Circulating ghrelin levels as function of gender, pubertal status and adiposity in childhood.


:Ghrelin, a natural GH secretagogue, exerts remarkable endocrine and non-endocrine activities such as orexigenic effect and modulation of the endocrine and metabolic response to variations in energy balance. Ghrelin levels have been reported to be negatively associated to insulin secretion, enhanced in anorexia and reduced in obesity. Ghrelin levels in childhood have never been evaluated. We measured morning ghrelin levels after overnight fasting in 29 healthy lean children (NC) and in 36 obese children (OBC). The results were compared with those recorded twice in 3 different sessions in healthy lean adults (NA). In NA ghrelin levels showed good within-subject reproducibility without gender-related differences. Ghrelin levels in NC [(median; 25 degrees -75 degrees centile): 426.0; 183.0-618.0 pg/ml] were similar to those in NA (380.5; 257.7-551.7 pg/ml). Ghrelin levels in OBC (229.5; 162.5-339.5 pg/ml) were lower (p<0.03) than in NC (426.0; 183.0-618.0 pg/ml). Both in NC and in OBC, ghrelin levels were independent of gender and pubertal status. In all children, ghrelin levels were negatively associated (p<0.05) to weight excess (r=-0.24), insulin (r=-0.28) and IGF-I (r=-0.4) levels. In conclusion, these findings demonstrate that morning ghrelin levels after overnight fasting show good within-subject reproducibility, and are similar in both sexes and do not vary from childhood to adulthood. In childhood, circulating ghrelin levels are reduced in obese subjects being negatively correlated to overweight and insulin secretion.


J Endocrinol Invest


Bellone S,Rapa A,Vivenza D,Castellino N,Petri A,Bellone J,Me E,Broglio F,Prodam F,Ghigo E,Bona G





Has Abstract


2002-05-01 00:00:00














  • Estrogen and progesterone receptors in the human vagina.

    abstract::Estrogen (E) and progesterone (Pg) receptor (R) levels were determined in the human vagina in relation to menopausal status, day of ovarian cycle and pregnancy. The results obtained confirmed that the human vagina contains ER and, in addition, demonstrated for the first time the presence of PgR in this organ in humans...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章


    authors: Di Carlo F,Racca S,Gallo E,Conti G,Russo A,Mondo F,Francalanci S

    更新日期:1985-04-01 00:00:00

  • Estrogenic suppression by different administration schedules of goserelin depot for treatment of endometriosis.

    abstract::Eighteen patients affected by laparoscopically confirmed endometriosis were randomly assigned to three different schedules of treatment with gonadotropin-releasing hormone agonist (GnRH-a) (goserelin depot formulation 3.6 mg) every 28 days for 6 months. Six women received the first implant in early follicular phase, 4...

    journal_title:Journal of endocrinological investigation

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Magini A,Pellegrini S,Tavella K,Forti G,Massi GB,Serio M

    更新日期:1993-11-01 00:00:00

  • Long-term follow-up of patients with hyperthyroidism due to Graves' disease treated with methimazole. Comparison of usual treatment schedule with drug discontinuation vs continuous treatment with low methimazole doses: a retrospective study.

    abstract::Antithyroid drugs may be proposed as the firstline therapy for hyperthyroidism due to Graves' disease since some patients undergo prolonged remission after drug withdrawal. On the other hand, some studies, though controversial, indicated that methimazole (MMI) has some immunomodulating activity. We retrospectively ana...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章


    authors: Mazza E,Carlini M,Flecchia D,Blatto A,Zuccarini O,Gamba S,Beninati S,Messina M

    更新日期:2008-10-01 00:00:00

  • Repeated transient hypergonadotropic amenorrhea during pharmacologic induction of multiple follicular development with exogenous gonadotropins.

    abstract::Human gonadotropins are widely used for induction of ovulation in the treatment of anovulatory infertility and for induction of multiple follicular development (MFD) in in vitro fertilization (IVF), gamete intrafallopian transfer (GIFT), and artificial insemination with husband's semen (AIH) programs. Reported is a pa...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章


    authors: Mais V,Melis GB,Antinori D,Paoletti AM,Strigini F,Guerriero S,de Ruggiero A,Fioretti P

    更新日期:1990-10-01 00:00:00

  • "Madonna of the Pinks" and "Madonna Dell'Impannata": Raphael Sanzio (1483-1520).

    abstract:: ...

    journal_title:Journal of endocrinological investigation

    pub_type: 历史文章,杂志文章


    authors: Lazzeri D,Al-Mousawi A,Nicoli F

    更新日期:2018-12-01 00:00:00

  • Twenty-four-hour prolactin secretory patterns in women with galactorrhea, normal menses, normal random prolacting levels and abnormal sellar tomograms.

    abstract::During a systematic study of women with idiopathic galactorrhea, we observed several patients with normal random serum prolactin (PRL) levels and normal menses, but abnormal sellar tomograms characteristic of a pituitary adenoma. To test the hypothesis that these women might have intermittent PRL hypersecretion, we st...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章


    authors: Kapcala LP,Molitch ME,Arno J,King LW,Reichlin S,Wolpert SM

    更新日期:1984-10-01 00:00:00

  • Serum 25 hydroxyvitamin D in employees of a Middle Eastern university hospital.

    abstract:BACKGROUND:The Middle East registers the highest rate of vitamin D deficiency worldwide. In Lebanon, previous studies looked at this deficiency in schoolchildren, university students, young adults and postmenopausal women. However, no previous study was performed in hospital workers. The objective of our study was to e...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章


    authors: Gannagé-Yared MH,Helou E,Zaraket V,Abi Akl S,Antonios L,Moussalli ML,Wakim S

    更新日期:2014-06-01 00:00:00

  • Hexarelin-induced growth hormone response in short stature. Comparison with growth hormone-releasing hormone plus pyridostigmine and arginine plus estrogen.

    abstract:UNLABELLED:Hexarelin (HEX) is a synthetic hexapeptide with strong GH-stimulating activity. We evaluated GH response (expressed as maximum value after stimulus [Cmax] and as area under the curve [AUC]) to HEX at the doses of 1 microg/kg i.v. (HEX 1) and 2 microg/kg i.v. (HEX 2), in comparison with the responses to GHRH ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章


    authors: Guzzaloni G,Grugni G,Morabito F

    更新日期:1999-05-01 00:00:00

  • Partially compensated hypoadrenalism presenting with persistent skin pigmentation.

    abstract::A 33-year-old female presented in 1966 with striking pigmentation, typical of Addison's disease, and amenorrhea. Endocrine assessment then showed normal basal serum cortisol and urinary hydroxysteroid levels, but serum cortisol did not respond to stimulation with either exogenous ACTH or lysine vasopressin. Steroid re...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章


    authors: Whitehead EM,Atkinson AB,Hadden DR,Weaver J,Sheridan B

    更新日期:1989-03-01 00:00:00

  • Expression and ligand binding of bombesin receptors in pulmonary and intestinal carcinoids.

    abstract:INTRODUCTION:Carcinoids are mainly found in the gastrointestinal (65%) and bronchopulmonary tract (25%). These neuroendocrine tumors secrete a wide range of bioactive peptides, including gastrin releasing peptide and neuromedin B, the mammalian analogs of bombesin. The purpose of this study was to investigate the quant...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章


    authors: Kuiper P,Verspaget HW,Biemond I,de Jonge-Muller ES,van Eeden S,van Velthuysen ML,Taal BG,Lamers CB

    更新日期:2011-10-01 00:00:00

  • Prolactin secretion in idiopathic hypogonadotropic hypogonadism during pulsatile luteinizing hormone-releasing hormone long-term administration.

    abstract::Recent data seem to suggest that LHRH may be involved in the modulation of PRL secretion. We studied the PRL pattern in 9 males (age range 18-38 yr) with idiopathic hypogonadotropic hypogonadism (IHH) before and during long-term pulsatile LHRH therapy (120-160 ng/kg bw every 120 min sc) in order to evaluate variations...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章


    authors: Giusti M,Traverso L,Cavagnaro P,Torre R,Durante R,Giordano G

    更新日期:1989-09-01 00:00:00

  • Endemic goiter in Morocco (Skoura-Toundoute areas in the high atlas).

    abstract::Endemic goiter in Morocco is localized in the Rif and Atlas mountains. In this study, performed in the Skoura-Toundoute areas (high Atlas), we demonstrate that iodine deficiency is the main factor involved in the development of endemic goiter. However it may not constitute the only etiological factor. The median urina...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章


    authors: Aquaron R,Zarrouck K,el Jarari M,Ababou R,Talibi A,Ardissone JP

    更新日期:1993-01-01 00:00:00

  • Effects of somatostatin in a case of severe hypoglycemia due to nesidioblastosis.

    abstract::The Authors have studied the effects of somatostatin (SRIF) treatment in an infant affected by hypoglycemia due to nesidioblastosis. During iv infusion with SRIF we observed a marked increase of blood glucose levels; concomitantly insulin secretion was almost completely suppressed. In contrast, during treatment with p...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章


    authors: Roti E,Ghinelli C,Bandini P,Del Rossi C,Emanuele R,Robuschi G,Gnudi A

    更新日期:1981-04-01 00:00:00

  • Current recommendations for levothyroxine treatment of differentiated thyroid cancer patients are not properly implemented in clinical practice.

    abstract:BACKGROUND:Levothyroxine (L-T4) treatment aims to minimize the risk of differentiated thyroid cancer (DTC) recurrence and should be tailored to patient risk stratification and potential morbidity from adverse effects. AIM:To evaluate the effectiveness of current recommendations on L-T4 treatment of DTC patients in cli...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章


    authors: Martins de Almeida JF,Gonçalves Tsumura W,Vaisman M,Montalli Assumpção LV,Ward LS

    更新日期:2012-11-01 00:00:00

  • Severe systemic complications of acromegaly.

    abstract::It is well accepted that mortality in acromegaly is increased because of cardiovascular and respiratory diseases while neoplastic complications account less to mortality. Amongst different cardiovascular complications the most frequent is biventricular hypertrophy, which occurs independently of hypertension and metabo...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审


    authors: Colao A,Pivonello R,Marzullo P,Auriemma RS,De Martino MC,Ferone D,Lombardi G

    更新日期:2005-01-01 00:00:00

  • Associations between serum uric acid and adipokines, markers of inflammation, and endothelial dysfunction.

    abstract:AIM:Serum uric acid is associated with the metabolic syndrome and its components, while its relationship with cardiovascular disease is controversial. The aim of the study was to evaluate the association between uric acid and adipokines, markers of inflammation, oxidative stress, and endothelial dysfunction, which are ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章


    authors: Bo S,Gambino R,Durazzo M,Ghione F,Musso G,Gentile L,Cassader M,Cavallo-Perin P,Pagano G

    更新日期:2008-06-01 00:00:00

  • Type 2 diabetes mellitus in children and adolescents.

    abstract::Over the last decade, there has been an alarming increase of Type 2 diabetes mellitus (T2DM) in youths, concomitant with the rise of obesity in this age group. T2DM is a progressive disease with a gradual increase in insulin resistance associated later with a decline in insulin secretion with fasting hyperglycemia. Pr...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审


    authors: Marcovecchio M,Mohn A,Chiarelli F

    更新日期:2005-10-01 00:00:00

  • Hypoproteinemia in acromegaly.

    abstract::Although it is well known that growth hormone may influence protein metabolism, few investigations have been undertaken on serum protein levels in acromegaly; recently hypoglobulinemia has been observed in this endocrine disorder. In 28 acromegalic patients and 56 control subjects sera have been analyzed for total pro...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章


    authors: Federspil G,Vettor R,Bossi A,Sicolo N

    更新日期:1979-04-01 00:00:00

  • Impact of short-term treatment with benzodiazepines and imidazopyridines on glucose metabolism in healthy subjects.

    abstract:AIM:In the last years there has been a progressive reduction of the average duration of sleep and an increase in the incidence of sleep disturbances. At the same time, an increase of the incidence of the metabolic syndrome has been described, partly attributable to the progressive worsening of dietary habits and the in...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,随机对照试验


    authors: Gramaglia E,Ramella Gigliardi V,Olivetti I,Tomelini M,Belcastro S,Calvi E,Dotta A,Ghigo E,Benso A,Broglio F

    更新日期:2014-02-01 00:00:00

  • Peptide receptor radionuclide therapy with 177Lu-DOTA-TATE as a promising treatment of malignant insulinoma: a series of case reports and literature review.

    abstract:INTRODUCTION:Insulinomas are a rare type of pancreatic neuroendocrine tumours characterized by insulin hypersecretion. They are considered malignant when metastases are present. Traditional therapies often promote only temporarily symptomatic relief and may be associated with severe adverse effects. There is scarce exp...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审


    authors: Magalhães D,Sampaio IL,Ferreira G,Bogalho P,Martins-Branco D,Santos R,Duarte H

    更新日期:2019-03-01 00:00:00

  • Diagnosis of normocalcemic hyperparathyroidism by oral calcium loading test.

    abstract::We evaluated the oral calcium-loading test (OCLT) in diagnosing normocalcemic primary hyperparathyroidism. Calcium and PTH levels were measured before, 60, 120 and 180 min after oral 1 g of calcium gluconolactate administration in 102 consecutive females with high circulating PTH levels, and 25 controls. Patients were...

    journal_title:Journal of endocrinological investigation

    pub_type: 临床试验,杂志文章


    authors: Hagag P,Revet-Zak I,Hod N,Horne T,Rapoport MJ,Weiss M

    更新日期:2003-04-01 00:00:00

  • The role of somatostatin (octreotide) in the regulation of melatonin secretion in healthy volunteers and in patients with primary hypothyroidism.

    abstract::Somatostatin has been found in the pineal gland of several animal species, which suggests that it may be involved in the regulation of melatonin secretion. Whether somatostatin has regulatory influence on melatonin secretion in man has never been unequivocally shown. We studied the nocturnal melatonin secretion in 8 h...

    journal_title:Journal of endocrinological investigation

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Wikner J,Wetterberg L,Röjdmark S

    更新日期:1999-07-01 00:00:00

  • Response of Paget's disease to human calcitonin in patients resistant to porcine calcitonin.

    abstract::Eleven patients with Paget's disease of bone, treated intermittently for 2-4 years with porcine calcitonin (pCT) and clinically resistant to pCT [no modifications of serum alkaline phosphatase (ALP) and urinary hydroxyproline ( uHOP ) during pCT administration] were treated with 0.5-0.25 mg/day of human calcitonin (hC...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章


    authors: Lo Cascio V,Adami S,Galvanini G,Lazzaretto R,Ferrari M,Tartarotti D,Scuro LA

    更新日期:1984-04-01 00:00:00

  • Changes in awakening cortisol response and midnight salivary cortisol are sensitive markers of strenuous training-induced fatigue.

    abstract::The aim of the study was to examine the effects of strenuous training on the hypothalamic- pituitary-adrenal axis activity. Exercise tests and saliva collections for analysis of awakening cortisol response (ACR) and midnight cortisol were performed before and after a 7-day period of intensified training in a group of ...

    journal_title:Journal of endocrinological investigation

    pub_type: 临床试验,杂志文章


    authors: Minetto MA,Lanfranco F,Tibaudi A,Baldi M,Termine A,Ghigo E

    更新日期:2008-01-01 00:00:00

  • Predictors of incomplete response to therapy among Filipino patients with papillary thyroid cancer in a tertiary hospital.

    abstract:BACKGROUND:Although survival rate in papillary thyroid cancer (PTC) is high, the risk of persistence and recurrence together with the dramatic rise in its incidence cannot be overemphasized. Filipinos are considered to be at greater risk for negative outcomes. A paradigm shift in the management of PTC introduces re-str...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章


    authors: Mendoza ES,Lopez AA,Valdez VA,Cunanan EC,Matawaran BJ,Kho SA,Sero-Gomez MH

    更新日期:2016-01-01 00:00:00

  • Immunohistochemical detection of estrogen and progesterone receptors in the normal urinary bladder and in pseudomembranous trigonitis.

    abstract::According to recent studies showing the presence of estrogens receptors (ERs) in the human female lower urinary tract, we performed ER and progesterone receptor (PR) assays in fresh frozen and paraffin embedded biopsies taken from the urinary bladder. Fourteen females undergoing endoscopy during staging for gynecologi...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章


    authors: Pacchioni D,Revelli A,Casetta G,Cassoni P,Piana P,Tizzani A,Bussolati G,Massobrio M

    更新日期:1992-11-01 00:00:00

  • Glycometabolic control in acromegalic patients with diabetes: a study of the effects of different treatments for growth hormone excess and for hyperglycemia.

    abstract:BACKGROUND:Diabetes mellitus is frequently observed in patients with acromegaly. Current therapies for acromegaly may impact glucose regulation, influencing insulin sensitivity and secretion. The question whether these therapies modify control and progression of diabetes once present is still open. AIM:Aim of our stud...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章


    authors: Cambuli VM,Galdiero M,Mastinu M,Pigliaru F,Auriemma RS,Ciresi A,Pivonello R,Amato M,Giordano C,Mariotti S,Colao A,Baroni MG

    更新日期:2012-02-01 00:00:00

  • Macroprolactinoma associated with Cushing's disease, successfully treated with cabergoline.

    abstract::Multiple pituitary hormone hypersecretions have already been described, but the co-occurrence of PRL and ACTH excess is very rare. To our knowledge, medical treatment with cabergoline only, avoiding pituitary surgery and radiotherapy in this type of tumor has never been reported before. This case report deals with a 3...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章


    authors: T'Sjoen G,Defeyter I,Van De Saffele J,Rubens R,Vandeweghe M

    更新日期:2002-02-01 00:00:00

  • A multimodality therapeutic approach in anaplastic thyroid carcinoma: study on 39 patients.

    abstract::The aim of this study was to investigate the role of multimodality treatment in patients with anaplastic thyroid carcinoma. From 1992 to 1999, 39 consecutive patients with a histologically or cytologically proven anaplastic thyroid carcinoma were referred to the Thyroid Center of Padua General Hospital. There were 28 ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章


    authors: Busnardo B,Daniele O,Pelizzo MR,Mazzarotto R,Nacamulli D,Devido D,Mian C,Girelli ME

    更新日期:2000-12-01 00:00:00

  • Female pseudohermaphroditism and inefficient peak bone mass in an untreated subject affected by 21-hydroxylase congenital adrenal hyperplasia.

    abstract::Here we describe a subject with congenital adrenal hyperplasia due to 21-hydroxylase deficiency (21-CAH), in its classical virilizing form, who presented at birth ambiguous genitalia and subsequently was assigned by the parents as male. At the age of 8 years, he underwent a two-step surgical correction of hypospadia a...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章


    authors: Valentino R,Savastano S,Tommaselli AP,Dorato M,Scarpitta MT,Calvanese E,Del Puente A,Lombardi G

    更新日期:2000-05-01 00:00:00