当前位置： SCI文献检索 > RESPIRATORY RESEARCH期刊下所有文献 > Protein kinase R-like endoplasmatic reticulum kinase is a mediator of stretch in ventilator-induced lung injury.

Protein kinase R-like endoplasmatic reticulum kinase is a mediator of stretch in ventilator-induced lung injury.

Abstract：

BACKGROUND:Acute respiratory distress syndrome (ARDS) is a severe form of lung injury characterized by damage to the epithelial barrier with subsequent pulmonary edema and hypoxic respiratory failure. ARDS is a significant medical problem in intensive care units with associated high care costs. There are many potential causes of ARDS; however, alveolar injury associated with mechanical ventilation, termed ventilator-induced lung injury (VILI), remains a well-recognized contributor. It is thus critical to understand the mechanism of VILI. Based on our published preliminary data, we hypothesized that the endoplasmic reticulum (ER) stress response molecule Protein Kinase R-like Endoplasmic Reticulum Kinase (PERK) plays a role in transmitting mechanosensory signals the alveolar epithelium. METHODS:ER stress signal responses to mechanical stretch were studied in ex-vivo ventilated pig lungs. To explore the effect of PERK inhibition on VILI, we ventilated live rats and compared lung injury parameters to non-ventilated controls. The effect of stretch-induced epithelial ER Ca2+ signaling on PERK was studied in stretched alveolar epithelial monolayers. To confirm the activation of PERK in human disease, ER stress signaling was compared between ARDS and non-ARDS lungs. RESULTS:Our studies revealed increased PERK-specific ER stress signaling in response to overstretch. PERK inhibition resulted in dose-dependent improvement of alveolar inflammation and permeability. Our data indicate that stretch-induced epithelial ER Ca2+ release is an activator of PERK. Experiments with human lung tissue confirmed PERK activation by ARDS. CONCLUSION:Our study provides evidences that PERK is a mediator stretch signals in the alveolar epithelium.

journal_name

Respir Res

journal_title

Respiratory research

authors

Dolinay T,Aonbangkhen C,Zacharias W,Cantu E,Pogoriler J,Stablow A,Lawrence GG,Suzuki Y,Chenoweth DM,Morrisey E,Christie JD,Beers MF,Margulies SS

doi

10.1186/s12931-018-0856-2

subject

Has Abstract

pub_date

2018-08-22 00:00:00

pages

157

issue

1

eissn

1465-9921

issn

1465-993X

pii

10.1186/s12931-018-0856-2

journal_volume

19

pub_type

杂志文章

相关文献

RESPIRATORY RESEARCH文献大全
  • BARD1 mediates TGF-β signaling in pulmonary fibrosis.

    abstract：BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a rapid progressive fibro-proliferative disorder with poor prognosis similar to lung cancer. The pathogenesis of IPF is uncertain, but loss of epithelial cells and fibroblast proliferation are thought to be central processes. Previous reports have shown that BARD1 expre...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-015-0278-3

    authors： André PA,Prêle CM,Vierkotten S,Carnesecchi S,Donati Y,Chambers RC,Pache JC,Crestani B,Barazzone-Argiroffo C,Königshoff M,Laurent GJ,Irminger-Finger I

    更新日期：2015-09-29 00:00:00

  • Hospitalisation and mortality in patients with comorbid COPD and heart failure: a systematic review and meta-analysis.

    abstract：BACKGROUND:Discrepancy exists amongst studies investigating the effect of comorbid heart failure (HF) on the morbidity and mortality of chronic obstructive pulmonary disease (COPD) patients. METHODS:MEDLINE and Embase were searched using a pre-specified search strategy for studies comparing hospitalisation, rehospital...

    journal_title：Respiratory research

    pub_type： 杂志文章,meta分析

    doi：10.1186/s12931-020-1312-7

    authors： Axson EL,Ragutheeswaran K,Sundaram V,Bloom CI,Bottle A,Cowie MR,Quint JK

    更新日期：2020-02-14 00:00:00

  • Perip7lakin is a target for autoimmunity in asthma.

    abstract：:The role of autoimmunity targeting epithelial antigens in asthma has been suggested, in particular in non-atopic and severe asthma. Periplakin, a desmosomal component, is involved in epithelial cohesion and intracellular signaling. We detected anti-periplakin IgG antibodies in 47/260 (18 %) patients with asthma, with ...

    journal_title：Respiratory research

    pub_type： 信件

    doi：10.1186/s12931-016-0441-5

    authors： Taillé C,Grootenboer-Mignot S,Estellat C,Roy C,Ly Ka So S,Pretolani M,Aubier M,Crestani B,Chollet-Martin S

    更新日期：2016-10-07 00:00:00

  • Could a defective epithelial sodium channel lead to bronchiectasis.

    abstract：BACKGROUND:Bronchiectasis is defined as a permanent dilation of the airways arising from chronic bronchial inflammation/infection. In 50% of cases, no etiology can be identified. Recently, the role of the epithelial sodium channel ENaC has been pointed out in the pathophysiology of cystic fibrosis, a disease due to mut...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-9-46

    authors： Fajac I,Viel M,Sublemontier S,Hubert D,Bienvenu T

    更新日期：2008-05-28 00:00:00

  • Detection of reactive oxygen species in isolated, perfused lungs by electron spin resonance spectroscopy.

    abstract：BACKGROUND:The sources and measurement of reactive oxygen species (ROS) in intact organs are largely unresolved. This may be related to methodological problems associated with the techniques currently employed for ROS detection. Electron spin resonance (ESR) with spin trapping is a specific method for ROS detection, an...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-6-86

    authors： Weissmann N,Kuzkaya N,Fuchs B,Tiyerili V,Schäfer RU,Schütte H,Ghofrani HA,Schermuly RT,Schudt C,Sydykov A,Egemnazarow B,Seeger W,Grimminger F

    更新日期：2005-07-31 00:00:00

  • Surfactant protein D attenuates sub-epithelial fibrosis in allergic airways disease through TGF-β.

    abstract：BACKGROUND:Surfactant protein D (SP-D) can regulate both innate and adaptive immunity. Recently, SP-D has been shown to contribute to the pathogenesis of airway allergic inflammation and bleomycin-induced pulmonary fibrosis. However, in allergic airways disease, the role of SP-D in airway remodeling remains unknown. Th...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-014-0143-9

    authors： Ogawa H,Ledford JG,Mukherjee S,Aono Y,Nishioka Y,Lee JJ,Izumi K,Hollingsworth JW

    更新日期：2014-11-29 00:00:00

  • Use of Berlin questionnaire in comparison to polysomnography and home sleep study in patients with obstructive sleep apnea.

    abstract：BACKGROUND:Obstructive sleep apnea syndrome (OSAS) is a common disorder with significant morbidity and mortality. We aimed to evaluate the predictive accuracy of the Berlin questionnaire in patients with suspected OSAS undergoing PSG in the sleep laboratory setting against those going through the Embletta™ portable dia...

    journal_title：Respiratory research

    pub_type： 杂志文章,随机对照试验

    doi：10.1186/s12931-019-1009-y

    authors： Ng SS,Tam W,Chan TO,To KW,Ngai J,Chan KKP,Yip WH,Lo RL,Yiu K,Ko FW,Hui DS

    更新日期：2019-02-22 00:00:00

  • Acute bronchodilator responsiveness and health outcomes in COPD patients in the UPLIFT trial.

    abstract：BACKGROUND:Debate continues as to whether acute bronchodilator responsiveness (BDR) predicts long-term outcomes in COPD. Furthermore, there is no consensus on a threshold for BDR. METHODS:At baseline and during the 4-year Understanding Potential Long-term Improvements in Function with Tiotropium (UPLIFT®) trial, patie...

    journal_title：Respiratory research

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1186/1465-9921-12-6

    authors： Hanania NA,Sharafkhaneh A,Celli B,Decramer M,Lystig T,Kesten S,Tashkin D

    更新日期：2011-01-11 00:00:00

  • Cell-specific expression of lung disease risk-related genes in the human small airway epithelium.

    abstract：BACKGROUND:The human small airway epithelium (SAE) plays a central role in the early events in the pathogenesis of most inherited and acquired lung disorders. Little is known about the molecular phenotypes of the specific cell populations comprising the SAE in humans, and the contribution of SAE specific cell populatio...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-020-01442-9

    authors： Zuo WL,Rostami MR,Shenoy SA,LeBlanc MG,Salit J,Strulovici-Barel Y,O'Beirne SL,Kaner RJ,Leopold PL,Mezey JG,Schymeinsky J,Quast K,Visvanathan S,Fine JS,Thomas MJ,Crystal RG

    更新日期：2020-07-29 00:00:00

  • Examining the role of ABC lipid transporters in pulmonary lipid homeostasis and inflammation.

    abstract：:Respiratory diseases including asthma and chronic obstructive pulmonary disease (COPD) are characterised by excessive and persistent inflammation. Current treatments are often inadequate for symptom and disease control, and hence new therapies are warranted. Recent emerging research has implicated dyslipidaemia in pul...

    journal_title：Respiratory research

    pub_type： 杂志文章,评审

    doi：10.1186/s12931-017-0526-9

    authors： Chai AB,Ammit AJ,Gelissen IC

    更新日期：2017-02-28 00:00:00

  • Abstracts from the 2018 Respiratory Effectiveness Group Summit : Amsterdam, the Netherlands. 22-24 March 2018.

    abstract：: ...

    journal_title：Respiratory research

    pub_type：

    doi：10.1186/s12931-018-0930-9

    authors：

    更新日期：2018-12-20 00:00:00

  • Therapeutic efficacy of α-1 antitrypsin augmentation therapy on the loss of lung tissue: an integrated analysis of 2 randomised clinical trials using computed tomography densitometry.

    abstract：BACKGROUND:Two randomised, double-blind, placebo-controlled trials have investigated the efficacy of IV alpha-1 antitrypsin (AAT) augmentation therapy on emphysema progression using CT densitometry. METHODS:Data from these similar trials, a 2-center Danish-Dutch study (n = 54) and the 3-center EXAcerbations and CT sca...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-11-136

    authors： Stockley RA,Parr DG,Piitulainen E,Stolk J,Stoel BC,Dirksen A

    更新日期：2010-10-05 00:00:00

  • 25-Hydroxycholesterol enhances cytokine release and Toll-like receptor 3 response in airway epithelial cells.

    abstract：BACKGROUND:25-hydroxycholesterol (25-HC) is one of the oxysterols, which are oxidized derivatives of cholesterol, and has been reported to be involved in the pathogenesis of atherosclerosis and Alzheimer's disease. In lung, the possible involvement of 25-HC in airway diseases has been revealed. In the present study, we...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-13-63

    authors： Koarai A,Yanagisawa S,Sugiura H,Ichikawa T,Kikuchi T,Furukawa K,Akamatsu K,Hirano T,Nakanishi M,Matsunaga K,Minakata Y,Ichinose M

    更新日期：2012-07-31 00:00:00

  • Outcome measures for airway clearance techniques in children with chronic obstructive lung diseases: a systematic review.

    abstract：BACKGROUND:Airway clearance techniques (ACTs) are an important aspect of the treatment of children with chronic obstructive lung diseases. Unfortunately, a sound evidence base is lacking and airway clearance strategies are largely based on clinical expertise. One of the reasons for the limited evidence is the lack of a...

    journal_title：Respiratory research

    pub_type： 杂志文章,评审

    doi：10.1186/s12931-020-01484-z

    authors： Lauwers E,Ides K,Van Hoorenbeeck K,Verhulst S

    更新日期：2020-08-17 00:00:00

  • Distinctive lung function trajectories from age 10 to 26 years in men and women and associated early life risk factors - a birth cohort study.

    abstract：:Pre-bronchodilator lung function including forced vital capacity (FVC), forced expiratory flow in 1 second (FEV1), their ratio (FEV1/FVC), and forced expiratory flow 25-75% (FEF25-75) measured at age 10, 18, and 26 years in the Isle of Wight birth cohort was analyzed for developmental patterns (trajectories). Early li...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-019-1068-0

    authors： Karmaus W,Mukherjee N,Janjanam VD,Chen S,Zhang H,Roberts G,Kurukulaaratchy RJ,Arshad H

    更新日期：2019-05-22 00:00:00

  • The cellular kinetics of lung alveolar epithelial cells and its relationship with lung tissue repair after acute lung injury.

    abstract：BACKGROUND:Organ regeneration in mammals is hypothesized to require a functional pool of stem or progenitor cells, but the role of these cells in lung regeneration is unknown. METHODS:Based on the fact that postnatal regeneration of alveolar tissue has been attributed to alveolar epithelial cells, we established a hem...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-016-0480-y

    authors： Zeng L,Yang XT,Li HS,Li Y,Yang C,Gu W,Zhou YH,Du J,Wang HY,Sun JH,Wen DL,Jiang JX

    更新日期：2016-12-07 00:00:00

  • Role of ATP-sensitive potassium channels on hypoxic pulmonary vasoconstriction in endotoxemia.

    abstract：BACKGROUND:ATP-regulated potassium channels (KATP) regulate pulmonary vascular tone and are involved in hypoxic pulmonary vasoconstriction (HPV). In patients with inflammation like sepsis or ARDS, HPV is impaired, resulting in a ventilation-perfusion mismatch and hypoxia. Since increase of vascular KATP channel Kir6.1 ...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-018-0735-x

    authors： Turzo M,Vaith J,Lasitschka F,Weigand MA,Busch CJ

    更新日期：2018-02-13 00:00:00

  • Allergic diseases and asthma in the family predict the persistence and onset-age of asthma: a prospective cohort study.

    abstract：BACKGROUND:Family history of asthma and other allergic diseases have been linked to the risk of childhood asthma previously, but little is known about their effect on the age-of-onset and persistency of asthma until young adulthood. METHODS:We assessed the effect of the family history of asthma and allergic diseases o...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-014-0152-8

    authors： Paaso EM,Jaakkola MS,Rantala AK,Hugg TT,Jaakkola JJ

    更新日期：2014-11-27 00:00:00

  • Pioglitazone is as effective as dexamethasone in a cockroach allergen-induced murine model of asthma.

    abstract：BACKGROUND:While glucocorticoids are currently the most effective therapy for asthma, associated side effects limit enthusiasm for their use. Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) activators include the synthetic thiazolidinediones (TZDs) which exhibit anti-inflammatory effects that suggest usef...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-8-90

    authors： Narala VR,Ranga R,Smith MR,Berlin AA,Standiford TJ,Lukacs NW,Reddy RC

    更新日期：2007-12-04 00:00:00

  • 24-h bronchodilation and inspiratory capacity improvements with glycopyrrolate/formoterol fumarate via co-suspension delivery technology in COPD.

    abstract：BACKGROUND:Symptoms of chronic obstructive pulmonary disease may vary throughout the day and it is important that therapeutic approaches provide 24-h symptom control. We report the results of two phase IIIb crossover studies, PT003011 and PT003012, investigating the 24-h lung function profile of GFF MDI (glycopyrrolate...

    journal_title：Respiratory research

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1186/s12931-017-0636-4

    authors： Reisner C,Gottschlich G,Fakih F,Koser A,Krainson J,Delacruz L,Arora S,Feldman G,Pudi K,Siddiqui S,Orevillo C,Maes A,St Rose E,Martin U

    更新日期：2017-08-18 00:00:00

  • Maintained inspiratory activity during proportional assist ventilation in surfactant-depleted cats early after surfactant instillation: phrenic nerve and pulmonary stretch receptor activity.

    abstract：BACKGROUND:Inspiratory activity is a prerequisite for successful application of patient triggered ventilation such as proportional assist ventilation (PAV). It has recently been reported that surfactant instillation increases the activity of slowly adapting pulmonary stretch receptors (PSRs) followed by a shorter inspi...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-7-38

    authors： Sindelar R,Rieger-Fackeldey E,Jonzon A,Schaller P,Schulze A,Sedin G

    更新日期：2006-03-10 00:00:00

  • Trends in prevalence and incidence of chronic respiratory diseases from 1990 to 2017.

    abstract：BACKGROUND:Chronic respiratory diseases (CRDs) are leading causes of morbidity worldwide. However, the spatial and temporal trends in prevalence and incidence of CRDs have not been estimated. METHODS:Based on data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2017, we analyzed the prevalence and...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-020-1291-8

    authors： Xie M,Liu X,Cao X,Guo M,Li X

    更新日期：2020-02-11 00:00:00

  • Local therapy with CpG motifs in a murine model of allergic airway inflammation in IFN-beta knock-out mice.

    abstract：BACKGROUND:CpG oligodeoxynucleotides (CpG-ODN) are capable of inducing high amounts of type I IFNs with many immunomodulatory properties. Furthermore, type-I IFNs have been proposed to play a key role in mediating effects of CpG-ODN. The precise role of IFN-beta in the immunomodulatory effects of CpG-ODN is not known. ...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-6-25

    authors： Matheu V,Treschow A,Teige I,Navikas V,Issazadeh-Navikas S

    更新日期：2005-03-05 00:00:00

  • Rate of progression of CT-quantified emphysema in male current and ex-smokers: a follow-up study.

    abstract：BACKGROUND:Little is known about the factors associated with CT-quantified emphysema progression in heavy smokers. The objective of this study was to investigate the effect of length of smoking cessation and clinical / demographical factors on the rate of emphysema progression and FEV1-decline in male heavy smokers. M...

    journal_title：Respiratory research

    pub_type： 杂志文章,随机对照试验

    doi：10.1186/1465-9921-14-55

    authors： Mohamed Hoesein FA,Zanen P,de Jong PA,van Ginneken B,Boezen HM,Groen HJ,Oudkerk M,de Koning HJ,Postma DS,Lammers JW

    更新日期：2013-05-20 00:00:00

  • Isolation of human beta-defensin-4 in lung tissue and its increase in lower respiratory tract infection.

    abstract：BACKGROUND:Human beta-defensin-4 (hBD-4), a new member of the beta-defensin family, was discovered by an analysis of the genomic sequence. The objective of this study was to clarify hBD-4 expression in human lung tissue, along with the inducible expression in response to infectious stimuli, localization, and antimicrob...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-6-130

    authors： Yanagi S,Ashitani J,Ishimoto H,Date Y,Mukae H,Chino N,Nakazato M

    更新日期：2005-11-04 00:00:00

  • The natural history of progressive fibrosing interstitial lung diseases.

    abstract：:A proportion of patients with certain types of interstitial lung disease (ILD), including chronic hypersensitivity pneumonitis and ILDs associated with autoimmune diseases, develop a progressive fibrosing phenotype that shows similarities in clinical course to idiopathic pulmonary fibrosis. Irrespective of the clinica...

    journal_title：Respiratory research

    pub_type： 杂志文章,评审

    doi：10.1186/s12931-019-1022-1

    authors： Kolb M,Vašáková M

    更新日期：2019-03-14 00:00:00

  • Diagnostic value of plasma and bronchoalveolar lavage samples in acute lung allograft rejection: differential cytology.

    abstract：:Diagnosis of acute lung allograft rejection is currently based on transbronchial lung biopsies. Additional methods to detect acute allograft dysfunction derived from plasma and bronchoalveolar lavage samples might facilitate diagnosis and ultimately improve allograft survival. This review article gives an overview of ...

    journal_title：Respiratory research

    pub_type： 杂志文章,评审

    doi：10.1186/s12931-016-0391-y

    authors： Speck NE,Schuurmans MM,Murer C,Benden C,Huber LC

    更新日期：2016-06-21 00:00:00

  • Pharmacological inhibition of GSK-3 in a guinea pig model of LPS-induced pulmonary inflammation: II. Effects on skeletal muscle atrophy.

    abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is accompanied by pulmonary inflammation and associated with extra-pulmonary manifestations, including skeletal muscle atrophy. Glycogen synthase kinase-3 (GSK-3) has been implicated in the regulation of muscle protein- and myonuclear turnover; two crucial process...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-14-117

    authors： Verhees KJ,Pansters NA,Baarsma HA,Remels AH,Haegens A,de Theije CC,Schols AM,Gosens R,Langen RC

    更新日期：2013-11-01 00:00:00

  • The influence of chlorine in indoor swimming pools on the composition of breathing phase of professional swimmers.

    abstract：OBJECTIVES:Swimming is one of the most popular forms of physical activity. Pool water is cleaned with chlorine, which - in combination with compounds contained in water - could form chloramines and trichloromethane in the swimmer's lungs. The aim of the present study was to examine the effect of swimming training in an...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-020-01350-y

    authors： Swinarew AS,Stanula AJ,Gabor J,Raif P,Paluch J,Karpiński J,Kubik K,Okła H,Ostrowski A,Tkacz E,Skoczyński S,Waśkiewicz Z,Rosemann T,Nikolaidis PT,Knechtle B

    更新日期：2020-04-15 00:00:00

  • Impact of gender on COPD expression in a real-life cohort.

    abstract：:Reports regarding gender-related differences in COPD expression have provided conflicting results. In the French Initiatives BPCO real-world cohort, which contained 688 patients (146 women) when data were extracted, women were matched with men (1:3 ratio: n = 107:275) on age (5-year intervals) and FEV1 (5% predicted i...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-15-20

    authors： Roche N,Deslée G,Caillaud D,Brinchault G,Court-Fortune I,Nesme-Meyer P,Surpas P,Escamilla R,Perez T,Chanez P,Pinet C,Jebrak G,Paillasseur JL,Burgel PR,INITIATIVES BPCO Scientific Committee.

    更新日期：2014-02-17 00:00:00