Abstract:
BACKGROUND:Familial adenomatous polyposis (FAP) is a rare, autosomal dominant disease clinically characterized by the early onset of many adenomatous polyps throughout the colon, which turn into colon cancer, if left untreated. In FAP patients, polyps can also occur in the upper gastrointestinal (GI) tract, especially in the duodenum. Adenomas beyond duodenum are rare and mostly located in the proximal jejunum and distal ileum. The management of such polyps can be either surgical or endoscopic, depending on the features of the polyp, Spigelman stage and patient's clinical conditions. Endoscopic mucosal resection (EMR) of jejunal polyps can be challenging, because of the thinner wall of jejunum, compared to the rest of the GI tract, and of the difficulty of maintaining control and stability of the scope. For these reasons, jejunal perforation is a likely occurrence. CASE PRESENTATION:A 65-year-old woman with a stage IV FAP, who had previously undergone abdominal surgery because of her disease, came to our attention because of numerous adenomatous-looking duodenal polyps and a 25 mm lesion in proximal jejunum. According to Spigelman staging system, patient was candidate for surgical resection, in light of the risk of developing small bowel cancer. Despite the benefits of surgery were clearly explained to her, she refused to undergo small bowel resection. Therefore, EMR of the largest duodenal polyp and of the jejunal lesion was planned. After the removal of the jejunal polyp, a small perforation was noted. We were able to rapidly close such perforation by using the Over-The-Scope-Clip system (OTSC, 12/6 t; Ovesco, Tübingen, Germany) pre-mounted onto a double balloon (DB) enteroscope. CONCLUSIONS:The endoscopic management of jejunal perforation can be tricky and the placement of traditional through-the-scope clips in a narrow space like jejunum may be difficult and time consuming. This case describes the use of the OTSC system pre-mounted onto a DB enteroscope for the closure of post-EMR jejunal perforation.
journal_name
BMC Gastroenteroljournal_title
BMC gastroenterologyauthors
Purchiaroni F,Nakajima T,Sakamoto T,Abe S,Saito Ydoi
10.1186/s12876-017-0718-2subject
Has Abstractpub_date
2017-12-08 00:00:00pages
152issue
1issn
1471-230Xpii
10.1186/s12876-017-0718-2journal_volume
17pub_type
杂志文章abstract:PURPOSE:To determine the indications for adjuvant chemotherapy (AC) in patients with stage IIa gastric cancer (T3N0M0 and T1N2M0) according to the 7th American Joint Committee on Cancer (AJCC). METHODS:A total of 1593 patients with T3N0M0 or T1N2M0 stage gastric cancer were identified from the Surveillance, Epidemiolo...
journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究
doi:10.1186/s12876-019-1096-8
更新日期:2019-12-02 00:00:00
abstract:BACKGROUND:Enhanced expression of MAdCAM-1 (mucosal addressin cell adhesion molecule-1) is associated with the onset and progression of inflammatory bowel disease. The clinical significance of elevated MAdCAM-1 expression is supported by studies showing that immunoneutralization of MAdCAM-1, or its ligands reduce infla...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230x-3-3
更新日期:2003-02-20 00:00:00
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doi:10.1186/s12876-016-0435-2
更新日期:2016-02-29 00:00:00
abstract:BACKGROUND:To perform a meta-analysis evaluating the diagnostic ability of fecal lactoferrin (FL) to distinguish inflammatory bowel disease (IBD) from irritable bowel syndrome (IBS). METHODS:The Medline, EMBASE, Web of Science, Cochrane library and CNKI databases were systematically searched for studies that used FL c...
journal_title:BMC gastroenterology
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1471-230X-14-121
更新日期:2014-07-07 00:00:00
abstract:BACKGROUND:Compared with biofluids, target tissues and organs more directly reflect the pathophysiological state of a disease process. In this study, a D-galactosamine (GalN) / lipopolysaccharide (LPS)-induced mouse model was constructed to investigate metabonomics of liver tissue and directly characterize metabolic ch...
journal_title:BMC gastroenterology
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doi:10.1186/1471-230X-13-73
更新日期:2013-04-29 00:00:00
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doi:10.1186/s12876-018-0910-z
更新日期:2018-12-05 00:00:00
abstract:BACKGROUND:Real-world comparisons of biologic treatment outcomes for ulcerative colitis (UC) or Crohn's disease (CD) patients are limited. We sought to evaluate the real-world effectiveness of vedolizumab (VDZ) and anti-tumor necrosis factor alpha (anti-TNFα) in UC and CD patients in Germany. METHODS:A retrospective c...
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doi:10.1186/s12876-020-01332-w
更新日期:2020-07-08 00:00:00
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journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-86
更新日期:2012-07-09 00:00:00
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journal_title:BMC gastroenterology
pub_type: 杂志文章,评审
doi:10.1186/s12876-016-0419-2
更新日期:2016-01-14 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2013-09-24 00:00:00
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journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-10-137
更新日期:2010-11-20 00:00:00
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doi:10.1186/1471-230X-10-1
更新日期:2010-01-10 00:00:00
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doi:10.1186/s12876-018-0758-2
更新日期:2018-02-21 00:00:00
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doi:10.1186/1471-230X-12-31
更新日期:2012-04-10 00:00:00
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pub_type: 杂志文章
doi:10.1186/1471-230X-12-135
更新日期:2012-09-25 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12876-014-0204-z
更新日期:2014-12-04 00:00:00
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doi:10.1186/s12876-015-0323-1
更新日期:2015-07-25 00:00:00
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pub_type: 杂志文章,随机对照试验
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doi:10.1186/1471-230X-11-107
更新日期:2011-10-06 00:00:00
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更新日期:2019-06-13 00:00:00
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pub_type: 杂志文章
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更新日期:2016-01-12 00:00:00
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pub_type: 杂志文章
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更新日期:2020-06-09 00:00:00
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journal_title:BMC gastroenterology
pub_type: 杂志文章
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更新日期:2012-06-19 00:00:00
abstract:BACKGROUND:Hepatitis B virus (HBV) is a hepatotropic DNA virus, and its DNA may be a potent inflammatory molecule. Interferon-inducible protein 16 (IFI16), a newly discovered DNA sensor, plays an important role in the process of inflammation in viral infections. Our study sought to identify a correlation between IFI16 ...
journal_title:BMC gastroenterology
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doi:10.1186/s12876-018-0791-1
更新日期:2018-05-09 00:00:00
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journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-13-91
更新日期:2013-05-20 00:00:00
abstract:BACKGROUND:It is believed that inflammatory bowel diseases (IBD) result from an imbalance in the intestinal immune response towards the luminal microbiome. Dectin-1 is a widely expressed pattern recognition receptor that recognizes fungi and upon recognition it mediates cytokine responses and skewing of the adaptive im...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-33
更新日期:2012-04-16 00:00:00
abstract:BACKGROUND:Perianal fistula surgery can damage the anal sphincters which may cause faecal incontinence. By measuring regional pressures, 3D-HRAM potentially provides better guidance for surgical strategy in patients with perianal fistulas. The aim was to measure regional anal pressures with 3D-HRAM and to compare these...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-018-0770-6
更新日期:2018-04-04 00:00:00
abstract:BACKGROUND:Gastroesophageal reflux (GER) is a disorder that is common by seen in childhood and may lead to severe complications. In this study, we ascertained the incidence of GER among the children who had typical and atypical complaints of GER and whether there was a difference between two groups comparing the findin...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-22
更新日期:2012-03-21 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2008-04-16 00:00:00