当前位置： SCI文献检索 > RESPIRATORY RESEARCH期刊下所有文献 > Role of PM2.5 in the development and progression of COPD and its mechanisms.

Role of PM2.5 in the development and progression of COPD and its mechanisms.

Abstract：

BACKGROUND:A multitude of epidemiological studies have shown that ambient fine particulate matter 2.5 (diameter < 2.5um; PM2.5) was associated with increased morbidity and mortality of chronic obstructive pulmonary disease (COPD). However, the underlying associated mechanisms have not yet been elucidated. We conducted this study to investigate the role of PM2.5 in the development of COPD and associated mechanisms. METHODS:We firstly conducted a cross-sectional study in Chinese han population to observe PM2.5 effects on COPD morbidity. Then, in vitro, we incubated human bronchial epithelial cells to different concentrations of PM2.5 for 24 h. The expression levels of IL-6 and IL-8 were detected by ELISA and the levels of MMPs, TGF-β1, fibronectin and collagen was determined by immunoblotting. In vivo, we subjected C57BL/6 mice to chronic prolonged exposure to PM2.5 for 48 weeks to study the influence of PM2.5 exposure on lung function, pulmonary structure and inflammation. RESULTS:We found that the effect of PM2.5 on COPD morbidity was associated with its levels and that PM2.5 and cigarette smoke could have a synergistic impact on COPD development and progression. Both vitro and vivo studies demonstrated that PM2.5 exposure could induce pulmonary inflammation, decrease lung function, and cause emphysematous changes. Furthermore, PM2.5 could markedly aggravated cigarette smoke-induced changes. CONCLUSIONS:In short, we found that prolonged chronic exposure to PM2.5 resulted in decreased lung function, emphysematous lesions and airway inflammation. Most importantly, long-term PM2.5 exposure exacerbateed cigarette smoke-induced changes in COPD.

journal_name

Respir Res

journal_title

Respiratory research

authors

Zhao J,Li M,Wang Z,Chen J,Zhao J,Xu Y,Wei X,Wang J,Xie J

doi

10.1186/s12931-019-1081-3

subject

Has Abstract

pub_date

2019-06-13 00:00:00

pages

120

issue

1

eissn

1465-9921

issn

1465-993X

pii

10.1186/s12931-019-1081-3

journal_volume

20

pub_type

杂志文章

相关文献

RESPIRATORY RESEARCH文献大全
  • CysLT1 receptor-induced human airway smooth muscle cells proliferation requires ROS generation, EGF receptor transactivation and ERK1/2 phosphorylation.

    abstract：BACKGROUND:Cysteine-containing leukotrienes (cysteinyl-LTs) are pivotal inflammatory mediators that play important roles in the pathophysiology of asthma, allergic rhinitis, and other inflammatory conditions. In particular, cysteinyl-LTs exert a variety of effects with relevance to the aetiology of asthma such as smoot...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-7-42

    authors： Ravasi S,Citro S,Viviani B,Capra V,Rovati GE

    更新日期：2006-03-22 00:00:00

  • Health care resource utilization and cost for asthma patients regularly treated with oral corticosteroids - a Swedish observational cohort study (PACEHR).

    abstract：BACKGROUND:Patients with severe uncontrolled asthma may receive oral corticosteroid (OCS) treatment regularly. The present study investigated the health care resource utilization and cost in regularly OCS treated Swedish asthma patients. METHODS:Primary care medical records data were linked to data from Swedish nation...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-018-0855-3

    authors： Janson C,Lisspers K,Ställberg B,Johansson G,Telg G,Thuresson M,Nordahl Christensen H,Larsson K

    更新日期：2018-09-03 00:00:00

  • Detection of reactive oxygen species in isolated, perfused lungs by electron spin resonance spectroscopy.

    abstract：BACKGROUND:The sources and measurement of reactive oxygen species (ROS) in intact organs are largely unresolved. This may be related to methodological problems associated with the techniques currently employed for ROS detection. Electron spin resonance (ESR) with spin trapping is a specific method for ROS detection, an...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-6-86

    authors： Weissmann N,Kuzkaya N,Fuchs B,Tiyerili V,Schäfer RU,Schütte H,Ghofrani HA,Schermuly RT,Schudt C,Sydykov A,Egemnazarow B,Seeger W,Grimminger F

    更新日期：2005-07-31 00:00:00

  • MUC1 deficiency mediates corticosteroid resistance in chronic obstructive pulmonary disease.

    abstract：BACKGROUND:Lung inflammation in COPD is poorly controlled by inhaled corticosteroids (ICS). Strategies to improve ICS efficacy or the search of biomarkers who may select those patients candidates to receive ICS in COPD are needed. Recent data indicate that MUC1 cytoplasmic tail (CT) membrane mucin can mediate corticost...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-018-0927-4

    authors： Milara J,Díaz-Platas L,Contreras S,Ribera P,Roger I,Ballester B,Montero P,Cogolludo Á,Morcillo E,Cortijo J

    更新日期：2018-11-20 00:00:00

  • Analysis of body mass index, weight loss and progression of idiopathic pulmonary fibrosis.

    abstract：BACKGROUND:Nintedanib is an approved therapy for idiopathic pulmonary fibrosis (IPF). Some patients treated with nintedanib experience weight loss. Exploratory data suggest that low body mass index or weight loss are associated with worse outcomes in patients with IPF. We investigated whether BMI at baseline or weight ...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-020-01528-4

    authors： Jouneau S,Crestani B,Thibault R,Lederlin M,Vernhet L,Valenzuela C,Wijsenbeek M,Kreuter M,Stansen W,Quaresma M,Cottin V

    更新日期：2020-11-25 00:00:00

  • Fluticasone furoate: once-daily evening treatment versus twice-daily treatment in moderate asthma.

    abstract：BACKGROUND:Inhaled corticosteroids are the recommended first-line treatment for asthma but adherence to therapy is suboptimal. The objectives of this study were to compare the efficacy and safety of once-daily (OD) evening and twice-daily (BD) regimens of the novel inhaled corticosteroid fluticasone furoate (FF) in ast...

    journal_title：Respiratory research

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1186/1465-9921-12-160

    authors： Woodcock A,Bleecker ER,Busse WW,Lötvall J,Snowise NG,Frith L,Jacques L,Haumann B,Bateman ED

    更新日期：2011-12-21 00:00:00

  • Pharmacology of airways and vessels in lung slices in situ: role of endogenous dilator hormones.

    abstract：:Small airway and vessels play a critical role in chronic airway and pulmonary vascular diseases, but their pharmacology has not been well characterised. We have studied airway and vascular responses in rat lung slices and separately in vitro using myography. In lung slices, under basal conditions, acetylcholine contra...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-7-111

    authors： Moreno L,Perez-Vizcaino F,Harrington L,Faro R,Sturton G,Barnes PJ,Mitchell JA

    更新日期：2006-08-21 00:00:00

  • Nebulization of the acidified sodium nitrite formulation attenuates acute hypoxic pulmonary vasoconstriction.

    abstract：BACKGROUND:Generalized hypoxic pulmonary vasoconstriction (HPV) occurring during exposure to hypoxia is a detrimental process resulting in an increase in lung vascular resistance. Nebulization of sodium nitrite has been shown to inhibit HPV. The aim of this project was to investigate and compare the effects of nebuliza...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-11-81

    authors： Egemnazarov B,Schermuly RT,Dahal BK,Elliott GT,Hoglen NC,Surber MW,Weissmann N,Grimminger F,Seeger W,Ghofrani HA

    更新日期：2010-06-21 00:00:00

  • Factors associated with hospitalization in bronchiectasis exacerbations: a one-year follow-up study.

    abstract：BACKGROUND:Bronchiectasis (BE) is a chronic structural lung disease with frequent exacerbations, some of which require hospital admission though no clear associated factors have been identified. We aimed to evaluate factors associated with hospitalization due to exacerbations during a 1-year follow-up period. METHODS:...

    journal_title：Respiratory research

    pub_type： 杂志文章,多中心研究

    doi：10.1186/s12931-017-0659-x

    authors： Menéndez R,Méndez R,Polverino E,Rosales-Mayor E,Amara-Elori I,Reyes S,Posadas T,Fernández-Barat L,Torres A

    更新日期：2017-09-30 00:00:00

  • Population specificity of the DNAI1 gene mutation spectrum in primary ciliary dyskinesia (PCD).

    abstract：BACKGROUND:Mutations in the DNAI1 gene, encoding a component of outer dynein arms of the ciliary apparatus, are the second most important genetic cause of primary ciliary dyskinesia (PCD), the genetically heterogeneous recessive disorder with the prevalence of ~1/20,000. The estimates of the DNAI1 involvement in PCD pa...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-11-174

    authors： Ziętkiewicz E,Nitka B,Voelkel K,Skrzypczak U,Bukowy Z,Rutkiewicz E,Humińska K,Przystałowska H,Pogorzelski A,Witt M

    更新日期：2010-12-08 00:00:00

  • Microbial dysbiosis and mortality during mechanical ventilation: a prospective observational study.

    abstract：BACKGROUND:Host-associated microbial communities have important roles in tissue homeostasis and overall health. Severe perturbations can occur within these microbial communities during critical illness due to underlying diseases and clinical interventions, potentially influencing patient outcomes. We sought to profile ...

    journal_title：Respiratory research

    pub_type： 杂志文章,随机对照试验

    doi：10.1186/s12931-018-0950-5

    authors： Lamarche D,Johnstone J,Zytaruk N,Clarke F,Hand L,Loukov D,Szamosi JC,Rossi L,Schenck LP,Verschoor CP,McDonald E,Meade MO,Marshall JC,Bowdish DME,Karachi T,Heels-Ansdell D,Cook DJ,Surette MG,PROSPECT Investigators.,C

    更新日期：2018-12-07 00:00:00

  • Prenatal fine particulate exposure associated with reduced childhood lung function and nasal epithelia GSTP1 hypermethylation: Sex-specific effects.

    abstract：BACKGROUND:In utero exposure to particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5) has been linked to child lung function. Overlapping evidence suggests that child sex and exposure timing may modify effects and associations may be mediated through glutathione S-transferase P1 (GSTP1) methylatio...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-018-0774-3

    authors： Lee AG,Le Grand B,Hsu HL,Chiu YM,Brennan KJ,Bose S,Rosa MJ,Brunst KJ,Kloog I,Wilson A,Schwartz J,Morgan W,Coull BA,Wright RO,Baccarelli AA,Wright RJ

    更新日期：2018-04-27 00:00:00

  • Recent advances in our understanding of human host responses to tuberculosis.

    abstract：:Tuberculosis remains one of the world's greatest public health challenges: 2 billion persons have latent infection, 8 million people develop active tuberculosis annually, and 2-3 million die. Recently, significant advances in our understanding of the human immune response against tuberculosis have occurred. The presen...

    journal_title：Respiratory research

    pub_type： 杂志文章,评审

    doi：10.1186/rr53

    authors： Schluger NW

    更新日期：2001-01-01 00:00:00

  • A comparison of four different models of acute respiratory distress syndrome in sheep.

    abstract：BACKGROUND:Acute respiratory distress syndrome (ARDS) can have various causes. The study objective was to investigate whether different pathophysiologic models of ARDS would show different respiratory, cardiovascular and inflammatory outcomes. METHODS:We performed a prospective, randomized study in 27 ventilated ewes ...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-020-01475-0

    authors： Engel M,Nowacki RME,Jonker EM,Ophelders D,Nikiforou M,Kloosterboer N,Zimmermann LJI,van Waardenburg DA,Kramer BW

    更新日期：2020-08-08 00:00:00

  • Approach to diagnosis and pathological examination in bronchial Dieulafoy disease: a case series.

    abstract：BACKGROUND:There are limited series concerning Dieulafoy disease of the bronchus. We describe the clinical presentation of a series of 7 patients diagnosed with Dieulafoy disease of the bronchus and provide information about the pathological diagnosis approach. PATIENTS AND METHODS:A retrospective review of patients w...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-9-58

    authors： Parrot A,Antoine M,Khalil A,Théodore J,Mangiapan G,Bazelly B,Fartoukh M

    更新日期：2008-08-05 00:00:00

  • The current position of surgical lung biopsy in the diagnosis of idiopathic pulmonary fibrosis.

    abstract：:A new international statement defines usual interstitial pneumonia (UIP) which is a histological and radiological form of idiopathic pulmonary fibrosis (IPF) more precisely than previously. In the diagnosis of IPF, either in high resolution computed tomography (HRCT) a UIP pattern must be present or alternatively spec...

    journal_title：Respiratory research

    pub_type： 杂志文章,评审

    doi：10.1186/1465-9921-14-43

    authors： Kaarteenaho R

    更新日期：2013-04-15 00:00:00

  • Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma.

    abstract：BACKGROUND:Identifying genetic determinants for lung function is important in providing insight into the pathophysiology of asthma. Signal transducer and activator of transcription 3 is a transcription factor latent in the cytoplasm; the gene (STAT3) is activated by a wide range of cytokines, and may play a role in lun...

    journal_title：Respiratory research

    pub_type： 杂志文章,随机对照试验

    doi：10.1186/1465-9921-6-52

    authors： Litonjua AA,Tantisira KG,Lake S,Lazarus R,Richter BG,Gabriel S,Silverman ES,Weiss ST

    更新日期：2005-06-03 00:00:00

  • Cleaved cytokeratin-18 is a mechanistically informative biomarker in idiopathic pulmonary fibrosis.

    abstract：BACKGROUND:Stress of the endoplasmic reticulum (ER) leading to activation of the unfolded protein response (UPR) and alveolar epithelial cell (AEC) apoptosis may play a role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Our objectives were to determine whether circulating caspase-cleaved cytokeratin-18 (c...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-13-105

    authors： Cha SI,Ryerson CJ,Lee JS,Kukreja J,Barry SS,Jones KD,Elicker BM,Kim DS,Papa FR,Collard HR,Wolters PJ

    更新日期：2012-11-20 00:00:00

  • Effect of chemokine receptor CXCR4 on hypoxia-induced pulmonary hypertension and vascular remodeling in rats.

    abstract：BACKGROUND:CXCR4 is the receptor for chemokine CXCL12 and reportedly plays an important role in systemic vascular repair and remodeling, but the role of CXCR4 in development of pulmonary hypertension and vascular remodeling has not been fully understood. METHODS:In this study we investigated the role of CXCR4 in the d...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-12-21

    authors： Yu L,Hales CA

    更新日期：2011-02-04 00:00:00

  • Azithromycin induces epidermal differentiation and multivesicular bodies in airway epithelia.

    abstract：BACKGROUND:Azithromycin (Azm) is a macrolide recognized for its disease-modifying effects and reduction in exacerbation of chronic airway diseases. It is not clear whether the beneficial effects of Azm are due to its anti-microbial activity or other pharmacological actions. We have shown that Azm affects the integrity ...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-019-1101-3

    authors： Arason AJ,Joelsson JP,Valdimarsdottir B,Sigurdsson S,Gudjonsson A,Halldorsson S,Johannsson F,Rolfsson O,Lehmann F,Ingthorsson S,Cherek P,Gudmundsson GH,Gardarsson FR,Page CP,Baldursson O,Gudjonsson T,Kricker JA

    更新日期：2019-06-24 00:00:00

  • Exogenous interleukin-6, interleukin-13, and interferon-γ provoke pulmonary abnormality with mild edema in enterovirus 71-infected mice.

    abstract：BACKGROUND:Neonatal mice developed neurological disease and pulmonary dysfunction after an infection with a mouse-adapted human Enterovirus 71 (EV71) strain MP4. However, the hallmark of severe human EV71 infection, pulmonary edema (PE), was not evident. METHODS:To test whether EV71-induced PE required a proinflammato...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-12-147

    authors： Huang SW,Lee YP,Hung YT,Lin CH,Chuang JI,Lei HY,Su IJ,Yu CK

    更新日期：2011-11-06 00:00:00

  • Anti-fibrotic effects of nintedanib in lung fibroblasts derived from patients with idiopathic pulmonary fibrosis.

    abstract：BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with poor prognosis. The kinase inhibitor nintedanib specific for vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR) and fibroblast growth factor receptor (FGFR) significantly reduced the rate ...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-014-0157-3

    authors： Hostettler KE,Zhong J,Papakonstantinou E,Karakiulakis G,Tamm M,Seidel P,Sun Q,Mandal J,Lardinois D,Lambers C,Roth M

    更新日期：2014-12-12 00:00:00

  • IL-33, diet-induced obesity, and pulmonary responses to ozone.

    abstract：BACKGROUND:Obesity augments pulmonary responses to ozone. We have reported that IL-33 contributes to these effects of obesity in db/db mice. The purpose of this study was to determine whether IL-33 also contributes to obesity-related changes in the response to ozone in mice with diet-induced obesity. METHODS:Male wild...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-020-01361-9

    authors： Kasahara DI,Shore SA

    更新日期：2020-04-23 00:00:00

  • Thiolated chitosan nanoparticles enhance anti-inflammatory effects of intranasally delivered theophylline.

    abstract：BACKGROUND:Chitosan, a polymer derived from chitin, has been used for nasal drug delivery because of its biocompatibility, biodegradability and bioadhesiveness. Theophylline is a drug that reduces the inflammatory effects of allergic asthma but is difficult to administer at an appropriate dosage without causing adverse...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-7-112

    authors： Lee DW,Shirley SA,Lockey RF,Mohapatra SS

    更新日期：2006-08-24 00:00:00

  • Allergen particle binding by human primary bronchial epithelial cells is modulated by surfactant protein D.

    abstract：BACKGROUND:Allergen-containing subpollen particles (SPP) are released from whole plant pollen upon contact with water or even high humidity. Because of their size SPP can preferentially reach the lower airways where they come into contact with surfactant protein (SP)-D. Our previous work demonstrated that SP-D increase...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-11-83

    authors： Schleh C,Erpenbeck VJ,Winkler C,Lauenstein HD,Nassimi M,Braun A,Krug N,Hohlfeld JM

    更新日期：2010-06-22 00:00:00

  • Could a defective epithelial sodium channel lead to bronchiectasis.

    abstract：BACKGROUND:Bronchiectasis is defined as a permanent dilation of the airways arising from chronic bronchial inflammation/infection. In 50% of cases, no etiology can be identified. Recently, the role of the epithelial sodium channel ENaC has been pointed out in the pathophysiology of cystic fibrosis, a disease due to mut...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-9-46

    authors： Fajac I,Viel M,Sublemontier S,Hubert D,Bienvenu T

    更新日期：2008-05-28 00:00:00

  • A systematic review of the role of vitamin insufficiencies and supplementation in COPD.

    abstract：BACKGROUND:Pulmonary inflammation, oxidants-antioxidants imbalance, as well as innate and adaptive immunity have been proposed as playing a key role in the development of COPD. The role of vitamins, as assessed either by food frequency questionnaires or measured in serum levels, have been reported to improve pulmonary ...

    journal_title：Respiratory research

    pub_type： 杂志文章,meta分析,评审

    doi：10.1186/1465-9921-11-171

    authors： Tsiligianni IG,van der Molen T

    更新日期：2010-12-06 00:00:00

  • Small airway bronchodilator response to different doses of salbutamol in 7-year-old children.

    abstract：:The Global Initiative for Asthma (GINA) guidelines do not specify a bronchodilator range for bronchodilator response (BDR) testing and simply recommend a salbutamol dose of 200 to 400 μg. We determined the oscillometric BDR results of children given low-dose (2 puffs, 200 μg) and standard-dose (4 puffs, 400 μg) salbut...

    journal_title：Respiratory research

    pub_type： 信件,随机对照试验

    doi：10.1186/s12931-017-0632-8

    authors： Yon DK,Jee HM,Ha EK,Lee SJ,Jung YH,Lee KS,Han MY

    更新日期：2017-08-03 00:00:00

  • Pectoralis muscle area and mortality in smokers without airflow obstruction.

    abstract：BACKGROUND:Low muscle mass is associated with increased mortality in the general population but its prognostic value in at-risk smokers, those without expiratory airflow obstruction, is unknown. We aimed to test the hypothesis that reduced muscle mass is associated with increased mortality in at-risk smokers. METHODS:...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-018-0771-6

    authors： Diaz AA,Martinez CH,Harmouche R,Young TP,McDonald ML,Ross JC,Han ML,Bowler R,Make B,Regan EA,Silverman EK,Crapo J,Boriek AM,Kinney GL,Hokanson JE,Estepar RSJ,Washko GR

    更新日期：2018-04-10 00:00:00

  • The TNFalpha gene relates to clinical phenotype in alpha-1-antitrypsin deficiency.

    abstract：BACKGROUND:Genetic variation may underlie phenotypic variation in chronic obstructive pulmonary disease (COPD) in subjects with and without alpha 1 antitrypsin deficiency (AATD). Genotype specific sub-phenotypes are likely and may underlie the poor replication of previous genetic studies. This study investigated subjec...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-9-52

    authors： Wood AM,Simmonds MJ,Bayley DL,Newby PR,Gough SC,Stockley RA

    更新日期：2008-07-11 00:00:00