Abstract:
BACKGROUND:Efficient and effective strategies for identifying cases of active tuberculosis (TB) in rural sub-Saharan Africa are lacking. Household contact tracing offers a potential approach to diagnose more TB cases, and to do so earlier in the disease course. METHODS:Adults newly diagnosed with active TB were recruited from public clinics in Vhembe District, South Africa. Study staff visited index case households and collected sputum specimens for TB testing via smear microscopy and culture. We calculated the yield and the number of households needed to screen (NHNS) to find one additional case. Predictors of new TB among household contacts were evaluated using multilevel logistic regression. RESULTS:We recruited 130 index cases and 282 household contacts. We identified 11 previously undiagnosed cases of bacteriologically-confirmed TB, giving a prevalence of 3.9% (95% CI: 2.0-6.9%) among contacts, a yield of 8.5 per 100 (95% CI: 4.2-15.1) index cases traced, and NHNS of 12 (95% CI: 7-24). The majority of new TB cases (10/11, 90.9%) were smear negative, culture positive. The presence of TB symptoms was not associated with an increased odds of active TB (aOR: 0.3, 95% CI: 0.1-1.4). CONCLUSIONS:Household contacts of recently diagnosed TB patients in rural South Africa have high prevalence of TB and can be feasibly detected through contact tracing, but more sensitive tests than sputum smear are required. Symptom screening among household contacts had low sensitivity and specificity for active TB in this study.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Little KM,Msandiwa R,Martinson N,Golub J,Chaisson R,Dowdy Ddoi
10.1186/s12879-018-3193-7subject
Has Abstractpub_date
2018-07-04 00:00:00pages
299issue
1issn
1471-2334pii
10.1186/s12879-018-3193-7journal_volume
18pub_type
杂志文章abstract:BACKGROUND:Scabies is an infectious disease that affects the skin caused by the mite Sarcoptes scabiei and it transmitted through close personal contact. Even though it is easily treatable disease, its prevalence is high and continuous as neglected tropical disease of resource-poor settings, and particularly affects yo...
journal_title:BMC infectious diseases
pub_type: 杂志文章,meta分析
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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更新日期:2014-12-10 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2020-06-01 00:00:00
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更新日期:2012-12-19 00:00:00
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更新日期:2014-08-13 00:00:00
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更新日期:2012-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2006-04-11 00:00:00
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更新日期:2013-08-30 00:00:00
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更新日期:2017-11-06 00:00:00
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更新日期:2009-04-12 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2016-08-09 00:00:00
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pub_type: 杂志文章
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更新日期:2019-01-07 00:00:00
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pub_type: 杂志文章,meta分析
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更新日期:2019-06-17 00:00:00