A possible role of VEGF in osteolytic bone metastasis of hepatocellular carcinoma.

Abstract:

:The incidence of bone metastasis was around 13% in 404 patients with hepatocellular carcinoma (HCC) who underwent treatment at the National Kyushu Cancer Center between 1988-97, which is a high value among various cancers. This is, in part, due to the prolonged survival time of HCC patients in recent years. Serum vascular endothelial growth factor (VEGF) levels were significantly elevated in HCC patients with bone metastases as compared to those in patients with liver cirrhosis/chronic hepatitis and HCC patients without bone metastasis. VEGF was positively stained in both the primary lesion and bone metastasis of HCC by immunohistochemistry. In the process of bone metastasis, an increase in bone resorption is a crucial step prior to invasion of the bone. VEGF, the most important angiogenic factor, has been shown to stimulate bone resorption through its effects on osteoclasts. Thus, HCC cells reach the bone marrow space, and then secrete VEGF which facilitates osteolytic bone metastasis. VEGF may also facilitate tumor growth in the bone by acting as an angiogenic factor once invasion of the bone is complete. This might be another reason for the high incidence of bone metastasis in HCC.

journal_name

J Exp Clin Cancer Res

authors

Iguchi H,Yokota M,Fukutomi M,Uchimura K,Yonemasu H,Hachitanda Y,Nakao Y,Tanaka Y,Sumii T,Funakoshi A

keywords:

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

309-13

issue

3

eissn

0392-9078

issn

1756-9966

journal_volume

21

pub_type

杂志文章
  • The calcimimetic R-568 induces apoptotic cell death in prostate cancer cells.

    abstract:BACKGROUND:Increased serum level of parathyroid hormone (PTH) was found in metastatic prostate cancers. Calcimimetic R-568 was reported to reduce PTH expression, to suppress cell proliferation and to induce apoptosis in parathyroid cells. In this study, we investigated the effect of R-568 on cellular survival of prosta...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/1756-9966-28-100

    authors: Li H,Ruan G,Li Z,Liu Z,Zheng X,Zheng H,Cheng G,Li B,Zhan M

    更新日期:2009-07-14 00:00:00

  • A synthetic cell-penetrating peptide derived from nuclear localization signal of EPS8 exerts anticancer activity against acute myeloid leukemia.

    abstract:BACKGROUND:Oncogenic roles of epidermal growth factor receptor pathway substrate no.8 (EPS8) have been widely reported in various tumors, making targeting of EPS8 an appealing prospect. Here, we describe the role of EPS8 in acute myeloid leukemia (AML) and consider the potential of EPS8 as an anti-AML target. Nuclear l...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-018-0682-x

    authors: Chen Y,Xie X,Wu A,Wang L,Hu Y,Zhang H,Li Y

    更新日期:2018-01-22 00:00:00

  • Inhibition of ATRA-induced myeloid differentiation in acute promyelocytic leukemia by a new protein tyrosine phosphatase inhibitor, 3,4-dephostatin.

    abstract::We previously reported that the expression and the activity of SHP-1, a non-transmembrane protein tyrosine phosphatase (PTPase) increased during myeloid differentiation of an acute promyelocytic leukemia cell line (HT93) induced by all-trans retinoic acid (ATRA). To examine whether inhibition of SHP-1 activity attenua...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:

    authors: Uesugi Y,Fuse I,Toba K,Kishi K,Hashimoto S,Furukawa T,Narita M,Takahashi M,Aizawa Y

    更新日期:2000-09-01 00:00:00

  • Laryngeal endocrinomas (carcinoids and relevant neoplasms): analysis of 278 reported cases.

    abstract::This study was carried out to provide extensive information obtained from statistical analysis of laryngeal endocrinomas for the use of investigators working in this particular research field. A total of 278 patients with both typical and atypical varieties of carcinoids, and with small/oat cell carcinomas (SCC/OCC) e...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:

    authors: Soga J,Osaka M,Yakuwa Y

    更新日期:2002-03-01 00:00:00

  • Regulation of TRIM24 by miR-511 modulates cell proliferation in gastric cancer.

    abstract:BACKGROUND:Increasing evidence highlights the important roles of tripartite motif containing 24 (TRIM24) in tumor initiation and malignant progression in many tumors, including gastric cancer (GC). Although TRIM24 expression is remarkably upregulated during GC carcinogenesis, the molecular mechanisms underlying TRIM24 ...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-017-0489-1

    authors: Fang Z,Zhang L,Liao Q,Wang Y,Yu F,Feng M,Xiang X,Xiong J

    更新日期:2017-01-23 00:00:00

  • Evaluation of skin perfusion after nipple-sparing mastectomy by indocyanine green dye. Preliminary results.

    abstract::The aim of the study was to investigate the blood supply of the normal nipple areola complex (NAC) and the spared areola complex after a nipple-sparing mastectomy using the analysis of the fluorescence from the indocianine green dye (ICG) injection. Between December 2002 and July 2003 we performed the ICG analysis in ...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:

    authors: De Lorenzi F,Yamaguchi S,Petit JY,Rietjens M,Garusi C,Martella S,Rey PC,Gennari R

    更新日期:2005-09-01 00:00:00

  • Expression of the chemokine receptor CXCR4 in human hepatocellular carcinoma and its role in portal vein tumor thrombus.

    abstract:BACKGROUND:This study was conducted to investigate the expression of CXCR4 in portal vein tumor thrombus (PVTT) tissue and its possible role in the invasiveness of tumor thrombus cells. METHODS:We detected differential expression of CXCR4 between PVTT and hepatocellular carcinoma (HCC) by an immunohistochemical assay....

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/1756-9966-29-156

    authors: Li N,Guo W,Shi J,Xue J,Hu H,Xie D,Wu M,Cheng S

    更新日期:2010-11-27 00:00:00

  • G-quadruplex ligand RHPS4 radiosensitizes glioblastoma xenograft in vivo through a differential targeting of bulky differentiated- and stem-cancer cells.

    abstract:BACKGROUND:Glioblastoma is the most aggressive and most lethal primary brain tumor in the adulthood. Current standard therapies are not curative and novel therapeutic options are urgently required. Present knowledge suggests that the continued glioblastoma growth and recurrence is determined by glioblastoma stem-like c...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-019-1293-x

    authors: Berardinelli F,Tanori M,Muoio D,Buccarelli M,di Masi A,Leone S,Ricci-Vitiani L,Pallini R,Mancuso M,Antoccia A

    更新日期:2019-07-16 00:00:00

  • Clinically meaningful response to the EGFR tyrosine kinase inhibitor gefitinib ('Iressa', ZD1839) in non small cell lung cancer.

    abstract::Preclinical research and ongoing clinical trials are validating epidermal growth factor receptor (EGFR) as a suitable molecular target in cancer therapy. Here we report the case of a 39-year-old non-smoking man with heavily pretreated stage IV bronchioloalveolar NSCLC who was treated with gefitinib ('Iressa', ZD1839) ...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:

    authors: Gelibter A,Ceribelli A,Milella M,Mottolese M,Vocaturo A,Cognetti F

    更新日期:2003-09-01 00:00:00

  • Inhibition of ATM reverses EMT and decreases metastatic potential of cisplatin-resistant lung cancer cells through JAK/STAT3/PD-L1 pathway.

    abstract:BACKGROUND:The cisplatin-resistance is still a main course for chemotherapy failure of lung cancer patients. Cisplatin-resistant cancer cells own higher malignance and exhibited increased metastatic ability, but the mechanism is not clear. In this study, we investigated the effects of Ataxia Telangiectasia Mutated (ATM...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-019-1161-8

    authors: Shen M,Xu Z,Xu W,Jiang K,Zhang F,Ding Q,Xu Z,Chen Y

    更新日期:2019-04-08 00:00:00

  • HOXD9 promotes the growth, invasion and metastasis of gastric cancer cells by transcriptional activation of RUFY3.

    abstract:BACKGROUND:The transcription factor HOXD9 is one of the members of the HOX family, which plays an important role in neoplastic processes. However, the role of HOXD9 in the growth and metastasis of gastric cancer (GC) remains to be elucidated. METHODS:In vitro functional role of HOXD9 and RURY3 in GC cells was determin...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-019-1399-1

    authors: Zhu H,Dai W,Li J,Xiang L,Wu X,Tang W,Chen Y,Yang Q,Liu M,Xiao Y,Zhang W,Lin J,Wang J,Liu G,Sun Y,Jiang P,Li G,Li A,Liu S,Chen Y,Wang J

    更新日期:2019-09-23 00:00:00

  • Evaluation of naphthalmustine, a nitrogen mustard derivative of naphthalimide as a rationally-designed anticancer agent.

    abstract::Naphthalmustine, 2-[2-[bis-(2-chloroethyl)amino]ethyl]-1H-benz[de]isoquinoline-1,3-dione (Compound 1) has been synthesized as a rationally designed new anticancer agent from N-(2-bromoethyl)naphthalimide. Its chemical alkylating activity exceeded that of nor-HN2 used as standard compound for comparison. Its antitumour...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:

    authors: Pain A,Samanta S,Dutta S,Saxena AK,Shanmugavel M,Kampasi H,Qazi GN,Sanyal U

    更新日期:2003-09-01 00:00:00

  • New combinatorial strategies to improve the PARP inhibitors efficacy in the urothelial bladder Cancer treatment.

    abstract:BACKGROUND:Novel therapeutic strategies are urgently needed for the treatment of metastatic Urothelial Bladder Cancer. DNA damaging repair (DDR) targeting has been introduced in cinical trials for bladder cancer patients that carry alterations in homologous DNA repair genes, letting to envisage susceptibility to the Po...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章,评审

    doi:10.1186/s13046-019-1089-z

    authors: Criscuolo D,Morra F,Giannella R,Visconti R,Cerrato A,Celetti A

    更新日期:2019-02-22 00:00:00

  • Efficacy and adverse effects of transdermal fentanyl and sustained-release oral morphine in treating moderate-severe cancer pain in Chinese population: a systematic review and meta-analysis.

    abstract:BACKGROUND:Previous meta-analysis suggested that transdermal fentanyl was not inferior to sustained-release oral morphine in treating moderate-severe cancer pain with less adverse effects. Now, we updated the data and performed a systematic review. METHODS:Updated cohort studies on transdermal fentanyl and oral morphi...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章,meta分析

    doi:10.1186/1756-9966-29-67

    authors: Yang Q,Xie DR,Jiang ZM,Ma W,Zhang YD,Bi ZF,Chen DL

    更新日期:2010-06-09 00:00:00

  • YAP and endothelin-1 signaling: an emerging alliance in cancer.

    abstract::The rational making the G protein-coupled receptors (GPCR) the centerpiece of targeted therapies is fueled by the awareness that GPCR-initiated signaling acts as pivotal driver of the early stages of progression in a broad landscape of human malignancies. The endothelin-1 (ET-1) receptors (ET-1R), known as ETA recepto...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章,评审

    doi:10.1186/s13046-021-01827-8

    authors: Tocci P,Blandino G,Bagnato A

    更新日期:2021-01-09 00:00:00

  • Intrabodies targeting human papillomavirus 16 E6 and E7 oncoproteins for therapy of established HPV-associated tumors.

    abstract:BACKGROUND:The oncogenic activity of the high risk human papillomavirus type 16 (HPV16) is fully dependent on the E6 and E7 viral oncoproteins produced during viral infection. The oncoproteins interfere with cellular homeostasis by promoting proliferation, inhibiting apoptosis and blocking epithelial differentiation, d...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-021-01841-w

    authors: Paolini F,Amici C,Carosi M,Bonomo C,Di Bonito P,Venuti A,Accardi L

    更新日期:2021-01-23 00:00:00

  • Eliciting cytotoxic T lymphocytes against human laryngeal cancer-derived antigens: evaluation of dendritic cells pulsed with a heat-treated tumor lysate and other antigen-loading strategies for dendritic-cell-based vaccination.

    abstract:BACKGROUND:Dendritic cells (DCs) have been used successfully in clinical pilot studies. However, tumor-specific immunity and clinical responses were only induced in certain cancer patients. It has been well documented that immunotherapy efficacy can be optimized for responses using antigen pulsing. METHODS:The human l...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-016-0295-1

    authors: Wei FQ,Sun W,Wong TS,Gao W,Wen YH,Wei JW,Wei Y,Wen WP

    更新日期:2016-01-22 00:00:00

  • Akt/FoxM1 signaling pathway-mediated upregulation of MYBL2 promotes progression of human glioma.

    abstract:BACKGROUND:MYB-related protein B (B-MYB/MYBL2), a member of the myeloblastosis family of transcription factors, has been reported for its role in the genesis and progression of tumors. Forkhead box M1 (FoxM1), another transcriptional factor, is considered to be an independent predictor of poor survival in many solid ca...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 临床试验,杂志文章

    doi:10.1186/s13046-017-0573-6

    authors: Zhang X,Lv QL,Huang YT,Zhang LH,Zhou HH

    更新日期:2017-08-07 00:00:00

  • Cisplatin, epirubicin and cyclophosphamide (PEC) in the treatment of advanced ovarian cancer.

    abstract::We report the long-term results of a series of patients affected by advanced epithelial ovarian cancer treated with the PEC combination (cisplatin 60 mg/m2, epirubicin 60 mg/m2 and cyclophosphamide 750 mg/m2, all at day 1, every 21 days). Response was evaluated after three cycles, and treatment continued in responsive...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:

    authors: Massacesi C,Bascioni R,Cellerino R,Scartozzi M,Bracci R,Alessandroni P,Antognoli S,Ciavattini A,De Nictolis M,Piga A

    更新日期:2000-03-01 00:00:00

  • Relationship between human mammaglobin mRNA expression in breast cancer tissue and clinico-pathologic features of the tumors.

    abstract::Human mammaglobin (hMAM) has recently been recognized as a breast associated glycoprotein. Although the biological role of hMAM is unknown, it has been previously reported that hMAM gene expression is a marker of low biological and clinical aggressiveness of breast cancer (BC). In this study, 148 cases of BC tissues w...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:

    authors: Roncella S,Ferro P,Bacigalupo B,Dessanti P,Giannico A,Gorji N,Moroni M,Tozzini S,Pensa F,Gianquinto D,Fais F,Pronzato P,Fedeli F

    更新日期:2006-03-01 00:00:00

  • Antisense oligonucleotide targeting Livin induces apoptosis of human bladder cancer cell via a mechanism involving caspase 3.

    abstract:BACKGROUND AND AIM:in recent years, Livin, a new member of IAPs family, is found to be a key molecule in cancers. Researchers consider Livin may become a new target for tumor therapy; however, the role of it in bladder cancer is still unclear. The purpose of this article is to investigate Antisense Oligonucleotide (ASO...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/1756-9966-29-63

    authors: Liu C,Wu X,Luo C,Hu Z,Yin Z,He Y,Du H,Zhang W,Jiang Q,Lin Y

    更新日期:2010-06-03 00:00:00

  • Analysis of the ORFK1 hypervariable regions reveal distinct HHV-8 clustering in Kaposi's sarcoma and non-Kaposi's cases.

    abstract:BACKGROUND:Classical Kaposi's Sarcoma (cKS) is a rare vascular tumor, which develops in subjects infected with Human Herpesvirus-8 (HHV-8). Beside the host predisposing factors, viral genetic variants might possibly be related to disease development. The aim of this study was to identify HHV-8 variants in patients with...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-014-0119-0

    authors: Cordiali-Fei P,Trento E,Giovanetti M,Lo Presti A,Latini A,Giuliani M,D'Agosto G,Bordignon V,Cella E,Farchi F,Ferraro C,Lesnoni La Parola I,Cota C,Sperduti I,Vento A,Cristaudo A,Ciccozzi M,Ensoli F

    更新日期:2015-01-16 00:00:00

  • Free radical scavenging, antitumor and anticarcinogenic activity of gossypin.

    abstract::Antioxidant, antitumor and anticarcinogenic activity of gossypin (3,5,8,3',4'-pentahydroxy-7-O glucosyl flavone) was carried out. The compound needed for 50% inhibition of superoxide, hydroxyl and nitric oxide radicals was 3 microg/ml, 41 microg/ml and 12 microg/ml, respectively. Gossypin also impart 50% inhibition at...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:

    authors: Babu BH,Jayram HN,Nair MG,Ajaikumar KB,Padikkala J

    更新日期:2003-12-01 00:00:00

  • Correlations between nuclear/cytoplasmic area ratio and classification of cervical smears.

    abstract::The aim of this study was to assess the nuclear/cytoplasmic (N/C) ratio using computerized image analysis of cervical smears with intraepithelial neoplasia (CIN) grade I to III associated or not with cellular changes of human papillomavirus (HPV) in an attempt to determine if this method is more sensitive for the esti...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:

    authors: Athanassiadou P,Kavantzas N,Gonidi M,Athanassiades P,Liossi A,Nakopoulou L,Petrakakou E,Davaris P

    更新日期:2001-12-01 00:00:00

  • Clinical significance of pancreatic circulating tumor cells using combined negative enrichment and immunostaining-fluorescence in situ hybridization.

    abstract:BACKGROUND:Circulating tumor cells (CTCs) hold great potential in both clinical application and basic research for the managements of cancer. However, it remains to be an enormous challenge to obtain efficient detection of pancreatic CTCs. New detection platforms for the detection of pancreatic CTCs are urgently requir...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-016-0340-0

    authors: Gao Y,Zhu Y,Zhang Z,Zhang C,Huang X,Yuan Z

    更新日期:2016-04-12 00:00:00

  • Alterations of dendritic cell subsets in the peripheral circulation of patients with cervical carcinoma.

    abstract::Patients with cervical carcinoma (CC) are frequently immunocompromised. Dendritic cells (DCs) are potent antigen-presenting cells. Using multicolor flow cytometry, the percentages of CD11c+ (DC1) and CD123+ (DC2) subsets, were determined in the peripheral blood of 37 patients with cervical carcinoma (CC), 54 patients ...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1756-9966-29-78

    authors: Ye F,Yu Y,Hu Y,Lu W,Xie X

    更新日期:2010-06-18 00:00:00

  • Molecular genetics of prostate cancer: clinical translational opportunities.

    abstract::Prostate cancer (PC) development reflects a complex sequence of biologic and molecular events. Several inheritable and somatic genetic changes have been identified. The knowledge of the molecular basis of PC can improve our understanding of the causes of this common cancer and provide information on prognosis and trea...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章,评审

    doi:

    authors: Vecchione A,Gottardo F,Gomella LG,Wildemore B,Fassan Ms,Bragantini E,Pagano F,Baffa R

    更新日期:2007-03-01 00:00:00

  • Enhancement of cisplatin sensitivity in Lewis Lung carcinoma by liposome-mediated delivery of a survivin mutant.

    abstract:BACKGROUND:A high concentration of cisplatin (CDDP) induces apoptosis in many tumor cell lines. CDDP has been administered by infusion to avoid severe toxicity. Recently, it has been reported that changes in survivin expression or function may lead to tumor sensitization to chemical and physical agents. The aim of this...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/1756-9966-29-46

    authors: Yu DD,Wang CT,Shi HS,Li ZY,Pan L,Yuan QZ,Leng F,Wen Y,Chen X,Wei YQ

    更新日期:2010-05-12 00:00:00

  • Cost of de novo acute myeloid leukemia induction therapy in adults: analysis of EORTC-GIMEMA AML10 and FLANG regimens.

    abstract::Since the social and financial impact of AML therapy is becoming more and more relevant we analyzed the cost of induction therapy of two different regimens. The first one is part of the widely employed EORTC-GIMEMA AML-10 and consists often days of therapy. The second (FLANG) is a short (three day), Fludarabine, Ara-C...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:

    authors: Clavio M,Quintino S,Masoudi B,Carrara S,Cerri R,Pierri I,Canepa L,Miglino M,Muner P,Damasio E,Gobbi M

    更新日期:2001-06-01 00:00:00

  • GANT61, a GLI inhibitor, sensitizes glioma cells to the temozolomide treatment.

    abstract:BACKGROUND:The aim of this study was to investigate the effect of downregulating Hedgehog pathway by GANT61 on human glioma cells, examine the consequent changes of temozolomide (TMZ)-induced effects and explore the molecular mechanisms. METHODS:The cytotoxicity of a Gli1/2 inhibitor, GANT61 was examined both alone an...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-016-0463-3

    authors: Li J,Cai J,Zhao S,Yao K,Sun Y,Li Y,Chen L,Li R,Zhai X,Zhang J,Jiang C

    更新日期:2016-11-28 00:00:00