Abstract:
BACKGROUND:Little is known about the prognostic impact of cirrhosis on long-term survival of patients with combined hepatocellular-cholangiocarcinoma (cHCC-CC) after hepatic resection. The aim of this study was to elucidate the long-term outcome of hepatectomy in cHCC-CC patients with cirrhosis. METHODS:A total of 144 patients who underwent curative hepatectomy for cHCC-CC were divided into two groups: cirrhotic group (n = 91) and noncirrhotic group (n = 53). Long-term postoperative outcomes were compared between the two groups. RESULTS:Patients with cirrhosis had worse preoperative liver function, higher frequency of HBV infection, and smaller tumor size in comparison to those without cirrhosis. The 5-year overall survival rate in cirrhotic group was significantly lower than that in non-cirrhotic group (34.5% versus 54.1%, P = 0.032). The cancer recurrence-related death rate was similar between the two groups (46.2% versus 39.6%, P = 0.446), while the hepatic insufficiency-related death rate was higher in cirrhotic group (12.1% versus 1.9%, P = 0.033). Multivariate analysis indicated that cirrhosis was an independent prognostic factor of poor overall survival (hazard ratio 2.072, 95% confidence interval 1.041-4.123; P = 0.038). CONCLUSIONS:The presence of cirrhosis is significantly associated with poor prognosis in cHCC-CC patietns after surgical resection, possibly due to decreased liver function.
journal_name
BMC Gastroenteroljournal_title
BMC gastroenterologyauthors
Zhou YM,Sui CJ,Zhang XF,Li B,Yang JMdoi
10.1186/s12876-017-0584-ysubject
Has Abstractpub_date
2017-02-10 00:00:00pages
25issue
1issn
1471-230Xpii
10.1186/s12876-017-0584-yjournal_volume
17pub_type
杂志文章abstract:BACKGROUND:Bicyclol, the most commonly-used liver hepatoprotective drug in China, is often selected to control disease progression in CHB patients who refuse anti-viral treatment. However, data on histological changes after bicyclol treatment in these patients are scarce. Therefore, this study has been conducted to fin...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-019-1005-1
更新日期:2019-06-13 00:00:00
abstract:BACKGROUND:Gastrointestinal fistula (GIF) in severe acute pancreatitis (SAP) is considered as a sparse episode and studied sporadically in the literature. There is paucity of data on the prediction of the effect on risk of GIF in patient with SAP. This study was aimed to investigate risk factors related to GIF in the d...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-017-0587-8
更新日期:2017-02-14 00:00:00
abstract:BACKGROUND:Extramedullary plasmacytoma is a very rare tumor derived from plasma cells and found outside the bone marrow. Most have been identified in patients with the more aggressive anaplastic form of the disease. Only a few cases of primary pancreatic plasmacytoma have been reported. CASE PRESENTATION:We present a ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-017-0729-z
更新日期:2017-12-20 00:00:00
abstract:BACKGROUND:Sleep disturbances are increasingly recognized as a common problem for children and adolescents with chronic pain conditions, but little is known about the prevalence, type, and impact of sleep problems in pediatric functional gastrointestinal disorders (FGIDs). The objectives of the current study were two-f...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-142
更新日期:2012-10-15 00:00:00
abstract:BACKGROUND:Patients with familial adenomatous polyposis (FAP) frequently undergo colectomy to reduce the 70 to 90% lifetime risk of colorectal cancer. After risk-reducing colectomy, duodenal cancer and complications from duodenal surgeries are the main cause of morbidity. Our objective was to prospectively describe the...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-018-0841-8
更新日期:2018-07-16 00:00:00
abstract:BACKGROUND AND AIM:Carbohydrate deficient transferrin (CDT) is the most specific serum biomarker of heavy alcohol consumption, defined as ≥ 350-420 g alcohol/week. Despite introduction of a standardized reference measurement technique, widespread use of CDT remains limited due to low sensitivity. The aim of this study ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-14-97
更新日期:2014-05-22 00:00:00
abstract:BACKGROUND:Benign biliary strictures may be a consequence of surgical procedures, chronic pancreatitis or iatrogenic injuries to the ampulla. Stents are increasingly being used for this indication, however it is not completely clear which stent type should be preferred. METHODS:A systematic review on stent placement f...
journal_title:BMC gastroenterology
pub_type: 杂志文章,评审
doi:10.1186/1471-230X-9-96
更新日期:2009-12-17 00:00:00
abstract:BACKGROUND:Glycoprotein 2 (GP2) was discovered as the major autoantigen of Crohn's disease (CD)-specific pancreatic autoantibodies (PAB). We investigated anti-GP2 IgA and IgG antibodies as novel serological parameters in CD and assessed their association with distinct disease phenotypes. METHODS:Anti-GP2 and anti-Sacc...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-102
更新日期:2012-08-06 00:00:00
abstract:BACKGROUND:Low 25-Hydroxy-vitamin-D; "25(OH)-D3" serum and vitamin D receptor (VDR) levels were recently correlated to advanced fibrosis. However, VDR mechanism in liver fibrosis modulations is not well understood. In this study, we aimed to evaluate changes in liver NK cells cytotoxicity due to modulations in VDR in C...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01248-5
更新日期:2020-04-10 00:00:00
abstract:BACKGROUND:We prepared an oral W/O microemulsion for the removal of colonic ammonia (ME-RCA). The effect of this microemulsion was influenced by the digestion process in the gastrointestinal tract. In this paper, we aim to show that stability was improved by using a microemulsion-based gel for the removal of colonic am...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-11-50
更新日期:2011-05-10 00:00:00
abstract:BACKGROUND:Inflammatory Bowel Diseases (IBD) affect psychological, family, social and professional dimensions of patients' life, leading to disability which is essential to quantify as part of Patient-Reported Outcomes (PROs) newly included in the targets to reach in IBD patients. Up to now, the IBD-Disability Index (I...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01246-7
更新日期:2020-04-16 00:00:00
abstract:BACKGROUND:Enhanced expression of MAdCAM-1 (mucosal addressin cell adhesion molecule-1) is associated with the onset and progression of inflammatory bowel disease. The clinical significance of elevated MAdCAM-1 expression is supported by studies showing that immunoneutralization of MAdCAM-1, or its ligands reduce infla...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230x-3-3
更新日期:2003-02-20 00:00:00
abstract:BACKGROUND:The use of thickeners is a standard therapy for decreasing episodes of regurgitation or vomiting in infants. However, it remains to be investigated whether thickener is effective for vomiting and/or chronic respiratory symptoms in children with cerebral palsy. METHODS:We enrolled 18 neurologically impaired ...
journal_title:BMC gastroenterology
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-230X-8-11
更新日期:2008-04-16 00:00:00
abstract:BACKGROUND:A marked expansion of the connective tissue population and an abnormal deposition of extracellular matrix proteins are hallmarks of chronic and acute injuries to liver tissue. Liver connective tissue cells, also called stellate cells, derived from fibrotic liver have been thoroughly characterized and corresp...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-4-30
更新日期:2004-12-03 00:00:00
abstract:BACKGROUND:Occurrence of metastatic cancer to the stomach is rare, particularly in patients with prostate cancer. Gastric metastasis generally presents as a solitary and submucosal lesion with a central depression. CASE PRESENTATION:We describe a case of gastric metastasis arising from prostate cancer, which is almost...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-017-0655-0
更新日期:2017-08-07 00:00:00
abstract:BACKGROUND:Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm that originates from follicular dendritic cells in lymphoid tissue while paraneoplastic pemphigus (PNP) is an autoimmune blistering disease associated with neoplasms. Pancreatic FDCS associated with PNP and myasthenia gravis (MG) is even rarer and h...
journal_title:BMC gastroenterology
pub_type: 杂志文章,评审
doi:10.1186/s12876-019-1008-y
更新日期:2019-06-14 00:00:00
abstract:BACKGROUND:In Brazil, it is estimated that between 2.5 and 4.9% of the general population present anti-hepatitis C virus (HCV) antibodies, which corresponds to as many as 3.9 to 7.6 million chronic carriers. Chronic liver disease is associated with HCV infection in 20% to 58% of the Brazilian patients. The objective of...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230x-2-18
更新日期:2002-08-08 00:00:00
abstract:BACKGROUND:Liver fibrosis is the result of continuous liver injury stemming from different etiological factors. Bile duct injury induces an altered expression of TGF-beta, which has an important role in liver fibrosis because this cytokine induces the expression of target genes such as collagens, PAI-1, TIMPs, and othe...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-9-81
更新日期:2009-10-31 00:00:00
abstract:BACKGROUND:An epidermoid cyst in an intrapancreatic accessory spleen (ECIPAS) in the pancreas head is an extremely rare condition. The natural course of this condition is not well known, and it is difficult to diagnose before surgery due to the lack of specific imaging findings. CASE PRESENTATION:A tumor was found in ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01540-4
更新日期:2020-11-20 00:00:00
abstract:BACKGROUND:Recent improvements in stone extraction implements and apparatus have lessened the complexity of the endoscopic bile duct stone treatment. However, despite confirmation of complete removal, cases of residual stones have been reported, which can result in recurrent biliary symptoms, cholangitis, and pancreati...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01428-3
更新日期:2020-08-24 00:00:00
abstract:BACKGROUND:Calprotectin is a stable neutrophil protein, which can be measured in faecal samples. The faecal level of calprotectin increases during disease activity in ulcerative colitis (UC). Nonetheless, the relevance of faecal calprotectin (FC) measurement during granulomonocytapheresis (GMA) for UC has not yet been ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-018-0853-4
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Symptoms suggestive of functional dyspepsia (FD) and irritable bowel syndrome (IBS) frequently overlap with those of gastroesophageal reflux disease. Despite the high prevalence of symptomatic overlap, the underlying etiology remains poorly defined. We assessed the correlation of symptomatic relief and healt...
journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-230X-13-145
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal recessive disorder caused by mutations in TYMP gene, encoding nuclear thymidine phosphorylase (TP). MNGIE mainly presents with gastrointestinal symptoms and is mostly misdiagnosed in many patients as malabsorption syndrome, inf...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01280-5
更新日期:2020-05-08 00:00:00
abstract:BACKGROUND:Previous results have shown that in rats with non-ascitic cirrhosis there is an altered transport of sugars and amino acids associated with elongated microvilli. These alterations returned to normal with the administration of Insulin-Like Growth Factor-I (IGF-I). The aims of this study were to explore the ev...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-4-12
更新日期:2004-06-14 00:00:00
abstract:BACKGROUND:An intravascular ultrasound catheter (IVUSc) was developed for intracardiac ultrasound to assess interventions with compelling results. However, intrahepatic vascular exploration was rarely tested and was always associated with X-ray techniques. The aim of this study was to demonstrate the feasibility to nav...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-021-01600-3
更新日期:2021-01-09 00:00:00
abstract:BACKGROUND:In a recent study we had evidence that sulphite oxidase (SO) may be a relevant autoantigen in primary sclerosing cholangitis (PSC). Aim of the present study was, therefore, to analyse humoral and cellular immune-reactivity towards SO in these patients in more detail. METHODS:Sera from 53 patients with PSC (...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-018-0787-x
更新日期:2018-05-02 00:00:00
abstract:BACKGROUND:Approximately 2.7 million Americans are chronically infected with hepatitis C virus (HCV). HCV patients with cirrhosis form the largest group of persons at high risk for hepatocellular carcinoma (HCC). Increased oxidative stress is regarded as a major mechanism of HCV-related liver disease progression. Defic...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-016-0432-5
更新日期:2016-02-29 00:00:00
abstract:BACKGROUND:CMUSE is a rare disease whose diagnosis remains difficult because the lesion is confined to the small bowel. CASE PRESENTATION:Here, we present a case of 43-year-old female patient suffered chronic abdominal pain for 20 years, and finally diagnosed with CMUSE. Capsule endoscopy was performed when general en...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-019-0962-8
更新日期:2019-04-03 00:00:00
abstract:BACKGROUND:Green tea has shown the role of chemoprevention for cancer. Recently, several studies suggested that green tea intake may have effect on esophageal cancer risk, whereas the results were inconsistent. METHODS:We performed a meta-analysis of all English and Chinese language studies of green tea consumption an...
journal_title:BMC gastroenterology
pub_type: 杂志文章,meta分析
doi:10.1186/1471-230X-12-165
更新日期:2012-11-21 00:00:00
abstract:BACKGROUND:Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive carcinomas of the gastrointestinal tract. We assessed the relevance of Slug in measuring the invasive potential of ESCC cells in vitro and in vivo in immunodeficient mice. METHODS:We utilized RNA interference to knockdown Slug gene expr...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-11-60
更新日期:2011-05-20 00:00:00