Abstract:
Background:While decolonization of Staphylococcus aureus reduces surgical site infection (SSI) rates following hip and knee arthroplasty, its cost-effectiveness is uncertain. We sought to examine the cost-effectiveness of a decolonization protocol for Staphylococcus aureus prior to hip and knee replacement in Alberta compared to standard care - no decolonization. Methods:Decision analytic models and a probabilistic sensitivity analysis were used for a cost-effectiveness analysis, with the effectiveness of decolonization based on a large published pre- and post- intervention trial. The primary outcomes of the models were infections prevented and health care costs. We modelled the cost-effectiveness of decolonization in a hypothetical cohort of adult patients undergoing hip and knee replacement in Alberta, Canada. Information on the incidence of complex surgical site infections (SSIs), as well as the cost of care for patients with and without SSIs was taken from a provincial infection control database, and health administrative data. Results:Use of the decolonization bundle was cost saving compared to usual care ($153/person), and resulted in 16 complex Staphylococcus aureus SSIs annually as opposed to 32 (with approximately 8000 hip or knee arthroplasties performed). The probabilistic sensitivity analysis demonstrated that the majority (84%) of the time the decolonization bundle was cost saving. The model was robust to one-way sensitivity analyses conducted within plausible ranges. There were small upfront costs associated with using a decolonization protocol, however, this model demonstrated cost savings over one year. In a Markov model that considered the impact of a decolonization bundle over a lifetime as it pertained to the need for subsequent joint replacements and patient quality of life, the bundle still resulted in cost savings ($161/person). Conclusions:Decolonization for Staphylococcus aureus prior to hip and knee replacements resulted in cost savings and fewer SSIs, and should be considered prior to these procedures.
journal_name
Antimicrob Resist Infect Controljournal_title
Antimicrobial resistance and infection controlauthors
Rennert-May E,Conly J,Smith S,Puloski S,Henderson E,Au F,Manns Bdoi
10.1186/s13756-019-0568-5subject
Has Abstractpub_date
2019-07-11 00:00:00pages
113issn
2047-2994pii
568journal_volume
8pub_type
杂志文章abstract:Background:The methicillin-resistant clone Staphylococcus capitis NRCS-A, involved in sepsis in neonatal intensive care units (NICUs) worldwide, is able to persist and spread in NICUs, suggesting the presence of reservoirs inside each setting. The purpose of the present study was to identify these reservoirs and to inv...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-019-0616-1
更新日期:2019-10-17 00:00:00
abstract:Objective:Coagulase-negative staphylococci (CoNS) are one of the major opportunistic pathogens and the incidence of CoNS bacteraemia is increasing. However, most of the CoNS-positive blood cultures are contaminants rather than true CoNS bacteraemia. In order to minimize contamination, we defined true CoNS bacteraemia a...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-019-0523-5
更新日期:2019-04-24 00:00:00
abstract:Objective:To describe the epidemiology of carbapenem-resistant Enterobacteriaceae (CRE) healthcare-associated infections (HAI) in Egyptian hospitals reporting to the national HAI surveillance system. Methods:Design: Descriptive analysis of CRE HAIs and retrospective observational cohort study using national HAI survei...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-019-0639-7
更新日期:2020-01-03 00:00:00
abstract:BACKGROUND:Although hematopoietic cell transplant (HCT) recipients are routinely exposed to classic risk factors for Clostridium difficile infection (CDI), few studies have assessed CDI risk in these high-risk patients, and data are especially lacking for pediatric HCT recipients. We aimed to determine incidence and ri...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-015-0081-4
更新日期:2015-10-14 00:00:00
abstract::[This corrects the article DOI: 10.1186/s13756-018-0315-3.]. ...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章,已发布勘误
doi:10.1186/s13756-018-0358-5
更新日期:2018-06-25 00:00:00
abstract:BACKGROUND:Antimicrobial resistance in Shiga toxin-producing Escherichia coli (STEC) O157 and non-O157 is a matter of increasing concern. The aim of the present study was to investigate the antimicrobial resistance profiles of STEC O157 and non-O157 recovered from feces of domestic farm animals in the agricultural Culi...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-015-0100-5
更新日期:2016-01-05 00:00:00
abstract:Background:The rising incidence of resistance to currently available antibiotics among pathogens, particularly Gram-negative pathogens, in complicated intra-abdominal infections (cIAIs) has become a challenge for clinicians. Ceftazidime/avibactam (CAZ-AVI) is a fixed-dose antibiotic approved in Europe and the United St...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-019-0652-x
更新日期:2019-12-21 00:00:00
abstract:BACKGROUND:Sub-Saharan African countries are transitioning to dolutegravir-based regimens, even for patients with extensive previous drug exposure, including first-generation integrase strand-transfer inhibitors (INSTI) such as raltegravir. Such exposure might have implications on cross-resistance to dolutegravir-based...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-020-00799-2
更新日期:2020-08-26 00:00:00
abstract:OBJECTIVE:Coronavirus disease (COVID-19) was officially declared a pandemic in March 2020. Many cases of COVID-19 are nosocomial, but to the best of our knowledge, no nosocomial outbreaks on psychiatric departments of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported in Europe. The differe...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-020-00853-z
更新日期:2020-12-01 00:00:00
abstract:UNLABELLED: BACKGROUND:We describe an outbreak of Bullous Impetigo (BI), caused by a (methicillin susceptible, fusidic acid resistant) Staphylococcus aureus (SA) strain, spa-type t408, at the neonatal and gynaecology ward of the Jeroen Bosch hospital in the Netherlands, from March-November 2011. METHODS:We performed ...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/2047-2994-1-37
更新日期:2012-11-20 00:00:00
abstract::The WHO SAVE LIVES: Clean Your Hands global hand hygiene campaign, launched in 2009 and celebrated annually on the 5th of May, features specific calls to action seeking to increase engagement from stakeholders' collaborations in hand hygiene improvement. WHO calls on everyone to be inspired by the global movement towa...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-019-0511-9
更新日期:2019-03-28 00:00:00
abstract:Background:Dispensary and use of antibiotics without prescriptions from qualified providers is a common practice in countries with poor pharmaceutical regulations and where due focus is not given to rational use. This practice is a main factor for the spread of antimicrobial resistance due to its non-reliance on pre-tr...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章,多中心研究
doi:10.1186/s13756-019-0571-x
更新日期:2019-07-16 00:00:00
abstract:Background:Acinetobacter baumannii causes frequently nosocomial infections worldwide. Its ability to survive on dry surfaces facilitates its spread and the persistence of endemic situations, especially in the intensive care units (ICUs).The objective of this paper is to describe a multicomponent intervention program de...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-019-0658-4
更新日期:2019-12-04 00:00:00
abstract:Background:Antibiotics require more prudent prescribing, dispensing and administration than other medicines because these medicines are at a greater risk of antimicrobial resistance (AMR). Studying the current medicine use practices and factors affecting the prescribing of an antibiotic would help decision makers to dr...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-019-0620-5
更新日期:2019-10-22 00:00:00
abstract:Background:Disinfectant products are often used on environmental surfaces (e.g. countertops, patient beds) and patient care equipment in healthcare facilities to help prevent the transmission of healthcare-associated infections. Ready-to-use (RTU) disinfectants in the form of pre-wetted towelettes are increasingly popu...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-018-0416-z
更新日期:2018-10-11 00:00:00
abstract:BACKGROUND:Social media may provide a tool, when coupled with a patient-included™ conference, to enhance the engagement among the general public. We describe authors and potential readers of Twitter content surrounding a patient-included™ scientific congress, the International Consortium for Prevention and Infection Co...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-021-00891-1
更新日期:2021-01-25 00:00:00
abstract:Background:Cockroaches are one of the most important and frequent insects responsible for harboring, transmission and dissemination of human pathogens in the hospital environment. The present research was done to study the phenotypic and genotypic characterization of antibiotic resistance in the Methicillin-resistant S...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-019-0505-7
更新日期:2019-03-13 00:00:00
abstract:BACKGROUND:The burden of health-care associated infections in low-income countries is high. Adequate hand hygiene is considered the most effective measure to reduce the transmission of nosocomial pathogens. We aimed to assess compliance with hand hygiene and perception and knowledge about hand hygiene before and after ...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-016-0165-9
更新日期:2017-01-05 00:00:00
abstract:BACKGROUND:Pseudomonas endocarditis is exceedingly rare, especially in patients without predisposing risks. We present such a case that included unexpected switches in antibacterial resistance profiles in two Pseudomonas aeruginosa (PA) strains with the same whole-genome sequence. The case also involved diagnostic and ...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-017-0245-5
更新日期:2017-08-29 00:00:00
abstract:Background:A substantial portion of Clostridium difficile infection (CDI) cases occur in communities, and community-onset CDI (CO-CDI) can lead to serious complications including mortality. This study aimed to identify the risk factors for a poor outcome in CO-CDI. Methods:We performed a retrospective review of all in...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-018-0365-6
更新日期:2018-06-15 00:00:00
abstract::A review of epidemiological studies on the incidence of MRSA infections overtime was performed along with an analysis of data available for download from Hospital Compare (https://data.medicare.gov/data/hospital-compare). We found the estimations of the incidence of MRSA infections varied widely depending upon the typ...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-017-0193-0
更新日期:2017-04-07 00:00:00
abstract:BACKGROUND:Staphylococcus aureus (S. aureus), including methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA), is an eminent human pathogen that can colonize the human host and cause severe life-threatening infections. The development of a reliable, simple and rapid assay for detecting S. ...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-020-00774-x
更新日期:2020-07-17 00:00:00
abstract:BACKGROUND:The extent of the occurrence of the plasmid-encoded colistin resistance genes mcr-1 and mcr-2 among humans is currently sparsely studied in Western Europe. OBJECTIVES:To determine the occurrence of MCR-producing Enterobacteriaceae in fecal samples of healthy humans with high occupational exposure to food an...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-017-0186-z
更新日期:2017-03-14 00:00:00
abstract:Background:Multidrug-resistant (MDR) Gram-negative bacterial species are an increasingly dangerous public health threat, and are now endemic in many areas of South Asia. However, there are a lack of comprehensive data from many countries in this region determining historic and current MDR prevalence. Enterotoxigenic Es...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-018-0377-2
更新日期:2018-07-20 00:00:00
abstract:BACKGROUND:While multi-drug resistant organisms (MDRO) are a global phenomenon, there are significant regional differences in terms of prevalence. Traveling to countries with a high MDRO prevalence increases the risk of acquiring such an organism. In this study we determined risk factors for MDRO colonization among pat...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-015-0071-6
更新日期:2015-07-25 00:00:00
abstract::The emerging COVID-19 pandemic poses many difficulties to medical professionals. One of them is the need to use personal protective equipment (PPE) in order to protect themselves and their families, while not compromising their care. Physical examination is one of the cornerstones of medical assessment but parts of it...
journal_title:Antimicrobial resistance and infection control
pub_type: 信件
doi:10.1186/s13756-020-00854-y
更新日期:2020-12-09 00:00:00
abstract:BACKGROUND:Bacterial surface contamination contributes to transmission of nosocomial infections. Chemical cleansers used to control surface contamination are often toxic and incorrectly implemented. Additional non-toxic strategies should be combined with regular cleanings to mitigate risks of human error and further de...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/2047-2994-3-28
更新日期:2014-09-17 00:00:00
abstract:BACKGROUND:Surgical site infections (SSI) are one of the most common healthcare associated infections in the low-middle income countries. Data on incidence and risk factors for SSI following surgeries in general and Obstetric and Gynecological surgeries in particular are scare. This study set out to identify risk facto...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-017-0223-y
更新日期:2017-06-14 00:00:00
abstract:Background:Despite many preventive measures, outbreaks with multi-drug resistant micro-organisms (MDROs) still occur. Moreover, current alert systems from healthcare organizations have shortcomings due to delayed or incomplete notifications, which may amplify the spread of MDROs by introducing infected patients into a ...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-018-0359-4
更新日期:2018-05-30 00:00:00
abstract:UNLABELLED: BACKGROUND:Cockroaches have been described as potential vectors for various pathogens for decades; although studies from neonatal intensive care units are scarce. This study assessed the vector potential of cockroaches (identified as Blatella germanica) in a neonatal intensive care unit setup in Tikur Anbe...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/2047-2994-1-12
更新日期:2012-03-16 00:00:00