Do we need new trials of procalcitonin-guided antibiotic therapy?

abstract：INTRODUCTION:The goal of the current study was to investigate the effect of aging on the development of endothelial dysfunction in a murine model of sepsis, and to compare it with the effect of genetic deficiency of the endothelial isoform of nitric oxide synthase (eNOS). METHODS:Cecal ligation and puncture (CLP) was ...

journal_title：Critical care (London, England)

authors： Coletta C,Módis K,Oláh G,Brunyánszki A,Herzig DS,Sherwood ER,Ungvári Z,Szabo C

更新日期：2014-09-16 00:00:00

abstract：:Several papers are discussed including the CARP (Coronary Artery Revascularisation Prophylaxis) trial, examining the role, if any, of preoperative coronary revascularisation and a study examining the heart rate in the intensive care unit (ICU) population. We also take a look at infections in the ICU with particular re...

journal_title：Critical care (London, England)

authors： Tomlinson LA,Forni LG

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:The aim of this study, conducted in 2006, was to find out whether changes in sedation management in German intensive care units took place in comparison with our survey from 2002. METHODS:We conducted a follow-up survey with a descriptive and comparative cross-sectional multi-center design. A postal survey ...

journal_title：Critical care (London, England)

authors： Martin J,Franck M,Sigel S,Weiss M,Spies C

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:Subarachnoid haemorrhage (SAH) may damage the hypothalamo-pituitary-adrenal gland (HPA) axis and disturb cortisol metabolism. There are no available data that relates to the response of the HPA axis in the acute phase of SAH. We aimed to characterise the behavior of serum adrenocorticotropic hormone (ACTH)...

journal_title：Critical care (London, England)

authors： Bendel S,Koivisto T,Ruokonen E,Rinne J,Romppanen J,Vauhkonen I,Kiviniemi V,Uusaro A

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:There are few data related to the effects of different sources of infection on outcome. We used the Sepsis Occurrence in Acutely ill Patients (SOAP) database to investigate differences in the impact of respiratory tract and abdominal sites of infection on organ failure and survival. METHODS:The SOAP study...

journal_title：Critical care (London, England)

authors： Volakli E,Spies C,Michalopoulos A,Groeneveld AB,Sakr Y,Vincent JL

更新日期：2010-01-01 00:00:00

abstract：:Those involved in the airway management of COVID-19 patients are particularly at risk. Here, we describe a practical, stepwise protocol for safe in-hospital airway management in patients with suspected or confirmed COVID-19 infection. ...

journal_title：Critical care (London, England)

authors： Sullivan EH,Gibson LE,Berra L,Chang MG,Bittner EA

更新日期：2020-06-05 00:00:00

abstract：:Progress in management of critically ill neurological patients has led to improved survival rates. However, severe residual neurological impairment, such as persistent coma, occurs in some survivors. This raises concerns about whether it is ethically appropriate to apply aggressive care routinely, which is also associ...

journal_title：Critical care (London, England)

authors： Weiss N,Galanaud D,Carpentier A,Naccache L,Puybasset L

更新日期：2007-01-01 00:00:00

abstract：:Several prognostic markers have been identified for patients admitted with acute cardiogenic pulmonary edema. Most of the markers are based on clinical risk scores. Unlike hypercapnic respiratory failure, acidosis is not an adverse predictor in these patients. Hemodynamic variables that assess pathophysiological mecha...

journal_title：Critical care (London, England)

authors： Schlosshan D,Elliott M

更新日期：2010-01-01 00:00:00

abstract：:The Surviving Sepsis Campaign guidelines for the management of severe sepsis and septic shock recommend that the initial hemodynamic resuscitation be done according to the protocol used by Rivers and colleagues in their well-known early goal-directed therapy (EGDT) study. However, it may well be that their patients we...

journal_title：Critical care (London, England)

authors： Perel A

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Sepsis-induced immunosuppression may result in death. The mechanisms of immune suppression include loss of macrophage and monocyte expression of the major histocompatibility complex, increased anti-inflammatory cytokine expression and decreased expression of proinflammatory cytokines. In this study, we sou...

journal_title：Critical care (London, England)

authors： Wu HP,Shih CC,Lin CY,Hua CC,Chuang DY

更新日期：2011-01-01 00:00:00

abstract：:Since most common diseases have been shown to be influenced by inherited variations in our genes, completion of the Human Genome Project and mapping of the human genome single-nucleotide polymorphisms will have a tremendous impact on our approach to medicine. New developments in genotyping techniques and bioinformatic...

journal_title：Critical care (London, England)

authors： Chiche JD,Cariou A,Mira JP

更新日期：2002-06-01 00:00:00

abstract：INTRODUCTION:The purpose of the present study was to critically review the existing body of evidence on ventilation modes for infants and children up to the age of 18 years. METHODS:The PubMed and EMBASE databases were searched using the search terms 'artificial respiration', 'instrumentation', 'device', 'devices', 'm...

journal_title：Critical care (London, England)

authors： Duyndam A,Ista E,Houmes RJ,van Driel B,Reiss I,Tibboel D

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Intensive care units (ICUs) face financial, bed management, and staffing constraints. Detailed data covering all aspects of patients' journeys into and through intensive care are now collected and stored in electronic health records: machine learning has been used to analyse such data in order to provide dec...

journal_title：Critical care (London, England)

authors： Shillan D,Sterne JAC,Champneys A,Gibbison B

更新日期：2019-08-22 00:00:00

abstract：:Owing to an increasing focus on the rising cost of medical care in the United States, bending the cost curve has become the central tenet of healthcare reform. The exact definition of this phrase, however, remains elusive. In order to affect change in the cost and quality of healthcare, the importance of comparative e...

journal_title：Critical care (London, England)

authors： Ghaferi AA

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Intravenous (IV) voriconazole is not recommended in patients with creatinine clearance <50 ml/min to avoid potentially toxic accumulation of sulfobutylether-β-cyclodextrin (SBECD). The purpose of this study was to evaluate the pharmacokinetics of SBECD, voriconazole, and voriconazole N-oxide in critically ...

journal_title：Critical care (London, England)

authors： Kiser TH,Fish DN,Aquilante CL,Rower JE,Wempe MF,MacLaren R,Teitelbaum I

更新日期：2015-02-03 00:00:00

abstract：:The rapid response system concept is one of the first patient-centered and organizational-wide systems aimed at preventing deaths and serious adverse events. It has been strongly argued that we need a benchmark that reflects the care of a deteriorating patient across the organization using a 'score to door time'; that...

journal_title：Critical care (London, England)

authors： Hillman KM

更新日期：2011-01-01 00:00:00

abstract：:Acute kidney injury (AKI) is now well recognized as an independent risk factor for increased morbidity and mortality, particularly when dialysis is needed. The wide variation in dialysis utilization contributes to a lack of consensus on what parameters should guide the decision to start dialysis. While the association...

journal_title：Critical care (London, England)

authors： Macedo E,Mehta RL

更新日期：2010-01-01 00:00:00

abstract：:Fluid resuscitation is a cornerstone of intensive care unit patient care, but prediction of the cardiovascular response remains difficult, despite many efforts in clinical research. The concept of responders and nonresponders illustrates such a difficulty. Many techniques have been tested, from strictly non-invasive t...

journal_title：Critical care (London, England)

authors： Payen D

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly adopted for the treatment of cardiogenic shock (CS). However, a marker of successful weaning remains largely unknown. Our hypothesis was that successful weaning is associated with sustained microcirculatory function during ECMO flow ...

journal_title：Critical care (London, England)

authors： Akin S,Dos Reis Miranda D,Caliskan K,Soliman OI,Guven G,Struijs A,van Thiel RJ,Jewbali LS,Lima A,Gommers D,Zijlstra F,Ince C

更新日期：2017-10-26 00:00:00

abstract：:This review documents important progress made in 2013 in the field of critical care respirology, in particular with regard to acute respiratory failure and acute respiratory distress syndrome. Twenty-five original articles published in the respirology and critical care sections of Critical Care are discussed in the fo...

journal_title：Critical care (London, England)

authors： Curley GF,Slutsky AS

更新日期：2014-10-15 00:00:00

abstract：INTRODUCTION:Some guidelines to prevent ventilator-associated pneumonia (VAP) do not establish a recommendation for the preferential use of either heat and moisture exchangers (HMEs) or heated humidifiers (HHs), while other guidelines clearly advocate the use of HMEs. The aim of this study was to determine the incidenc...

journal_title：Critical care (London, England)

authors： Lorente L,Lecuona M,Jiménez A,Mora ML,Sierra A

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:This small observational study was motivated by our belief that scaling the tidal volume in mechanically ventilated patients to the size of the injured lung is safer and more 'physiologic' than scaling it to predicted body weight, i.e. its size before it was injured. We defined Total Lung Capacity (TLC) as...

journal_title：Critical care (London, England)

authors： Mattingley JS,Holets SR,Oeckler RA,Stroetz RW,Buck CF,Hubmayr RD

更新日期：2011-01-01 00:00:00

abstract：:The recent bus crash in Switzerland involving many children provides several lessons for the pre-hospital care community. The use of multiple helicopters that are capable of flying at night and that carry advanced medical pre-hospital teams undoubtedly saved lives following the tragedy. We describe the medical respons...

journal_title：Critical care (London, England)

authors： Lyon RM,Sanders J

更新日期：2012-07-11 00:00:00

abstract：:Metrics typically used to report the performance of an early warning score (EWS), such as the area under the receiver operator characteristic curve or C-statistic, are not useful for pre-implementation analyses. Because physiological deterioration has an extremely low prevalence of 0.02 per patient-day, these metrics ...

journal_title：Critical care (London, England)

authors： Romero-Brufau S,Huddleston JM,Escobar GJ,Liebow M

更新日期：2015-08-13 00:00:00

abstract：INTRODUCTION:Sepsis is characterized by systemic microvascular dysfunction. Endothelial progenitor cells (EPCs) are critically involved in maintaining vascular homeostasis under both physiological and pathological conditions. The aim of the present study was to analyze the endothelial progenitor cell system in patients...

journal_title：Critical care (London, England)

authors： Patschan SA,Patschan D,Temme J,Korsten P,Wessels JT,Koziolek M,Henze E,Müller GA

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:The early aggressive management of the acute coagulopathy of trauma may improve survival in the trauma population. However, the timely identification of lethal exsanguination remains challenging. This study validated six scoring systems and algorithms to stratify patients for the risk of massive transfusio...

journal_title：Critical care (London, England)

authors： Brockamp T,Nienaber U,Mutschler M,Wafaisade A,Peiniger S,Lefering R,Bouillon B,Maegele M,TraumaRegister DGU.

更新日期：2012-07-20 00:00:00

abstract：:Heart rate variability in the frequency domain can now be obtained at the bedside in the ICU. Promising data suggest that it may help to characterize a patient response to a spontaneous breathing trial. Refinement of the analysis could even help to predict the outcome of extubation or at least help to detect early pat...

journal_title：Critical care (London, England)

authors： Brochard L

更新日期：2014-03-31 00:00:00

abstract：:This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency medicine 2017. Other selected articles can be found online at http://ccforum.com/series/annualupdate2017 . Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www...

journal_title：Critical care (London, England)

authors： Tagami T,Yasunaga H,Yokota H

更新日期：2017-03-21 00:00:00

abstract：INTRODUCTION:Partial pressure of end-tidal carbon dioxide (PetCO2) during cardiopulmonary resuscitation (CPR) correlates with cardiac output and consequently has a prognostic value in CPR. In our previous study we confirmed that initial PetCO2 value was significantly higher in asphyxial arrest than in ventricular fibri...

journal_title：Critical care (London, England)

authors： Lah K,Križmarić M,Grmec S

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:The aim of the present multicenter study was to assess long term (36 months) health related quality of life in patients after critical illness, compare ICU survivors health related quality of life to that of the general population and examine the impact of pre-existing disease and factors related to ICU ca...

journal_title：Critical care (London, England)

authors： Orwelius L,Nordlund A,Nordlund P,Simonsson E,Bäckman C,Samuelsson A,Sjöberg F

更新日期：2010-01-01 00:00:00