The International Sepsis Forum's controversies in sepsis: corticosteroids should be used to treat septic shock.


:The use of corticosteroids in septic shock remains controversial. It has been demonstrated that high doses of steroids (30 mg/kg methylprednisolone) for short periods of time are not beneficial. More recent studies using smaller doses (200-300 mg/day hydrocortisone) for longer periods of time have shown beneficial effects. These positive effects have included reversal of shock, trends toward decreased organ system dysfunction and decreased mortality. Based on the high proportion of patients who have relative adrenal insufficiency, the benefits of low doses of steroids and the minimal risks, steroids should be used to treat septic shock.


Crit Care


Goodman S,Sprung CL,International Sepsis Forum.





Has Abstract


2002-10-01 00:00:00












  • Epidemiology of critically ill patients in intensive care units: a population-based observational study.

    abstract:INTRODUCTION:Epidemiologic assessment of critically ill people in Intensive Care Units (ICUs) is needed to ensure the health care system can meet current and future needs. However, few such studies have been published. METHODS:Population-based analysis of all adult ICU care in the Canadian province of Manitoba, 1999 t...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,多中心研究


    authors: Garland A,Olafson K,Ramsey CD,Yogendran M,Fransoo R

    更新日期:2013-09-30 00:00:00

  • Circulating bioactive adrenomedullin as a marker of sepsis, septic shock and critical illness.

    abstract:BACKGROUND:Biomarkers can be of help to understand critical illness and to identify and stratify sepsis. Adrenomedullin is a vasoactive hormone, with reported prognostic and potentially therapeutic value in sepsis. The primary aim of this study was to investigate the association of circulating bioactive adrenomedullin ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Lundberg OHM,Lengquist M,Spångfors M,Annborn M,Bergmann D,Schulte J,Levin H,Melander O,Frigyesi A,Friberg H

    更新日期:2020-11-04 00:00:00

  • Biomarkers of sepsis: time for a reappraisal.

    abstract:INTRODUCTION:Sepsis biomarkers can have important diagnostic, therapeutic, and prognostic functions. In a previous review, we identified 3370 references reporting on 178 different biomarkers related to sepsis. In the present review, we evaluate the progress in the research of sepsis biomarkers. METHODS:Using the same ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Pierrakos C,Velissaris D,Bisdorff M,Marshall JC,Vincent JL

    更新日期:2020-06-05 00:00:00

  • Treatment of central line-associated bloodstream infections.

    abstract:: ...

    journal_title:Critical care (London, England)

    pub_type: 社论


    authors: Guenezan J,Drugeon B,Marjanovic N,Mimoz O

    更新日期:2018-11-16 00:00:00

  • Use of noninvasive ventilation in immunocompromised patients with acute respiratory failure: a systematic review and meta-analysis.

    abstract:BACKGROUND:Acute respiratory failure (ARF) remains a common hazardous complication in immunocompromised patients and is associated with increased mortality rates when endotracheal intubation is needed. We aimed to evaluate the effect of early noninvasive ventilation (NIV) compared with oxygen therapy alone in this pati...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,meta分析,评审


    authors: Huang HB,Xu B,Liu GY,Lin JD,Du B

    更新日期:2017-01-07 00:00:00

  • Alarms in the intensive care unit: how can the number of false alarms be reduced?

    abstract::Many alarms, as they now exist in most monitoring systems, are not usually perceived as helpful by the medical staff because of the high incidence of false alarms. This paper gives an overview of the problems related to their current design and the objectives of monitoring. The current approaches used to improve the s...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Chambrin MC

    更新日期:2001-08-01 00:00:00

  • Does pulse pressure variation predict fluid responsiveness in critically ill patients? A systematic review and meta-analysis.

    abstract:INTRODUCTION:Fluid resuscitation is crucial in managing hemodynamically unstable patients. The last decade witnessed the use of pulse pressure variation (PPV) to predict fluid responsiveness. However, as far as we know, no systematic review and meta-analysis has been carried out to evaluate the value of PPV in predicti...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,meta分析,评审


    authors: Yang X,Du B

    更新日期:2014-11-27 00:00:00

  • Phenotype changes and impaired function of dendritic cell subsets in patients with sepsis: a prospective observational analysis.

    abstract:INTRODUCTION:Patients with sepsis often demonstrate severely impaired immune responses. The hallmark of this state of immunoparalysis is monocytic deactivation characterized by decreased human leukocyte antigen (HLA)-DR expression and reduced production of proinflammatory cytokines. Recently, diminished numbers of dend...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Poehlmann H,Schefold JC,Zuckermann-Becker H,Volk HD,Meisel C

    更新日期:2009-01-01 00:00:00

  • Clinical review: Intensive care follow-up--what has it told us?

    abstract::The majority of intensive care practitioners, until comparatively recently, was content to discharge surviving patients to the care of referring primary specialty colleagues who would undertake subsequent inpatient and outpatient care. With the exception of mortality statistics from clinical studies, the practitioners...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Broomhead LR,Brett SJ

    更新日期:2002-10-01 00:00:00

  • Eubaric hyperoxia: controversies in the management of acute traumatic brain injury.

    abstract::Controversy exists on the role of hyperoxia in major trauma with brain injury. Hyperoxia on arterial blood gas has been associated with acute lung injury and pulmonary complications, impacting clinical outcome. The hyperoxia could be reflective of the physiological interventions following major systemic trauma. Despit...

    journal_title:Critical care (London, England)

    pub_type: 评论,杂志文章


    authors: Narotam PK

    更新日期:2013-10-16 00:00:00

  • Statistics review 2: samples and populations.

    abstract::The previous review in this series introduced the notion of data description and outlined some of the more common summary measures used to describe a dataset. However, a dataset is typically only of interest for the information it provides regarding the population from which it was drawn. The present review focuses on...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Whitley E,Ball J

    更新日期:2002-04-01 00:00:00

  • Blood transfusion during cardiac surgery is associated with inflammation and coagulation in the lung: a case control study.

    abstract:INTRODUCTION:Blood transfusion is associated with increased morbidity and mortality in cardiac surgery patients, but cause-and-effect relations remain unknown. We hypothesized that blood transfusion is associated with changes in pulmonary and systemic inflammation and coagulation occurring in patients who do not meet t...

    journal_title:Critical care (London, England)

    pub_type: 临床试验,杂志文章


    authors: Tuinman PR,Vlaar AP,Cornet AD,Hofstra JJ,Levi M,Meijers JC,Beishuizen A,Schultz MJ,Groeneveld AJ,Juffermans NP

    更新日期:2011-01-01 00:00:00

  • Clinical review: Tokyo - protecting the health care worker during a chemical mass casualty event: an important issue of continuing relevance.

    abstract::Determine the effectiveness of decontamination, and perform thorough dry or wet decontamination, depending on the circumstances. Always remain cognizant of the fact that, even after decontamination has been completed, contamination may not have been completely eliminated. Perform periodic monitoring to determine wheth...

    journal_title:Critical care (London, England)

    pub_type: 历史文章,杂志文章,评审


    authors: Okumura S,Okumura T,Ishimatsu S,Miura K,Maekawa H,Naito T

    更新日期:2005-08-01 00:00:00

  • Uncalibrated pulse power analysis fails to reliably measure cardiac output in patients undergoing coronary artery bypass surgery.

    abstract:INTRODUCTION:Uncalibrated arterial pulse power analysis has been recently introduced for continuous monitoring of cardiac index (CI). The aim of the present study was to compare the accuracy of arterial pulse power analysis with intermittent transpulmonary thermodilution (TPTD) before and after cardiopulmonary bypass (...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Broch O,Renner J,Höcker J,Gruenewald M,Meybohm P,Schöttler J,Steinfath M,Bein B

    更新日期:2011-01-01 00:00:00

  • Preload-independent mechanisms contribute to increased stroke volume following large volume saline infusion in normal volunteers: a prospective interventional study.

    abstract:INTRODUCTION:Resuscitation with saline is a standard initial response to hypotension or shock of almost any cause. Saline resuscitation is thought to generate an increase in cardiac output through a preload-dependent (increased end-diastolic volume) augmentation of stroke volume. We sought to confirm this to be the mec...

    journal_title:Critical care (London, England)

    pub_type: 临床试验,杂志文章


    authors: Kumar A,Anel R,Bunnell E,Zanotti S,Habet K,Haery C,Marshall S,Cheang M,Neumann A,Ali A,Kavinsky C,Parrillo JE

    更新日期:2004-06-01 00:00:00

  • Role of selective V2-receptor-antagonism in septic shock: a randomized, controlled, experimental study.

    abstract:INTRODUCTION:V(2)-receptor (V(2)R) stimulation potentially aggravates sepsis-induced vasodilation, fluid accumulation and microvascular thrombosis. Therefore, the present study was performed to determine the effects of a first-line therapy with the selective V(2)R-antagonist (Propionyl(1)-D-Tyr(Et)(2)-Val(4)-Abu(6)-Arg...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,随机对照试验


    authors: Rehberg S,Ertmer C,Lange M,Morelli A,Whorton E,Dünser M,Strohhäcker AK,Lipke E,Kampmeier TG,Van Aken H,Traber DL,Westphal M

    更新日期:2010-01-01 00:00:00

  • Hyperchloremia and moderate increase in serum chloride are associated with acute kidney injury in severe sepsis and septic shock patients.

    abstract:BACKGROUND:Acute kidney injury and hyperchloremia are commonly present in critically ill septic patients. Our study goal was to evaluate the association of hyperchloremia and acute kidney injury in severe sepsis and septic shock patients. METHODS:In this retrospective cohort study in a provincial tertiary care hospita...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Suetrong B,Pisitsak C,Boyd JH,Russell JA,Walley KR

    更新日期:2016-10-06 00:00:00

  • The continuum of critical care.

    abstract::Until relatively recently, critical illness was considered as a separate entity and the intensive care unit (ICU), often a little cut-off from other areas of the hospital, was in many cases used as a last resort for patients so severely ill that it was no longer possible to care for them on the general ward. However, ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Vincent JL

    更新日期:2019-06-14 00:00:00

  • Effect of antiviral therapy on the outcomes of mechanically ventilated patients with herpes simplex virus detected in the respiratory tract: a systematic review and meta-analysis.

    abstract:BACKGROUND:Herpes simplex virus (HSV) is frequently detected in the respiratory tract of mechanically ventilated patients. The aim of this study was to assess current evidence to determine whether antiviral therapy is associated with better outcomes in these patients. METHODS:MEDLINE, ISI Web of Science, Cochrane Data...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Hagel S,Scherag A,Schuierer L,Hoffmann R,Luyt CE,Pletz MW,Kesselmeier M,Weis S

    更新日期:2020-09-29 00:00:00

  • Serum neutrophil gelatinase-associated lipocalin at inception of renal replacement therapy predicts survival in critically ill patients with acute kidney injury.

    abstract:INTRODUCTION:Neutrophil gelatinase-associated lipocalin (NGAL) is a promising novel biomarker that correlates with the severity and outcome of acute kidney injury (AKI). However, its prognostic utility during the late course of AKI, especially in patients that require renal replacement therapy (RRT) remains unknown. Th...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Kümpers P,Hafer C,Lukasz A,Lichtinghagen R,Brand K,Fliser D,Faulhaber-Walter R,Kielstein JT

    更新日期:2010-01-01 00:00:00

  • Decreased CX3CR1 messenger RNA expression is an independent molecular biomarker of early and late mortality in critically ill patients.

    abstract:BACKGROUND:Chemokine (C-X3-C motif) receptor 1 (CX3CR1) was identified as the most differentially expressed gene between survivors and non-survivors in two independent cohorts of septic shock patients and was proposed as a marker of sepsis-induced immunosuppression. Whether such a biomarker is associated with mortality...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Friggeri A,Cazalis MA,Pachot A,Cour M,Argaud L,Allaouchiche B,Floccard B,Schmitt Z,Martin O,Rimmelé T,Fontaine-Kesteloot O,Page M,Piriou V,Bohé J,Monneret G,Morisset S,Textoris J,Vallin H,Blein S,Maucort-Boulch D,

    更新日期:2016-06-30 00:00:00

  • Shock subtypes by left ventricular ejection fraction following out-of-hospital cardiac arrest.

    abstract:BACKGROUND:Post-resuscitation hemodynamic instability following out-of-hospital cardiac arrest (OHCA) may occur from myocardial dysfunction underlying cardiogenic shock and/or inflammation-mediated distributive shock. Distinguishing the predominant shock subtype with widely available clinical metrics may have prognosti...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Anderson RJ,Jinadasa SP,Hsu L,Ghafouri TB,Tyagi S,Joshua J,Mueller A,Talmor D,Sell RE,Beitler JR

    更新日期:2018-06-15 00:00:00

  • Microcirculatory perfusion disturbances in septic shock: results from the ProCESS trial.

    abstract:BACKGROUND:We sought to determine the effects of alternative resuscitation strategies on microcirculatory perfusion and examine any association between microcirculatory perfusion and mortality in sepsis. METHODS:This was a prospective, formally designed substudy of participants in the Protocolized Care in Early Septic...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Massey MJ,Hou PC,Filbin M,Wang H,Ngo L,Huang DT,Aird WC,Novack V,Trzeciak S,Yealy DM,Kellum JA,Angus DC,Shapiro NI,ProCESS investigators.

    更新日期:2018-11-20 00:00:00

  • Community-acquired polymicrobial pneumonia in the intensive care unit: aetiology and prognosis.

    abstract:INTRODUCTION:The frequency and clinical significance of polymicrobial aetiology in community-acquired pneumonia (CAP) patients admitted to the ICU have been poorly studied. The aim of the present study was to describe the prevalence, clinical characteristics and outcomes of severe CAP of polymicrobial aetiology in pati...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Cillóniz C,Ewig S,Ferrer M,Polverino E,Gabarrús A,Puig de la Bellacasa J,Mensa J,Torres A

    更新日期:2011-01-01 00:00:00

  • Tracheal extubation and reintubation of the critically ill--challenges coming and going.

    abstract::Tracheal reintubation is a common event in critical care. Elmer and colleagues provide the first comparison of complication rates of initial and subsequent reintubation(s) during the same hospitalization. Their work shows an increased risk of complications associated with reintubation, in particular hypoxemia and hypo...

    journal_title:Critical care (London, England)

    pub_type: 评论,杂志文章


    authors: Parotto M,Cooper RM

    更新日期:2015-03-27 00:00:00

  • Forced oscillation assessment of respiratory mechanics in ventilated patients.

    abstract::The forced oscillation technique (FOT) is a method for non-invasively assessing respiratory mechanics that is applicable both in paralysed and non-paralysed patients. As the FOT requires a minimal modification of the conventional ventilation setting and does not interfere with the ventilation protocol, the technique i...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Navajas D,Farré R

    更新日期:2001-01-01 00:00:00

  • Clinical course and outcome of 107 patients infected with the novel coronavirus, SARS-CoV-2, discharged from two hospitals in Wuhan, China.

    abstract:BACKGROUND:In December 2019, coronavirus disease 2019 (COVID-19) outbreak was reported from Wuhan, China. Information on the clinical course and prognosis of COVID-19 was not thoroughly described. We described the clinical courses and prognosis in COVID-19 patients. METHODS:Retrospective case series of COVID-19 patien...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Wang D,Yin Y,Hu C,Liu X,Zhang X,Zhou S,Jian M,Xu H,Prowle J,Hu B,Li Y,Peng Z

    更新日期:2020-04-30 00:00:00

  • Ethics roundtable debate: withdrawal of tube feeding in a patient with persistent vegetative state where the patients wishes are unclear and there is family dissension.

    abstract::The decision to withdraw or withhold life supporting treatment in moribund patients is difficult under any circumstances. When the patient becomes incompetent to clarify their wishes regarding continued maintenance in long-term facilities, surrogates sometimes cannot agree, further clouding the issue. We examine a cas...

    journal_title:Critical care (London, England)

    pub_type: 社论


    authors: Buckley T,Crippen D,DeWitt AL,Fisher M,Liolios A,Scheetz CL,Whetstine LM

    更新日期:2004-04-01 00:00:00

  • Glial fibrillary acidic protein as a biomarker in severe traumatic brain injury patients: a prospective cohort study.

    abstract:INTRODUCTION:Glial fibrillary acidic protein (GFAP) may serve as a serum marker of traumatic brain injury (TBI) that can be used to monitor biochemical changes in patients and gauge the response to treatment. However, the temporal profile of serum GFAP in the acute period of brain injury and the associated utility for ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Lei J,Gao G,Feng J,Jin Y,Wang C,Mao Q,Jiang J

    更新日期:2015-10-12 00:00:00

  • Long-term survival of chronic dialysis patients following survival from an episode of multiple-organ failure.

    abstract:INTRODUCTION:This study aimed to examine the long-term outcome for patients with end-stage renal failure (ESRF) who survived multiple-organ failure. METHODS:We performed a review of databases from the renal medicine service and intensive care units (ICU) of the participating hospitals within Imperial College Healthcar...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Chapman RJ,Templeton M,Ashworth S,Broomhead R,McLean A,Brett SJ

    更新日期:2009-01-01 00:00:00