is no information on the expression of RelB in COPD or if RelB prevents C...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-015-0214-6

    authors： Sheridan JA,Zago M,Nair P,Li PZ,Bourbeau J,Tan WC,Hamid Q,Eidelman DH,Benedetti AL,Baglole CJ

    更新日期：2015-05-06 00:00:00

  • Electronic cigarette vapour increases virulence and inflammatory potential of respiratory pathogens.

    abstract：INTRODUCTION:Bacteria have been extensively implicated in the development of smoking related diseases, such as COPD, by either direct infection or bacteria-mediated inflammation. In response to the health risks associated with tobacco exposure, the use of electronic cigarettes (e-cigs) has increased. This study compare...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-019-1206-8

    authors： Gilpin DF,McGown KA,Gallagher K,Bengoechea J,Dumigan A,Einarsson G,Elborn JS,Tunney MM

    更新日期：2019-12-18 00:00:00

  • Five novel clinical phenotypes for critically ill patients with mechanical ventilation in intensive care units: a retrospective and multi database study.

    abstract：BACKGROUND:Although protective mechanical ventilation (MV) has been used in a variety of applications, lung injury may occur in both patients with and without acute respiratory distress syndrome (ARDS). The purpose of this study is to use machine learning to identify clinical phenotypes for critically ill patients with...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-020-01588-6

    authors： Su L,Zhang Z,Zheng F,Pan P,Hong N,Liu C,He J,Zhu W,Long Y,Liu D

    更新日期：2020-12-10 00:00:00

  • Relationship between age and bronchodilator response at diagnosis in adult-onset asthma.

    abstract：BACKGROUND:Possible variation in bronchodilator response (BDR) according to age at the diagnosis of adult-onset asthma is unknown. Our aim was to assess if BDR in FEV1 is related to age at diagnosis of adult-onset asthma and how many subjects fulfill the 400 mL criterion of BDR, the suggested cut-off for asthma-like re...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-020-01441-w

    authors： Tommola M,Won HK,Ilmarinen P,Jung H,Tuomisto LE,Lehtimäki L,Niemelä O,Kim TB,Kankaanranta H

    更新日期：2020-07-13 00:00:00

  • Activation of the nicotinamide N-methyltransferase (NNMT)-1-methylnicotinamide (MNA) pathway in pulmonary hypertension.

    abstract：BACKGROUND:Pulmonary arterial hypertension (PAH) is associated with inflammatory response but it is unknown whether it is associated with alterations in NNMT activity and MNA plasma concentration. Here we examined changes in NNMT-MNA pathway in PAH in rats and humans. METHODS:PAH in rats was induced by a single subcut...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-016-0423-7

    authors： Fedorowicz A,Mateuszuk Ł,Kopec G,Skórka T,Kutryb-Zając B,Zakrzewska A,Walczak M,Jakubowski A,Łomnicka M,Słomińska E,Chlopicki S

    更新日期：2016-08-31 00:00:00

  • Landscape of transcription and long non-coding RNAs reveals new insights into the inflammatory and fibrotic response following ventilator-induced lung injury.

    abstract：BACKGROUND:Mechanical ventilation can cause ventilator-induced lung injury (VILI) and lung fibrosis; however, the underlying mechanisms are still not fully understood. RNA sequencing is a powerful means for detecting vitally important protein-coding transcripts and long non-coding RNAs (lncRNAs) on a genome-wide scale,...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-018-0822-z

    authors： Wang L,Zhang N,Zhang Y,Xia J,Zhan Q,Wang C

    更新日期：2018-06-22 00:00:00

  • Regenerative defect in vastus lateralis muscle of patients with chronic obstructive pulmonary disease.

    abstract：BACKGROUND:Impaired skeletal muscle regeneration could contribute to the progression of muscle atrophy in patients with chronic obstructive pulmonary disease (COPD). METHODS:Satellite cells and myogenesis-related proteins were compared between healthy subjects and patients with COPD, with or without muscle atrophy. Sa...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-15-35

    authors： Thériault ME,Paré MÈ,Lemire BB,Maltais F,Debigaré R

    更新日期：2014-03-25 00:00:00

  • CD8 positive T cells express IL-17 in patients with chronic obstructive pulmonary disease.

    abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a progressive and irreversible chronic inflammatory disease of the lung. The nature of the immune reaction in COPD raises the possibility that IL-17 and related cytokines may contribute to this disorder. This study analyzed the expression of IL-17A and IL-17F a...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-12-43

    authors： Chang Y,Nadigel J,Boulais N,Bourbeau J,Maltais F,Eidelman DH,Hamid Q

    更新日期：2011-04-10 00:00:00

  • Low-molecular-weight heparin reduces hyperoxia-augmented ventilator-induced lung injury via serine/threonine kinase-protein kinase B.

    abstract：BACKGROUND:High-tidal-volume mechanical ventilation and hyperoxia used in patients with acute lung injury (ALI) can induce the release of cytokines, including high-mobility group box-1 (HMGB1), oxygen radicals, neutrophil infiltration, and the disruption of epithelial and endothelial barriers. Hyperoxia has been shown ...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-12-90

    authors： Li LF,Yang CT,Huang CC,Liu YY,Kao KC,Lin HC

    更新日期：2011-07-05 00:00:00

  • COL6A3 polymorphisms were associated with lung cancer risk in a Chinese population.

    abstract：BACKGROUND:Lung cancer is one of the leading cause of cancer-related death in the world. Recently, many clinical researches have reported that COL6A3 had strong role in many diseases. The aim of this study was to evaluate the association between single nucleotide polymorphisms (SNPs) in COL6A3 and lung cancer susceptib...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-019-1114-y

    authors： Duan Y,Liu G,Sun Y,Wu J,Xiong Z,Jin T,Chen M

    更新日期：2019-07-08 00:00:00

  • Association of time-to-treatment with outcomes of Pneumocystis pneumonia with respiratory failure in HIV-negative patients.

    abstract：BACKGROUND:The prevalence of pneumocystis pneumonia (PCP) and associated hypoxic respiratory failure is increasing in human immunodeficiency virus (HIV)-negative patients. However, no prior studies have evaluated the effect of early anti-PCP treatment on clinical outcomes in HIV-negative patient with severe PCP. Theref...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-019-1188-6

    authors： Ko RE,Na SJ,Huh K,Suh GY,Jeon K

    更新日期：2019-09-26 00:00:00

  • Oral tolerance inhibits pulmonary eosinophilia in a cockroach allergen induced model of asthma: a randomized laboratory study.

    abstract：BACKGROUND:Antigen desensitization through oral tolerance is becoming an increasingly attractive treatment option for allergic diseases. However, the mechanism(s) by which tolerization is achieved remain poorly defined. In this study we endeavored to induce oral tolerance to cockroach allergen (CRA: a complex mixture o...

    journal_title：Respiratory research

    pub_type： 杂志文章,随机对照试验

    doi：10.1186/1465-9921-11-160

    authors： Vaickus LJ,Bouchard J,Kim J,Natarajan S,Remick DG

    更新日期：2010-11-23 00:00:00

  • Isolation of human beta-defensin-4 in lung tissue and its increase in lower respiratory tract infection.

    abstract：BACKGROUND:Human beta-defensin-4 (hBD-4), a new member of the beta-defensin family, was discovered by an analysis of the genomic sequence. The objective of this study was to clarify hBD-4 expression in human lung tissue, along with the inducible expression in response to infectious stimuli, localization, and antimicrob...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-6-130

    authors： Yanagi S,Ashitani J,Ishimoto H,Date Y,Mukae H,Chino N,Nakazato M

    更新日期：2005-11-04 00:00:00

  • Azithromycin induces epidermal differentiation and multivesicular bodies in airway epithelia.

    abstract：BACKGROUND:Azithromycin (Azm) is a macrolide recognized for its disease-modifying effects and reduction in exacerbation of chronic airway diseases. It is not clear whether the beneficial effects of Azm are due to its anti-microbial activity or other pharmacological actions. We have shown that Azm affects the integrity ...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-019-1101-3

    authors： Arason AJ,Joelsson JP,Valdimarsdottir B,Sigurdsson S,Gudjonsson A,Halldorsson S,Johannsson F,Rolfsson O,Lehmann F,Ingthorsson S,Cherek P,Gudmundsson GH,Gardarsson FR,Page CP,Baldursson O,Gudjonsson T,Kricker JA

    更新日期：2019-06-24 00:00:00

  • Therapeutic effect of budesonide/formoterol, montelukast and N-acetylcysteine for bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation.

    abstract：BACKGROUND:Bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic stem cell transplantation (HSCT) is currently treated with systemic corticosteroids despite poor efficacy and side effects. This study investigated the therapeutic effect of budesonide/formoterol, montelukast and n-acetylcysteine, which a...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-016-0380-1

    authors： Kim SW,Rhee CK,Kim YJ,Lee S,Kim HJ,Lee JW

    更新日期：2016-05-26 00:00:00

  • Transposable elements and their potential role in complex lung disorder.

    abstract：:Transposable elements (TEs) are a class of mobile genetic elements (MGEs) that were long regarded as junk DNA, which make up approximately 45% of the genome. Although most of these elements are rendered inactive by mutations and other gene silencing mechanisms, TEs such as long interspersed nuclear elements (LINEs) ar...

    journal_title：Respiratory research

    pub_type： 杂志文章,评审

    doi：10.1186/1465-9921-14-99

    authors： Sargurupremraj M,Wjst M

    更新日期：2013-10-05 00:00:00

  • Role and regulation of MKP-1 in airway inflammation.

    abstract：:Mitogen-activated protein kinase (MAPK) phosphatase 1 (MKP-1) is a protein with anti-inflammatory properties and the archetypal member of the dual-specificity phosphatases (DUSPs) family that have emerged over the past decade as playing an instrumental role in the regulation of airway inflammation. Not only does MKP-1...

    journal_title：Respiratory research

    pub_type： 杂志文章,评审

    doi：10.1186/s12931-017-0637-3

    authors： Moosavi SM,Prabhala P,Ammit AJ

    更新日期：2017-08-10 00:00:00

  • Phenotyping community-acquired pneumonia according to the presence of acute respiratory failure and severe sepsis.

    abstract：BACKGROUND:Acute respiratory failure (ARF) and severe sepsis (SS) are possible complications in patients with community-acquired pneumonia (CAP). The aim of the study was to evaluate prevalence, characteristics, risk factors and impact on mortality of hospitalized patients with CAP according to the presence of ARF and ...

    journal_title：Respiratory research

    pub_type： 杂志文章,多中心研究

    doi：10.1186/1465-9921-15-27

    authors： Aliberti S,Brambilla AM,Chalmers JD,Cilloniz C,Ramirez J,Bignamini A,Prina E,Polverino E,Tarsia P,Pesci A,Torres A,Blasi F,Cosentini R

    更新日期：2014-03-04 00:00:00

  • Validated and longitudinally stable asthma phenotypes based on cluster analysis of the ADEPT study.

    abstract：BACKGROUND:Asthma is a disease of varying severity and differing disease mechanisms. To date, studies aimed at stratifying asthma into clinically useful phenotypes have produced a number of phenotypes that have yet to be assessed for stability and to be validated in independent cohorts. The aim of this study was to def...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-016-0482-9

    authors： Loza MJ,Djukanovic R,Chung KF,Horowitz D,Ma K,Branigan P,Barnathan ES,Susulic VS,Silkoff PE,Sterk PJ,Baribaud F,ADEPT (Airways Disease Endotyping for Personalized Therapeutics) and U-BIOPRED (Unbiased Biomarkers for the Prediction

    更新日期：2016-12-15 00:00:00

  • Clinical use of exhaled volatile organic compounds in pulmonary diseases: a systematic review.

    abstract：:There is an increasing interest in the potential of exhaled biomarkers, such as volatile organic compounds (VOCs), to improve accurate diagnoses and management decisions in pulmonary diseases. The objective of this manuscript is to systematically review the current knowledge on exhaled VOCs with respect to their poten...

    journal_title：Respiratory research

    pub_type： 杂志文章,meta分析,评审

    doi：10.1186/1465-9921-13-117

    authors： van de Kant KD,van der Sande LJ,Jöbsis Q,van Schayck OC,Dompeling E

    更新日期：2012-12-21 00:00:00

  • Sex-specific lung functional changes in adult mice exposed only to second-hand smoke in utero.

    abstract：BACKGROUND:An increasing number of epidemiological and experimental studies have associated exposure to second-hand smoke (SHS) during pregnancy with adverse outcomes in newborns. As we have previously shown in mice, in utero exposure to SHS at critical stages of fetal development, results in altered lung responses and...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-017-0591-0

    authors： Noël A,Xiao R,Perveen Z,Zaman H,Le Donne V,Penn A

    更新日期：2017-06-27 00:00:00

  • The need for fast-track, high-quality and low-cost studies about the role of the BCG vaccine in the fight against COVID-19.

    abstract：:Bacillus Calmette-Guérin (BCG) vaccination is routine and near-universal in many low- and middle-income countries (LMIC). It has been suggested that BCG can have a protective effect on COVID-19 morbidity and mortality. This commentary discusses the limitations of the evidence around BCG and COVID-19. We argue that hig...

    journal_title：Respiratory research

    pub_type： 信件,评审

    doi：10.1186/s12931-020-01439-4

    authors： Pereira M,Paixão E,Trajman A,de Souza RA,da Natividade MS,Pescarini JM,Pereira SM,Barreto FR,Ximenes R,Dalcomo M,Ichihara MY,Nunes C,Barral-Netto M,Barreto ML

    更新日期：2020-07-11 00:00:00

  • Serum biomarkers in interstitial lung diseases.

    abstract：:The use of biomarkers in medicine lies in their ability to detect disease and support diagnostic and therapeutic decisions. New research and novel understanding of the molecular basis of the disease reveals an abundance of exciting new biomarkers who present a promise for use in the everyday clinical practice. The pas...

    journal_title：Respiratory research

    pub_type： 杂志文章,评审

    doi：10.1186/1465-9921-6-78

    authors： Tzouvelekis A,Kouliatsis G,Anevlavis S,Bouros D

    更新日期：2005-07-21 00:00:00

  • The revised ATS/ERS/JRS/ALAT diagnostic criteria for idiopathic pulmonary fibrosis (IPF)--practical implications.

    abstract：:Idiopathic pulmonary fibrosis (IPF), the most prevalent idiopathic interstitial pneumonia, is associated with a poor prognosis. An accurate diagnosis of IPF is essential for optimal management. The recent ATS/ERS/JRS/ALAT recommendations on the diagnosis and management of IPF were developed from a systematic review of...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-14-S1-S2

    authors： Wells AU

    更新日期：2013-01-01 00:00:00

  • Blood and sputum eosinophils in COPD; relationship with bacterial load.

    abstract：BACKGROUND:Sputum and blood eosinophil counts predict corticosteroid effects in COPD patients. Bacterial infection causes increased airway neutrophilic inflammation. The relationship of eosinophil counts with airway bacterial load in COPD patients is uncertain. We tested the hypothesis that bacterial load and eosinophi...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-017-0570-5

    authors： Kolsum U,Donaldson GC,Singh R,Barker BL,Gupta V,George L,Webb AJ,Thurston S,Brookes AJ,McHugh TD,Wedzicha JA,Brightling CE,Singh D

    更新日期：2017-05-08 00:00:00

  • Surfactant proteins, SP-A and SP-D, in respiratory fungal infections: their role in the inflammatory response.

    abstract：:Pulmonary surfactant is a complex fluid that comprises phospholipids and four proteins (SP-A, SP-B, SP-C, and SP-D) with different biological functions. SP-B, SP-C, and SP-D are essential for the lungs' surface tension function and for the organization, stability and metabolism of lung parenchyma. SP-A and SP-D, which...

    journal_title：Respiratory research

    pub_type： 杂志文章,评审

    doi：10.1186/s12931-016-0385-9

    authors： Carreto-Binaghi LE,Aliouat el M,Taylor ML

    更新日期：2016-06-01 00:00:00

  • Expression of Toll-like receptor 2 is up-regulated in monocytes from patients with chronic obstructive pulmonary disease.

    abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is characterised by pulmonary and systemic inflammation which flare-up during episodes of acute exacerbation (AECOPD). Given the role of Toll-like receptors (TLRs) in the induction of inflammatory responses we investigated the involvement of TLRs in COPD pathogene...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-7-64

    authors： Pons J,Sauleda J,Regueiro V,Santos C,López M,Ferrer J,Agustí AG,Bengoechea JA

    更新日期：2006-04-10 00:00:00