Abstract:
BACKGROUND:Bleeding after endoscopic submucosal dissection (ESD) in antithrombotic drug users is still one of the important issues to be solved. We performed scheduled second-look endoscopy (SLE) 5 days after ESD, when the resumption of antithrombotic agents is assumed to have achieved a steady state, rather than on the day after ESD. We investigated bleeding incidence and the status of ulcers. METHODS:A total of 299 lesions in 299 patients subjected to ESD for gastric neoplasms were enrolled. A double dose of proton pump inhibitors was administered after ESD. SLE was planned 5 days after ESD. Post-ESD bleeding occurring before SLE was defined as early phase post-ESD bleeding, whereas bleeding after SLE was defined as later phase post-ESD bleeding. Forrest IIa and IIb ulcers are defined as high-risk ulcers requiring prophylactic hemostasis. We investigated risk factors for post-ESD bleeding, particularly focusing on the use of antithrombotic agents and the presence of high-risk ulcers requiring prophylactic hemostasis during SLE. RESULTS:Under a double dose of proton pump inhibitors, early phase post-ESD bleeding occurred in 2.3% of non-users (5/218) and 6.2% of users of antithrombotic agents (5/81). High-risk ulcers were found in 19.0% of the cases during scheduled SLE (55/289). Later phase bleeding occurred in 5.5% of cases [2.8% of non-users (6/213) and 13.2% of users of antithrombotic agents (10/76)]. Cox regression analysis revealed that the risk factor for post-ESD bleeding was antithrombotic treatment (HR: 3.56; 95% CI: 1.63-8.02, p = 0.002) alone. Among patients with high-risk ulcers, a statistically significant increase in bleeding was observed in the later phase in patients under antithrombotic therapy, compared to those not receiving any antithrombotic agents (p = 0.001). CONCLUSIONS:Antithrombotic treatment is a risk factor for post-ESD bleeding despite SLE being scheduled 5 days after ESD. Later phase post-ESD bleeding was observed in 13.2% of the patients under antithrombotic treatment even after prophylactic hemostasis for high-risk ulcers. TRIAL REGISTRATION:This study was registered in the UMIN Clinical Trials Registry System ( 000023306 ). Retrospectively registered on 23rd July 2016.
journal_name
BMC Gastroenteroljournal_title
BMC gastroenterologyauthors
Izumikawa K,Iwamuro M,Inaba T,Ishikawa S,Kuwaki K,Sakakihara I,Yamamoto K,Takahashi S,Tanaka S,Wato M,Okada Hdoi
10.1186/s12876-018-0774-2subject
Has Abstractpub_date
2018-04-10 00:00:00pages
46issue
1issn
1471-230Xpii
10.1186/s12876-018-0774-2journal_volume
18pub_type
杂志文章abstract:BACKGROUND:Cystic echinococcosis (CE) is one of emerging zoonotic parasitic diseases throughout the world, having significant medical and economic importance in developing countries. The western and northwestern China is considered as CE endemic areas. In northeastern China's Heilongjiang Province, the increasing numbe...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-015-0256-8
更新日期:2015-03-10 00:00:00
abstract:BACKGROUND:Reactive lymphoid hyperplasia (RLH) of the liver is very rarely reported, and we encountered two cases of RLH of the liver in a patient with colon cancer. CASE PRESENTATION:In the first case, a 77-year-old woman was admitted for the surgical removal of a ascending colon cancer. A hepatic tumor in the left l...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-6-25
更新日期:2006-09-12 00:00:00
abstract:BACKGROUND:Tuberous Sclerosis Complex (TSC) is a complex and heterogeneous genetic disease that has well-established clinical diagnostic criteria. These criteria do not include gastrointestinal tumors. CASE PRESENTATION:We report a 45-year-old patient with a clinical and molecular diagnosis of TSC and a family history...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01481-y
更新日期:2020-11-23 00:00:00
abstract:BACKGROUND:Little data exists on the factors associated with health care seeking behaviour for primary symptoms of colorectal cancer (CRC). This study aimed to identify individual, provider and psychosocial factors associated with (i) ever seeking medical advice and (ii) seeking early medical advice for primary symptom...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-100
更新日期:2012-08-03 00:00:00
abstract:BACKGROUND:The use of thickeners is a standard therapy for decreasing episodes of regurgitation or vomiting in infants. However, it remains to be investigated whether thickener is effective for vomiting and/or chronic respiratory symptoms in children with cerebral palsy. METHODS:We enrolled 18 neurologically impaired ...
journal_title:BMC gastroenterology
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-230X-8-11
更新日期:2008-04-16 00:00:00
abstract:BACKGROUND:Measurements of CFTR function in rectal biopsies ex vivo have been used for diagnosis and prognosis of Cystic Fibrosis (CF) disease. Here, we aimed to evaluate this procedure regarding: i) viability of the rectal specimens obtained by biopsy forceps for ex vivo bioelectrical and biochemical laboratory analys...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-13-91
更新日期:2013-05-20 00:00:00
abstract:BACKGROUND:Colon cancer is one of the most aggressive human malignancies, with a very poor prognosis. Although it has been suggested that different isoforms of the lymphoid enhancer factor (LEF-1) have opposing biological activities, the biological outcome of aberrant LEF-1 activation in colon cancer is still unclear. ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-53
更新日期:2012-05-28 00:00:00
abstract:BACKGROUND:Perforation of the colon occurring during or shortly following colonoscopy or barium enema is a rare complication of collagenous colitis (CC). "Spontaneous" perforation in CC, in which no instigating factor is identified, is even less common, with only five cases reported to date. We report herein an additio...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-016-0533-1
更新日期:2016-10-06 00:00:00
abstract:BACKGROUND:Studies concerning clinical course and outcome of acute pancreatitis (AP) according to etiologies were rare, especially after year 2000. This study was designed to investigate the difference between the clinical course of alcoholic and biliary AP. METHODS:Of the 153 patients diagnosed as AP with a first att...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-015-0323-1
更新日期:2015-07-25 00:00:00
abstract:BACKGROUND:The impact of viral subtype on the rate of sustained virological response (SVR) to antiviral therapy in patients chronically infected with hepatitis C genotype 1 subtype 1a and 1b has not been extensively investigated. The aim of this study is to determine whether the HCV genotype 1 subtypes 1a and 1b respon...
journal_title:BMC gastroenterology
pub_type: 临床试验,杂志文章
doi:10.1186/1471-230X-12-162
更新日期:2012-11-16 00:00:00
abstract:BACKGROUND:Pancreatic ductal adenocarcinoma (PDAC) rarely metastasizes to the brain; therefore, the features of brain metastasis of PDAC are still unknown. We encountered simultaneous metastases to the brain and lung in a PDAC patient after curative surgery. Case presentation A 68-year-old man with PDAC in the tail of ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01587-3
更新日期:2021-01-06 00:00:00
abstract:BACKGROUND:Autoimmune hepatitis causes chronic hepatitis and often leads to cirrhosis and death without treatment. We wanted to see if having access to primary care or insurance prior to diagnosis is associated with better outcomes for patients in an urban, public hospital with mostly socioeconomically disadvantaged Hi...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-015-0318-y
更新日期:2015-07-28 00:00:00
abstract:BACKGROUND:Signet ring cell carcinoma of the colon and rectum is rare, and most cases are detected at an advanced stage. We present a case of primary signet ring cell carcinoma detected at an early stage by magnifying endoscopy with narrow-band imaging (NBI) and crystal violet staining. CASE PRESENTATION:A 73-year-old...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-015-0317-z
更新日期:2015-07-24 00:00:00
abstract:BACKGROUND:A variety of extra-intestinal manifestations (EIMs), including hepatobiliary complications, are associated with inflammatory bowel disease (IBD). Mesenchymal stem cells (MSCs) have been shown to play a potential role in the therapy of IBD. This study was designed to investigate the effect and mechanism of MS...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-018-0850-7
更新日期:2018-08-13 00:00:00
abstract:BACKGROUND:Gastrointestinal fistula (GIF) in severe acute pancreatitis (SAP) is considered as a sparse episode and studied sporadically in the literature. There is paucity of data on the prediction of the effect on risk of GIF in patient with SAP. This study was aimed to investigate risk factors related to GIF in the d...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-017-0587-8
更新日期:2017-02-14 00:00:00
abstract:BACKGROUND:Patients with familial adenomatous polyposis (FAP) frequently undergo colectomy to reduce the 70 to 90% lifetime risk of colorectal cancer. After risk-reducing colectomy, duodenal cancer and complications from duodenal surgeries are the main cause of morbidity. Our objective was to prospectively describe the...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-018-0841-8
更新日期:2018-07-16 00:00:00
abstract:BACKGROUND:A gluten-free diet (GFD) is the only effective treatment for celiac patients and assessing adherence to this diet is important. Celiac disease Adherence Test (CDAT) is a valid English-language questionnaire that is used for assessing the adherence to the GFD. In the present study, we aimed to translate the C...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01396-8
更新日期:2020-07-29 00:00:00
abstract:BACKGROUND:Benign biliary strictures may be a consequence of surgical procedures, chronic pancreatitis or iatrogenic injuries to the ampulla. Stents are increasingly being used for this indication, however it is not completely clear which stent type should be preferred. METHODS:A systematic review on stent placement f...
journal_title:BMC gastroenterology
pub_type: 杂志文章,评审
doi:10.1186/1471-230X-9-96
更新日期:2009-12-17 00:00:00
abstract:BACKGROUND:The evidence on the role of gut microbiota in post-infectious irritable bowel syndrome (PI-IBS) is convincing. Lactobacillus spp. positively affect IBS symptoms, although the mechanisms through which probiotics exert their beneficial effects are largely unknown. The aim of the study is to evaluate the role o...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-017-0605-x
更新日期:2017-04-14 00:00:00
abstract:BACKGROUND:A marked expansion of the connective tissue population and an abnormal deposition of extracellular matrix proteins are hallmarks of chronic and acute injuries to liver tissue. Liver connective tissue cells, also called stellate cells, derived from fibrotic liver have been thoroughly characterized and corresp...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-4-30
更新日期:2004-12-03 00:00:00
abstract:BACKGROUND:Acute pancreatitis is the most common complication of diagnostic and therapeutic endoscopic retrograde cholangiopancreatography (ERCP). In spite of continuing research, no pharmacologic agent capable of effectively reducing the incidence of ERCP-induced pancreatitis has found its way into clinical practise. ...
journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-230X-13-11
更新日期:2013-01-15 00:00:00
abstract:BACKGROUND:MCAD-deficiency is the most common inborn error of fatty acid oxidation now included in many newborn screening programms using MS/MS. During prolonged catabolic episodes, patients may suffer from metabolic decompensation with dysfunction of liver, skeletal- and heart muscle as well as brain. In anabolism, ne...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-119
更新日期:2012-08-30 00:00:00
abstract:BACKGROUND:Delayed gastric emptying (DGE) is one of the most frequent complications after pancreaticoduodenectomy (PD). This meta-analysis aimed to evaluate the effect of antecolic versus retrocolic reconstruction of gastro/duodenojejunostomy on DGE after PD. METHODS:Randomized controlled trials (RCTs) comparing antec...
journal_title:BMC gastroenterology
pub_type: 杂志文章,meta分析
doi:10.1186/s12876-015-0300-8
更新日期:2015-06-16 00:00:00
abstract:BACKGROUND:Haemolytic uraemic syndrome is a rarely seen in adults often leading to critical illness. This case highlights how difficult it can be to establish a diagnosis and treat when a patient presents with bloody diarrhoea. CASE PRESENTATION:A 17-year-old Iraqi man presented to the emergency department with abdomi...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-019-1071-4
更新日期:2019-08-28 00:00:00
abstract:BACKGROUND:Microscopic colitis presents with similar symptoms to classic inflammatory bowel diseases. Osteoporosis is a common complication of Crohn's disease but there are no data concerning bone metabolism in microscopic colitis. AIMS:The aim of the present study was to evaluate bone density and metabolism in patien...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-11-58
更新日期:2011-05-19 00:00:00
abstract:BACKGROUND:Enteroaggregative Escherichia coli (EAEC) causes diarrhea, malnutrition and poor growth in children. Human breast milk decreases disease-causing bacteria by supplying nutrients and antimicrobial factors such as lysozyme. Goat milk with and without human lysozyme (HLZ) may improve the repair of intestinal bar...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-106
更新日期:2012-08-11 00:00:00
abstract:BACKGROUND:Partial External Biliary Diversion (PEBD) is a surgical intervention to treat children with Progressive Familial Intrahepatic Cholestasis (PFIC) and Alagille syndrome (AGS). PEBD can reduce disease progression, and examining the alterations in biliary lipid composition may be a prognostic factor for outcome....
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-8-47
更新日期:2008-10-20 00:00:00
abstract:BACKGROUND:Vedolizumab has become a standard treatment for the inflammatory bowel diseases ulcerative colitis (UC) and Crohn's disease (CD). However, there is an ongoing debate on the ideal individual treatment algorithms and means to predict treatment response are not routinely established. AIMS:We aimed to describe ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-021-01604-z
更新日期:2021-01-22 00:00:00
abstract:BACKGROUND:The elderly population presents higher morbidity of H. pylori associated diseases in proximal stomach. The specific pathogenesis and mechanism have not been clearly addressed. The gastric environment for H. pylori colonization is dynamic with increasing age. The aim of present study is to investigate the cor...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-018-0883-y
更新日期:2018-10-29 00:00:00
abstract:BACKGROUND:There are many pathological conditions with hepatic iron overload. Classical definite diagnostic methods of these disorders are invasive and based on a direct tissue biopsy material. For the last years the role of MR imaging in liver diagnostics has been increasing. MRI shows changes of liver intensity in pa...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-10-13
更新日期:2010-01-27 00:00:00