Angiotensin converting enzyme insertion or deletion polymorphism and coronary restenosis: meta-analysis of 16 studies.

Abstract:

OBJECTIVE:To assess the association between genotype at the insertion or deletion polymorphism of the angiotensin converting enzyme gene and risk of coronary restenosis after percutaneous coronary intervention. DESIGN:Meta-analysis of studies before July 2001 that reported on these genotypes and risk of coronary restenosis after a percutaneous coronary intervention, with or without coronary stenting. RESULTS:16 studies, involving 4631 patients undergoing a percutaneous coronary intervention, yielded 1683 patients with restenosis after a mean weighted follow up of 5.5 months. The combined odds ratio for restenosis in people with the DD genotype was 1.23 (99% confidence interval 1.03 to 1.46). When studies were grouped by size, however, the combined odds ratios for restenosis in people with the DD genotype were 1.94 (1.39 to 2.71) for studies with less than 100 cases, 1.33 (0.92 to 1.93) for studies with 100-200 cases, and 0.92 (0.72 to 1.18) for studies with more than 200 cases (trend P=0.02). Similarly, when studies were grouped by genotyping procedures, significantly larger odds ratios were found in the studies that did not conceal disease status from laboratory staff and in the studies that did not use a second polymerase chain reaction amplification to reduce genetic mistyping. CONCLUSION:Compared with other studies, larger and more rigorous studies show a weaker association between the angiotensin converting enzyme gene DD genotype and restenosis. Publication bias or detection biases can produce artefactual associations at least as large as those that might be expected for common polymorphisms in complex diseases, suggesting the need for larger and more rigorous genetic epidemiological investigations than are now customary.

journal_name

BMJ

authors

Bonnici F,Keavney B,Collins R,Danesh J

doi

10.1136/bmj.325.7363.517

keywords:

subject

Has Abstract

pub_date

2002-09-07 00:00:00

pages

517-20

issue

7363

eissn

0959-8138

issn

1756-1833

journal_volume

325

pub_type

杂志文章,meta分析
  • South African minister accused of human rights abuse.

    abstract::South African Health Minister Dr. Manto Tshabalala-Msimang was accused of human rights abuse for refusing to supply zidovudine to all HIV-positive pregnant women. The accusations were laid by Dr. Costa Gazi, a South African doctor employed in the state health system with the Human Rights Commission. Dr. Gazi believe...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 新闻

    doi:

    authors: Sidley P

    更新日期:2000-01-29 00:00:00

  • Oral contraception and risk of a cerebral thromboembolic attack: results of a case-control study.

    abstract:OBJECTIVE:To assess the risk of cerebral thromboembolism in women using low dose oral contraceptives. DESIGN:A retrospective case-control study. SETTING:All Danish medical, neurological, neurosurgical, and gynaecological departments. SUBJECTS:All 794 women in Denmark aged 15-44 who had suffered a cerebral thromboemb...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.306.6883.956

    authors: Lidegaard O

    更新日期:1993-04-10 00:00:00

  • India bans female feticide.

    abstract::About 70% of all abortions performed in Delhi, India, are terminations due to the fetus being female. Private clinics make a profit out of offering sex determination tests. The new bill (the Prenatal Diagnostic Techniques Bill) introduced in Lok Sabha by Deputy Health Minister Pawan Singh Ghatowatr would stop "sex d...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 新闻

    doi:10.1136/bmj.309.6952.428

    authors: Imam Z

    更新日期:1994-08-13 00:00:00

  • Female circumcision is curbed in Egypt.

    abstract::In the wake of the death of an 11-year-old girl the Egyptian government has banned any government-affiliated medical staff from performing female circumcision. Egyptian health policy has shifted from trying to control the practice by keeping it under government supervision towards condemnation. In October 1995 the h...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 新闻

    doi:10.1136/bmj.313.7052.249

    authors: Wiens J

    更新日期:1996-08-03 00:00:00

  • Estimating the high risk group for cardiovascular disease in the Norwegian HUNT 2 population according to the 2003 European guidelines: modelling study.

    abstract:OBJECTIVE:To estimate the high risk group for cardiovascular disease in a well defined Norwegian population according to European guidelines and the systematic coronary risk evaluation system. DESIGN:Modelling study. SETTING:Nord-Tröndelag health study 1995-7 (HUNT 2), Norway. PARTICIPANTS:5548 participants of the N...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.38555.648623.8F

    authors: Getz L,Sigurdsson JA,Hetlevik I,Kirkengen AL,Romundstad S,Holmen J

    更新日期:2005-09-10 00:00:00

  • Contribution of dihydrotestosterone to male sexual behaviour.

    abstract:OBJECTIVE:To document the relative importance of endogenous sex steroids in modulating the frequency of orgasms, the dominant aspect of sexual behaviour in healthy eugonadal men. DESIGN:Measurement of adrenal and testicular sex steroids in a sample of army recruits and study of their relation to frequency of orgasms a...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.310.6990.1289

    authors: Mantzoros CS,Georgiadis EI,Trichopoulos D

    更新日期:1995-05-20 00:00:00

  • The SSSPIN study-spin in studies of spin: meta-research analysis.

    abstract:OBJECTIVES:To identify and calculate the prevalence of spin in studies of spin. DESIGN:Meta-research analysis (research on research). SETTING:35 studies of spin in the scientific literature. MAIN OUTCOME MEASURES:Spin, categorised as: reporting practices that distort the presentation and interpretation of results, c...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,meta分析

    doi:10.1136/bmj.l6202

    authors: Bero L,Chiu K,Grundy Q

    更新日期:2019-12-18 00:00:00

  • Baby food industry lobbies WHO on breast feeding advice.

    abstract::In the existing WHO guidelines, complementary feeding at 4-6 months is advocated. However, many nutrition specialists believe that these guidelines lead to complementary foods being offered from the age of 3 months, or even earlier, subsequently suggesting that the WHO should change its recommendations to about 6 mon...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 新闻

    doi:

    authors: Yamey G

    更新日期:2000-09-09 00:00:00

  • Improved prognosis since 1969 of myocardial infarction treated in a coronary care unit: lack of relation with changes in severity.

    abstract:OBJECTIVE:To study changes from 1969 to 1983 in the prognosis of patients with acute myocardial infarction treated in a coronary care unit. DESIGN:Mortality follow up of all patients with definite acute myocardial infarction. SETTING:The coronary care unit of the Royal Melbourne Hospital, a tertiary referral centre. ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.299.6704.892

    authors: Hopper JL,Pathik B,Hunt D,Chan WW

    更新日期:1989-10-07 00:00:00

  • Intake of fish and marine n-3 polyunsaturated fatty acids and risk of breast cancer: meta-analysis of data from 21 independent prospective cohort studies.

    abstract:OBJECTIVES:To investigate the association between intake of fish and n-3 polyunsaturated fatty acids (n-3 PUFA) and the risk of breast cancer and to evaluate the potential dose-response relation. DESIGN:Meta-analysis and systematic review of prospective cohort studies. DATA SOURCES:PubMed and Embase up to December 20...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,meta分析,评审

    doi:10.1136/bmj.f3706

    authors: Zheng JS,Hu XJ,Zhao YM,Yang J,Li D

    更新日期:2013-06-27 00:00:00

  • Dealing with extracontractual referrals.

    abstract:OBJECTIVE:To describe the mechanism established by Richmond, Twickenham, and Roehampton Health Authority to manage extracontractual referral requests made on behalf of its resident population and to examine its working in the first three months of the new arrangements. DESIGN:Description of the procedures for managing...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.303.6801.499

    authors: Williamson JD

    更新日期:1991-08-31 00:00:00

  • Prescribing injectable and oral methadone to opiate addicts: results from the 1995 national postal survey of community pharmacies in England and Wales.

    abstract:OBJECTIVE:To establish the extent of prescribing injectable and oral methadone to opiate addicts and the practice characteristics and dispensing arrangements attached to these prescriptions. DESIGN:National survey of 25% random sample of community (high street) pharmacies through postal questionnaire, with four mailin...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.313.7052.270

    authors: Strang J,Sheridan J,Barber N

    更新日期:1996-08-03 00:00:00

  • Slow walking speed and cardiovascular death in well functioning older adults: prospective cohort study.

    abstract:OBJECTIVE:To study the relation between low walking speed and the risk of death in older people, both overall and with regard to the main causes of death. DESIGN:Prospective cohort study. SETTING:Dijon centre (France) of the Three-City study. PARTICIPANTS:3208 men and women aged >or=65 living in the community, recru...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,多中心研究

    doi:10.1136/bmj.b4460

    authors: Dumurgier J,Elbaz A,Ducimetière P,Tavernier B,Alpérovitch A,Tzourio C

    更新日期:2009-11-10 00:00:00

  • Use of probiotic Lactobacillus preparation to prevent diarrhoea associated with antibiotics: randomised double blind placebo controlled trial.

    abstract:OBJECTIVE:To determine the efficacy of a probiotic drink containing Lactobacillus for the prevention of any diarrhoea associated with antibiotic use and that caused by Clostridium difficile. DESIGN:Randomised double blind placebo controlled study. PARTICIPANTS:135 hospital patients (mean age 74) taking antibiotics. E...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/bmj.39231.599815.55

    authors: Hickson M,D'Souza AL,Muthu N,Rogers TR,Want S,Rajkumar C,Bulpitt CJ

    更新日期:2007-07-14 00:00:00

  • Blood pressure control by home monitoring: meta-analysis of randomised trials.

    abstract:OBJECTIVE:To determine the effect of home blood pressure monitoring on blood pressure levels and proportion of people with essential hypertension achieving targets. DESIGN:Meta-analysis of 18 randomised controlled trials. PARTICIPANTS:1359 people with essential hypertension allocated to home blood pressure monitoring...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,meta分析

    doi:10.1136/bmj.38121.684410.AE

    authors: Cappuccio FP,Kerry SM,Forbes L,Donald A

    更新日期:2004-07-17 00:00:00

  • Trial of brief intermittent neuroleptic prophylaxis for selected schizophrenic outpatients: clinical outcome at one year.

    abstract::A study was conducted to investigate a novel approach to the prophylaxis of schizophrenic relapse. The treatment strategy comprised brief intermittent courses of neuroleptic agents begun as soon as non-psychotic symptoms believed to be early signs of relapse appeared. Fifty four stable, remitted outpatients meeting th...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/bmj.298.6679.985

    authors: Jolley AG,Hirsch SR,McRink A,Manchanda R

    更新日期:1989-04-15 00:00:00

  • What do I want from health research and researchers when I am a patient?

    abstract::I have attempted to adopt the perspective of a patient--albeit one with a rather atypical background--to explore what I want from health research and researchers. This has left me with the impression that health researchers could serve the interests of the public more effectively in a variety of ways, and that they wo...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.310.6990.1315

    authors: Chalmers I

    更新日期:1995-05-20 00:00:00

  • Influence of moving to the UK on maternal health behaviours: prospective cohort study.

    abstract:OBJECTIVE:To compare health behaviours during pregnancy (smoking and alcohol consumption) and after birth (initiation and duration of breast feeding) between British/Irish white mothers and mothers from ethnic minority groups; and, in mothers from ethnic minority groups, to examine whether indicators of acculturation (...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.39532.688877.25

    authors: Hawkins SS,Lamb K,Cole TJ,Law C,Millennium Cohort Study Child Health Group.

    更新日期:2008-05-10 00:00:00

  • The quality of health care in prison: results of a year's programme of semistructured inspections.

    abstract:OBJECTIVES:To assess, as part of wider inspections by HM Inspectorate of Prisons, the extent and quality of health care in prisons in England and Wales. DESIGN:Inspections based on a set of "expectations" derived mainly from existing healthcare quality standards published by the prison service and existing ethical gui...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.315.7120.1420

    authors: Reed J,Lyne M

    更新日期:1997-11-29 00:00:00

  • Systematic review of mental health interventions for patients with common somatic symptoms: can research evidence from secondary care be extrapolated to primary care?

    abstract:OBJECTIVES:To determine the strength of evidence for the effectiveness of mental health interventions for patients with three common somatic conditions (chronic fatigue syndrome, irritable bowel syndrome, and chronic back pain). To assess whether results obtained in secondary care can be extrapolated to primary care an...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,评审

    doi:10.1136/bmj.325.7372.1082

    authors: Raine R,Haines A,Sensky T,Hutchings A,Larkin K,Black N

    更新日期:2002-11-09 00:00:00

  • Purpura and dermal thinning associated with high dose inhaled corticosteroids.

    abstract:OBJECTIVE:To assess the effect of high dose inhaled corticosteroids on skin. DESIGN:Cross sectional study of patients receiving treatment for chest diseases. SETTING:Outpatient chest clinic in a teaching hospital. PATIENTS:68 Patients divided into four groups of similar age--namely, 15 receiving long term oral predn...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.300.6739.1548

    authors: Capewell S,Reynolds S,Shuttleworth D,Edwards C,Finlay AY

    更新日期:1990-06-16 00:00:00

  • Knowledge and use of secondary contraception among patients requesting termination of pregnancy.

    abstract::The results of a survey of 769 patients attending the St. James's University Fertility Control Clinic, England, for abortion services showed that patients seeing general practitioners were less knowledgeable than those attending specialist clinics. There was a demonstrated need for counseling on pill and condom use a...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.306.6877.556

    authors: Bromham DR,Cartmill RS

    更新日期:1993-02-27 00:00:00

  • Acceptability of low molecular weight heparin thromboprophylaxis for inpatients receiving palliative care: qualitative study.

    abstract:OBJECTIVE:To find out what inpatients with advanced cancer who are receiving palliative care think about the effect of thromoprophylaxis on overall quality of life. DESIGN:Qualitative study using audiotaping of semistructured interviews. SETTING:Regional cancer centre in Wales. PARTICIPANTS:28 inpatients with advanc...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.38733.616065.802

    authors: Noble SI,Nelson A,Turner C,Finlay IG

    更新日期:2006-03-11 00:00:00

  • Diabetes registers: a grassroots approach.

    abstract:OBJECTIVES:To compile a register of diabetic patients within the catchment area of a district general hospital and evaluate the characteristics of the population using aggregated data from a general practice audit. DESIGN:Cross sectional study. Practices identified all known diabetics and completed a questionnaire fro...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.307.6911.1046

    authors: Howitt AJ,Cheales NA

    更新日期:1993-10-23 00:00:00

  • Congo polio immunisation campaign gets go ahead.

    abstract::Since the World Health Organization (WHO) set a goal in 1988 of eradicating polio worldwide by 2000, the incidence of the disease has declined by 90% around the world, with national immunization days conducted in more than 120 countries. More than 450 million children were immunized in 1998 alone. Now, with only abo...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 新闻

    doi:10.1136/bmj.318.7186.756

    authors: Mach A

    更新日期:1999-03-20 00:00:00

  • Prospective cohort study of retinal vessel diameters and risk of hypertension.

    abstract:OBJECTIVE:To examine the relation between diameters of the retinal arterioles and 10 year incidence of hypertension. DESIGN:Population based prospective cohort study. SETTING:Beaver Dam eye study. PARTICIPANTS:2451 normotensive people aged 43 to 84 years. MAIN OUTCOME MEASURES:Diameters of retinal arterioles and ve...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.38124.682523.55

    authors: Wong TY,Shankar A,Klein R,Klein BE,Hubbard LD

    更新日期:2004-07-10 00:00:00

  • Prevalence of diabetes in a predominantly Asian community: preliminary findings of the Coventry diabetes study.

    abstract::To assess the prevalence of both diagnosed and undiagnosed diabetes mellitus in an area of predominantly Asian population the Coventry diabetes study is carrying out house to house screening for diabetes in people aged 20 and over in Foleshill, Coventry. In the first five of 12 areas to be studied 2130 of 2283 Asian (...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.298.6665.18

    authors: Simmons D,Williams DR,Powell MJ

    更新日期:1989-01-07 00:00:00

  • Prevalence of antibodies to hepatitis B, hepatitis C, and HIV and risk factors in entrants to Irish prisons: a national cross sectional survey.

    abstract:OBJECTIVES:To determine the prevalence of antibodies to hepatitis B core antigen, hepatitis C virus, and HIV in entrants to Irish prisons and to examine risk factors for infection. DESIGN:Cross sectional, anonymous survey, with self completed risk factor questionnaire and oral fluid specimen for antibody testing. SET...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.323.7323.1209

    authors: Long J,Allwright S,Barry J,Reynolds SR,Thornton L,Bradley F,Parry JV

    更新日期:2001-11-24 00:00:00

  • Familial risks of squamous cell carcinoma of the head and neck: retrospective case-control study.

    abstract:OBJECTIVE:To determine the contribution of inheritance to the incidence of squamous cell carcinoma of the head and neck. DESIGN:Historical cohort study. First degree relatives of cases with squamous cell carcinoma of the head and neck made up the exposed cohort and first degree relatives of spouses of cases made up th...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.313.7059.716

    authors: Foulkes WD,Brunet JS,Sieh W,Black MJ,Shenouda G,Narod SA

    更新日期:1996-09-21 00:00:00

  • Rectal artemether versus intravenous quinine for the treatment of cerebral malaria in children in Uganda: randomised clinical trial.

    abstract:OBJECTIVE:To compare the efficacy and safety of rectal artemether with intravenous quinine in the treatment of cerebral malaria in children. DESIGN:Randomised, single blind, clinical trial. SETTING:Acute care unit at Mulago Hospital, Uganda's national referral and teaching hospital in Kampala. PARTICIPANTS:103 child...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/bmj.330.7487.334

    authors: Aceng JR,Byarugaba JS,Tumwine JK

    更新日期:2005-02-12 00:00:00