Abstract:
BACKGROUND:Preterm neonates undergo many painful procedures as part of their standard care in the neonatal intensive care unit. However, pain treatment is inadequate in many of these routine procedures. In the present study, we investigated the impact and mechanism of combined music and touch intervention (CMT) on the pain response in premature infants. METHODS:Sixty-two preterm neonates (gestational age of <37 weeks) were randomly assigned to either the experimental or control group. Infants in the experimental group underwent painful procedures with CMT, and those in the control group underwent painful procedures without CMT. Blood samples were collected from all infants at the beginning of hospitalization and 2 weeks later to assess the cortisol and β-endorphin concentrations. Differences in the levels of cortisol and β-endorphin between two groups were examined using analysis of covariance (ANCOVA). RESULTS:In total, 3707 painful procedures were performed on 62 neonates during their hospitalization. The average number of painful procedures in the control group (n = 35.5) was higher than that in the experimental group (n = 29.0) during hospitalization, although no significant difference was reached (P > 0.05). After 2 weeks, the Premature Infant Pain Profile scores were significantly higher in the control group than experimental group (13.000 ± 0.461 vs 10.500 ± 0.850, respectively; P < 0.05). The cortisol concentration was not significantly different between the control and experimental groups either at the beginning of hospitalization (131.000 ± 18.190 vs 237.200 ± 43.860, respectively; P > 0.05) or 2 weeks later (162.400 ± 23.580 vs 184.600 ± 21.170, respectively; P > 0.05). However, the serum β-endorphin concentration was higher in the experimental group than in the control group both at the beginning of hospitalization (1.640 ± 0.390 vs 1.179 ± 0.090, respectively; P < 0.05) and 2 weeks later (2.290 ± 0.740 vs 1.390 ± 0.410, respectively; P < 0.05). CONCLUSIONS:CMT might decrease the pain response of preterm neonates by significantly improving the β-endorphin concentration, but not the blood cortisol concentration. TRIAL REGISTRATION:Current Controlled Trials ISRCTN14131492 . Registered on 01 Aug 2016.
journal_name
BMC Pediatrjournal_title
BMC pediatricsauthors
Qiu J,Jiang YF,Li F,Tong QH,Rong H,Cheng Rdoi
10.1186/s12887-016-0755-ysubject
Has Abstractpub_date
2017-01-26 00:00:00pages
38issue
1issn
1471-2431pii
10.1186/s12887-016-0755-yjournal_volume
17pub_type
杂志文章,随机对照试验相关文献
BMC Pediatrics文献大全abstract:BACKGROUND:Prompt initiation of empiric therapy is common practice in case of suspected meningitis or encephalitis. However, in children the most common pathogens are viruses that usually do not require and are not covered by the applied anti-infective treatment. Novel multiplex PCR (mPCR) panels provide rapid on-site ...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-020-1944-2
更新日期:2020-02-05 00:00:00
abstract:BACKGROUND:Necrotizing enterocolitis (NEC) is a devastating disease that is relatively frequently diagnosed in term infants with congenital heart disease (CHD), compared with term infants without CHD, in whom NEC is rare. The exact pathogenesis of NEC in term infants with CHD is unknown, but it is hypothesized that isc...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-020-02446-6
更新日期:2020-12-07 00:00:00
abstract:BACKGROUND:The "Staying Healthy in Child Care" Australian guidelines provide for illness and disease exclusions and encourage vaccination of staff in child care settings, however these requirements are not subject to accreditation and licensing, and their level of implementation is unknown. This study aimed to describe...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-12-98
更新日期:2012-07-13 00:00:00
abstract:BACKGROUND:This study aims to describe the predictive factors of severe obesity in children followed in French Guiana. METHODS:In this observational study, the patients from the French Guianese Childhood Obesity Group database were prospectively included, after giving a statement of patient's non opposition. RESULTS:...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-018-1158-z
更新日期:2018-06-09 00:00:00
abstract:BACKGROUND:Bacterial meningitis is more common in the neonatal period than any other time in life; however, it is still a challenge for the evidence based diagnosis. Strategy for identification of neonatal bacterial meningitis pathogens is presented by evaluating three different available methods to establish evidence-...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-14-224
更新日期:2014-09-08 00:00:00
abstract:BACKGROUND:Arthrogryposis multiplex congenita is an etiopathogenetically heterogeneous disorder characterised by non-progressive multiple intra-articular contractures, which can be recognised at birth. The frequency is estimated at 1 in 3,000 newborns. Etiopathogenesis of arthrogryposis is multifactorial. CASE PRESENT...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-13-184
更新日期:2013-11-11 00:00:00
abstract:BACKGROUND:Intravenous immunoglobulin (IVIG) is commonly used to improve the immunomodulatory effects, although its regulatory effect on premature Treg cells is unclear. The purpose of this study is to study the effect of high dose of IVIG (HD-IVIG) on Treg cells expression and cytokine profile in premature birth. MET...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-018-1055-5
更新日期:2018-02-21 00:00:00
abstract::An amendment to this paper has been published and can be accessed via the original article. ...
journal_title:BMC pediatrics
pub_type: 已发布勘误
doi:10.1186/s12887-020-02397-y
更新日期:2020-10-24 00:00:00
abstract:BACKGROUND:Neonatal near miss cases occur more often than neonatal deaths and could enable a more comprehensive analysis of risk factors, short-term outcomes and prognostic factors in neonates born to mothers with severe obstetric complications. The objective was to assess the incidence, presentation and perinatal outc...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-015-0362-3
更新日期:2015-04-17 00:00:00
abstract:BACKGROUND:Surgical correction of orofacial clefts greatly mitigates negative outcomes. However, access to reconstructive surgery is limited in developing countries. The present study reviews epidemiological data from a single charitable organization, Smile Train, with a database of surgical cases from 33 African count...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-015-0328-5
更新日期:2015-02-14 00:00:00
abstract:BACKGROUND:Neonatal jaundice is a common finding in newborns in Asia, including Indonesia. In some cases, the serum total bilirubin levels exceeds the 95th percentile for hours of life (neonatal hyperbilirubinemia). Severe neonatal hyperbilirubinemia (NH) could lead to kernicterus and neonatal death. Glucose-6-Phosphag...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-019-1882-z
更新日期:2019-12-20 00:00:00
abstract:BACKGROUND:Antiretroviral treatment means many HIV infected children are surviving with a highly stigmatised condition. There is a paucity of data to inform policies for this growing cohort. Hence we carried out a study on the health, schooling, needs, aspirations, perspectives and knowledge of HIV infected and affecte...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-016-0643-5
更新日期:2016-07-22 00:00:00
abstract:BACKGROUND:Infections in newborns remain one of the most significant problems in modern medicine. Escherichia coli is an important cause of neonatal bloodstream and respiratory tract infections and is associated with high mortality. The aim of our study was to investigate the epidemiology of E. coli infection in Polish...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-14-274
更新日期:2014-10-18 00:00:00
abstract:BACKGROUND:This report summarizes the clinical characteristics of intractable anemia as part of the clinical presentation of Hirschsprung's disease (HD) and aims to strengthen clinicians' ability to recognize early signs of HD. CASE PRESENTATION:An 11-year-old boy with a 6-year history of intractable anemia, low hemog...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-020-02423-z
更新日期:2020-11-16 00:00:00
abstract:BACKGROUND:Severe acute malnutrition affects around 17 million under-five children in the world, of which the highest burden is accounted by Sub-Saharan Africa where Ethiopia is found. Though there are few individual, inconsistent and inconclusive studies, there is no nationally representative study on treatment outcom...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-020-02188-5
更新日期:2020-07-07 00:00:00
abstract:BACKGROUND:Problems experienced within the first year of an infant's life can be precursors of later mental health conditions. The purpose of this study was to examine the frequency and continuity of difficult behaviors in infants at 3 and 6 months of age and the associations of these difficulties with biomedical and p...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-12-44
更新日期:2012-04-11 00:00:00
abstract:BACKGROUND:Infants born at extreme prematurity are at high risk of developmental disability. A major risk factor for disability is having a low level of thyroid hormone described as hypothyroxinaemia, which is recognised to be a frequent phenomenon in these infants. Derangements of critical thyroid function during the ...
journal_title:BMC pediatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-2431-8-26
更新日期:2008-06-30 00:00:00
abstract:BACKGROUND:Systemic fungal infection (SFI) is one of leading causes of morbidity and mortality in very low birth weight (VLBW) preterm infants. Because early diagnosis of SFI is challenging due to nonspecific manifestations, prophylaxis becomes crucial. This study aimed to assess effectiveness of oral nystatin as an an...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-020-02074-0
更新日期:2020-04-17 00:00:00
abstract:BACKGROUND:While survival rates for preterm infants have increased, the risk for adverse long-term neurodevelopmental and behavioral outcomes remains very high. In response to the need for novel, evidence-based interventions that prevent such outcomes, we have assessed Family Nurture Intervention (FNI), a novel dual mo...
journal_title:BMC pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2431-13-148
更新日期:2013-09-24 00:00:00
abstract:BACKGROUND:The emerging field of Information and Communications Technology (ICT) has brought about new interaction styles. Its excessive use may lead to addictive behaviours. The objective is to determine the prevalence of the problematic use of ICT such as Internet, mobile phones and video games, among adolescents enr...
journal_title:BMC pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1186/s12887-016-0674-y
更新日期:2016-08-22 00:00:00
abstract:BACKGROUND:Several environmental factors favour the occurrence of acute respiratory disease, which is the main reason for paediatric consultations in our country (Colombia). Tobacco smoke is considered a significant environmental pollutant with a great impact on health. The objective of this study is to estimate the pr...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-020-02193-8
更新日期:2020-06-16 00:00:00
abstract:BACKGROUND:The aim of this study was to revise the 2003 Fenton Preterm Growth Chart, specifically to: a) harmonize the preterm growth chart with the new World Health Organization (WHO) Growth Standard, b) smooth the data between the preterm and WHO estimates, informed by the Preterm Multicentre Growth (PreM Growth) stu...
journal_title:BMC pediatrics
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1471-2431-13-59
更新日期:2013-04-20 00:00:00
abstract:BACKGROUND:Premedication before neonatal intubation is heterogeneous and contentious. The combination of a short acting, rapid onset opioid with a muscle relaxant is considered suitable by many experts. The purpose of this study was to describe the tolerance and conditions of intubation following anaesthesia with atrop...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-14-120
更新日期:2014-05-07 00:00:00
abstract:BACKGROUND:Approximately 13% of Canadian mothers report difficulty accessing health care for their infants, yet little is known about the factors associated with difficulty. Therefore, we examined factors associated with difficulty accessing non-routine health care for Canadian infants, from birth to 14 months of age, ...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-016-0733-4
更新日期:2016-11-25 00:00:00
abstract:BACKGROUND:Intestinal parasitic infection is diversified illness and diseases caused millions morbidity among under-five children lives in developing countries particularly vulnerable rural communities. Deworming coverage in such community is low. The aim of this study was to determine the prevalence and associated ris...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-019-1731-0
更新日期:2019-10-27 00:00:00
abstract:BACKGROUND:The influence of socio-economic determinants on choice of infant male circumcision provider is not known in areas with high population coverage such as rural Africa. The overall aim of this study was to determine the key socio-economic factors which influence the choice of infant male circumcision provider i...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-017-0937-2
更新日期:2017-08-29 00:00:00
abstract:BACKGROUND:Neonatal mortality remains a serious global public health problem, but Sub-Saharan Africa (SSA), in particular, is largely affected. Current evidence on neonatal mortality is essential to inform programs and policies, yet there is a scarcity of information concerning neonatal mortality in our study area. The...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-020-1963-z
更新日期:2020-02-15 00:00:00
abstract:BACKGROUND:Type 1 diabetes mellitus (T1DM) is highly prevalent in Kuwait with incidence of around 40.1/100,000 individuals. Evidence indicate that vitamin D plays an important role in modulating the immune system and could thus impact the onset and high prevalence of T1DM. We report serum vitamin D levels in Kuwaiti ch...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-016-0629-3
更新日期:2016-07-16 00:00:00
abstract:BACKGROUND:Concepts such as participation and environment may differ across cultures. Consequently, to use a measure like the Participation and Environment Measure for Children and Youth (PEM-CY) in other than the original English-speaking contexts, cultural adaptation needs to be assured. The aim of this study was to ...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-020-02343-y
更新日期:2020-10-24 00:00:00
abstract:BACKGROUND:Screening for elevated serum alanine aminotransferase (ALAT) can help identifying individuals at the risks of chronic and metabolic diseases, but blood collection is invasive and cannot be widely used for investigations. Considered as simple and inexpensive screening indices, individual characteristics and a...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-020-02033-9
更新日期:2020-03-20 00:00:00