Abstract:
:Identification of new biomarkers of food and nutrient intake has developed fast over the past two decades and could potentially provide important new tools for compliance monitoring and dietary intake assessment in nutrition and health science. In recent years, metabolomics has played an important role in identifying a large number of putative biomarkers of food intake (BFIs). However, the large body of scientific literature on potential BFIs outside the metabolomics area should also be taken into account. In particular, we believe that extensive literature reviews should be conducted and that the quality of all suggested biomarkers should be systematically evaluated. In order to cover the literature on BFIs in the most appropriate and consistent manner, there is a need for appropriate guidelines on this topic. These guidelines should build upon guidelines in related areas of science while targeting the special needs of biomarker methodology. This document provides a guideline for conducting an extensive literature search on BFIs, which will provide the basis to systematically validate BFIs. This procedure will help to prioritize future work on the identification of new potential biomarkers and on validating these as well as other biomarker candidates, thereby providing better tools for future studies in nutrition and health.
journal_name
Genes Nutrjournal_title
Genes & nutritionauthors
Praticò G,Gao Q,Scalbert A,Vergères G,Kolehmainen M,Manach C,Brennan L,Pedapati SH,Afman LA,Wishart DS,Vázquez-Fresno R,Andres-Lacueva C,Garcia-Aloy M,Verhagen H,Feskens EJM,Dragsted LOdoi
10.1186/s12263-018-0592-8subject
Has Abstractpub_date
2018-02-20 00:00:00pages
3eissn
1555-8932issn
1865-3499pii
592journal_volume
13pub_type
杂志文章,评审abstract::Anthocyanins (AC) are water-soluble natural pigments found in various parts of higher plants. Despite their limited oral bioavailability and very low post-absorption plasma concentrations, the dietary consumption of these pigments has been proposed to be associated with a significant protection against several human p...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-014-0404-8
更新日期:2014-07-01 00:00:00
abstract::Transmembrane protease, serine 6 (TMPRSS6), is likely to be involved in iron metabolism through its pleiotropic effect on hepcidin concentrations. Recently, genome-wide association studies have identified common variants in the TMPRSS6 gene to be linked to anaemia and low iron status. To get a more precise evaluation ...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-014-0442-2
更新日期:2015-01-01 00:00:00
abstract::The demand for diet products is continuously increasing, together with that for natural food ingredients. Stevioside and other steviol glycosides extracted from the leaves of the plant Stevia rebaudiana Bertoni are the first natural high-potency sweeteners to be approved for consumption in the United States and the Eu...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-014-0401-y
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Methionine, a central molecule in one-carbon metabolism, is an essential amino acid required for normal growth and development. Despite its importance to biological systems, methionine is toxic when administered at supra-physiological levels. The aim of this study was to investigate the effects of short-term...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1186/s12263-017-0576-0
更新日期:2017-09-06 00:00:00
abstract:BACKGROUND:Obesity is characterized by low-grade chronic inflammation and an excess of adipose tissue. The ASC gene encodes a protein that is part of the NLRP3 inflammasome, a cytosolic multiprotein complex that is associated with inflammation and metabolic alterations. To our knowledge, there is no evidence regarding ...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1186/s12263-020-00674-0
更新日期:2020-08-27 00:00:00
abstract::The traditional Mediterranean diet (MedDiet) has shown beneficial effects on cognitive decline. Nevertheless, diet-gene interactions have been poorly evaluated. We aimed to investigate diet-gene interaction in the PREDIMED-NAVARRA randomized trial. A total of 522 participants (67 ± 6 years at baseline) enrolled in the...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-014-0393-7
更新日期:2014-05-01 00:00:00
abstract::A large number of genome-wide association studies, transferability studies, and candidate gene studies performed in diverse populations around the world have identified gene variants that are associated with common human obesity. The mounting evidence suggests that these obesity gene variants interact with multiple en...
journal_title:Genes & nutrition
pub_type: 杂志文章,评审
doi:10.1186/s12263-017-0581-3
更新日期:2017-10-30 00:00:00
abstract::Functional polymorphisms in endogenous antioxidant defense genes including manganese superoxide dismutase (MnSOD), catalase (CAT), and glutathione peroxidase (GPX-1) have been linked with risk of cancer at multiple sites. Although it is presumed that these germline variants impact disease risk by altering the host's a...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-011-0257-3
更新日期:2012-04-01 00:00:00
abstract::Multiple factors have been implicated in the age-related declines in brain function. Thus, it is unlikely that modulating only a single factor will be effective at slowing this decline. A better approach is to identify small molecules that have multiple biological activities relevant to the maintenance of brain functi...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-009-0142-5
更新日期:2009-12-01 00:00:00
abstract::Low plasma levels of high-density lipoprotein cholesterol (HDL-C) are identified as a risk factor for cardiovascular disease (CVD). Sexual dimorphism, however, is widely reported in both HDL-C and CVD, with the underlying explanations of these sexual differences not fully understood. HDL-C is a complex trait influence...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-008-0075-4
更新日期:2008-07-01 00:00:00
abstract::Biomarkers of food intake (BFIs) are a promising tool for limiting misclassification in nutrition research where more subjective dietary assessment instruments are used. They may also be used to assess compliance to dietary guidelines or to a dietary intervention. Biomarkers therefore hold promise for direct and objec...
journal_title:Genes & nutrition
pub_type: 杂志文章,评审
doi:10.1186/s12263-018-0603-9
更新日期:2018-05-30 00:00:00
abstract::There is growing interest in the potential health benefits of diets that involve regular periods of fasting. While animal studies have provided compelling evidence that feeding patterns such as alternate-day fasting can increase longevity and reduce incidence of many chronic diseases, the evidence from human studies i...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-014-0432-4
更新日期:2014-11-01 00:00:00
abstract::The apolipoprotein E (APOE) genotype is an important risk factor for ageing and age-related diseases. The APOE4 genotype (in contrast to APOE3) has been shown to be associated with oxidative stress and chronic inflammation. Metallothioneins (MT) exhibit antioxidant and anti-inflammatory activity, and MT overexpression...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-012-0282-x
更新日期:2012-04-01 00:00:00
abstract::Folic acid is an essential nutrient that is required for one-carbon biosynthetic processes and for methylation of biomolecules. Deficiency of this micronutrient leads to disturbances in normal physiology of cell. Chronic alcoholism is well known to be associated with folate deficiency, which is due in part to folate m...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-012-0318-2
更新日期:2013-03-01 00:00:00
abstract::The aim of this study was to examine the relationship between the L55M and Q192R paraoxonase (PON1) polymorphisms and obesity in a population of adult Mexican workers. The study population included 127 adult individuals from the Universidad Autónoma del Estado de Morelos, ranging in age from 20 to 56 years and represe...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-011-0215-0
更新日期:2011-11-01 00:00:00
abstract::The suitability of C. elegans as a model for the question of nutritional science is a controversial topic. The discussion makes clear that C. elegans is its own best model for revealing, via genetic approaches, biological principles of nutritional behavior, and the biochemical function of vitamins. In this case, the m...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1186/s12263-018-0625-3
更新日期:2019-01-09 00:00:00
abstract:Background:The neurodegenerative disorder Alzheimer's disease is caused by the accumulation of toxic aggregates of β-amyloid in the human brain. On the one hand, hyperhomocysteinemia has been shown to be a risk factor for cognitive decline in Alzheimer's disease. On the other hand, betaine has been demonstrated to atte...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1186/s12263-018-0611-9
更新日期:2018-07-27 00:00:00
abstract::Genetic variation in bitter taste receptors, such as hTAS2R38, may affect food preferences and intake. The aim of the present study was to investigate the association between bitter taste receptor haplotypes and the consumption of vegetables, fruits, berries and sweet foods among an adult Finnish population. A cross-s...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-014-0433-3
更新日期:2014-11-01 00:00:00
abstract:Background:Evidence suggests that prenatal exposure to n-3 long-chain polyunsaturated fatty acids (LCPUFA) reduces the incidence of allergic disease in children. LCPUFAs are produced from dietary precursors catalyzed by desaturases and elongases encoded by the FADS1/2 and ELOVL5 genes. DNA methylation regulates gene ac...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1186/s12263-019-0644-8
更新日期:2019-06-18 00:00:00
abstract::A substantial and growing consumer demand exists for plant-based functional foods that improve general health and wellbeing. Amongst consumed phytochemicals, the polyphenolic compounds tend to be the most bioactive. Many commonly consumed polyphenols have been shown to have specific and potent health-promoting activit...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-009-0148-z
更新日期:2010-03-01 00:00:00
abstract::Current evidence indicates that genetic testing for obesity risk has limited affective or behavioral impact, but few studies have explored the effects among individuals who self-identify as having weight problems. Here, we report findings from in-depth telephone interviews with seven overweight or obese volunteers who...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-013-0374-2
更新日期:2014-01-01 00:00:00
abstract:Background:The multidisciplinary nature of nutrition research is one of its main strengths. At the same time, however, it presents a major obstacle to integrate data analysis, especially for the terminological and semantic interpretations that specific research fields or communities are used to. To date, a proper ontol...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1186/s12263-018-0601-y
更新日期:2018-04-30 00:00:00
abstract::Breast cancer is the second most frequent cancer affecting women worldwide after lung cancer. The toxicity factor associated with synthetic drugs has turned the attention toward natural compounds as the primary focus of interest as anticancer agents. Vitamin E derivatives consisting of the well-established tocopherols...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-011-0224-z
更新日期:2012-01-01 00:00:00
abstract::A long-term high-fat diet may result in a fatty liver. However, whether or not high-fat diets affect the hepatic circadian clock is controversial. The objective of this study is to investigate the effects of timed high-fat diet on the hepatic circadian clock and clock-controlled peroxisome proliferator-activated recep...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-013-0333-y
更新日期:2013-09-01 00:00:00
abstract::The innate immune receptor toll-like receptor 4 (TLR4) has been implicated in mediating some of the effects of dietary lipids on inflammation and type 2 diabetes (T2D). Similar to TLR4, the nucleotide-binding oligomerization domains (Nods) 1 and 2 are also proteins of innate immunity, which can respond to lipids and i...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-012-0287-5
更新日期:2012-07-01 00:00:00
abstract::It is widely accepted that metabolic disorders, such as obesity, are closely linked to lifestyle and diet. Recently, the central role played by the intestinal microbiota in human metabolism and in progression of metabolic disorders has become evident. In this context, animal studies and human trials have demonstrated ...
journal_title:Genes & nutrition
pub_type: 杂志文章,评审
doi:10.1186/s12263-017-0566-2
更新日期:2017-06-15 00:00:00
abstract::A complex and heterogeneous microflora performs sugar and lactic acid fermentations in food products. Depending on the fermentable food matrix (dairy, meat, vegetable etc.) as well as on the species composition of the microbiota, specific combinations of molecules are produced that confer unique flavor, texture, and t...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-011-0226-x
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:The ability to digest lactose after weaning, namely, lactase persistence (LP), is encoded by polymorphisms in the MCM6 gene and varies widely in frequency among different human populations. Although, evolution of LP-related genetic variants was investigated in many groups of Sub-Saharan African, Middle Easte...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1186/s12263-017-0573-3
更新日期:2017-08-24 00:00:00
abstract:UNLABELLED:Intake of anthocyanin-rich foods has been associated with a reduced risk of cardiovascular diseases. Supplementation with anthocyanin-rich extracts from black rice or purple sweet potato was reported to attenuate atherosclerotic lesion development in apolipoprotein E-deficient (apo E(-/-)) mice. However, the...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1007/s12263-010-0171-0
更新日期:2010-12-01 00:00:00
abstract:Background:Diminished brain levels of two neurohormones, 5-hydroxytryptamine (5-HT; serotonin) and 1,25-dihydroxyvitamin D3 (1,25D; active vitamin D metabolite), are proposed to play a role in the atypical social behaviors associated with psychological conditions including autism spectrum disorders and depression. We r...
journal_title:Genes & nutrition
pub_type: 杂志文章
doi:10.1186/s12263-018-0605-7
更新日期:2018-07-11 00:00:00