Abstract:
:A high incidence of left ventricular diastolic dysfunction and increased risk of cardiovascular events have been reported in patients with diabetes mellitus. Sodium glucose cotransporter 2 (SGLT2) inhibitors selectively inhibit kidney glucose and sodium reabsorption, and cardiovascular benefits of SGLT2 inhibitors beyond other antidiabetic drugs have been reported in type 2 diabetes mellitus (T2DM) clinical trials. However, underlying mechanisms contributing to the improvement of cardiovascular outcomes have not been clearly identified. In this review, likely mechanisms of SGLT2 inhibitors contributing to a favorable cardiovascular outcomes are discussed based on experimental and clinical studies on cardiac function.
journal_name
Cardiovasc Ultrasoundjournal_title
Cardiovascular ultrasoundauthors
Matsumura K,Sugiura Tdoi
10.1186/s12947-019-0177-8subject
Has Abstractpub_date
2019-11-13 00:00:00pages
26issue
1issn
1476-7120pii
10.1186/s12947-019-0177-8journal_volume
17pub_type
杂志文章abstract::Pulmonary embolism is a common cardiovascular emergency, but it is still often misdiagnosed due to its unspecific clinical symptoms. Elevated troponin concentrations are associated with greater morbidity and mortality in patients with pulmonary embolism. Right ventricular ischemia due to increased right ventricular af...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-8-50
更新日期:2010-11-24 00:00:00
abstract:OBJECTIVE:Correlate the anatomic features of atrioventricular septal defect with echocardiographic images. MATERIALS AND METHODS:Sixty specimen hearts were studied by sequential segmental analysis. Echocardiograms were performed on 34 patients. Specimen hearts with findings equivalent to those of echocardiographic ima...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-6-33
更新日期:2008-06-24 00:00:00
abstract::A 63-year-old man was admitted to our hospital with a complaint of right lateroabdominal pain. He was diagnosed with metastatic colon cancer, and then developed multiple brain embolic infarctions 7 days after admission. Transesophageal echocardiography showed that mobile, echo-dense masses were attached to the anterio...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-9-8
更新日期:2011-02-28 00:00:00
abstract::Quadricuspid aortic valve is a rare congenital malformation of the aortic valve. Its diagnosis is often missed even with the use of transthoracic echocardiogram. Many of these patients progress to aortic incompetence later in life, hence requiring surgical intervention. In the case described in this report, a 61-year-...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-8-36
更新日期:2010-09-02 00:00:00
abstract:AIMS:We sought to determine which echocardiographic markers of left ventricular (LV) remodeling and diastolic dysfunction can contribute as incremental and independent prognostic information in addition to current clinical risk markers of ischemic LV systolic dysfunction in the Surgical Treatment for Ischemic Heart Fai...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/s12947-020-00195-1
更新日期:2020-05-28 00:00:00
abstract:BACKGROUND:To explore the association between the ratio of tricuspid annular plane systolic excursion (TAPSE) and pulmonary arterial systolic pressure (PASP), and long- and short-term outcomes in mechanically ventilated septic shock patients. METHODS:Septic shock patients admitted to the intensive care unit (ICU) were...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/s12947-020-00198-y
更新日期:2020-06-12 00:00:00
abstract::In the standard accepted concept, contractility is the intrinsic ability of heart muscle to generate force and to shorten, independently of changes in the preload or afterload with fixed heart rates. At molecular level the crux of the contractile process lies in the changing concentrations of Ca2+ ions in the myocardi...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章,评审
doi:10.1186/1476-7120-3-27
更新日期:2005-09-08 00:00:00
abstract::Echocardiography has the ability to noninvasively explore hemodynamic variables during pharmacologic or exercise stress test in patients with heart failure. In this review, we detail some important potential applications of stress echocardiography in patients with heart failure. In patients with coronary artery diseas...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章,评审
doi:10.1186/1476-7120-2-11
更新日期:2004-07-30 00:00:00
abstract::Real-time three-dimensional (RT-3D) echocardiography has entered the clinical practice but true incremental value over standard two-dimensional echocardiography (2D) remains uncertain when applied to stress echo. The aim of the present study is to establish the additional value of RT-3D stress echo over standard 2D st...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-6-31
更新日期:2008-06-20 00:00:00
abstract:BACKGROUND:The effect of aggressive medical therapy on quantitative coronary plaque burden is not generally known, especially in ethnic Chinese. AIMS:We reasoned that Cardiac CT could conveniently quantify early coronary atherosclerosis in our patient population, and hypothesized that serial observation could differen...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-8-5
更新日期:2010-03-12 00:00:00
abstract:BACKGROUND:A hybrid approach to minimally invasive perventricular closure of VSD in infants is safe and effective, and has been performed under guidance of transesophageal echocardiography (TEE). We applied transthoracic echocardiographic (TTE) guidance to this hybrid approach, and compare results guided by TTE with th...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-11-8
更新日期:2013-03-11 00:00:00
abstract:BACKGROUND:In the last recent years a new percutaneous procedure, the MitraClip, has been validated for the treatment of mitral regurgitation. MitraClip procedure is a promising alternative for patients unsuitable for surgery as it reduces the risk of death related to surgery ensuring a similar result. Few data are pre...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-11-13
更新日期:2013-05-04 00:00:00
abstract::To make assessment of paravalvular aortic leakage (PVL) after transcatheter aortic valve implantation (TAVI) more uniform the second Valve Academic Research Consortium (VARC) recently updated the echocardiographic criteria for mild, moderate and severe PVL. In the VARC recommendation the assessment of the circumferent...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章,评审
doi:10.1186/s12947-016-0080-5
更新日期:2016-09-06 00:00:00
abstract:BACKGROUND:We hypothesized that longitudinal pulmonary arterial deformation during the cardiac cycle reflects pulmonary arterial capacitance. To examine this hypothesis, we assessed whether tissue Doppler-derived pulmonary annular motion could serve as a novel way to evaluate pulmonary arterial capacitance in pediatric...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/s12947-016-0081-4
更新日期:2016-09-07 00:00:00
abstract:BACKGROUND:Takotsubo cardiomyopathy is an acute cardiac syndrome characterized by transient LV regional wall motion abnormalities (with peculiar apical ballooning appearance), chest pain or dyspnea, ST-segment elevation and minor elevations of cardiac enzyme levels CASE PRESENTATION:A 68-year-old woman was admitted to...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-5-18
更新日期:2007-04-06 00:00:00
abstract:BACKGROUND:Aortic valve stenosis (AS) is the most common primary valvular heart disease leading to surgical or percutaneous aortic valve replacement (AVR) in Europe and its prevalence keeps growing. While other risk factors in severe AS are well documented, little is known about the prognostic value of left atrial (LA)...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/s12947-020-00231-0
更新日期:2021-01-02 00:00:00
abstract::Miniaturization has evolved in the creation of a pocket-size imaging device which can be utilized as an ultrasound stethoscope. This study assessed the additional diagnostic power of pocket size device by both experts operators and trainees in comparison with physical examination and its appropriateness of use in comp...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-8-51
更新日期:2010-11-26 00:00:00
abstract::The growing need for coronary evaluation has raised interest in non-radioactive, non-invasive monitoring systems. In particular, radiation exposure during coronary investigations has been shown to be a possible cause of an enhanced risk of secondary tumors. Literature search has indicated that transthoracic echocardio...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章,评审
doi:10.1186/s12947-016-0048-5
更新日期:2016-01-19 00:00:00
abstract:BACKGROUND:Fetal anemia is associated with a hyperdynamic circulation and cardiac remodeling. Rapid intrauterine transfusion (IUT) of blood with high hematocrit and viscosity into the umbilical vein used to treat this condition can temporarily further affect fetal heart function. The aim of this study was to evaluate t...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/s12947-020-00214-1
更新日期:2020-08-13 00:00:00
abstract:OBJECTIVE:Cardiac resynchronization therapy is proven efficacious in patients with heart failure (HF). Presence of biventricular HF is associated with a worse prognosis than having only left ventricular (LV) HF and pacing might deteriorate heart function. The aim of the study was to assess a possible significance of ri...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-9-28
更新日期:2011-10-26 00:00:00
abstract::A 25-year-old woman with a history of kidney transplantation for lupus nephritis was referred for the evaluation and management of a mass incidentally found on echocardiography. An oval and pedunculated mass attached to the tricuspid valve was managed with nonsurgical treatment. No symptoms and complications attributa...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-7-44
更新日期:2009-09-04 00:00:00
abstract:BACKGROUND:In studies where cross-sectional images of coronary arteries obtained with different imaging modalities are compared, the importance of correct co-localization and matching of images along the coronary artery longitudinal axis is obvious. However, it appears neglected that correct spatial orientation of the ...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-10-12
更新日期:2012-03-22 00:00:00
abstract:BACKGROUND:Cardiac resynchronization therapy (CRT) is generally associated with a low to moderate increase of the left ventricular ejection fraction (LVEF). In some patients, however, LVEF improves remarkably and reaches near-normal values. The aim of the present study was to further characterize these so called 'super...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-8-35
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:The percentage of hypertrophic cardiomyopathy (HCM) patients who are in high risk for Sudden Death (SD) constitutes only a minority of all HCM population but the incidence of SD in this subset is high (at least 5% annually). The identification of this small but important proportion of high risk HCM patients ...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-7-37
更新日期:2009-07-26 00:00:00
abstract:OBJECTIVE:Left ventricular wall stress has been investigated in a variety of populations, but the effect of food intake has not been evaluated. We assessed whether left ventricular wall stress is affected by food intake in healthy subjects. METHODS:Twenty-three healthy subjects aged 25.6 ± 4.5 years were investigated....
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-12-2
更新日期:2014-01-28 00:00:00
abstract:BACKGROUND:While echocardiographic grading of left ventricular (LV) diastolic dysfunction (DD) is used every day, the relationship between echocardiographic DD grade and hemodynamic abnormalities is uncertain. METHODS:We identified 460 consecutive patients who underwent transthoracic echocardiography within 24 h of el...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/s12947-015-0023-6
更新日期:2015-06-24 00:00:00
abstract::In this case report we describe a rare case of right atrium myxoma that coexisted with antiphospholipid syndrome in a young woman. We describe the unusual findings and diagnostic challenges combined with a review of the literature. ...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-7-47
更新日期:2009-10-11 00:00:00
abstract:BACKGROUND:Dual imaging stress echocardiography, combining the evaluation of wall motion and coronary flow reserve (CFR) on the left anterior descending artery (LAD), and computed tomography coronary angiography (CTCA) are established techniques for assessing prognosis in chest pain patients. In this study we compared ...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/s12947-015-0013-8
更新日期:2015-04-21 00:00:00
abstract:INTRODUCTION:In vivo and in vitro evidence suggests that adenosine and its agonists play key roles in the process of ischemic preconditioning. The effects of low-dose adenosine infusion on ischemic preconditioning have not been thoroughly studied in humans. AIMS:We hypothesised that a low-dose adenosine infusion could...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章,随机对照试验
doi:10.1186/1476-7120-7-52
更新日期:2009-11-05 00:00:00
abstract:INTRODUCTION:Serial monitoring of patients participating in clinical trials of carotid artery therapy requires noninvasive precision methods that are inexpensive, safe and widely available. Noninvasive ultrasonic duplex Doppler velocimetry provides a precision method that can be used for recruitment qualification, pre-...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-8-39
更新日期:2010-09-07 00:00:00