Small airway bronchodilator response to different doses of salbutamol in 7-year-old children.

Abstract:

:The Global Initiative for Asthma (GINA) guidelines do not specify a bronchodilator range for bronchodilator response (BDR) testing and simply recommend a salbutamol dose of 200 to 400 μg. We determined the oscillometric BDR results of children given low-dose (2 puffs, 200 μg) and standard-dose (4 puffs, 400 μg) salbutamol to compare the small airway responses of healthy controls (defined using criteria based on the guidelines developed at the American Thoracic Society) and exclusion subjects (defined as any child that did not meet the inclusion criteria for healthy controls). The oscillometric reactance of small airways is significantly associated with the dose of salbutamol used for BDR testing in exclusion children. We suggest use of the standard-dose of salbutamol for oscillometric BDR testing.

journal_name

Respir Res

journal_title

Respiratory research

authors

Yon DK,Jee HM,Ha EK,Lee SJ,Jung YH,Lee KS,Han MY

doi

10.1186/s12931-017-0632-8

subject

Has Abstract

pub_date

2017-08-03 00:00:00

pages

148

issue

1

eissn

1465-9921

issn

1465-993X

pii

10.1186/s12931-017-0632-8

journal_volume

18

pub_type

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