TRPM7 promotes the epithelial-mesenchymal transition in ovarian cancer through the calcium-related PI3K / AKT oncogenic signaling.

abstract：BACKGROUND:Kindlin-2 is a member of the focal adhesion protein family that regulates invasion and metastasis in multiple malignancies; however, little is known about the role of Kindlin-2 in hepatocellular carcinoma (HCC) progression. METHODS:Immunohistochemistry was used to investigate Kindlin-2 expression in 177 pai...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Lin J,Lin W,Ye Y,Wang L,Chen X,Zang S,Huang A

更新日期：2017-09-29 00:00:00

abstract：:The heterogeneous tumor microenvironment (TME) is highly complex and not entirely understood. These complex configurations lead to the generation of oxygen-deprived conditions within the tumor niche, which modulate several intrinsic TME elements to promote immunosuppressive outcomes. Decoding these communications is n...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Bhattacharya S,Calar K,de la Puente P

更新日期：2020-05-01 00:00:00

abstract：:Escherichia coli cytosine deaminase (CD), which is a prokaryotic enzyme, converts nontoxic prodrug 5-fluorocytosine (5-FC) into the toxic chemotherapeutic agent 5-fluorouracil (5-FU). To investigate an enzyme/prodrug gene therapy for colorectal cancer, using adenoviral gene transfer of the E. coli CD gene associated w...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Koyama F,Sawada H,Fujii H,Hirao T,Ueno M,Hamada H,Nakano H

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Partial epithelial mesenchymal transition (p-EMT) was found to play a potential role in the initial stage of metastasis in human head and neck squamous cell carcinoma (HNSCC). Some long noncoding RNAs (lncRNAs) have been reported to function as promoters or inhibitors of cancer metastasis. This study aimed t...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Xiong HG,Li H,Xiao Y,Yang QC,Yang LL,Chen L,Bu LL,Zhang WF,Zhang JL,Sun ZJ

更新日期：2019-06-25 00:00:00

abstract：BACKGROUND:Non-small cell lung cancer (NSCLC) patients with sensitive epidermal growth factor receptor (EGFR) mutations are successfully treated with EGFR tyrosine kinase inhibitors (EGFR-TKIs); however, resistance to treatment inevitably occurs. Given lipid metabolic reprogramming is widely known as a hallmark of canc...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Huang Q,Wang Q,Li D,Wei X,Jia Y,Zhang Z,Ai B,Cao X,Guo T,Liao Y

更新日期：2019-03-15 00:00:00

abstract：:The aim of the present study was to assess the role of virtual cystoscopy in the identification of bladder tumors. Fifteen patients (11 men and 4 women, median age: 61 years, range: 46-74 years) with a positive finding of bladder tumor at fiber-optic cystoscopy were studied by multislice-CT. Scans were downloaded to a...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Marini M,Stasolla A,D'Aprile MR,Colaiacomo MC,Lo Mele L,Maccioni F,Iori S,Binda B,Izzo L

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:Retinoic acid-inducible gene-I (Rig-I) is an intracellular viral RNA receptor, which specifically recognizes double-stranded viral RNA initiating antiviral innate immunity. Increasing evidences showed that Rig-I had broader roles in antibacterial immunity and cancer protection. However, the potential roles a...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhu H,Xu WY,Hu Z,Zhang H,Shen Y,Lu S,Wei C,Wang ZG

更新日期：2017-01-05 00:00:00

abstract：:Occult carcinoma cells in peripheral blood of breast cancer (BC) patients is generally associated with poor disease prognosis. Reverse transcriptase-polymerase chain reaction (RT-PCR) is a sensitive method for revealing rare circulating cancer cells. The target mRNA must be carefully chosen, as it must be expressed on...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Roncella S,Ferro P,Bacigalupo B,Pronzato P,Tognoni A,Falco E,Gianquinto D,Ansaldo V,Dessanti P,Fais F,Rosai J,Fedeli F

更新日期：2005-06-01 00:00:00

abstract：:Survivin is a novel member of the inhibitor of apoptosis (IAP) protein family, and its aberrant expression in cancer cells has been shown to be associated with tumorigenesis, cancer progression, radiation/drug resistance and shorter patient survival. Survivin is also expressed in certain human adult tissues and cells,...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhang M,Yang J,Li F

更新日期：2006-09-01 00:00:00

abstract：:Primary lymphoma of the breast is a rare disease that has been estimated to represent from 0.05% to 0.53% of all malignant breast tumors and approximately 2.2% of all extranodal lymphomas. The aim of this study is to review all cases of primary lymphoma of the breast at the Institute of Oncology and Radiology of Serbi...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Babovic N,Jelic S,Jovanovic V

更新日期：2000-06-01 00:00:00

abstract：:Tumours involving the scrotum are rare and primary malignant melanoma is among the rarest of these lesions. Between 1949 and 1996 only 7 cases have been reported. We present two cases of scrotal melanoma. The current recommendations and management strategies are discussed on the basis of a review of the literature. ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Berkmen F,Tandoğdu R,Ardjçoğlu A

更新日期：1998-03-01 00:00:00

abstract：:Adenosquamous carcinomas of the colorectum are rare neoplasms. Our experience with two cases is presented in this paper. One patient, who complained of bloody stool, was found to have adenocarcinoma in the sigmoid colon. He received a laparoscopy-assisted sigmoidectomy. The histological examination revealed that the t...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Fukui R,Hata F,Yasoshima T,Furuhata T,Honma T,Nakajima F,Nishimori H,Isomura H,Katsuramaki T,Tanaka H,Kobayashi K,Hirata K

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is the major histological type of liver cancer with high morbidity and mortality worldwide. Long noncoding RNAs (lncRNA) has been proved to be associated with various cancer types, while its regulation in HCC is largely unknown. METHODS:To figure out the specific role of lncRN...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Wang YG,Wang T,Shi M,Zhai B

更新日期：2019-04-10 00:00:00

abstract：PURPOSE:The association between striking life events, an important stress and acute anxiety disorder, and the occurrence of primary breast cancer is unclear. The current meta-analysis was designed to assess the relationship between striking life events and primary breast cancer incidence in women. METHODS:Systematic c...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Lin Y,Wang C,Zhong Y,Huang X,Peng L,Shan G,Wang K,Sun Q

更新日期：2013-08-13 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is one of the frequently occurred malignancies in the world. To date, several onco-microRNAs (miRNAs or miRs), including miR-96, have been identified in the pathogenesis of CRC. In the present study, we aimed to corroborate the oncogenic effect of miR-96 on CRC and to identify the spe...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yue C,Chen J,Li Z,Li L,Chen J,Guo Y

更新日期：2020-11-12 00:00:00

abstract：BACKGROUND:Thyroid cancer is one of the most prevalent malignancies in endocrine system. Further understanding and revealing the molecular mechanism underlying thyroid cancer are indispensable for the development of effective diagnosis and treatments. In the present study, we attempted to provide novel basis for target...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Liu H,Deng H,Zhao Y,Li C,Liang Y

更新日期：2018-11-21 00:00:00

abstract：BACKGROUND:The transcription factor HOXD9 is one of the members of the HOX family, which plays an important role in neoplastic processes. However, the role of HOXD9 in the growth and metastasis of gastric cancer (GC) remains to be elucidated. METHODS:In vitro functional role of HOXD9 and RURY3 in GC cells was determin...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhu H,Dai W,Li J,Xiang L,Wu X,Tang W,Chen Y,Yang Q,Liu M,Xiao Y,Zhang W,Lin J,Wang J,Liu G,Sun Y,Jiang P,Li G,Li A,Liu S,Chen Y,Wang J

更新日期：2019-09-23 00:00:00

abstract：BACKGROUND:Previous meta-analysis suggested that transdermal fentanyl was not inferior to sustained-release oral morphine in treating moderate-severe cancer pain with less adverse effects. Now, we updated the data and performed a systematic review. METHODS:Updated cohort studies on transdermal fentanyl and oral morphi...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yang Q,Xie DR,Jiang ZM,Ma W,Zhang YD,Bi ZF,Chen DL

更新日期：2010-06-09 00:00:00

abstract：BACKGROUND:The aim of this study was to determine a predictive indicator of gemcitabine (GEM) efficacy in unresectable pancreatic cancer using tissue obtained by endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNA). METHODS:mRNAs extracted from 35 pancreatic tubular adenocarcinoma tissues obtained by E...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Ashida R,Nakata B,Shigekawa M,Mizuno N,Sawaki A,Hirakawa K,Arakawa T,Yamao K

更新日期：2009-06-16 00:00:00

abstract：:In the original publication of this manuscript [1], Fig. 5E lower panel was incorrect due to an error in the preparation of these figures for publication. It was noticed that in the lower panel of Fig. 5E, one mouse image of ApoE-/- + PBS group (upper) was a photograph coming from ApoE-/- + BAPN pre-treatment group (l...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Lai H,Zhao X,Qin Y,Ding Y,Chen R,Li G,Labrie M,Ding Z,Zhou J,Hu J,Ma D,Fang Y,Gao Q

更新日期：2019-10-15 00:00:00

abstract：BACKGROUND:Investigation of the expression of an intestinal stem cell marker in esophageal adenocarcinomas (EAC) with and without Barrett's Esophagus (BE), with respect to a cancer stem cell (CSC) hypothesis. MATERIALS AND METHODS:Expression of a putative intestinal stem cell marker LgR5 was analyzed in esophageal can...

journal_title：Journal of experimental & clinical cancer research : CR

authors： von Rahden BH,Kircher S,Lazariotou M,Reiber C,Stuermer L,Otto C,Germer CT,Grimm M

更新日期：2011-02-23 00:00:00

abstract：:In papillary thyroid carcinoma lymphnode metastases at presentation do not seem to adversely affect survival, but do increase the risk of loco-regional tumor recurrence. The value of systematic versus selective lymphadenectomy is far less standardized, whereas the role of postoperative radioiodine in preventing either...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Ducci M,Appetecchia M,Marzetti M

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND:Hippo/YAP pathway is known to be important for development, growth and organogenesis, and dysregulation of this pathway leads to tumor progression. We and others find that YAP is up-regulated in pancreatic ductal adenocarcinoma (PDAC) and associated with worse prognosis of patients. Activated pancreatic stel...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Jiang Z,Zhou C,Cheng L,Yan B,Chen K,Chen X,Zong L,Lei J,Duan W,Xu Q,Li X,Wang Z,Ma Q,Ma J

更新日期：2018-03-27 00:00:00

abstract：BACKGROUND:Berberine (BBR), a component from traditional Chinese medicine, has been shown to possess anti-tumor activity against a wide spectrum of cancer cells including human lung cancer, but the detailed mechanism underlining this has not been well elucidated. METHODS:In this study, the effect of berberine on cell ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zheng F,Tang Q,Wu J,Zhao S,Liang Z,Li L,Wu W,Hann S

更新日期：2014-04-26 00:00:00

abstract：BACKGROUND:Manganese superoxide dismutase (MnSOD) upregulating FoxM1 have previously been demonstrated promoting lung cancer stemness. Isovitexin exhibits antitumor activities in various cancers. This study aimed to assess whether isovitexin inhibits hepatic carcinoma stem-like cells (HCSLCs) features via regulating Mn...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Cao X,Liu L,Yuan Q,Li X,Cui Y,Ren K,Zou C,Chen A,Xu C,Qiu Y,Quan M,Zhang J,Cao J,Chen X

更新日期：2019-06-17 00:00:00

abstract：BACKGROUND:DNA methylation has been widely used in classification, early diagnosis, therapy and prediction of metastasis as well as recurrence of cervical cancer. DNMT methyltransferase 1 (DNMT1), which plays a significant role in maintaining DNA methylation status and regulating the expression of tumor suppressor gene...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhang Y,Chen FQ,Sun YH,Zhou SY,Li TY,Chen R

更新日期：2011-10-17 00:00:00

abstract：:Human mammaglobin (hMAM) has recently been recognized as a breast associated glycoprotein. Although the biological role of hMAM is unknown, it has been previously reported that hMAM gene expression is a marker of low biological and clinical aggressiveness of breast cancer (BC). In this study, 148 cases of BC tissues w...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Roncella S,Ferro P,Bacigalupo B,Dessanti P,Giannico A,Gorji N,Moroni M,Tozzini S,Pensa F,Gianquinto D,Fais F,Pronzato P,Fedeli F

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:This is a retrospective cross sectional study aimed to verify whether Multiplex Ligation-dependent Probe Amplification (MLPA), a quantitative molecular assay, may represent a valuable reflex test in breast cancer with equivocal HER2 expression by immunohistochemistry and HER2 gene signals/nucleus (s/n) rangi...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Ercolani C,Marchiò C,Di Benedetto A,Fabi A,Perracchio L,Vici P,Sperati F,Buglioni S,Arena V,Pescarmona E,Sapino A,Terrenato I,Mottolese M

更新日期：2017-10-13 00:00:00

abstract：BACKGROUND:The sustained growth of tumors necessitates neovascularization. As one of the potent endogenous vascular inhibitors, endostatin has been widely used in antiangiogenesis therapy for tumor. Cisplatin is normally administered in chemotherapy for lung cancer but accompanied with serious side effects. In the curr...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Bai RZ,Wu Y,Liu Q,Xie K,Wei YQ,Wang YS,Liu K,Luo Y,Su JM,Hu B,Liu JY,Li Q,Niu T,Zhao ZW,Yang L

更新日期：2009-03-05 00:00:00

abstract：:Metastatic colorectal carcinoma (CRC) has an inevitable fatal outcome except in a small percentage of selected patients, approximately 10-20%, with good prognosis after successful complete operative removal of the liver metastases. In patients not eligible for surgical resection of the liver metastases, chemotherapy i...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Popov IP,Milicevic M,Kecmanovic D,Tomasevic Z,Radosevic-Jelic Lj,Borojevic N,Micev MT,Kezic I

更新日期：2006-09-01 00:00:00