Effect of revealing authors' conflicts of interests in peer review: randomized controlled trial.

Abstract:

OBJECTIVE:To assess the effect of disclosing authors' conflict of interest declarations to peer reviewers at a medical journal. DESIGN:Randomized controlled trial. SETTING:Manuscript review process at the Annals of Emergency Medicine. PARTICIPANTS: Reviewers (n=838) who reviewed manuscripts submitted between 2 June 2014 and 23 January 2018 inclusive (n=1480 manuscripts). INTERVENTION:Reviewers were randomized to either receive (treatment) or not receive (control) authors' full International Committee of Medical Journal Editors format conflict of interest disclosures before reviewing manuscripts. Reviewers rated the manuscripts as usual on eight quality ratings and were then surveyed to obtain "counterfactual scores"-that is, the scores they believed they would have given had they been assigned to the opposite arm-as well as attitudes toward conflicts of interest. MAIN OUTCOME MEASURE:Overall quality score that reviewers assigned to the manuscript on submitting their review (1 to 5 scale). Secondary outcomes were scores the reviewers submitted for the seven more specific quality ratings and counterfactual scores elicited in the follow-up survey. RESULTS:Providing authors' conflict of interest disclosures did not affect reviewers' mean ratings of manuscript quality (Mcontrol=2.70 (SD 1.11) out of 5; Mtreatment=2.74 (1.13) out of 5; mean difference 0.04, 95% confidence interval -0.05 to 0.14), even for manuscripts with disclosed conflicts (Mcontrol= 2.85 (1.12) out of 5; Mtreatment=2.96 (1.16) out of 5; mean difference 0.11, -0.05 to 0.26). Similarly, no effect of the treatment was seen on any of the other seven quality ratings that the reviewers assigned. Reviewers acknowledged conflicts of interest as an important matter and believed that they could correct for them when they were disclosed. However, their counterfactual scores did not differ from actual scores (Mactual=2.69; Mcounterfactual=2.67; difference in means 0.02, 0.01 to 0.02). When conflicts were reported, a comparison of different source types (for example, government, for-profit corporation) found no difference in effect. CONCLUSIONS:Current ethical standards require disclosure of conflicts of interest for all scientific reports. As currently implemented, this practice had no effect on any quality ratings of real manuscripts being evaluated for publication by real peer reviewers.

journal_name

BMJ

authors

John LK,Loewenstein G,Marder A,Callaham ML

doi

10.1136/bmj.l5896

subject

Has Abstract

pub_date

2019-11-06 00:00:00

pages

l5896

eissn

0959-8138

issn

1756-1833

journal_volume

367

pub_type

杂志文章,随机对照试验
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    doi:10.1136/bmj.302.6774.437

    authors: Anderson IB,Sørensen TI,Prener A

    更新日期:1991-02-23 00:00:00

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    doi:10.1136/bmj.305.6862.1130

    authors: Jarman B,Bosanquet N

    更新日期:1992-11-07 00:00:00

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    abstract:OBJECTIVE:To compare the risk of detention under the Mental Health Act 1983 in a representative group of people with psychotic disorders from different ethnic groups. SETTING:Two defined geographical areas in south London. DESIGN:Annual period prevalent cases of psychosis were identified in 1993 in the study areas fr...

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    更新日期:1996-03-02 00:00:00

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    pub_type: 杂志文章,多中心研究

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    更新日期:2009-06-16 00:00:00

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    journal_title:BMJ (Clinical research ed.)

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    journal_title:BMJ (Clinical research ed.)

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    doi:10.1136/bmj.e7594

    authors: Arnheim-Dahlström L,Hällgren J,Weibull CE,Sparén P

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    doi:10.1136/bmj.301.6760.1074

    authors: Spencer J,Lindsell D,Mastorakou I

    更新日期:1990-11-10 00:00:00

  • Compression ultrasonography for diagnostic management of patients with clinically suspected deep vein thrombosis: prospective cohort study.

    abstract:OBJECTIVE:To evaluate the safety of withholding anticoagulant treatment from patients with clinically suspected deep vein thrombosis but normal findings on compression ultrasonography. DESIGN:Compression ultrasonography was done with a simplified diagnostic procedure limited to the common femoral vein in the groin and...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,多中心研究

    doi:10.1136/bmj.316.7124.17

    authors: Cogo A,Lensing AW,Koopman MM,Piovella F,Siragusa S,Wells PS,Villalta S,Büller HR,Turpie AG,Prandoni P

    更新日期:1998-01-03 00:00:00

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    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.306.6883.979

    authors: Jarman B

    更新日期:1993-04-10 00:00:00

  • Obstetric care and proneness of offspring to suicide as adults: case-control study.

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    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.317.7169.1346

    authors: Jacobson B,Bygdeman M

    更新日期:1998-11-14 00:00:00

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    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1136/bmj.38498.387569.8F

    authors: Green J,Young J,Forster A,Mallinder K,Bogle S,Lowson K,Small N

    更新日期:2005-08-06 00:00:00

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    更新日期:1992-06-13 00:00:00

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    更新日期:2008-11-18 00:00:00

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    pub_type: 杂志文章

    doi:10.1136/bmj.d108

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    更新日期:2011-01-25 00:00:00

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    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/bmj.319.7224.1547

    authors: Jones J,Wilson A,Parker H,Wynn A,Jagger C,Spiers N,Parker G

    更新日期:1999-12-11 00:00:00

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    abstract:OBJECTIVE:Although the Polypill concept (proposed in 2003) is promising in terms of benefits for cardiovascular risk management, the potential costs and adverse effects are its main pitfalls. The objective of this study was to identify a tastier and safer alternative to the Polypill: the Polymeal. METHODS:Data on the ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,评审

    doi:10.1136/bmj.329.7480.1447

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    更新日期:2004-12-18 00:00:00

  • Association of bacteria and viruses with wheezy episodes in young children: prospective birth cohort study.

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    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

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    authors: Bisgaard H,Hermansen MN,Bønnelykke K,Stokholm J,Baty F,Skytt NL,Aniscenko J,Kebadze T,Johnston SL

    更新日期:2010-10-04 00:00:00

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    pub_type: 杂志文章

    doi:10.1136/bmj.298.6684.1350

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    更新日期:1989-05-20 00:00:00

  • Association between body mass index and cardiovascular disease mortality in east Asians and south Asians: pooled analysis of prospective data from the Asia Cohort Consortium.

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    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,meta分析,评审

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    更新日期:2013-10-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1136/bmj.311.7011.986

    authors: Heitmann BL,Lissner L

    更新日期:1995-10-14 00:00:00

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    pub_type: 杂志文章,评审

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    更新日期:2015-09-21 00:00:00

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    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

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    更新日期:2019-10-31 00:00:00

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    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,meta分析,评审

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    更新日期:2010-08-18 00:00:00

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    journal_title:BMJ (Clinical research ed.)

    pub_type: 社论

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    更新日期:1989-02-18 00:00:00

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    pub_type: 杂志文章

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    更新日期:1995-02-25 00:00:00

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    更新日期:1997-03-22 00:00:00

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    pub_type: 杂志文章

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    更新日期:2013-04-23 00:00:00

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    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,评审

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    更新日期:2002-11-30 00:00:00

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    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.f4262

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    更新日期:2013-07-18 00:00:00

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    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

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    更新日期:1997-07-26 00:00:00