Reduction of calprotectin and phosphate during testosterone therapy in aging men: a randomized controlled trial.

Abstract:

OBJECTIVES:To investigate the effect of testosterone treatment on biomarkers calprotectin, fibroblast growth factor 23 (FGF23), soluble Klotho, phosphate, calcium, parathyroid hormone, creatinine and estimated glomerular filtration rate. DESIGN:Randomized, double-blinded, placebo-controlled study. SETTING:Odense Androgen Study-the effect of Testim and training in hypogonadal men. PARTICIPANTS:Men aged 60-78 years old with a low normal concentration of free of bioavailable testosterone <7.3 nmol/L and waist circumference >94 cm recruited from 2008 to 2009 (N = 48) by advertisement. INTERVENTION:Participants were randomized to receive 5-10 g gel/50-100 mg testosterone (Testim®, Ipsen, France) or 5-10 g gel/placebo. RESULTS:The plasma levels of calprotectin and phosphate were significantly reduced in the group receiving testosterone therapy (gel) compared to the placebo group (p < 0.05). Testosterone treatment did not have any significant effect on plasma levels of FGF23 or soluble Klotho. The reduction in phosphate levels was inversely associated with bioavailable testosterone. CONCLUSION:Compared to the placebo group, 6 months of testosterone therapy (gel) reduced calprotectin and phosphate levels suggesting decreased inflammation and decreased cardiovascular risk.

journal_name

J Endocrinol Invest

authors

Pedersen L,Christensen LL,Pedersen SM,Andersen M

doi

10.1007/s40618-016-0597-3

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

529-538

issue

5

eissn

0391-4097

issn

1720-8386

pii

10.1007/s40618-016-0597-3

journal_volume

40

pub_type

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