Effect of sodium depletion on pressor responsiveness in ACTH-induced hypertension in man.

Abstract:

:1. Pressor responsiveness to angiotensin II (AII) and phenylephrine (PHE) was measured before and after 5 days of ACTH (1 mg i.m. daily) in six normal men maintained on low sodium diet (15 mmol daily). 2. ACTH caused a significant increase in systolic blood pressure of 9 mmHg. 3. There was no change in pressor responsiveness to AII with ACTH. 4. ACTH increased pressor responsiveness to PHE for both systolic and diastolic blood pressure, with a fall in the threshold for response from 0.9 to 0.6 micrograms/kg per min. 5. Increased pressor sensitivity to catecholamines during ACTH administration in man is not sodium-dependent.

authors

Connell JM,Fisher BM,Davidson G,Fraser R,Whitworth JA

doi

10.1111/j.1440-1681.1987.tb00382.x

subject

Has Abstract

pub_date

1987-03-01 00:00:00

pages

237-42

issue

3

eissn

0305-1870

issn

1440-1681

journal_volume

14

pub_type

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