Moderate-to-high normal levels of thyrotropin is a risk factor for urinary incontinence and an unsuitable quality of life in women over 65 years.

abstract：:1. In order to investigate further whether the increased sensitivity to inhibition by nifedipine of the responses to noradrenaline of aortae from spontaneously hypertensive stroke-prone (SHRSP) rats is related to the development of the hypertension, we have compared the sensitivity to noradrenaline, potassium chloride...

journal_title：Clinical and experimental pharmacology & physiology

authors： Jiang GC,Iwanov V,Moulds RF

更新日期：1995-01-01 00:00:00

abstract：:The amino acid sequence of human renin was identified for the first time. This was determined from the nucleotide sequence of exons in the human renin gene identified in a genomic library by recombinant DNA techniques. Examination of amino acid residues involved in the enzymatic hydrolysis by human renin of the unique...

journal_title：Clinical and experimental pharmacology & physiology

authors： Morris BJ,Catanzaro DF,Hardman J,Mesterovic N,Tellam J,Hort Y,Bennetts BH,Shine J

更新日期：1984-07-01 00:00:00

abstract：:1. The aim of the present study was to explore the effects of CPU0213, a dual endothelin ET(A)/ET(B) receptor antagonist, and nifedipine, a calcium antagonist, in relieving pulmonary hypertension (PH). Both endothelin receptor and calcium antagonists have been reported to be effective in alleviating the remodelling of...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cui B,Cheng YS,Dai DZ,Li N,Zhang TT,Dai Y

更新日期：2009-02-01 00:00:00

abstract：:1. There was no significant difference between the systolic blood pressure (SBP) of offspring derived from SHRSP mother and WKY father and the SBP of offspring derived from WKY mother and SHRSP father at the developing stage (5-13 weeks of age). 2. The degree of genetic determinations of SBP in stroke-prone spontaneou...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ikeda K,Nara Y,Nabica T,Fujimoto A,Endo J,Ishino H,Yamori Y

更新日期：1991-09-01 00:00:00

abstract：:Diabetes mellitus and depressive disorders are both common chronic diseases that increase functional disability and social burden. Cognitive impairment is a potentially debilitating feature of depression. Previous evidence indicates that the antidiabetic drug metformin could be suitable for diabetic patients with cogn...

journal_title：Clinical and experimental pharmacology & physiology

authors： Guo M,Mi J,Jiang QM,Xu JM,Tang YY,Tian G,Wang B

更新日期：2014-09-01 00:00:00

abstract：:1. Pericytes are cells of microvessels (arterioles, capillaries and venules) that wrap around endothelial cells. They are most abundant on venules and are common on capillaries. 2. The pericyte population is highly variable between different tissues and organs, probably in a manner reflecting postarteriolar hydrostati...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sims DE

更新日期：2000-10-01 00:00:00

abstract：:Receptors for parathyroid hormone (PTH) in the renal tubule are coupled to adenylate cyclase stimulation. PTH causes a rise in urinary cAMP by leakage from adenylate cyclase stimulation. PTH causes a rise in urinary cAMP by leakage from cells of the proximal convoluted tubule. The effects of alpha-adrenergic agonists ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Woodcock EA,McLeod JK,Johnston CI

更新日期：1984-07-01 00:00:00

abstract：:1. Carbachol (CCh)-induced desensitization to CCh was interrupted by a transient resensitization during its early stage, with concomitant changes at the muscarinic receptor/G-protein level in smooth muscle of guinea-pig taenia caeci. To assess whether such a peculiar desensitizing process may heterologously regulate s...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hishinuma S,Matsumoto Y,Sato R,Saito M

更新日期：2007-01-01 00:00:00

abstract：:The effect of cyclic GMP was investigated using guinea-pig tracheal smooth muscle. 8-Bromo-cyclic GMP showed a dose-dependent relaxation of spontaneous tension of tracheal smooth muscle. Administration of sodium nitroprusside induced dose-dependent relaxation of tracheal smooth muscle as well as an increase in tissue ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Suzuki K,Takagi K,Satake T,Sugiyama S,Ozawa T

更新日期：1986-01-01 00:00:00

abstract：:1. Deviation supersensitivity and post-junctional supersensitivity are important determinants in the control of the response of smooth muscle. 2. Post-junctional supersensitivity is a process whereby effector cells have augmented responsiveness as a consequence of an impaired physiological stimulus. Deviation supersen...

journal_title：Clinical and experimental pharmacology & physiology

authors： Head RJ

更新日期：1989-06-01 00:00:00

abstract：:1. In the present study, we investigated the associations of nicotinamide phosphoribosyltransferase (NAMPT)-3186 C/T and -948G/T polymorphisms with the risk of Type 2 diabetes mellitus (T2DM) and their impact on the efficacy of repaglinide in Chinese Han T2DM patients. 2. In all, 170 patients with T2DM and 129 healthy...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sheng FF,Dai XP,Qu J,Lei GH,Lu HB,Wu J,Xu XJ,Pei Q,Dong M,Liu YZ,Zhou HH,Liu ZQ

更新日期：2011-08-01 00:00:00

abstract：:1. Studies using animal experimental models have suggested that the beta2-adrenoceptor is uncoupled in association with alterations in the expression of G-protein-coupled receptor kinases (GRK) 2/3 in heart failure. However, the functional expression of the components of this pathway in human disease has not been full...

journal_title：Clinical and experimental pharmacology & physiology

authors： Dzimiri N,Basco C,Moorji A,Afrane B,Al-Halees Z

更新日期：2002-03-01 00:00:00

abstract：:Recent in vitro experiments have indicated that human resistin increases the number of lipoprotein particles secreted by the human hepatocytes and also influences their quality, in terms of generating more proatherogenic lipid particles. The aim of this study is to investigate associations of plasma resistin and perip...

journal_title：Clinical and experimental pharmacology & physiology

authors： Joksić J,Sopić M,Spasojević-Kalimanovska V,Gojković T,Zeljković A,Vekić J,Andjelkovic K,Kalimanovska-Oštrić D,Jelić-Ivanović Z

更新日期：2016-01-01 00:00:00

abstract：:1. Dexamethasone (Dex)-induced hypertension is characterized by endothelial dysfunction associated with nitric oxide (NO) deficiency and increased superoxide (O2-) production. Atorvastatin (Ato) possesses pleiotropic properties that have been reported to improve endothelial function through increased availability of N...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mondo CK,Yang WS,Zhang N,Huang TG

更新日期：2006-11-01 00:00:00

abstract：:1. Arterial baroreceptor denervation produces acute hypertension, but chronically denervated animals have an average arterial pressure that is similar to that of baroreceptor intact animals. 2. Although cardiopulmonary baroreceptors and renal compensations have been suggested to mediate the restoration of a normal ave...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sved AF,Schreihofer AM,Kost CK Jr

更新日期：1997-01-01 00:00:00

abstract：:1. The present review focuses on the cytotoxic effects of iodinated contrast media (CM) that are shared by all types of CM. 2. Although the clinical nephrotoxicity of CM has been progressively improved, all currently available CM still possess a level of cytotoxicity, which is probably caused by iodine. 3. The toxicit...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sendeski MM

更新日期：2011-05-01 00:00:00

abstract：:1. The effects of ouabain and acetazolamide on the secretion of pancreatic juice stimulated by secretin in anaesthetized dogs were investigated. 2. Intra-arterial injection of ouabain (1-10 micrograms) and acetazolamide (1-10 mg) caused dose-dependent decreases in the volume of pancreatic juice. When both drugs were a...

journal_title：Clinical and experimental pharmacology & physiology

authors： Iwatsuki K,Horiuchi A,Yonekura Y,Chiba S

更新日期：1989-03-01 00:00:00

abstract：:Alpha-pinene (α-pinene) is an organic compound, found in the oils of many species of coniferous trees, especially pine. α-Pinene reportedly has antioxidant and anti-inflammatory activities; however, its effects on osteoblasts are unknown. This study investigated the effects of α-pinene on osteoblast differentiation an...

journal_title：Clinical and experimental pharmacology & physiology

authors： Min HY,Son HE,Jang WG

更新日期：2020-05-01 00:00:00

abstract：:1. The effect of cicletanine, a novel antihypertensive agent with natriuretic activity, on blood pressure and progression of renal failure of 5/6 nephrectomized spontaneously hypertensive rats with salt loading was examined. 2. All nephrectomized rats were randomly assigned to one of four groups and their diet was cha...

journal_title：Clinical and experimental pharmacology & physiology

authors： Nakamoto H,Suzuki H,Ohishi A,Katsumata H,Sakaguchi H,Saruta T

更新日期：1999-03-01 00:00:00

abstract：:This study investigates the effect of chronic consumption of a high-fat diet rich in corn oil (CO-HFD) on atrial cells ultrastructure, antioxidant levels and markers of intrinsic cell death of both control and type 1 diabetes mellitus (T1DM)-induced rats. Adult male rats (10 rats/group) were divided into four groups: ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Eid RA,Eleawa SM,Alkhateeb MA,Aldera H,Zaki MSA,Al-Shraim M,Saeed MA,El-Kott AF,Alaa Eldeen M,Alassiri M,Alshehri MM,Salem Al-Shudiefat AA,Khalil MA

更新日期：2019-12-01 00:00:00

abstract：:Short-term salt loading and salt restriction in a group of normal pregnant women produced no changes in lying, sitting or standing blood pressures or heart rates. Home blood pressures showed no trend to change over the periods of altered salt intake. Although plasma volume and plasma renin activity changed with altere...

journal_title：Clinical and experimental pharmacology & physiology

authors： McEniery PJ,Hunyor SN,Cooper KA,Gallery ED,Gyory AZ,Boyce ES

更新日期：1985-05-01 00:00:00

abstract：:1. The aim of the present study was to perform an in vivo estimation of the Michaelis-Menten constants of the major metabolic pathways of paracetamol (APAP). 2. A two-occasion, single-dose cross-over trial was performed using 60 and 90 mg/kg doses of APAP in healthy patients undergoing third molar dental extraction. P...

journal_title：Clinical and experimental pharmacology & physiology

authors： Reith D,Medlicott NJ,Kumara De Silva R,Yang L,Hickling J,Zacharias M

更新日期：2009-01-01 00:00:00

abstract：:1. We have reported previously that instant coffee contains ligands for opiate receptors with characteristics similar to those of opiate antagonists. 2. A concentrate of receptor-active ligands from instant coffee was prepared by serial treatments involving Amberlite XAD-2, flash chromatography and gel permeation chro...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wynne KN,Familari M,Boublik JH,Drummer OH,Rae ID,Funder JW

更新日期：1987-10-01 00:00:00

abstract：:Anaemia is an important issue in patients undergoing haemodialysis. We aimed to identify a better dosing schedule of a fixed monthly dose of continuous erythropoietin receptor activator (CERA) in patients with chronic kidney disease (CKD) on haemodialysis. The CERA dosing schedule included 100 μg once monthly for 2 mo...

journal_title：Clinical and experimental pharmacology & physiology

authors： Liu WS,Chu DC,Chan HL,Li SY,Liu CK,Yang CY,Chen YW,Lee PC,Lai YT,Lin CC

更新日期：2016-10-01 00:00:00

abstract：:1. The present study examined the cytosolic Ca(2+) regulatory machinery involved in the vasorelaxation produced by petasin, a sesquiterpene isolated from Petasites formosanus. 2. Aortic rings isolated from Sprague-Dawley rats were exposed to petasin (0.01-100 micromol/L) to elucidate its vascular effects on isometric ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang GJ,Lin YL,Chen CH,Wu XC,Liao JF,Ren J

更新日期：2010-03-01 00:00:00

abstract：:1. Enzymatic bioremediation is potentially a rapid method of removing environmental pesticide residues. Applications include the treatment of residues resulting from agricultural production and processing industries, such as the treatment of irrigation waters, surface-contaminated fruit and vegetables and spent dip li...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sutherland TD,Horne I,Weir KM,Coppin CW,Williams MR,Selleck M,Russell RJ,Oakeshott JG

更新日期：2004-11-01 00:00:00

abstract：:1. During the destruction of articular cartilage, fibrinolytic enzymes and matrix metalloproteinases (MMP) may contribute to the related pathology. The activities, antigens and messenger RNA (mRNA) levels of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) in articular cartilage...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kikuchi H,Shimada W,Nonaka T,Ueshima S,Tanaka S

更新日期：1996-10-01 00:00:00

abstract：:1. Aqueous celery extract was administered intraperitoneally to genetically hypercholesterolaemic (RICO) and normocholesterolaemic (RAIF) rats via Alzet osmotic pumps over a 13 day period. 2. The serum cholesterol concentration of the celery extract-treated RICO rats was found to be significantly lower (P < 0.05) than...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tsi D,Tan BK

更新日期：1996-03-01 00:00:00

abstract：:Urapidil had blocking activity on alpha 1-adrenoceptors in the rat isolated caudal artery (pA2 congruent to 7) and in the anaesthetized rat. Urapidil had no clonidine like agonistic activity on alpha 2-adrenoceptors in preparations of the guinea-pig ileum (prejunctional) or dog saphenous vein (post-junctional). Urapid...

journal_title：Clinical and experimental pharmacology & physiology

authors： Verberne AJ,Rand MJ

更新日期：1984-07-01 00:00:00

abstract：:Posture changes may differ between types of hypertensive disease. The aim is to evaluate the orthostatic response of impedance cardiography (ICG) measurements in uncomplicated and hypertensive pregnancies. Measurements were performed in supine and standing position in 202 women: 41 uncomplicated pregnancies (UP), 59 g...

journal_title：Clinical and experimental pharmacology & physiology

authors： Staelens AS,Vonck S,Mesens T,Tomsin K,Molenberghs G,Gyselaers W

更新日期：2015-10-01 00:00:00