Abstract:
:The use of corticosteroids in septic shock remains controversial. It has been demonstrated that high doses of steroids (30 mg/kg methylprednisolone) for short periods of time are not beneficial. More recent studies using smaller doses (200-300 mg/day hydrocortisone) for longer periods of time have shown beneficial effects. These positive effects have included reversal of shock, trends toward decreased organ system dysfunction and decreased mortality. Based on the high proportion of patients who have relative adrenal insufficiency, the benefits of low doses of steroids and the minimal risks, steroids should be used to treat septic shock.
journal_name
Crit Carejournal_title
Critical care (London, England)authors
Goodman S,Sprung CL,International Sepsis Forum.doi
10.1186/cc1537keywords:
subject
Has Abstractpub_date
2002-10-01 00:00:00pages
381-3issue
5eissn
1364-8535issn
1466-609Xjournal_volume
6pub_type
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