The development of a World Health Organisation international standard for islet cell antibodies: the aims and design of an international collaborative study.

Abstract:

:Islet cell antibodies (ICA) are a specific marker for Type 1 (insulin-dependent) diabetes mellitus. ICA are found in the serum of over 80% of newly diagnosed patients and the levels of ICA are directly of prognostic value. Standardisation of ICA and the uniform reporting of ICA levels in international units is critical to preclinical/clinical research and the development of assays for ICA as diagnostics, in particular for the differential diagnosis of late onset Type 1 and Type 2 diabetes. Proficiency studies carried out by the Immunology of Diabetes Workshops on Standardization have clearly shown that a single reference material, serum sample 673, obtained by Dr J. Ludvigsson, has significantly reduced inter- and intra-assay variability in the reporting of ICA levels. Nevertheless, this material is a frozen serum of limited shelf-life and is difficult to distribute on a worldwide and routine basis. Therefore, the Immunology of Diabetes Workshop Standardization Committee and the Juvenile Diabetes Foundation International requested that the National Institute for Biological Standards and Control (NIBSC) organise an international collaborative study to compare the activities of lyophilised, stable ICA preparations. In addition, the purpose was to investigate if sample 673 could also serve as a standard for GAD65 and IA-2 antibodies. Twenty participants in eight countries have been recruited to the study.

journal_name

Diabetes Metab Res Rev

authors

Mire-Sluis AR,Das RG,Lernmark A

doi

10.1002/(sici)1520-7560(199901/02)15:1<72::aid-dmr

keywords:

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

72-7

issue

1

eissn

1520-7552

issn

1520-7560

pii

10.1002/(SICI)1520-7560(199901/02)15:1<72::AID-DMR

journal_volume

15

pub_type

杂志文章
  • Diabetes in pregnancy outcomes: a systematic review and proposed codification of definitions.

    abstract::Rising rates of diabetes in pregnancy have led to an escalation in research in this area. As in any area of clinical research, definitions of outcomes vary from study to study, making it difficult to compare research findings and draw conclusions. Our aim was to compile and create a repository of definitions, which co...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.2640

    authors: International Association of Diabetes in Pregnancy Study Group (IADPSG) Working Group on Outcome Definitions.,Feig DS,Corcoy R,Jensen DM,Kautzky-Willer A,Nolan CJ,Oats JJ,Sacks DA,Caimari F,McIntyre HD

    更新日期:2015-10-01 00:00:00

  • Serum ferritin and glucose homeostasis: change in the association by glycaemic state.

    abstract:BACKGROUND:Data on the association between body iron and glucose homeostasis by the three glycaemic states are scarce. Thus, we investigated the association between body iron as assessed by a serum ferritin concentration and glucose homeostasis using homeostasis model assessment (HOMA) of insulin resistance (HOMA-IR) a...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.2628

    authors: Aregbesola A,Virtanen JK,Voutilainen S,Mursu J,Lagundoye A,Kauhanen J,Tuomainen TP

    更新日期:2015-07-01 00:00:00

  • Association of ELMO1 gene polymorphism and diabetic nephropathy among Egyptian patients with type 2 diabetes mellitus.

    abstract:BACKGROUND AND OBJECTIVE:Diabetic nephropathy (DN) is the most common cause of end stage renal failure or even death among patients with type 2 diabetes mellitus. Genetic predisposition is widely studied among these patients to identify manageable aspects of the disease pathogenesis. This study was carried out to test ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.3299

    authors: Bayoumy NMK,El-Shabrawi MM,Leheta OF,Abo El-Ela AEM,Omar HH

    更新日期:2020-07-01 00:00:00

  • Prevalence of hyperglycaemia in singleton versus twin pregnancy.

    abstract:BACKGROUND:There is conflicting information regarding the risk of gestational diabetes mellitus in twin pregnancies. This study was conducted to determine whether the risk of gestational diabetes mellitus is higher in pregnant Japanese women with twin versus singleton pregnancy. METHODS:The prevalence of gestational d...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.2586

    authors: Morikawa M,Yamada T,Akaishi R,Kojima T,Nishida R,Koyama T,Cho K,Minakami H

    更新日期:2015-02-01 00:00:00

  • Independent markers of nonalcoholic fatty liver disease in a gentrifying population-based Chinese cohort.

    abstract:BACKGROUND:Prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing in developing countries, but its causes are not known. We aimed to ascertain the prevalence and determinants of NAFLD in a new largely unmedicated population-based cohort from the rapidly gentrifying region of Pinggu, China. METHODS:We ran...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.3156

    authors: Zhou X,Li Y,Zhang X,Guan YY,Puentes Y,Zhang F,Speliotes EK,Ji L

    更新日期:2019-07-01 00:00:00

  • Effectiveness of bedside investigations to diagnose peripheral artery disease among people with diabetes mellitus: a systematic review.

    abstract::Non-invasive tests for the detection of peripheral artery disease (PAD) among individuals with diabetes mellitus are important to estimate the risk of amputation, ulceration, wound healing and the presence of cardiovascular disease, yet there are no consensus recommendations to support a particular diagnostic modality...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.2703

    authors: Brownrigg JR,Hinchliffe RJ,Apelqvist J,Boyko EJ,Fitridge R,Mills JL,Reekers J,Shearman CP,Zierler RE,Schaper NC,International Working Group on the Diabetic Foot.

    更新日期:2016-01-01 00:00:00

  • Combination therapy with insulin and oral agents: optimizing glycemic control in patients with type 2 diabetes mellitus.

    abstract::The United Kingdom Prospective Diabetes Study (UKPDS) showed that tight glycemic control with any of several therapeutic regimens has the potential to significantly reduce the risk for long-term microvascular complications of type 2 diabetes. An important question that remains to be answered is what is the best approa...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.304

    authors: Yki-Järvinen H

    更新日期:2002-09-01 00:00:00

  • Diabetic fatty liver disease is associated with specific changes in blood-borne markers.

    abstract:BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) can lead to cirrhosis and hepatocellular carcinoma and is strongly associated with obesity and insulin resistance. The aim of this study was to assess if plasma markers associated with NAFLD are increased in people with concomitant diabetes compared with those withou...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.2269

    authors: Sharma S,Barrett F,Adamson J,Todd A,Megson IL,Zentler-Munro PL,MacRury SM

    更新日期:2012-05-01 00:00:00

  • Urinary biomarkers involved in type 2 diabetes: a review.

    abstract::Diabetes mellitus is one of the most challenging health concerns of the 21st century. With at least 30% of the diabetic population remaining undiagnosed, effective and early diagnosis is of critical concern. Development of a diagnostic test, more convenient and reliable than those currently used, would therefore be hi...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.1068

    authors: Matheson A,Willcox MD,Flanagan J,Walsh BJ

    更新日期:2010-03-01 00:00:00

  • Role of previous treatment with sulfonylureas in diabetic patients with acute myocardial infarction: results from a nationwide French registry.

    abstract:BACKGROUND:The cardiovascular effects of sulfonylureas (SU) in diabetic patients are controversial and it has been suggested that diabetic patients with acute myocardial infarction while on SU were at increased risk. OBJECTIVES:To assess the in-hospital outcome of patients with acute myocardial infarction according to...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,多中心研究

    doi:10.1002/dmrr.498

    authors: Danchin N,Charpentier G,Ledru F,Vaur L,Guéret P,Hanania G,Blanchard D,Lablanche JM,Genès N,Cambou JP

    更新日期:2005-03-01 00:00:00

  • Advanced glycosylation end products (AGEs), insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 (IGFBP-3) in patients with type 2 diabetes mellitus.

    abstract:BACKGROUND:Advanced glycosylation end product (AGE) formation is a major mechanism for the development of complications in diabetes, and the possible roles of insulin-like growth factor 1 (IGF-1) and IGF binding protein 3 (IGFBP-3) are not clearly established. METHODS:We examined the associations of AGEs, free IGF-I a...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/(sici)1520-7560(200003/04)16:2<106::aid-dm

    authors: Garay-Sevilla ME,Nava LE,Malacara JM,Wróbel K,Wróbel K,Pérez U

    更新日期:2000-03-01 00:00:00

  • Programmed disorders of beta-cell development and function as one cause for type 2 diabetes? The GK rat paradigm.

    abstract::Now that the reduction in beta-mass has been clearly established in humans with type 2 diabetes mellitus (T2DM) 1-4, the debate focuses on the possible mechanisms responsible for decreased beta-cell number and impaired beta-cell function and their multifactorial etiology. Appropriate inbred rodent models are essential...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.566

    authors: Portha B

    更新日期:2005-11-01 00:00:00

  • Retinal capillary basement membrane thickness in diabetic mice genetically modified at the haptoglobin locus.

    abstract:BACKGROUND:Individuals with diabetes mellitus (DM) homozygous for the haptoglobin (Hp) 1 allele are at decreased risk of retinopathy as compared to DM individuals with the Hp 2 allele. We sought to recapitulate these findings in DM mice genetically modified at the Hp locus. METHODS:An early morphological characteristi...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.654

    authors: Miller-Lotan R,Miller B,Nakhoul F,Aronson D,Asaf R,Levy AP

    更新日期:2007-02-01 00:00:00

  • Prevention of type 2 diabetes mellitus: is it feasible?

    abstract::The increasing global prevalence of type 2 diabetes mellitus (T2DM) requires the implementation of preventive strategies to halt this trend, tailored to the specific needs of individual regions. Risk factors for T2DM are among the main targets for improving health outcomes and curbing the development of diabetes; exce...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.2513

    authors: Palermo A,Maggi D,Maurizi AR,Pozzilli P,Buzzetti R

    更新日期:2014-03-01 00:00:00

  • Cardiovascular disease in patients with type 1 diabetes: Early evaluation, risk factors and possible relation with cardiac autoimmunity.

    abstract::Cardiovascular disease now is the leading cause of mortality among patients with type 1 diabetes (T1D). The risk of death from cardiovascular events in subjects with T1D is 2-10 times higher than the general population, depending on blood glucose control. Although complications of cardiovascular disease occur in middl...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.3423

    authors: Shi M,Tang R,Huang F,Zhong T,Chen Y,Li X,Zhou Z

    更新日期:2020-11-30 00:00:00

  • Oestradiol levels may differ between premenopausal women, ages 18-50, with type 1 diabetes and matched controls.

    abstract:BACKGROUND:This study aimed to investigate whether oestradiol differs between premenopausal women with and without type 1 diabetes and whether levels are associated with such factors as age, reproductive history or diabetes management. METHODS:Oestradiol in premenopausal women with type 1 diabetes (n = 89; age = 18-50...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.2829

    authors: Hassan LS,Monson RS,Danielson KK

    更新日期:2017-02-01 00:00:00

  • Effect of six years intensified multifactorial treatment on levels of hs-CRP and adiponectin in patients with screen detected type 2 diabetes: the ADDITION-Netherlands randomized trial.

    abstract:BACKGROUND:Levels of high-sensitivity C-reactive protein (hs-CRP) and adiponectin, reflecting chronic inflammation, are associated with cardiovascular disease in type 2 diabetes. The long-term effects of multifactorial therapy in type 2 diabetes patients on CRP and adiponectin are unknown. METHODS:The ADDITION-NL stud...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/dmrr.2669

    authors: den Ouden H,Berends J,Stellato RK,Beulens JW,Rutten GE

    更新日期:2015-10-01 00:00:00

  • New developments in the biomechanics of the diabetic foot.

    abstract::Biomechanical issues are now widely recognized as being important in the treatment of diabetic foot disease. The purpose of the present review is to identify advances that have occurred since the previous International Conference on the Diabetic Foot in 1995 in the understanding of foot biomechanics in relation to dia...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/1520-7560(200009/10)16:1+<::aid-dmrr130>3.

    authors: Cavanagh PR,Ulbrecht JS,Caputo GM

    更新日期:2000-09-01 00:00:00

  • The association between fasting plasma glucose and all-cause and cause-specific mortality by gender: The rural Chinese cohort study.

    abstract:BACKGROUND:To evaluate the association between fasting plasma glucose (FPG) and mortality by gender. METHODS:A total of 17 248 eligible participants from a rural Chinese prospective cohort population were included. The same questionnaire interview and anthropometric and laboratory measurements were performed at both b...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.3129

    authors: Liu L,Chen X,Liu Y,Sun X,Yin Z,Li H,Zhang M,Wang B,Ren Y,Zhao Y,Liu D,Zhou J,Liu X,Zhang D,Cheng C,Liu F,Zhou Q,Xu Q,Xiong Y,Liu J,You Z,Hong S,Wang C,Hu D

    更新日期:2019-05-01 00:00:00

  • The elevated gene expression level of the A(2B) adenosine receptor is associated with hyperglycemia in women with gestational diabetes mellitus.

    abstract:BACKGROUND:Adenosine receptors denoted by A1 , A2A , A2B , and A3 and encoded by ADORA1, ADORA2A, ADORA2B, and ADORA3 genes, respectively, are adenosine-activated G-protein-coupled receptors that play an important role in obesity and type 2 diabetes mellitus. However, little is known about their significance in gestati...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.2446

    authors: Wojcik M,Zieleniak A,Mac-Marcjanek K,Wozniak LA,Cypryk K

    更新日期:2014-01-01 00:00:00

  • Stroke in patients with diabetes mellitus.

    abstract::The article's objective is to review the key advances in the scientific literature related to the association of stroke with diabetes mellitus and to summarize the current approaches to stroke prevention in diabetic patients. The key findings from the literature regarding stroke incidence in patients with diabetes, sp...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.490

    authors: Mankovsky BN,Ziegler D

    更新日期:2004-07-01 00:00:00

  • Pancreatic fat accumulation is associated with decreased β-cell function and deterioration in glucose tolerance in Korean adults.

    abstract:AIMS:This study was designed to investigate the association between pancreatic fat content (PFC) and insulin secretory capacity as well as glucose tolerance in Korean adults. MATERIALS:A total of 39 participants (mean age 49.9 years, 53% males) without a previous history of diabetes, or those previously diagnosed as h...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.3425

    authors: Chin SO,Hwang YC,Cho IJ,Jeong IK,Ahn KJ,Chung HY

    更新日期:2020-11-30 00:00:00

  • The prevalence of GAD antibodies in Korean women with gestational diabetes mellitus and their clinical characteristics during and after pregnancy.

    abstract:BACKGROUND:We conducted this research in order to evaluate the prevalence of glutamic acid decarboxylase antibodies (GADA) in Korean women with gestational diabetes mellitus (GDM), to identify the clinical characteristics of these women, and to gauge the prevalence of diabetes among them after childbirth. METHODS:We s...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.963

    authors: Yu SH,Park S,Kim HS,Park SY,Yim CH,Han KO,Yoon HK,Jang HC,Chung HY,Kim SH

    更新日期:2009-05-01 00:00:00

  • Advanced complicated diabetes mellitus is associated with a reduced risk of thoracic and abdominal aortic aneurysm rupture: a population-based cohort study.

    abstract:BACKGROUND:Studies have associated diabetes mellitus (DM) with the reduced risk of abdominal aortic aneurysm and thoracic aortic aneurysm and dissection. We used the national insurance data of Taiwan to examine these correlations for an Asian population. The association was also evaluated by DM severity. METHODS:We id...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.2585

    authors: Tsai CL,Lin CL,Wu YY,Shieh DC,Sung FC,Kao CH

    更新日期:2015-02-01 00:00:00

  • New insights into the epidemiology of type 1 diabetes in Mediterranean countries.

    abstract::In Mediterranean countries, the incidence (per 100,000 per year) of Type 1 diabetes in children aged under 15 years shows wide variation from country to country, ranging from 2.45 in Macedonia to 34.4 in Sardinia. By interacting with environmental factors such as diet, toxins or viral infections, the HLA plus non-HLA ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/(sici)1520-7560(199903/04)15:2<133::aid-dm

    authors: Muntoni S,Muntoni S

    更新日期:1999-03-01 00:00:00

  • Open bypass and endoluminal therapy: complementary techniques for revascularization in diabetic patients with critical limb ischaemia.

    abstract::The use of endovascular therapy (EVT) for lower extremity atherosclerosis is markedly increasing while open surgical bypass is in decline. The results of EVT for critical limb ischaemia (CLI) are difficult to evaluate, especially for patients with diabetes. To date, only one randomized, prospective trial has been publ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.829

    authors: Mills JL Sr

    更新日期:2008-05-01 00:00:00

  • Low-intensity exercise increases skeletal muscle protein expression of PPARdelta and UCP3 in type 2 diabetic patients.

    abstract:BACKGROUND:Physical exercise provides health benefits for people with type 2 diabetes mellitus, partly by enhancing skeletal muscle insulin action. We tested the hypothesis that changes in expression of key genes in skeletal muscles relate to exercise-induced improvements in type 2 diabetic patients. METHODS:We determ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.656

    authors: Fritz T,Krämer DK,Karlsson HK,Galuska D,Engfeldt P,Zierath JR,Krook A

    更新日期:2006-11-01 00:00:00

  • Exosomes and diabetes.

    abstract::Diabetes is a group of metabolic diseases characterized by elevated blood glucose levels that drive the development of life-threatening complications. Diabetes results from a situation of insufficient insulin action, either by deficient production of the hormone by the pancreas, or by the development of insulin resist...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.3107

    authors: Castaño C,Novials A,Párrizas M

    更新日期:2019-03-01 00:00:00

  • Polyneuropathy in type 1 and type 2 diabetes: comparison of nerve conduction studies, thermal perception thresholds and intraepidermal nerve fibre densities.

    abstract:BACKGROUND:To evaluate possible differences in distal polyneuropathy (PN) characteristics and degree of abnormalities for various small and large fibre parameters in diabetes type 1 (DM1) and type 2 (DM2). METHODS:Sixty-six DM1 and 57 DM2 patients with or without PN symptoms were included. Nerve conduction studies (NC...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.1049

    authors: Løseth S,Mellgren SI,Jorde R,Lindal S,Stålberg E

    更新日期:2010-02-01 00:00:00

  • Glucose monitoring by reverse iontophoresis.

    abstract::Glucose can be extracted through intact skin by electro-osmotic flow (a process called 'reverse iontophoresis') upon the application of a low-level electrical current. Recently we have combined iontophoretic extraction with an in situ glucose sensor in a device called the GlucoWatch biographer. Clinical results with t...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.210

    authors: Potts RO,Tamada JA,Tierney MJ

    更新日期:2002-01-01 00:00:00