Abstract：
INTRODUCTION:Since the introduction of the quadrivalent human papillomavirus vaccine, young girls and women have reported a broad range of symptoms. These have been described as possible adverse effects of the vaccine. In this study, we describe demographic characteristics, symptomatology, clinical and laboratory test results in patients referred with suspected adverse effects in the Region of Southern Denmark. METHODS:We conducted a retrospective, descriptive study. The patients filled out a questionnaire, were interviewed by a doctor and received a standard physical examination and laboratory tests. RESULTS:The study comprised 200 patients. The median age at referral was 22 (interquartile range (IQR): 19.5-26) years, and age at first vaccination was 14 (IQR: 12-21) years. The most common symptoms were headache (93%), fatigue/tiredness (93%) and dizziness when standing up (90%). The median number of symptoms in each patient was 15. Five patients (2.5%) were diagnosed with postural orthostatic tachycardia syndrome (POTS). Of all patients, 183 (91.5%) were terminated without a somatic diagnosis, one patient (0.5%) was terminated with a functional disorder and 11 patients (5.5%) were still in diagnostic workup when the present study concluded. CONCLUSIONS:The patients reported a wide range of symptoms. We found an overall low prevalence of POTS. It should be further investigated whether these patients might suffer from a functional disorder rather than from adverse effects associated with the vaccine. FUNDING:none. TRIAL REGISTRATION:not relevant.
journal_name
Dan Med Jjournal_title
Danish medical journalauthors
Cramon C,Poulsen CL,Hartling UB,Holden IK,Johansen ISsubject
Has Abstractpub_date
2017-07-01 00:00:00issue
7issn
2245-1919pii
A5398journal_volume
64pub_type
杂志文章abstract：INTRODUCTION:Cell-free DNA testing (cfDNA testing) in maternal plasma has recently been implemented in Danish healthcare. Prior to that we wanted to evaluate the preferences among pregnant women, partners and health professionals regarding cfDNA testing compared with invasive prenatal diagnostics. METHODS:Responders w...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2018-05-01 00:00:00
abstract：:Hip dysplasia and hip joint deformities in general are recognized as possible precursors of osteoarthritic development. Early and correct identification of hip dysplasia is important in order to offer timely joint preserving treatment. In the contemporary literature, several controversies exist, and some of these were...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2012-06-01 00:00:00
abstract：INTRODUCTION:The aim of the study is to identify how disease management programmes for patients with a chronic disease work. This issue is explored from the patients' perspective. Specifically, we study how transition and coordination are related to the patient's perception of quality of care, with a particular focus o...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2016-03-01 00:00:00
abstract：:Both non-pathological psychological stress states and mental disorders are associated with molecular, cellular and epidemiological signs of accelerated aging. Oxidative stress on nucleic acids is a critical component of cellular and organismal aging, and a suggested pathogenic mechanism in several age-related somatic ...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2013-07-01 00:00:00
abstract：INTRODUCTION:Patient blood management strategies for total hip and knee arthroplasty are controversial. They range from pre-operative haemoglobin optimisation to intra- and post-operative interventions. The aim of this study was to assess the various treatment modalities with respect to blood loss, haemoglobin levels a...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2015-12-01 00:00:00
abstract：INTRODUCTION:Despite rehabilitation programmes offered to all patients with newly diagnosed type 2 diabetes in Denmark, a number of patients either never accomplish good diabetes regulation or the regulation deteriorates with time. Therefore, new approaches are needed. The aim of the present study is to examine whether...
journal_title：Danish medical journal
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2013-12-01 00:00:00
abstract：INTRODUCTION:This is a systematic review of existing literature on the diagnostic modalities and treatment of traumatic abdominal wall hernia caused by bicycle handlebar injury in children. METHODS: A systematic literature search was conducted covering incidents involving children below 17 years of age. Data were extr...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2018-01-01 00:00:00
abstract：:Heart failure is a complex clinical syndrome and one of the leading causes of morbidity and mortality with a prevalence of 1%-2% of the adult population. The prognosis is poor with a 5-year mortality rate of 50%, which partly can be attributed to the presence of concomitant comorbidity, including neurological and psyc...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2018-04-01 00:00:00
abstract：INTRODUCTION:The treatment strategy for appendiceal mass is controversial, ranging from operation or image-guided drainage to conservative treatment with or without antibiotics. The aim of this study was to assess the various treatment modalities with respect to complications and treatment failure. METHODS:The analysi...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2014-08-01 00:00:00
abstract：INTRODUCTION:Neoadjuvant chemotherapy (NACT) has been found useful in downstaging tumours in women with primary operable breast cancer without increasing mortality. As a result of several studies supporting this, the Danish Breast Cancer Cooperative Group implemented new guidelines for the treatment of primary operable...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2020-11-04 00:00:00
abstract：BACKGROUND:High levels of pro-inflammatory cytokines are present in the gut of patients with inflammatory bowel disease (IBD) and have a crucial role in the dysfunction of mucosal homeostasis. Caudal-related homeobox transcription factor 2 (CDX2) is an essential regulator of intestinal epithelium homeostasis. When expr...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2014-03-01 00:00:00
abstract：INTRODUCTION:The aim of this study was to compare cancer mortality among migrant patients with cancer mortality in Danish-born patients. MATERIAL AND METHODS:This was a historical prospective cohort study. All non-Western migrants (n = 56,273) who were granted a right to residency in Denmark between 1 January 1993 and...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2014-06-01 00:00:00
abstract：INTRODUCTION:The use of positron emission tomography with 2-deoxy-2-18F-fluoro-D-glucose integrated with CT (18F-FDG-PET/CT) in oncology is common. Unexpected incidental findings are occasionally recognised and can represent clinically relevant lesions or conditions. This study aims to assess the occurrence, clinical s...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2020-09-07 00:00:00
abstract：INTRODUCTION:Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is an uncommon congenital heart abnormality. The aim of this study was to describe a single-centre experience with surgical repair of this condition. METHODS:We performed a retrospective analysis of cases from February 2004 to...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2015-09-01 00:00:00
abstract：:End-stage liver diseases represent major health problems that are currently treated by liver transplantation. However, given the world-wide shortage of donor livers novel strategies are needed for therapeutic treatment. Adult stem cells have the ability to self-renew and differentiate into the more specialized cell ty...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2013-05-01 00:00:00
abstract：INTRODUCTION:There is no consensus among hip surgeons in Denmark on how to follow up patients after total hip arthroplasty (THA). Agreement on the need for radiographic examinations is also lacking. The purpose of this study was to evaluate if routine outpatient post-operative radiographs, obtained three and 12 months ...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2013-04-01 00:00:00
abstract：INTRODUCTION:Age and comorbidity are associated with length of stay (LOS) and mortality. Our aim was to compare acutely ill elderly medical patients in geriatric care with general medical care, and to examine the effects of comprehensive geriatric assessment (CGA). MATERIAL AND METHODS:In an observational study, we us...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2012-06-01 00:00:00
abstract：INTRODUCTION:Difficult airway management is associated with an increased risk of morbidity and mortality. Several preoperative risk factors associated with airway management difficulties have been proposed; however, no clear guideline for airway assessments exists. We therefore hypothesised that Danish airway assessmen...
journal_title：Danish medical journal
pub_type： 杂志文章,多中心研究
doi：
更新日期：2016-10-01 00:00:00
abstract：INTRODUCTION:Severely painful or dysfunctional destroyed wrists can be reconstructed by fusion, interposition of soft-tissue or by arthroplasty using artificial materials. Total and partial wrist arthroplasty (T/PWA) has been used on a regular basis since the 1960's. The objective of this study was to review the litera...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2014-05-01 00:00:00
abstract：INTRODUCTION:Due to disagreement on optimal timing of inguinal hernia repair in children, we explored how Danish surgeons plan repair in children at different ages and with different symptoms. METHODS:A validated questionnaire on timing of inguinal hernia repair in children was sent to all surgeons performing paediatr...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2020-12-22 00:00:00
abstract：INTRODUCTION:Pain and distress during minor hospital-related procedures is a familiar problem in many children. Inadequate relief of children's procedural pain and distress not only affects the experience of the children and their parents, but also adversely impacts procedural success. We aimed to review the safety and...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2013-06-01 00:00:00
abstract：:Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by pain, swelling and progressive destruction of the joints leading to loss of function and invalidity. The bone destruction in RA is characterised by two distinct features: structural joint damage and hand bone loss, and their prevention is an im...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2018-03-01 00:00:00
abstract：INTRODUCTION:This study explored whether health-related quality of life (HRQOL) changes following Roux-en-Y gastric bypass surgery were associated with identifiable socio-demographic or clinical characteristics, and it examined the impact on health outcomes of changes in the Danish criteria for bariatric surgery. MATE...
journal_title：Danish medical journal
pub_type： 临床试验,杂志文章
doi：
更新日期：2014-07-01 00:00:00
abstract：INTRODUCTION:Recently, we established that a group of obese children and adolescents had a higher blood pressure (BP) than a healthy control group. In the present study, we investigate whether the higher BP in the obese group was influenced by BP cuff sizes. METHODS:A total of 104 obese patients aged 10-18 years were ...
journal_title：Danish medical journal
pub_type： 临床试验,杂志文章
doi：
更新日期：2016-01-01 00:00:00
abstract：:Difficulties with airway management in relation to general anaesthesia have been a challenge for the anaesthesiologist since the birth of anaesthesia. Massive landmark improvements have been made and general anaesthesia is now regarded as a safe procedure. However, rare, difficult airway management still occurs and it...
journal_title：Danish medical journal
pub_type： 杂志文章,评审
doi：
更新日期：2016-05-01 00:00:00
abstract：INTRODUCTION:Tonsillectomy may be performed by several methods. It is continuously being discussed which method is preferable with regard to postoperative haemorrhage, pain, activity and nutrition. MATERIAL AND METHODS:The present study is a prospective non-randomized study of tonsillectomy. It included 198 patients a...
journal_title：Danish medical journal
pub_type： 临床试验,杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：INTRODUCTION:Patients with diabetes suffering from hypoglycaemia may be treated by a Mobile Emergency Care Unit (MECU) and are often released at the scene following treatment. Some of these patients experience secondary hypoglycaemia and require renewed treatment or admission to hospital. The present study was initiate...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2015-04-01 00:00:00
abstract：INTRODUCTION:Danish healthcare seeks to improve cancer survival through improved diagnostics, rapid treatment and increased focus on cancer prevention and early help-seeking. In neuro-oncology, this has resulted in the Integrated Brain Cancer Pathway (IBCP). The paper explores how the pathway works in the initial phase...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2012-05-01 00:00:00
abstract：INTRODUCTION:Pelvic sepsis after Hartmann's procedure for low rectal cancer is a frequent complication. It has been reported at a frequency of 12.2-17.2% and has even reached 33% when the transection level of the rectum is ≤ 2 cm from the anal verge. The aim of this study was to examine whether intersphincteric proctec...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2014-12-01 00:00:00
abstract：INTRODUCTION:Spontaneous reporting of adverse drug reactions (ADRs) is used for continuous risk-benefit evaluation of marketed pharmaceutical products and for signal detection. The Adverse Drug Event Manager (ADEM) is a service offered to clinicians employed at hospitals in the Capital Region of Denmark. The ADEM assis...
journal_title：Danish medical journal
pub_type： 杂志文章
doi：
更新日期：2017-01-01 00:00:00
