Impact of matrix-assisted laser desorption/ionization time of flight mass spectrometric evaluation on the clinical outcomes of patients with bacteremia and fungemia in clinical settings lacking an antimicrobial stewardship program: a pre-post quasi experi

Abstract:

BACKGROUNDS:Several studies have evaluated the impact of matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS) combined with antimicrobial stewardship in patients with positive blood cultures; clinical outcomes improved. However, in many hospitals, antimicrobial stewardship is not available because of restricted medical resources. Thus, we investigated the impact of evaluation by MALDI-TOF MS on the clinical outcomes of patients with bacteremia and fungemia treated in a clinical setting lacking an antimicrobial stewardship program (ASP). METHODS:We designed a pre-post quasi experimental study and retrospectively reviewed the medical records of patients aged > 18 years old with bacteremia and fungemia during two periods: October-December 2012 and October-December 2013. Conventional methods were used to detect microbial pathogens in 2012, and MALDI-TOF MS was employed in 2013. Clinical outcomes compared between periods were the time to pathogen identification, time to effective therapy, 30-day all-cause mortality, time to microbiological clearance, length of ICU stay, and rate of recurrence of the same bloodstream infection (BSI). RESULTS:A total of 556 patients were enrolled; 302 patients in 2012, and 254 in 2013. The use of MALDI-TOF MS without an ASP reduced the time to pathogen identification (86.4 vs. 63.5 h, P < 0.001) but did not significantly reduce the time to effective therapy (27.4 vs. 23.2 h, P = 0.187). Also, none of the following differed significantly between the two periods: mortality (17.5 vs. 15.7%, P = 0.571), the time to microbiological clearance (3.6 vs. 3.7 days, P = 0.675), the length of ICU stay (16.8 vs. 14.7 days, P = 0.706), and the recurrence rate of the same BSI (5.0 vs. 2.8%, P = 0.183). CONCLUSIONS:The use of MALDI-TOF MS alone in a setting lacking an ASP did not afford clinical benefits. An ASP combined with MALDI-TOF MS is necessary to improve clinical outcomes.

journal_name

BMC Infect Dis

journal_title

BMC infectious diseases

authors

Jeon YD,Seong H,Kim D,Ahn MY,Jung IY,Jeong SJ,Choi JY,Song YG,Yong D,Lee K,Kim JM,Ku NS

doi

10.1186/s12879-018-3299-y

subject

Has Abstract

pub_date

2018-08-09 00:00:00

pages

385

issue

1

issn

1471-2334

pii

10.1186/s12879-018-3299-y

journal_volume

18

pub_type

杂志文章
  • Blood and alveolar lymphocyte subsets in pulmonary cytomegalovirus infection after lung transplantation.

    abstract:BACKGROUND:Cytomegalovirus (CMV) pneumonitis has been shown to be associated with lymphocytic alveolitis after lung transplantation. In the present study, we investigated a series of bronchoalveolar (BAL) and blood samples, collected in the absence of rejection or acute infectious episodes. in order -1: to evaluate int...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-1-15

    authors: Stéphan F,Bernaudin JF,Cesari D,Fajac A,Grenet D D,Caubarrere I,Stern M

    更新日期:2001-01-01 00:00:00

  • The use of a geographic information system to identify a dairy goat farm as the most likely source of an urban Q-fever outbreak.

    abstract:BACKGROUND:A Q-fever outbreak occurred in an urban area in the south of the Netherlands in May 2008. The distribution and timing of cases suggested a common source. We studied the spatial relationship between the residence locations of human cases and nearby small ruminant farms, of which one dairy goat farm had experi...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-10-69

    authors: Schimmer B,Ter Schegget R,Wegdam M,Züchner L,de Bruin A,Schneeberger PM,Veenstra T,Vellema P,van der Hoek W

    更新日期:2010-03-16 00:00:00

  • Wound infection with Vibrio harveyi following a traumatic leg amputation after a motorboat propeller injury in Mallorca, Spain: a case report and review of literature.

    abstract:BACKGROUND:Vibrio spp. are aquatic bacteria that are ubiquitous in warm estuarine and marine environments, of which 12 species are currently known to cause infections in humans. So far, only five human infections with V. harveyi have been reported. CASE PRESENTATION:A 26-year old patient was transferred to our center ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1186/s12879-020-4789-2

    authors: Brehm TT,Berneking L,Rohde H,Chistner M,Schlickewei C,Sena Martins M,Schmiedel S

    更新日期:2020-02-04 00:00:00

  • Safety of poly-L-lactic acid (New-Fill®) in the treatment of facial lipoatrophy: a large observational study among HIV-positive patients.

    abstract:BACKGROUND:Facial lipoatrophy is a frequently reported condition associated with use of antiretroviral (ARV) drugs. Poly-L-lactic acid (PLLA) acid has been used to correct facial lipoatrophy in people with HIV since 2004 both in Europe and the United States. The objective of this study was to establish, in real life co...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-2334-14-474

    authors: Duracinsky M,Leclercq P,Herrmann S,Christen MO,Dolivo M,Goujard C,Chassany O

    更新日期:2014-09-01 00:00:00

  • The general status of patients and limited physical activity as risk factors of Methicillin-resistant Staphylococcus aureus occurrence in long-term care facilities residents in Krakow, Poland.

    abstract:BACKGROUND:The aim of this study was to investigate the epidemiology and resistance of methicillin-resistant Staphylococcus aureus (MRSA) isolates from long-term care facilities (LTCF) residents and to analyze the potential risk factors for MRSA occurrence, defined as MRSA colonization and/or infection. METHODS:Point ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-2334-14-271

    authors: Romaniszyn D,Pobiega M,Wójkowska-Mach J,Chmielarczyk A,Gryglewska B,Adamski P,Heczko PB,Ochońska D,Bulanda M

    更新日期:2014-05-18 00:00:00

  • Prevalence of HIV-associated ophthalmic disease among patients enrolling for antiretroviral treatment in India: a cross-sectional study.

    abstract:BACKGROUND:The ocular manifestations of HIV may lead to visual impairment or blindness. In India, patients typically initiate antiretroviral treatment (ART) with low CD4 cell counts when the risk of ocular complications may be high. The objective of this study was to determine the prevalence and types of HIV-associated...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-9-158

    authors: Pathai S,Deshpande A,Gilbert C,Lawn SD

    更新日期:2009-09-23 00:00:00

  • Prevalence and risk factors for significant liver fibrosis among HIV-monoinfected patients.

    abstract:BACKGROUND:HIV-monoinfected patients may be at risk for significant liver fibrosis, but its prevalence and determinants in these patients are unknown. Since HIV-monoinfected patients do not routinely undergo liver biopsy, we evaluated the prevalence and risk factors of significant hepatic fibrosis in this group using t...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-10-116

    authors: DallaPiazza M,Amorosa VK,Localio R,Kostman JR,Lo Re V 3rd

    更新日期:2010-05-13 00:00:00

  • Evaluating clinical effectiveness of 13-valent pneumococcal conjugate vaccination against pneumonia among middle-aged and older adults in Catalonia: results from the EPIVAC cohort study.

    abstract:BACKGROUND:Benefits using the 13-valent pneumococcal conjugate vaccine (PCV13) in adults are controversial. This study investigated clinical effectiveness of PCV13 vaccination in preventing hospitalisation from pneumonia among middle-aged and older adults. METHODS:Population-based cohort study involving 2,025,730 indi...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-018-3096-7

    authors: Vila-Corcoles A,Ochoa-Gondar O,de Diego C,Satue E,Aragón M,Vila-Rovira A,Gomez-Bertomeu F,Magarolas R,Figuerola-Massana E,Raga X,Perez MO,Ballester F

    更新日期:2018-04-27 00:00:00

  • Outbreak of Middle East respiratory syndrome coronavirus in Saudi Arabia: a retrospective study.

    abstract:BACKGROUND:The Middle East respiratory syndrome (MERS) is proposed to be a zoonotic disease. Dromedary camels have been implicated due to reports that some confirmed cases were exposed to camels. Risk factors for MERS coronavirus (MERS-CoV) infections in humans are incompletely understood. This study aimed to describe ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-016-2137-3

    authors: Aleanizy FS,Mohmed N,Alqahtani FY,El Hadi Mohamed RA

    更新日期:2017-01-05 00:00:00

  • Male circumcision and prevalence of genital human papillomavirus infection in men: a multinational study.

    abstract:BACKGROUND:Accumulated evidence from epidemiological studies and more recently from randomized controlled trials suggests that male circumcision (MC) may substantially protect against genital HPV infection in men. The purpose of this study was to assess the association between MC and genital HPV infection in men in a l...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-13-18

    authors: Albero G,Villa LL,Lazcano-Ponce E,Fulp W,Papenfuss MR,Nyitray AG,Lu B,Castellsagué X,Abrahamsen M,Smith D,Bosch FX,Salmerón J,Quiterio M,Giuliano AR

    更新日期:2013-01-17 00:00:00

  • Diagnostic value of symptoms and laboratory data for pertussis in adolescent and adult patients.

    abstract:BACKGROUND:Several symptoms are classically thought to be suggestive of pertussis in children, but the diagnostic value of these symptoms in adolescent and adult patients is unclear. We evaluated the accuracy of the clinical findings for the early presumptive diagnosis of pertussis in adolescent and adult patients. Fur...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-13-129

    authors: Miyashita N,Akaike H,Teranishi H,Kawai Y,Ouchi K,Kato T,Hayashi T,Okimoto N

    更新日期:2013-03-11 00:00:00

  • Risk factors for long-term mortality in patients admitted with severe infection.

    abstract:BACKGROUND:Severe infection is a main cause of mortality. We aim to describe risk factors for long-term mortality among inpatients with severe infection. METHODS:Prospective cohort study in a 600-bed university hospital in Portugal including all patients with severe infection admitted into intensive care, medical, sur...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-018-3054-4

    authors: Francisco J,Aragão I,Cardoso T

    更新日期:2018-04-05 00:00:00

  • Factors affecting immunogenicity of BCG in infants, a study in Malawi, The Gambia and the UK.

    abstract:BACKGROUND:BCG immunogenicity in infants differs between populations and these differences have been attributed to various factors. In this study, the influence of geographical location, season of birth, timing of vaccination, micronutrient status (zinc) and inflammatory status (C-reactive protein, CRP) were assessed. ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-14-184

    authors: Hur YG,Gorak-Stolinska P,Lalor MK,Mvula H,Floyd S,Raynes J,Ben-Smith A,Fitchett JR,Flanagan KL,Burl S,Ota MO,Crampin AC,Smith SG,Dockrell HM

    更新日期:2014-04-05 00:00:00

  • Description and validation of a spectrum score method to measure antimicrobial de-escalation in healthcare associated pneumonia from electronic medical records data.

    abstract:BACKGROUND:Comparison of antimicrobial de-escalation rates between healthcare settings is problematic. To objectively and electronically measure de-escalation a method based upon the spectrum of antimicrobial regimens administered (i.e., spectrum score) was developed. METHODS:A Delphi process was used to develop appli...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-015-0933-9

    authors: Madaras-Kelly K,Jones M,Remington R,Caplinger C,Huttner B,Samore M

    更新日期:2015-04-25 00:00:00

  • Diagnosis-linked antibiotic prescribing in Swedish primary care - a comparison between in-hours and out-of-hours.

    abstract:BACKGROUND:The rise in antibiotic resistance is a global public health concern, and antibiotic overuse needs to be reduced. Earlier studies of out-of-hours care have indicated that antibiotic prescribing is less appropriate than that of in-hours care. However, no study has compared the out-of-hours treatment of infecti...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-020-05334-7

    authors: Cronberg O,Tyrstrup M,Ekblom K,Hedin K

    更新日期:2020-08-20 00:00:00

  • Intimate relationship characteristics as determinants of HIV risk among men who have sex with regular male sex partners: a cross-sectional study in Guangzhou, China.

    abstract:BACKGROUND:China faces a serious HIV epidemic among men who have sex with men (MSM), and a large proportion of new infections are attributed to their regular male sex partners (RP). The objective of this study was to investigate the association between intimate relationship characteristics and HIV-related behaviors amo...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-018-3044-6

    authors: He J,Xu HF,Cheng WB,Zhang SJ,Gu J,Hao YT,Hao C

    更新日期:2018-04-02 00:00:00

  • Microdistribution of the resistance of malaria vectors to deltamethrin in the region of Plateau (southeastern Benin) in preparation for an assessment of the impact of resistance on the effectiveness of Long Lasting Insecticidal Nets (LLINs).

    abstract:BACKGROUND:This study aims to research two areas, one with a resistant and the other with a susceptible profile of An. gambiae to deltamethrin in the region of Plateau (southern Benin). In each area, eight localities were sought. Both areas were needed for the assessment of the impact of malaria vector resistance to py...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-14-103

    authors: Sovi A,Djègbè I,Soumanou L,Tokponnon F,Gnanguenon V,Azondékon R,Oké-Agbo F,Okè M,Adéchoubou A,Massougbodji A,Corbel V,Akogbéto M

    更新日期:2014-02-25 00:00:00

  • Changes of CD103-expressing pulmonary CD4+ and CD8+ T cells in S. japonicum infected C57BL/6 mice.

    abstract:BACKGROUND:Recent studies have shown that CD103 is an important marker for tissue-resident memory T cells (TRM) which plays an important role in anti-infection. However, the role of CD103+ TRM was not elucidated in the progress of S. japonicum infection induced disease. METHODS:6-8 weeks old C57BL/6 mice were infected...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-019-4633-8

    authors: Zhao Y,Yang Q,Jin C,Feng Y,Xie S,Xie H,Qi Y,Qiu H,Chen H,Tao A,Mu J,Qin W,Huang J

    更新日期:2019-11-27 00:00:00

  • First report on cutaneous infectious granuloma caused by Schizophyllum commune.

    abstract:BACKGROUND:Schizophyllum commune, a basidiomycetous fungus, is a common invader of rotten wood. This fungus rarely causes mycotic disease in humans, especially cutaneous infection. In this paper, we describe the first case of cutaneous granuloma caused by S. commune in a Chinese woman. CASE PRESENTATION:A 25-year-old ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-018-3187-5

    authors: Tian L,Mu Y,Zhang H,Su X,Yang C,Shu X,Qing D

    更新日期:2018-06-26 00:00:00

  • Tuberculosis mortality and associated factors at King Abdulaziz Medical City Hospital.

    abstract:BACKGROUND:Tuberculosis (TB) continues to be a public health challenge in Saudi Arabia, particularly for the elderly. This study was conducted to estimate mortality per 1000 person-year among TB and resistant TB cases and to identifying factors associated with mortality. METHODS:This is a retrospective cohort study of...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-019-4063-7

    authors: Aljadani R,Ahmed AE,Al-Jahdali H

    更新日期:2019-05-16 00:00:00

  • Evaluation of the Widal tube agglutination test for the diagnosis of typhoid fever among children admitted to a rural hdospital in Tanzania and a comparison with previous studies.

    abstract:BACKGROUND:The diagnosis of typhoid fever is confirmed by culture of Salmonella enterica serotype Typhi (S. typhi). However, a more rapid, simpler, and cheaper diagnostic method would be very useful especially in developing countries. The Widal test is widely used in Africa but little information exists about its relia...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-10-180

    authors: Ley B,Mtove G,Thriemer K,Amos B,von Seidlein L,Hendriksen I,Mwambuli A,Shoo A,Malahiyo R,Ame SM,Kim DR,Ochiai LR,Clemens JD,Reyburn H,Wilfing H,Magesa S,Deen JL

    更新日期:2010-06-22 00:00:00

  • The impact of virus infections on pneumonia mortality is complex in adults: a prospective multicentre observational study.

    abstract:BACKGROUND:Various viruses are known to be associated with pneumonia. However, the impact of viral infections on adult pneumonia mortality remains unclear. This study aimed to clarify the effect of virus infection on pneumonia mortality among adults stratified by virus type and patient comorbidities. METHODS:This mult...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12879-017-2858-y

    authors: Katsurada N,Suzuki M,Aoshima M,Yaegashi M,Ishifuji T,Asoh N,Hamashige N,Abe M,Ariyoshi K,Morimoto K,Adult Pneumonia Study Group-Japan.

    更新日期:2017-12-06 00:00:00

  • Undiagnosed Cryptococcus gattii meningitis leading to subsequent ventriculoperitoneal shunt infection in a patient with symptoms of normal pressure hydrocephalus: case report and literature review.

    abstract:BACKGROUND:Cryptococcus gattii is known to be an etiologic agent of human cryptococcosis, particularly in immunocompetent persons. C. gattii infection usually involves the central nervous system, the respiratory tract, or may be disseminated. Here we report an atypical manifestation of C. gattii infection in a patient ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,评审

    doi:10.1186/s12879-018-3165-y

    authors: Dhitinanmuang W,Chongtrakool P,Jitmuang A

    更新日期:2018-06-04 00:00:00

  • Transmission dynamics for Methicilin-resistant Staphalococous areus with injection drug user.

    abstract:BACKGROUND:Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterial pathogen resistance to antibiotics including methicillin. The resistance first emerged in 1960 in a healthcare setting only after two years of using methicillin as a viable treatment for methicillin-susceptible Staphylococcus aureus. MRSA lead...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-018-2973-4

    authors: Wagner R,Agusto FB

    更新日期:2018-02-07 00:00:00

  • Field evaluation of a recombinase polymerase amplification assay for the diagnosis of Schistosoma japonicum infection in Hunan province of China.

    abstract:BACKGROUND:Current diagnostic methods for Schistosoma japonicum infection are insensitive for low-density infections. Therefore, a new diagnostic assay based on recombinase polymerase amplification (RPA) technology was established and assessed for field applification. METHODS:The S.japonicum RPA assay was developed to...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-017-2182-6

    authors: Xing W,Yu X,Feng J,Sun K,Fu W,Wang Y,Zou M,Xia W,Luo Z,He H,Li Y,Xu D

    更新日期:2017-02-21 00:00:00

  • Critically ill patients with diabetes and Middle East respiratory syndrome: a multi-center observational study.

    abstract:BACKGROUND:Diabetes is a risk factor for infection with coronaviruses. This study describes the demographic, clinical data, and outcomes of critically ill patients with diabetes and Middle East Respiratory Syndrome (MERS). METHODS:This retrospective cohort study was conducted at 14 hospitals in Saudi Arabia (September...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12879-021-05771-y

    authors: Jose J,Al-Dorzi HM,Al-Omari A,Mandourah Y,Al-Hameed F,Sadat M,Al Qasim E,Alraddadi B,Al Harthy A,Al Mekhlafi GA,Almotairi A,Al Khatib K,Abdulmomen A,Qushmaq I,Sindi AA,Mady A,Solaiman O,Al-Raddadi R,Maghrabi K,Ragab

    更新日期:2021-01-19 00:00:00

  • A population-based analysis of invasive fungal disease in haematology-oncology patients using data linkage of state-wide registries and administrative databases: 2005 - 2016.

    abstract:BACKGROUND:Little is known about the morbidity and mortality of invasive fungal disease (IFD) at a population level. The aim of this study was to determine the incidence, trends and outcomes of IFD in all haematology-oncology patients by linking Victorian hospital data to state-based registries. METHODS:Episodes of IF...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-019-3901-y

    authors: Valentine JC,Morrissey CO,Tacey MA,Liew D,Patil S,Peleg AY,Ananda-Rajah MR

    更新日期:2019-03-21 00:00:00

  • Monitoring prevention or emergence of HIV drug resistance: results of a population-based foundational survey of early warning indicators in mainland Tanzania.

    abstract:BACKGROUND:In Tanzania, routine individual-level testing for HIV drug resistance (HIVDR) using laboratory genotyping and phenotyping is not feasible due to resource constraints. To monitor the prevention or emergence of HIVDR at a population level, WHO developed generic strategies to be adapted by countries, which incl...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-14-196

    authors: Juma JM,Tiberio JK,Abuya MI,Kilama BK,Somi GR,Sambu V,Banda R,Jullu BS,Ramadhani AA

    更新日期:2014-04-11 00:00:00

  • Immune responses in patients with HIV infection after vaccination with recombinant Hepatitis B virus vaccine.

    abstract:BACKGROUND:Patients with HIV infection are at risk of co-infection with HBV, as the routes of transmission are shared and thus immunization with HBV vaccine could be protective in them. The aim of the present study was to assess the efficacy of recombinant vaccine in treatment-naive HIV positive patients and healthy co...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-6-65

    authors: Pasricha N,Datta U,Chawla Y,Singh S,Arora SK,Sud A,Minz RW,Saikia B,Singh H,James I,Sehgal S

    更新日期:2006-03-30 00:00:00

  • Age- and region-specific hepatitis B prevalence in Turkey estimated using generalized linear mixed models: a systematic review.

    abstract:BACKGROUND:To provide a clear picture of the current hepatitis B situation, the authors performed a systematic review to estimate the age- and region-specific prevalence of chronic hepatitis B (CHB) in Turkey. METHODS:A total of 339 studies with original data on the prevalence of hepatitis B surface antigen (HBsAg) in...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,meta分析,评审

    doi:10.1186/1471-2334-11-337

    authors: Toy M,Önder FO,Wörmann T,Bozdayi AM,Schalm SW,Borsboom GJ,van Rosmalen J,Richardus JH,Yurdaydin C

    更新日期:2011-12-12 00:00:00