Relative inhibitory potency and plasma drug levels of angiotensin converting enzyme inhibitors in the rat.

abstract：:Cholangiocarcinoma (CCA) is a progressively fatal form of cancer originating from the malignant transformation of hepatic biliary cholangiocytes. The present study reports for the first time in vitro growth inhibitory activities of β-eudesmol, the bioactive sesquiterpenoid present in the rhizome of Atractylodes lancea...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mathema VB,Chaijaroenkul W,Karbwang J,Na-Bangchang K

更新日期：2017-11-01 00:00:00

abstract：:KISS1 and KISS1R, a novel pair of metastasis suppressors, are likely to be associated with the prognosis of colorectal cancer (CRC). Here, a meta-analysis was performed to study the role of KISS1 and KISS1R in CRC. Heterogeneity, stability and publication bias were all estimated. Six publications describing a total of...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang XQ,Fang PF,Zhang C,Xu YY,Song XB,Liang J,Xia QR

更新日期：2019-07-01 00:00:00

abstract：:1. Mechanisms underlying the generation and propagation of gastrointestinal slow wave depolarizations have long been controversial. The present review aims to collate present knowledge on this subject with specific reference to slow waves in gastric smooth muscle. 2. At present, there is strong agreement that intersti...

journal_title：Clinical and experimental pharmacology & physiology

authors： van Helden DF,Laver DR,Holdsworth J,Imtiaz MS

更新日期：2010-04-01 00:00:00

abstract：:1. Resistance changes of the afferent and efferent arterioles determine blood flow and filtration rate in the kidney. The tone of both vessels results from the influence of nerves and humoral and paracrine factors, through a balance of constrictor and dilator systems. Angiotensin (Ang) II and nitric oxide (NO) are imp...

journal_title：Clinical and experimental pharmacology & physiology

authors： Patzak A,Lai E,Persson PB,Persson AE

更新日期：2005-05-01 00:00:00

abstract：:The therapeutic potential of the antimicrobial peptide cathelicidin (Camp) administration in sepsis has been widely investigated. However, little is known about the pathophysiological roles of cathelicidin in septic cardiomyopathy. In a lipopolysaccharide (LPS)-induced endotoxaemic model, we found that the mRNA and pr...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhai T,Zhang J,Zhang Y,Wu Y

更新日期：2020-04-01 00:00:00

abstract：:1. The concentration of renin and angiotensinogen (Ao) and the activity of angiotensin I-converting enzyme (ACE) was measured in the ascites fluid of nephrotic rats obtained 8 days after puromycin aminonucleoside (PAN) injection. 2. Ascites fluid, serum and urine proteins of these rats were analysed by sodium dodecyl ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cruz C,Correa-Rotter R,Mézquita C,Medina-Campos ON,Pedraza-Chaverrí J

更新日期：1998-07-01 00:00:00

abstract：:1. Rabbits were treated with the antiparasitic drug ivermectin at subcutaneous doses of 0.2, 1 and 2.5 mg/kg and blood collected weekly for 4 weeks thereafter for measuring some blood parameters. At a dose of 0.2 or 1 mg/kg the drug had no significant effect on any of the parameters measured. At a dose of 2.5 mg/kg, t...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ali BH

更新日期：1990-10-01 00:00:00

abstract：:Posture changes may differ between types of hypertensive disease. The aim is to evaluate the orthostatic response of impedance cardiography (ICG) measurements in uncomplicated and hypertensive pregnancies. Measurements were performed in supine and standing position in 202 women: 41 uncomplicated pregnancies (UP), 59 g...

journal_title：Clinical and experimental pharmacology & physiology

authors： Staelens AS,Vonck S,Mesens T,Tomsin K,Molenberghs G,Gyselaers W

更新日期：2015-10-01 00:00:00

abstract：:1. Electrolytic lesions were made in various brain regions of the rat, and the effects of these lesions on nociceptive threshold and the antinociceptive actions of morphine were tested using a shock titration technique. 2. Lesions in the medial thalamus, the periaqueductal grey area, or the caudate nucleus, had no eff...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yeung JC,Yaksh TL,Rudy TA

更新日期：1975-05-01 00:00:00

abstract：:1. The effects of ouabain and acetazolamide on the secretion of pancreatic juice stimulated by secretin in anaesthetized dogs were investigated. 2. Intra-arterial injection of ouabain (1-10 micrograms) and acetazolamide (1-10 mg) caused dose-dependent decreases in the volume of pancreatic juice. When both drugs were a...

journal_title：Clinical and experimental pharmacology & physiology

authors： Iwatsuki K,Horiuchi A,Yonekura Y,Chiba S

更新日期：1989-03-01 00:00:00

abstract：:1. We wished to determine whether, during pregnancy, there is reduced renal response to atrial distension, whether secretion of atrial natriuretic factor (ANF) is suppressed and whether neural input from the atrial volume receptors to the central nervous system is altered. 2. Conscious, chronically instrumented female...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kaufman S

更新日期：1995-02-01 00:00:00

abstract：:1. We tested the hypothesis that the pattern and the intensity of autonomic mechanisms causing vasoconstriction in the resting bronchial circulation of awake dogs also exists in awake sheep. It was also postulated that sighing behaviour and the associated bronchovascular dilatation induced by non-adrenergic, non-choli...

journal_title：Clinical and experimental pharmacology & physiology

authors： McIlveen S,White S,Parsons G

更新日期：1997-12-01 00:00:00

abstract：:The activity of dopamine-beta-hydroxylase (D beta H) in the serum was measured in patients with quadriplegia and in healthy subjects. We assume that the plasma D beta H levels reflect sympathetic tone. Quadriplegics had significantly lower D beta H levels at rest. After head-up tilting a significant decrease in D beta...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ohry A,Rabinowitz R,Korczyn AD

更新日期：1980-07-01 00:00:00

abstract：:1. In the mammalian central nervous system, GABA is the main inhibitory neurotransmitter. GABA is a highly flexible molecule and, thus, can exist in many low-energy conformations. Conformationally restricted analogues of GABA have been used to help identify three major GABA receptors, termed GABAA, GABAB and GABAC rec...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chebib M,Johnston GA

更新日期：1999-11-01 00:00:00

abstract：:1. (-)[125I]-Cyanopindolol (CYP) binding to non-beta-adrenoceptor sites in dog kidney was characterized in homogenate preparations and their distribution in sections determined using autoradiography. 2. In homogenate studies, (-)[125I]-CYP bound to a single population of non-interacting sites (Bmax = 5.45, s.e.m. = 1....

journal_title：Clinical and experimental pharmacology & physiology

authors： Lew R,Summers RJ

更新日期：1987-09-01 00:00:00

abstract：:The effect of cyclic GMP was investigated using guinea-pig tracheal smooth muscle. 8-Bromo-cyclic GMP showed a dose-dependent relaxation of spontaneous tension of tracheal smooth muscle. Administration of sodium nitroprusside induced dose-dependent relaxation of tracheal smooth muscle as well as an increase in tissue ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Suzuki K,Takagi K,Satake T,Sugiyama S,Ozawa T

更新日期：1986-01-01 00:00:00

abstract：:Afferent splanchnic nerve stimulation with different frequencies in Wistar Kyoto rats caused depressor and pressor responses depending on the frequency employed. Similar visceral afferent activation in spontaneously hypertensive rats caused depressor responses at all frequencies of stimulation. It is suggested that th...

journal_title：Clinical and experimental pharmacology & physiology

authors： Koyama S,Manning JW

更新日期：1985-01-01 00:00:00

abstract：:1. A method is described which allows the determination of liquid junction potentials between biological fluid samples of less than 1 nL with a reproducibility of 10%. This was achieved by use of a micro-method and the use of 3% agarose added to the electrolyte in the measuring electrodes. 2. Validation was performed ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sugo E,Györy AZ

更新日期：1989-07-01 00:00:00

abstract：:1. The present study was performed to test the hypothesis that the reactive oxygen species (ROS)-angiotensinogen (AGT)-renin angiotensin system (RAS) axis is sequentially activated in the development of diabetic nephropathy in Zucker diabetic fatty (ZDF) obese rats. 2. Genetic pairs of male ZDF obese and control ZDF l...

journal_title：Clinical and experimental pharmacology & physiology

authors： Miyata K,Ohashi N,Suzaki Y,Katsurada A,Kobori H

更新日期：2008-08-01 00:00:00

abstract：:1. The physiological relevance of cardiac and vascular alpha-adrenoceptors may increase in disease states in which beta-adrenoceptors are altered. To test this, positive inotropic and vasoconstrictor responses to phenylephrine were measured in isolated tissues from rats with experimentally-induced hyperthyroidism, hyp...

journal_title：Clinical and experimental pharmacology & physiology

authors： Brown L,Amos G,Miller B

更新日期：1994-09-01 00:00:00

abstract：:Urapidil had blocking activity on alpha 1-adrenoceptors in the rat isolated caudal artery (pA2 congruent to 7) and in the anaesthetized rat. Urapidil had no clonidine like agonistic activity on alpha 2-adrenoceptors in preparations of the guinea-pig ileum (prejunctional) or dog saphenous vein (post-junctional). Urapid...

journal_title：Clinical and experimental pharmacology & physiology

authors： Verberne AJ,Rand MJ

更新日期：1984-07-01 00:00:00

abstract：:This study investigated the effect of muscarinic M1 and M2 receptor antagonists on the rocuronium-induced train of four (TOF) fade and tetanic fade, respectively. Ex-vivo phrenic nerves and diaphragms were obtained from adult Sprague-Dawley rats and stabilized in Krebs buffer; the nerve-stimulated muscle TOF fade was ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kim YB,Lee S,Lee KC,Kim HJ,Ro YJ,Yang HS

更新日期：2017-07-01 00:00:00

abstract：:1. Rapid ventricular rate (VR) and rhythm irregularity during atrial fibrillation (AF) impair cardiac performance. Although digoxin has been widely used in patients with AF, its efficacy for the control of VR and rhythm irregularity is unsatisfactory. Whether low-dose amiodarone is more effective remains unclear. 2. W...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tse HF,Lam YM,Lau CP,Cheung BM,Kumana CR

更新日期：2001-05-01 00:00:00

abstract：:1. By selectively modifying adenosine metabolism via adenosine deaminase or adenosine kinase inhibitors, it may be possible to enhance the receptor-mediated protective actions of adenosine in a site- and event-specific fashion. 2. We characterized cardioprotective actions of the adenosine deaminase inhibitor erythro-2...

journal_title：Clinical and experimental pharmacology & physiology

authors： Willems L,Headrick JP

更新日期：2005-03-01 00:00:00

abstract：:1. Serial observations of blood pressure after unilateral adrenalectomy for aldosterone-producing adenoma revealed an incidence of hypotension (systolic BP less than fifth percentile for age- and sex-matched normal population) of 27% at 2 years, more than 5 times that predicted. 2. Serial observations of volume regula...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gordon RD,Hawkins PG,Hamlet SM,Tunny TJ,Klemm SA,Backmann AW,Finn WL

更新日期：1989-04-01 00:00:00

abstract：:The epithelial sodium channel (ENaC) has long been recognized as playing a vital role in blood pressure (BP) regulation due to its involvement in fluid balance. The genes encoding the three ENaC subunits are likewise important contributors to hypertension, both in rare monogenic diseases and in the general population....

journal_title：Clinical and experimental pharmacology & physiology

authors： Büsst CJ

更新日期：2013-08-01 00:00:00

abstract：:1. The present study evaluated changes in autonomic control of the cardiovascular system in conscious rats following blockade of endothelin (ET) receptors with bosentan. 2. Rats were treated with bosentan or vehicle (5% gum arabic) for 7 days by gavage. 3. Baseline heart rate (HR) was higher in the bosentan-treated gr...

journal_title：Clinical and experimental pharmacology & physiology

authors： Souza HC,Terzini GC,da Silva VJ,Martins-Pinge MC,Salgado HC,Salgado MC

更新日期：2008-07-01 00:00:00

abstract：:Ischaemia reperfusion (I/R) is associated with liver injury and impaired regeneration during partial hepatectomy (PH). The aim of this study was to investigate the effect of thymoquinone (TQ), the active compound of essential oil obtained from Nigella sativa seeds, on rat liver after PH. Male Wistar rats were divided ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Bouhlel A,Bejaoui M,Ben Mosbah I,Hadj Abdallah N,Ribault C,Viel R,Hentati H,Corlu A,Ben Abdennebi H

更新日期：2018-05-07 00:00:00

abstract：:Recently, the roles of gene polymorphisms in poor responsiveness to aspirin were extensively investigated, with conflicting results. Therefore, we performed this meta-analysis to better assess the relationship between candidate genetic variants and poor responsiveness to aspirin. Eligible articles were searched in Pub...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yang J,Chen X,Zhou J,Hu S,Tang Y

更新日期：2018-05-21 00:00:00

abstract：:Ageing is associated with increased prevalences of both atrial and ventricular arrhythmias, reflecting disruption of the normal sequence of ion channel activation and inactivation generating the propagated cardiac action potential. Experimental models with specific ion channel genetic modifications have helped clarify...

journal_title：Clinical and experimental pharmacology & physiology

authors： Jeevaratnam K,Chadda KR,Salvage SC,Valli H,Ahmad S,Grace AA,Huang CL

更新日期：2017-12-01 00:00:00