Abstract:
:To monitor delivered dose and trigger plan adaptation when deviation becomes unacceptable, a clinical treatment dose (Tx-Dose) reconstruction system based on three-dimensional (3D)/four-dimensional (4D)-cone beam computed tomograpy (CBCT) images was developed and evaluated on various treatment sites, particularly for lung cancer patient treated by stereotactic body radiation therapy (SBRT). This system integrates with our treatment planning system (TPS), Linacs recording and verification system (R&V), and CBCT imaging system, consisting of three modules: Treatment Schedule Monitoring module (TSM), pseudo-CT Generating module (PCG), and Treatment Dose Reconstruction/evaluation module (TDR). TSM watches the treatment progress in the R&V system and triggers the PCG module when new CBCT is available. PCG retrieves the CBCTs and performs planning CT to CBCT deformable registration (DIR) to generate pseudo-CT. The 4D-CBCT images are taken for target localization and correction in lung cancer patient before treatment. To take full advantage of the valuable information carried by 4D-CBCT, a novel phase-matching DIR scheme was developed to generate 4D pseudo-CT images for 4D dose reconstruction. Finally, TDR module creates TPS scripts to automate Tx-Dose calculation on the pseudo-CT images. Both initial quantitative commissioning and patient-specific qualitative quality assurance of the DIR tool were utilized to ensure the DIR quality. The treatment doses of ten patients (six SBRT-lung, two head and neck (HN), one breast and one prostate cancer patients) were retrospectively constructed and evaluated. The target registration error (mean ± STD: 1.05 ± 1.13 mm) of the DIR tool is comparable to the interobserver uncertainty (0.88 ± 1.31 mm) evaluated by a publically available lung-landmarks dataset. For lung SBRT patients, the D99 of the final cumulative Tx-Dose of GTV is 93.8 ± 5.5% (83.7-100.1%) of the originally planned D99 . CTV D99 decreases by 3% and mean ipsilateral parotid dose increases by 11.5% for one of the two HN patients. In conclusion, we have demonstrated the feasibility and effectiveness of a treatment dose verification system in our clinical setting.
journal_name
J Appl Clin Med Physjournal_title
Journal of applied clinical medical physicsauthors
Qin A,Gersten D,Liang J,Liu Q,Grill I,Guerrero T,Stevens C,Yan Ddoi
10.1002/acm2.12474subject
Has Abstractpub_date
2018-11-01 00:00:00pages
166-176issue
6issn
1526-9914journal_volume
19pub_type
杂志文章abstract:PURPOSE:Beam matching occurs on all linacs to some degree and when two are more are matched to each other, patients are able to be transferred between machines. Quality assurance of plans can also be performed "distributively" on any of the matched linacs. The degree to which machines are matched and how this translate...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1002/acm2.12567
更新日期:2019-04-01 00:00:00
abstract::Radiographic film dosimetry provides fast, convenient 2-D dose distributions, but is challenged by the dependence of film response on scatter conditions (i.e., energy dependence). Verification of delivered dose in the surface buildup region is important for intensity modulated radiation therapy (IMRT) when volumes of ...
journal_title:Journal of applied clinical medical physics
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更新日期:2008-10-24 00:00:00
abstract::The aim of this study was to assess the performance of a gantry-mounted detector system and a couch set detector system using a systematic multileaf collimator positional error manually introduced for volumetric-modulated arc therapy. Four head and neck and esophagus VMAT plans were evaluated by measurement using an e...
journal_title:Journal of applied clinical medical physics
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更新日期:2014-05-08 00:00:00
abstract:PURPOSE:To report our early experiences with failure mode and effects analysis (FMEA) in a community practice setting. METHODS:The FMEA facilitator received extensive training at the AAPM Summer School. Early efforts focused on department education and emphasized the need for process evaluation in the context of high ...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1002/acm2.12190
更新日期:2017-11-01 00:00:00
abstract:PURPOSE:To evaluate the quality of patient-specific complicated treatment plans, including commercialized treatment planning systems (TPS) and commissioned beam data, we developed a process of quality assurance (QA) using a Monte Carlo (MC) platform. Specifically, we constructed an interface system that automatically c...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1002/acm2.12718
更新日期:2019-10-01 00:00:00
abstract::The purpose of this work is to evaluate the volumetric-modulated arc therapy (VMAT) multicriteria optimization (MCO) algorithm clinically available in the RayStation treatment planning system (TPS) and its ability to reduce treatment planning time while providing high dosimetric plan quality. Nine patients with locali...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1120/jacmp.v16i3.5410
更新日期:2015-05-08 00:00:00
abstract::Increasingly, the advent of multislice CT scanners, volume CT scanners, and total body spiral acquisition modes has led to the use of Multi Planar Reconstruction and 3D datasets. In considering 3D resolution properties of a CT system it is important to note that both the in-plane (x,y) and z-axis (slice thickness) inf...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1120/jacmp.v17i5.6294
更新日期:2016-09-08 00:00:00
abstract:OBJECTIVES:To evaluate the influence of MRI scanning parameters on texture analysis features. METHODS:Publicly available data from the Reference Image Database to Evaluate Therapy Response (RIDER) project sponsored by The Cancer Imaging Archive included MRIs on a phantom comprised of 18 25-mm doped, gel-filled tubes, ...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1002/acm2.12482
更新日期:2018-11-01 00:00:00
abstract::This study extends the 'zero scan' method for CT imaging of polymer gel dosimeters to include multislice acquisitions. Multislice CT images consisting of 24 slices of 1.2 mm thickness were acquired of an irradiated polymer gel dosimeter and processed with the zero scan technique. The results demonstrate that zero scan...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1120/jacmp.v15i4.4360
更新日期:2014-07-08 00:00:00
abstract::This article compares two algorithms for determining beam weights and wedge filters for conformal treatment planning. One algorithm, which is based on dose-gradient analysis, provides analytic formulas for determining beam weights, wedge angles, and collimator angles (i.e., wedge orientations) so that the dose distrib...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1120/jacmp.v3i3.2562
更新日期:2002-07-01 00:00:00
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journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1120/jacmp.v15i4.4889
更新日期:2014-07-08 00:00:00
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journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1120/jacmp.v17i3.6017
更新日期:2016-05-08 00:00:00
abstract::A spreadsheet-based model for economically characterizing the operation of a radiation treatment program has been used to perform a quantitative financial analysis of scheduled and unscheduled downtime. The incremental cost of downtime is broken down into three categories: remuneration of in-house or third party servi...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1120/jacmp.v1i2.2647
更新日期:2000-04-01 00:00:00
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journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1002/acm2.13003
更新日期:2020-10-01 00:00:00
abstract:PURPOSE:The objective of this study was to evaluate the impact of the magnetic field regulation in conjunction with the volumetric repainting technique on the spot positions and range in pencil beam scanning proton therapy. METHODS:"Field regulation" - a feature to reduce the switching time between layers by applying ...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1002/acm2.13045
更新日期:2020-10-15 00:00:00
abstract:PURPOSE:To quantify the effects of combining layer-based repainting and respiratory gating as a strategy to mitigate the dosimetric degradation caused by the interplay effect between a moving target and dynamic spot-scanning proton delivery. METHODS:An analytic routine modeled three-dimensional dose distributions of p...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1002/acm2.12702
更新日期:2019-09-01 00:00:00
abstract::Modern three-dimensional image-guided intracavitary high dose rate (HDR) brachytherapy is often used in combination with external beam radiotherapy (EBRT) to manage cervical cancer. Intrafraction motion of critical organs relative to the HDR applicator in the time between the planning CT and treatment delivery can cau...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1002/acm2.12462
更新日期:2018-11-01 00:00:00
abstract::Part II of this review article presents four case studies for which peak skin doses are calculated following the methods outlined in Part I of this review. The data available in the cases ranges from proprietary dose reports to fluoroscopy time and number of digital acquisition frames only. Flowcharts are provided for...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1120/jacmp.v13i1.3693
更新日期:2012-01-05 00:00:00
abstract::For most computed tomography (CT) simulators, radiation therapists must remove the flat couch top to perform daily CT quality assurance (QA), and then use separate tools to perform localization-laser QA. This process wastes time and effort and creates the opportunity for accidents to occur. In this study, we tested a ...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1120/jacmp.v10i3.2844
更新日期:2009-06-17 00:00:00
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journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1120/jacmp.v13i5.3845
更新日期:2012-09-06 00:00:00
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journal_title:Journal of applied clinical medical physics
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更新日期:2006-06-16 00:00:00
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journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
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更新日期:2006-11-28 00:00:00
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journal_title:Journal of applied clinical medical physics
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更新日期:2016-07-08 00:00:00
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journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
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更新日期:2016-05-08 00:00:00
abstract::The monochromatic images acquired by Gemstone spectral imaging (GSI) mode on the GE CT750 HD theoretically determines the computed tomography (CT) number more accurately than that of conventional scanner. Using the former, the CT number is calculated from (synthesized) monoenergetic X-ray data. We reasoned that the mo...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
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更新日期:2013-09-06 00:00:00
abstract::This work compares two accelerated partial breast irradiation modalities, MammoSite brachytherapy and three dimensional conformal radiotherapy (3D-CRT), to a new method, SAVI brachytherapy, following NSABP B-39 guidelines. A total of 21 patients treated at UC San Diego with the SAVI device were evaluated in this compa...
journal_title:Journal of applied clinical medical physics
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更新日期:2009-12-03 00:00:00
abstract:PURPOSE:This study evaluates the feasibility of lung dose prediction based on target contour and patient anatomy for breast patients treated with proton therapy. METHODS:Fifty-two randomly selected patients were included in the cohort, who were treated to 50.4-66.4 Gy(RBE) to the left (36), right (15), or bilateral (1...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章,随机对照试验
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更新日期:2018-11-01 00:00:00
abstract:PURPOSE:This study evaluates the clinical use of the RUBY modular QA phantom for linac QA to validate the integrity of IGRT workflows including the congruence of machine isocenter, imaging isocenter, and room lasers. The results have been benchmarked against those obtained with widely used systems. Additionally, the RU...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
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更新日期:2020-10-01 00:00:00
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journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
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更新日期:2020-05-01 00:00:00
abstract::The necessity to build or adapt radiotherapy rooms in reduced areas leads to the search for unconventional solutions for shielding projects. In most cases, adding metals to the primary barriers is the best alternative to shield rooms properly. However, when photons with energies equal or higher than 10 MV interact wit...
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更新日期:2014-11-08 00:00:00