Effects of heparin on vascular dysfunction in diabetic rats.


:1. Treatment with heparin has beneficial effects in diabetic nephropathy. The occurrence of increased urinary albumin excretion in diabetic patients reflects general vascular dysfunction, including increased transcapillary permeability of macromolecules. The aim of the present study was to evaluate the effects of heparin on vascular dysfunction in diabetic rats. 2. Male Sprague-Dawley rats were used in two studies. Diabetes was induced by 65 mg/kg, i.v., streptozotocin. In one study, diabetic rats were dosed subcutaneously with different heparin fractions for 8 months and the transcapillary escape rate of albumin (TERalb) was measured in anaesthetized animals. In the other study, heparin was given for 6 weeks, followed by tissue albumin clearance measurements in awake rats. Normal and diabetic rats receiving saline served as controls. 3. Blood glucose did not differ among the diabetic groups and ranged from 22 to 26 mmol/L. The mean (+/- SD) TERalb was increased by diabetes compared with values in normal rats (17.5 +/- 3 vs 14.1 +/- 3.3%/h, respectively). Neither unfractionated nor low molecular weight heparin significantly affected this increase. [131I]-Albumin clearance was significantly increased in diabetic rats in the eye, skin and skeletal muscle tissues compared with normal rats (0.17-0.40 vs 0.1-0.23 microL plasma/g per min). Low molecular weight heparin treatment did not affect the increased organ albumin clearance. 4. In conclusion, heparin treatment does not affect diabetes-induced vascular dysfunction as expressed by increased TERalb and clearance of albumin in rats.


Oturai PS





Has Abstract


1999-05-01 00:00:00












  • Comparison of neurite outgrowth with neurofilament protein subunit levels in neuroblastoma cells following mercuric oxide exposure.

    abstract::1. The objectives of the study were to establish that inhibition of neuronal differentiation in culture (assessed by neurite outgrowth) can be used as a broad spectrum in vitro measure of neurotoxicity. 2. To establish whether a rapid measure of neurite outgrowth could be used. Thus the study examined the relationship...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Abdulla EM,Calaminici M,Campbell IC

    更新日期:1995-05-01 00:00:00

  • Barriers to successful delivery of short interfering RNA after systemic administration.

    abstract::1. RNA interference in vivo has tremendous potential, both with respect to the elucidation of protein function in animals and as a therapeutic platform in humans. In vitro, short interfering RNA (siRNA) has been shown to completely silence gene expression in mammalian cells at low picomolar concentrations. 2. Although...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: White PJ

    更新日期:2008-11-01 00:00:00

  • Blood pressure regulation via the epithelial sodium channel: from gene to kidney and beyond.

    abstract::The epithelial sodium channel (ENaC) has long been recognized as playing a vital role in blood pressure (BP) regulation due to its involvement in fluid balance. The genes encoding the three ENaC subunits are likewise important contributors to hypertension, both in rare monogenic diseases and in the general population....

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Büsst CJ

    更新日期:2013-08-01 00:00:00

  • Sympathetic rhythms and nervous integration.

    abstract::1. The present review focuses on some of the processes producing rhythms in sympathetic nerves influencing cardiovascular functions and considers their potential relevance to nervous integration. 2. Two mechanisms are considered that may account for rhythmic sympathetic discharges. First, neuronal elements of peripher...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Gilbey MP

    更新日期:2007-04-01 00:00:00

  • Characterization of two polyclonal peptide antibodies that recognize the carboxy terminus of angiotensin II AT1A and AT1B receptors.

    abstract::1. The differential identification of the angiotensin AT1A and AT1B receptor subtypes is impaired by the existing>96% homology of both receptors. In the present study, we characterized two polyclonal rabbit peptide antibodies, namely alpha-AT1A and alpha-AT1B, that recognize the C-terminal region of mouse AT1A and AT1...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Hoffmann A,Cool DR

    更新日期:2005-11-01 00:00:00

  • Effects of cicletanine on the progression of renal failure in 5/6 nephrectomized hypertensive rats.

    abstract::1. The effect of cicletanine, a novel antihypertensive agent with natriuretic activity, on blood pressure and progression of renal failure of 5/6 nephrectomized spontaneously hypertensive rats with salt loading was examined. 2. All nephrectomized rats were randomly assigned to one of four groups and their diet was cha...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Nakamoto H,Suzuki H,Ohishi A,Katsumata H,Sakaguchi H,Saruta T

    更新日期:1999-03-01 00:00:00

  • Multiple oscillators, dynamic synchronization and sympathetic control.

    abstract::1. Intermittent bursts of activity are a robust feature of the discharges of sympathetic nerves. There are at least two major mechanisms producing such discharges: (i) phasic inputs influencing sympathetic circuits; and (ii) oscillators embedded within sympathetic networks. The functional significance of patterned and...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Gilbey MP

    更新日期:2001-01-01 00:00:00

  • Comparison of the activity of circular and longitudinal myometrium from pregnant rats: co-ordination between muscle layers.

    abstract::1. Contractions and electrical activity were recorded from isolated segments of longitudinal (L) and circular (C) myometrium from rats on gestation days 16-17 and 21 before and during parturition. 2. The segments were arranged so that the activity of the two layers could be monitored simultaneously and independently. ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Tomiyasu BA,Chen CJ,Marshall JM

    更新日期:1988-09-01 00:00:00

  • Increased cardiac sympathetic drive and reduced vagal modulation following endothelin receptor antagonism in healthy conscious rats.

    abstract::1. The present study evaluated changes in autonomic control of the cardiovascular system in conscious rats following blockade of endothelin (ET) receptors with bosentan. 2. Rats were treated with bosentan or vehicle (5% gum arabic) for 7 days by gavage. 3. Baseline heart rate (HR) was higher in the bosentan-treated gr...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Souza HC,Terzini GC,da Silva VJ,Martins-Pinge MC,Salgado HC,Salgado MC

    更新日期:2008-07-01 00:00:00

  • Mechanisms of myocardial protection by amino acids: facts and hypotheses.

    abstract::1. Positive inotropic effect of taurine and improvement of cardiac performance of failing heart are mediated through the modulation of Ca2+ movement through the sarcolemma. 2. Cardioprotection with glutamate and aspartate is related to enhanced anaerobic energy formation in mitochondria coupled with succinate formatio...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Pisarenko OI

    更新日期:1996-08-01 00:00:00

  • Atrial natriuretic factor in chronic renal failure: studies in man and the rat.

    abstract::1. Plasma concentration and atrial content of atrial natriuretic factor (ANF) were measured in rats with chronic renal failure induced by subtotal nephrectomy. 2. Plasma ANF was higher, and atrial ANF content lower in rats with renal failure when compared with sham-operated controls. 3. Plasma renin activity (PRA) and...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Hodsman GP,Jackson B,Debrevi LM,Ogawa K,Johnston CI

    更新日期:1987-03-01 00:00:00

  • Piretanide and urinary excretion of ions in rat. Effect of indomethacin.

    abstract::1. Piretanide is a new loop diuretic resembling furosemide. The effects of this diuretic on various parameters of renal function and on the excretion of the major ions were studied on anaesthetized, hydrated rats. 2. Piretanide induced a marked diuresis and increased sodium, potassium, chloride and calcium excretion. ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Nguyen-Simonnet H,Gauthier C,Pellet M

    更新日期:1981-07-01 00:00:00

  • Deleterious effects of salt intake other than effects on blood pressure.

    abstract::1. Salt intake is not only known to play an important role in determining blood pressure (BP) but has been shown to have other deleterious effects independent of BP. 2. Epidemiological and animal studies have provided evidence that salt intake may have an adverse effect on stroke mortality independent of BP. 3. Signif...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Antonios TF,MacGregor GA

    更新日期:1995-03-01 00:00:00

  • Inhibition of cytokine release by and cardiac effects of type IV phosphodiesterase inhibition in early, profound endotoxaemia in vivo.

    abstract::1. In rats, inhibition of type IV phosphodiesterase (PDE4) attenuates acute renal failure and early (hours) mortality induced by high-dose endotoxin. Because it is unlikely that protection of renal function accounts for improved early survivability, most likely PDE4 inhibition exerts multiple beneficial effects in end...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Tofovic SP,Zacharia LC,Carcillo JA,Jackson EK

    更新日期:2000-10-01 00:00:00

  • Naloxone blocks the cardiac effects of myocardial ischaemia and reperfusion in the rat isolated heart.

    abstract::The effects of naloxone on contractility and cardiac rhythm were studied in the rat isolated perfused heart during myocardial ischaemia and reperfusion. Pretreatment of the rat isolated perfused heart with naloxone abolished the reduction in left ventricular pressures and attenuated greatly the arrhythmias due to myoc...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Zhan ZY,Lee AY,Wong TM

    更新日期:1985-07-01 00:00:00

  • Cholinergic prejunctional inhibition of nitrergic neurotransmission in the guinea-pig isolated basilar artery.

    abstract::1. The effects of endogenous and exogenous acetylcholine (ACh) on nitrergic relaxations elicited by electrical field stimulation (EFS) were studied in guinea-pig endothelium-denuded basilar artery preparations precontracted with 1 micromol/L prostaglandin F(2 alpha) and a possible role of K+ channels in mediating the ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 更正并重新发布的文章,杂志文章


    authors: Jiang F,Li CG,Rand MJ

    更新日期:1999-10-01 00:00:00

  • Continuous fluoxetine administration prevents recurrence of pulmonary arterial hypertension and prolongs survival in rats.

    abstract::1. The serotonin transporter (SERT) is strongly implicated in the pathogenesis of pulmonary arterial hypertension (PAH) in patients and animal models. Inhibitors of SERT have been reported to attenuate or reverse experimental PAH, which makes them potential therapeutic options for the treatment of PAH in humans. Howev...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Zhu SP,Mao ZF,Huang J,Wang JY

    更新日期:2009-08-01 00:00:00

  • Multiple inferences using confidence intervals.

    abstract::1. In a recent review article, the problem of making false-positive inferences as a result of making multiple comparisons between groups of experimental units or between experimental outcomes was addressed. 2. It was concluded that the most universally applicable solution was to use the Ryan-Holm step-down Bonferroni ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Ludbrook J

    更新日期:2000-03-01 00:00:00

  • MicroRNA-645 promotes metastasis of osteosarcoma via targeting tumor suppressor NM23 nucleoside diphosphate kinase 2.

    abstract::Osteosarcoma is the most common non-hematological primary bony malignancy in children and young adults with tumor metastasis being a common event at diagnosis. Understanding the pathogenesis of metastatic osteosarcoma may help identify potential therapeutic targets. In this study, we found that the level of microRNA-6...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Jiao GJ,Zhang SJ,Li Y,Wu WL,Liu HC

    更新日期:2018-12-01 00:00:00

  • Single-unit sympathetic discharge pattern in pathological conditions associated with elevated cardiovascular risk.

    abstract::1. Although measuring the rate of firing of multi-unit muscle sympathetic nerve activity (MSNA) has provided important information in many aspects of cardiovascular medicine, measuring single-unit vasoconstrictor activity provides a better understanding of the possible mechanisms underlying disturbed sympathetic nervo...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Lambert E,Dawood T,Schlaich M,Straznicky N,Esler M,Lambert G

    更新日期:2008-04-01 00:00:00

  • Differential expression of GAS5 in rapamycin-induced reversion of glucocorticoid resistance.

    abstract::This study evaluates the association between the long noncoding RNA GAS5 levels and the anti-proliferative effect of the glucocorticoid (GC) methylprednisolone (MP) alone and in combination with rapamycin in peripheral blood mononuclear cells (PBMCs) obtained from healthy donors. The effect of MP, rapamycin, and MP pl...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Lucafò M,Bravin V,Tommasini A,Martelossi S,Rabach I,Ventura A,Decorti G,De Iudicibus S

    更新日期:2016-06-01 00:00:00

  • Diabetic retinopathy: early functional changes.

    abstract::1. The present review reports some of the earliest physiological changes that occur in the diabetic retina prior to any clinical or anatomical changes in an animal model of diabetes. 2. Using chemically induced diabetes (by streptozotocin) in rats, retinal blood flow and vitreal and retinal oxygen tension were determi...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Alder VA,Su EN,Yu DY,Cringle SJ,Yu PK

    更新日期:1997-09-01 00:00:00

  • The action of aspirin on plasma kininogen and other plasma proteins in rheumatoid patients: relationship to disease activity.

    abstract::1. When six female seropositive rheumatoid patients were given placebo therapy for 48 h, their plasma kininogen level, 9.2 +/- 0.7 microgram bradykinin equivalents (bk eq) per ml, was found to be 59% greater than that of a group of eight healthy female volunteers (5.8 +/- 0.5 microgram/ml). 2. When the rheumatoid pati...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 临床试验,杂志文章


    authors: Sharma JN,Zeitlin IJ,Brooks PM,Buchanan WW,Dick WC

    更新日期:1980-07-01 00:00:00

  • Stimulation of brain cannabinoid CB1 receptors can ameliorate hypertension in spontaneously hypertensive rats.

    abstract::Excessive activation of the sympatho-adrenomedullary system plays a pathogenic role in triggering and sustaining essential hypertension. We previously reported that, in normotensive rats, intracerebroventricularly (i.c.v.) administered neuropeptides, corticotropin-releasing factor and bombesin induced activation of th...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Shimizu T,Yamamoto M,Zou S,Shimizu S,Higashi Y,Saito M

    更新日期:2020-07-01 00:00:00

  • Effects of torasemide on renal haemodynamics and function in anaesthetized dogs.

    abstract::1. We examined the effects of torasemide (0.3 and 1 mg/kg i.v.) on renal haemodynamics and function employing renal clearance and stop-flow techniques in anaesthetized dogs and compared these with furosemide (1 and 3 mg/kg i.v.). 2. Torasemide and furosemide did not influence renal haemodynamics, in the renal clearanc...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Uchida T,Hayashi K,Suzuki Y,Matsumura Y

    更新日期:1991-07-01 00:00:00

  • Drug resistance and cancer stem cells: the shared but distinct roles of hypoxia-inducible factors HIF1α and HIF2α.

    abstract::Chemotherapy resistance is a major contributor to poor treatment responses and tumour relapse, the development of which has been strongly linked to the action of cancer stem cells (CSCs). Mounting evidence suggests that CSCs are reliant on low oxygen conditions and hypoxia-inducible factors 1α and 2α (HIF1α and HIF2α)...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Schöning JP,Monteiro M,Gu W

    更新日期:2017-02-01 00:00:00

  • Effect of pregnancy in the rabbit on the pressor response to angiotensin and noradrenaline.

    abstract::The pressor responses to angiotensin II injections of 29, 117 and 468 pmol/kg and infusion at 54 pmol/kg per min were compared in near-term pregnant and matched non-pregnant rabbits. The responses to noradrenaline injections of 652, 2608 and 10 432 pmol/kg and infusion at 1185 pmol/kg per min were similarly compared. ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Joels N,Humphreys PW

    更新日期:1985-11-01 00:00:00

  • Rodent motor and neuropsychological behaviour measured in home cages using the integrated modular platform SmartCage™.

    abstract::1. To facilitate investigation of diverse rodent behaviours in rodents' home cages, we have developed an integrated modular platform, the SmartCage(™) system (AfaSci, Inc. Burlingame, CA, USA), which enables automated neurobehavioural phenotypic analysis and in vivo drug screening in a relatively higher-throughput and...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Khroyan TV,Zhang J,Yang L,Zou B,Xie J,Pascual C,Malik A,Xie J,Zaveri NT,Vazquez J,Polgar W,Toll L,Fang J,Xie X

    更新日期:2012-07-01 00:00:00

  • Dose-dependent effect of alcohol on insulin-like growth factor systems in male rats.

    abstract::1. Chronic alcohol treatment has been reported to be associated with liver and kidney damage. The insulin-like growth factor (IGF) is the major growth factor related to alcohol consumption. However, the effect of alcohol on the IGF system in the liver and kidney has not been fully elucidated. Thus, the present study w...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Park SH,Heo JS,Kang CW

    更新日期:2004-01-01 00:00:00

  • The influence of coumarin on tissue levels of radio-labelled plasma protein and povidone (polyvinylpyrrolidine) in normal and thermally injured rats.

    abstract::1. The administration of coumarin resulted in a two-fold increase in the entry of 51Cr-labelled rat plasma protein into otherwise normal tissues. 2. Prior treatment of rats with coumarin allowed about 50% more radio-labelled protein to enter the tissues immediately after thermal injury than occurred with thermal injur...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Piller NB

    更新日期:1976-11-01 00:00:00