Abstract:
BACKGROUND:The evidence on the role of gut microbiota in post-infectious irritable bowel syndrome (PI-IBS) is convincing. Lactobacillus spp. positively affect IBS symptoms, although the mechanisms through which probiotics exert their beneficial effects are largely unknown. The aim of the study is to evaluate the role of Lactobacillus casei DG (LC-DG) and its postbiotic (PB) in modulating the inflammatory/immune-response in PI-IBS in an ex-vivo organ culture model. METHODS:Ex vivo cultures of ileal and colonic mucosa from 10 PI-IBS, diarrhea predominant subtype (D) patients, and 10 healthy controls (HC) were treated with LPS, LC-DG and PB. Interleukin (IL)-1α, IL-6, IL-8 and IL-10 mRNA levels were assessed by real-time PCR and Toll like receptor 4 (TLR-4) protein expression by Western blotting. RESULTS:At baseline, IL-1α, IL-6 and IL-8 mRNA levels as well as TLR-4 protein expression were significantly higher while IL-10 mRNA levels were lower in PI-IBS D than in HC in both ileum and colon. LC-DG and PB significantly reduced the mRNA levels of pro-inflammatory cytokines and TLR-4 while increased that of IL-10 after LPS stimulation. The protective effect was more pronounced for PB than LC-DG treatment. CONCLUSION:LC-DG and its PB attenuate the inflammatory mucosal response in an ex-vivo organ culture model of PI-IBS D.
journal_name
BMC Gastroenteroljournal_title
BMC gastroenterologyauthors
Compare D,Rocco A,Coccoli P,Angrisani D,Sgamato C,Iovine B,Salvatore U,Nardone Gdoi
10.1186/s12876-017-0605-xsubject
Has Abstractpub_date
2017-04-14 00:00:00pages
53issue
1issn
1471-230Xpii
10.1186/s12876-017-0605-xjournal_volume
17pub_type
杂志文章abstract:BACKGROUND:There are many pathological conditions with hepatic iron overload. Classical definite diagnostic methods of these disorders are invasive and based on a direct tissue biopsy material. For the last years the role of MR imaging in liver diagnostics has been increasing. MRI shows changes of liver intensity in pa...
journal_title:BMC gastroenterology
pub_type: 杂志文章
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更新日期:2014-12-10 00:00:00
abstract:BACKGROUND:We aimed to provide empirical evidence of how spectrum effects can affect the sensitivity of histological assessment of Helicobacter pylori infection, which may contribute to explain the heterogeneity in prevalence estimates across populations with expectedly similar prevalence. METHODS:Cross-sectional eval...
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journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-3-12
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journal_title:BMC gastroenterology
pub_type: 杂志文章
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更新日期:2011-10-06 00:00:00
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pub_type: 杂志文章,多中心研究
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journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-9-76
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journal_title:BMC gastroenterology
pub_type: 杂志文章
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journal_title:BMC gastroenterology
pub_type: 杂志文章
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更新日期:2014-04-11 00:00:00
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pub_type: 杂志文章
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journal_title:BMC gastroenterology
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journal_title:BMC gastroenterology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2014-02-13 00:00:00
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更新日期:2014-05-22 00:00:00
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journal_title:BMC gastroenterology
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2010-11-08 00:00:00
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journal_title:BMC gastroenterology
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更新日期:2012-09-25 00:00:00
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pub_type: 杂志文章
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更新日期:2020-03-30 00:00:00
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pub_type: 杂志文章
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更新日期:2017-12-20 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2014-01-12 00:00:00
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pub_type: 杂志文章
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更新日期:2012-08-06 00:00:00
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pub_type: 杂志文章,多中心研究
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