Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study.

abstract：OBJECTIVE:To determine whether screening Danish men aged 65 or more for abdominal aortic aneurysms reduces mortality. DESIGN:Single centre randomised controlled trial. SETTING:All five hospitals in Viborg County, Denmark. PARTICIPANTS:All 12,639 men born during 1921-33 and living in Viborg County. In 1994 we include...

journal_title：BMJ (Clinical research ed.)

authors： Lindholt JS,Juul S,Fasting H,Henneberg EW

更新日期：2005-04-02 00:00:00

abstract：OBJECTIVES:To investigate the claim that 90% of episodes of low back pain that present to general practice have resolved within one month. DESIGN:Prospective study of all adults consulting in general practice because of low back pain over 12 months with follow up at 1 week, 3 months, and 12 months after consultation. ...

journal_title：BMJ (Clinical research ed.)

authors： Croft PR,Macfarlane GJ,Papageorgiou AC,Thomas E,Silman AJ

更新日期：1998-05-02 00:00:00

abstract：OBJECTIVE:To assess whether an assertive outreach intervention after suicide attempt could reduce the frequency of subsequent suicidal acts, compared with standard treatment. DESIGN:Randomised, parallel group, superiority trial with blinded outcome assessment. SETTING:Outpatient intervention at one location at Copenh...

journal_title：BMJ (Clinical research ed.)

authors： Morthorst B,Krogh J,Erlangsen A,Alberdi F,Nordentoft M

更新日期：2012-08-22 00:00:00

abstract：:For many years Tayside has benefited from a successful opportunistic cytology screening programme. In recent years, however, the decrease in mortality due to cervical cancer has levelled off, with most cases of severe disease arising in women who have not been screened. In view of this the health board developed a new...

journal_title：BMJ (Clinical research ed.)

authors： Robertson AJ,Reid GS,Stoker CA,Bissett C,Waugh N,Fenton I,Rowan J,Halkerston R

更新日期：1989-07-15 00:00:00

abstract：:Several viral infections have been reported to result in more severe disease in pregnant than non-pregnant women, but the relative risks have not been well characterised. This has now been done for Lassa fever in a prospective study of 68 pregnant and 79 non-pregnant women who were admitted to hospital in Sierra Leone...

journal_title：BMJ (Clinical research ed.)

authors： Price ME,Fisher-Hoch SP,Craven RB,McCormick JB

更新日期：1988-09-03 00:00:00

abstract：OBJECTIVE:To evaluate the impact of the revised diagnostic criteria for diabetes mellitus adopted by the American Diabetes Association on prevalence of diabetes and on classification of patients. For epidemiological purposes the American criteria use a fasting plasma glucose concentration >=7.0 mmol/l in contrast with ...

journal_title：BMJ (Clinical research ed.)

authors：

更新日期：1998-08-08 00:00:00

abstract：OBJECTIVE:To estimate the impact of a national primary care pay for performance scheme, the Quality and Outcomes Framework in England, on emergency hospital admissions for ambulatory care sensitive conditions (ACSCs). DESIGN:Controlled longitudinal study. SETTING:English National Health Service between 1998/99 and 20...

journal_title：BMJ (Clinical research ed.)

authors： Harrison MJ,Dusheiko M,Sutton M,Gravelle H,Doran T,Roland M

更新日期：2014-11-11 00:00:00

abstract：:In a one year prospective study within the Trent Regional Health Authority the demand for neonatal intensive care was estimated to be 1.1 cots per 1000 births. Intensive care level 1 (as defined by the British Paediatric Association and British Association for Perinatal Paediatrics) was determined by two separate tech...

journal_title：BMJ (Clinical research ed.)

authors： Field DJ,Hodges S,Mason E,Burton P,Yates J,Wale S

更新日期：1989-11-25 00:00:00

abstract：OBJECTIVES:To examine the association of plasma caffeine concentrations during pregnancy with fetal growth and to compare this with relations with reported caffeine intake. DESIGN:Prospective population based study. SETTING:District general hospital, inner London. SUBJECTS:Women booking for delivery between 1982 and...

journal_title：BMJ (Clinical research ed.)

authors： Cook DG,Peacock JL,Feyerabend C,Carey IM,Jarvis MJ,Anderson HR,Bland JM

更新日期：1996-11-30 00:00:00

abstract：OBJECTIVES:To investigate the feasibility of obtaining signed consent for submission of patient identifiable data to a national clinical audit database and to identify factors influencing the consent process and its success. DESIGN:Feasibility study. SETTING:Seven paediatric intensive care units in England. PARTICIP...

journal_title：BMJ (Clinical research ed.)

authors： McKinney PA,Jones S,Parslow R,Davey N,Darowski M,Chaudhry B,Stack C,Parry G,Draper ES,PICANet Consent Study Group.

更新日期：2005-04-16 00:00:00

abstract：OBJECTIVES:To determine the accuracy of a clinical decision rule (the traffic light system developed by the National Institute for Health and Clinical Excellence (NICE)) for detecting three common serious bacterial infections (urinary tract infection, pneumonia, and bacteraemia) in young febrile children. DESIGN:Retro...

journal_title：BMJ (Clinical research ed.)

authors： De S,Williams GJ,Hayen A,Macaskill P,McCaskill M,Isaacs D,Craig JC

更新日期：2013-02-13 00:00:00

abstract：OBJECTIVE:To evaluate the effects of a multifaceted empowerment strategy on the actual use of single embryo transfer after in vitro fertilisation. DESIGN:Randomised controlled trial. SETTING:Five in vitro fertilisation clinics in the Netherlands. PARTICIPANTS:308 couples (women aged <40) on the waiting list for a fi...

journal_title：BMJ (Clinical research ed.)

authors： van Peperstraten A,Nelen W,Grol R,Zielhuis G,Adang E,Stalmeier P,Hermens R,Kremer J

更新日期：2010-09-30 00:00:00

abstract：OBJECTIVE:To compare the efficacy and safety of rectal artemether with intravenous quinine in the treatment of cerebral malaria in children. DESIGN:Randomised, single blind, clinical trial. SETTING:Acute care unit at Mulago Hospital, Uganda's national referral and teaching hospital in Kampala. PARTICIPANTS:103 child...

journal_title：BMJ (Clinical research ed.)

authors： Aceng JR,Byarugaba JS,Tumwine JK

更新日期：2005-02-12 00:00:00

abstract：OBJECTIVE:To discover whether the wartime government evacuation of children from London and other population centres to rural districts was associated with any increase in childhood leukaemia. DESIGN:Observational study of mortality from leukaemia among the childhood population of England and Wales in relation to the ...

journal_title：BMJ (Clinical research ed.)

authors： Kinlen LJ,John SM

更新日期：1994-11-05 00:00:00

abstract：:Objectives To estimate small for gestational age birth prevalence and attributable neonatal mortality in low and middle income countries with the INTERGROWTH-21st birth weight standard.Design Secondary analysis of data from the Child Health Epidemiology Reference Group (CHERG), including 14 birth cohorts with gestatio...

journal_title：BMJ (Clinical research ed.)

authors： Lee AC,Kozuki N,Cousens S,Stevens GA,Blencowe H,Silveira MF,Sania A,Rosen HE,Schmiegelow C,Adair LS,Baqui AH,Barros FC,Bhutta ZA,Caulfield LE,Christian P,Clarke SE,Fawzi W,Gonzalez R,Humphrey J,Huybregts L,Kariuki

更新日期：2017-08-17 00:00:00

abstract：OBJECTIVE:To investigate explanations for social inequalities in health with respect to health related social mobility and cumulative socioeconomic circumstances over the first three decades of life. DESIGN:Longitudinal follow up. SETTING:Great Britain. SUBJECTS:Data from the 1958 birth cohort study (all children bo...

journal_title：BMJ (Clinical research ed.)

authors： Power C,Matthews S,Manor O

更新日期：1996-08-24 00:00:00

abstract：:Lifetime fertility, abortion rates, and the proportion of pregnancies resulting in induced abortion were investigated in 105 district health authorities in England. In 1995, a total of 147,851 abortions occurred among women living in England, compared with 613,257 live births; a ratio of 1:4. This was equivalent to ...

journal_title：BMJ (Clinical research ed.)

authors： Raleigh VS

更新日期：1998-06-06 00:00:00

abstract：OBJECTIVE:To assess whether a late evening meal would improve nitrogen balance in patients with cirrhosis of the liver. DESIGN:Randomised crossover study of meal schedules comparing three meals a day with four or six meals a day, the four and six meal schedules both including a late evening meal (2300). SETTING:Metab...

journal_title：BMJ (Clinical research ed.)

authors： Swart GR,Zillikens MC,van Vuure JK,van den Berg JW

更新日期：1989-11-11 00:00:00

abstract：OBJECTIVES:To investigate whether sending patients a copy of their referral letter can reduce non-attendance at outpatient departments. DESIGN:Blinded randomised controlled trial. SETTING:13 general practices in Exeter, Devon. SUBJECTS:2078 new consultant referrals from 26 doctors. MAIN OUTCOME MEASURES:Non-attenda...

journal_title：BMJ (Clinical research ed.)

authors： Hamilton W,Round A,Sharp D

更新日期：1999-05-22 00:00:00

abstract：OBJECTIVE:To compare whether differences exist between alternating pressure overlays and alternating pressure mattresses in the development of new pressure ulcers, healing of existing pressure ulcers, and patient acceptability. DESIGN:Pragmatic, open, multicentre, randomised controlled trial. SETTING:11 hospitals in ...

journal_title：BMJ (Clinical research ed.)

authors： Nixon J,Cranny G,Iglesias C,Nelson EA,Hawkins K,Phillips A,Torgerson D,Mason S,Cullum N

更新日期：2006-06-17 00:00:00

abstract：OBJECTIVE:To assess the risk of pulmonary embolism, ischaemic stroke, and myocardial infarction associated with combined oral contraceptives according to dose of oestrogen (ethinylestradiol) and progestogen. DESIGN:Observational cohort study. SETTING:Data from the French national health insurance database linked with...

journal_title：BMJ (Clinical research ed.)

authors： Weill A,Dalichampt M,Raguideau F,Ricordeau P,Blotière PO,Rudant J,Alla F,Zureik M

更新日期：2016-05-10 00:00:00

abstract：OBJECTIVE:To determine the relative importance of appropriate prescribing for asthma in explaining high rates of hospital admission for asthma among east London general practices. DESIGN:Poisson regression analysis describing relation of each general practice's admission rates for asthma with prescribing for asthma an...

journal_title：BMJ (Clinical research ed.)

authors： Griffiths C,Sturdy P,Naish J,Omar R,Dolan S,Feder G

更新日期：1997-02-15 00:00:00

abstract：OBJECTIVE:To compare the prevalence of antibody to and proviral DNA of the retrovirus HTLV-I in relatives of 11 British patients with tropical spastic paraparesis who had migrated from Jamaica before they developed symptoms, and to examine factors possibly related to transmission of HTLV-I. DESIGN:Migrant, family stud...

journal_title：BMJ (Clinical research ed.)

authors： Cruickshank JK,Richardson JH,Morgan OS,Porter J,Klenerman P,Knight J,Newell AL,Rudge P,Dalgleish AG

更新日期：1990-02-03 00:00:00

abstract：OBJECTIVES:To investigate the association between contemporary combined hormonal contraceptives (including progestogen types in combined preparations and all progestogen-only products) and overall and specific types of ovarian cancer. DESIGN:Prospective, nationwide cohort study. SETTING:Denmark, 1995-2014. PARTICIPA...

journal_title：BMJ (Clinical research ed.)

authors： Iversen L,Fielding S,Lidegaard Ø,Mørch LS,Skovlund CW,Hannaford PC

更新日期：2018-09-26 00:00:00

abstract：OBJECTIVE:To examine whether the risk of breast cancer is increased by a recent term pregnancy. DESIGN:Population based case-control study. SETTING:Eight areas in the United States. SUBJECTS:Cases were 2279 multiparous women residents of the eight areas aged 25-49 who were diagnosed as having breast cancer during 19...

journal_title：BMJ (Clinical research ed.)

authors： Cummings P,Stanford JL,Daling JR,Weiss NS,McKnight B

更新日期：1994-06-25 00:00:00

abstract：OBJECTIVE:To assess evidence from randomised clinical trials about the effectiveness of extracts of Boswellia serrata (frankincense). DESIGN:Systematic review. DATA SOURCES:Electronic searches on Medline, Embase, Cinahl, Amed, and Cochrane Library. Hand searches of conference proceedings, bibliographies, and departme...

journal_title：BMJ (Clinical research ed.)

authors： Ernst E

更新日期：2008-12-17 00:00:00

abstract：OBJECTIVE:To assess predictors of mortality in a population of people prescribed methadone. DESIGN:Retrospective cohort study. SETTING:Geographically defined population in Tayside, Scotland. PARTICIPANTS:2378 people prescribed and dispensed liquid methadone between January 1993 and February 2004. MAIN OUTCOME MEASU...

journal_title：BMJ (Clinical research ed.)

authors： McCowan C,Kidd B,Fahey T

更新日期：2009-06-16 00:00:00

abstract：:A study was carried out analysing the operation of a drug rationalisation programme in a central London teaching district that had evolved from experience over 17 years. Creation of a limited list of about 700 drugs had been achieved by local consensus. Drug selection was based on appraisal of efficacy, safety, and co...

journal_title：BMJ (Clinical research ed.)

authors： Baker JA,Lant AF,Sutters CA

更新日期：1988-08-13 00:00:00

abstract：OBJECTIVE:To compare the efficacy of surgery with disc prosthesis versus non-surgical treatment for patients with chronic low back pain. DESIGN:A prospective randomised multicentre study. SETTING:Five university hospitals in Norway. PARTICIPANTS:173 patients with a history of low back pain for at least one year, Osw...

journal_title：BMJ (Clinical research ed.)

authors： Hellum C,Johnsen LG,Storheim K,Nygaard OP,Brox JI,Rossvoll I,Rø M,Sandvik L,Grundnes O,Norwegian Spine Study Group.

更新日期：2011-05-19 00:00:00

abstract：OBJECTIVE:To determine the outcome of administration of neuroleptics to patients with senile dementia of Lewy body type confirmed at necropsy. DESIGN:Retrospective analysis of clinical notes blind to neuropathological diagnosis. SETTING:Specialist psychogeriatric assessment units referring cases for necropsy to a tea...

journal_title：BMJ (Clinical research ed.)

authors： McKeith I,Fairbairn A,Perry R,Thompson P,Perry E

更新日期：1992-09-19 00:00:00