Systematic quantitative overviews of the literature to determine the value of diagnostic tests for predicting acute appendicitis: study protocol.


BACKGROUND:Suspected acute appendicitis is the most frequent cause for emergency operations in visceral surgery worldwide. In approximately twenty percent of all cases however, the diagnosis is incorrect and patients undergo surgery without having acute appendicitis. Operations of bland appendices put patients at risk and entail a serious waste of resources. Several highly accurate tests have been introduced to diagnose acute appendicitis. The false positive rate however, has not changed over the last twenty years. Given the variation that exists in both practice and research, the uncertainty regarding the quality of the underlying evidence, there is a clear need for comprehensive, systematic and quantitative overviews of the diagnostic value of the various tests purported to be predictive of acute appendicitis. METHODS:Literature will be identified searching general bibliographic databases (MEDLINE and EMBASE), specialist computer databases (DARE, Cochrane Database of Systematic Reviews, conference proceedings, MEDION, SCISEARCH, BIOSIS) without language restrictions. We will contact experts and the manufacturers of tests. Hand-searching will complete our searches. Identified articles will be selected according to populations, tests, outcomes and study design. Papers meeting the selection criteria will be appraised to rate their methodological quality. Analysis will include exploration of heterogeneity in results. We will conduct meta-analyses to generate summary estimates of test accuracy measures and summary ROC curves where appropriate. If meta-analysis is considered to be inappropriate, we will describe the identified evidence in the context of appraised quality. DISCUSSION:These reviews should lead to formulation of recommendations for current practice and future research.


BMC Surg


BMC surgery


Bachmann LM,Bischof DB,Bischofberger SA,Bonani MG,Osann FM,Steurer J





Has Abstract


2002-04-10 00:00:00








  • Sphincter saving anorectoplasty (SSARP) for the reconstruction of Anorectal malformations.

    abstract:BACKGROUND:This report describes a new technique of sphincter saving anorectoplasty (SSARP) for the repair of anorectal malformations (ARM). METHODS:Twenty six males with high ARM were treated with SSARP. Preoperative localization of the center of the muscle complex is facilitated using real time sonography and comput...

    journal_title:BMC surgery

    pub_type: 杂志文章


    authors: Pratap A,Tiwari A,Kumar A,Adhikary S,Singh SN,Paudel BH,Bartaula R,Mishra B

    更新日期:2007-09-24 00:00:00

  • Are there too many screw holes in plates for fracture fixation?

    abstract:BACKGROUND:Implant breakage after the fixation of traumatic fractures is rare; however, when it occurs, it is debilitating for the patients and a challenge for surgeons. The purpose of this study was to analyze and identify the independent risk factors for implant breakage of traumatic fractures treated with plate oste...

    journal_title:BMC surgery

    pub_type: 杂志文章


    authors: Lv H,Chang W,Yuwen P,Yang N,Yan X,Zhang Y

    更新日期:2017-04-21 00:00:00

  • Mesenteric ischemia: the importance of differential diagnosis for the surgeon.

    abstract:BACKGROUND:Intestinal ischemia is an abdominal emergency that accounts for approximately 2% of gastrointestinal illnesses. It represents a complex of diseases caused by impaired blood perfusion to the small and/or large bowel including acute arterial mesenteric ischemia (AAMI), acute venous mesenteric ischemia (AVMI), ...

    journal_title:BMC surgery

    pub_type: 杂志文章


    authors: Reginelli A,Iacobellis F,Berritto D,Gagliardi G,Di Grezia G,Rossi M,Fonio P,Grassi R

    更新日期:2013-01-01 00:00:00

  • Perforated carcinoma of the caecum presenting as necrotising fasciitis of the abdominal wall, the key to early diagnosis and management.

    abstract:BACKGROUND:Necrotising Fasciitis is a life threatening soft tissue infection which requires aggressive, early surgical management. CASE PRESENTATION:We present a rare case of a retroperitoneal perforation of a carcinoma of the caecum presenting as a necrotising fasciitis of the anterior abdominal wall. CONCLUSION:Thi...

    journal_title:BMC surgery

    pub_type: 杂志文章


    authors: Marron CD,McArdle GT,Rao M,Sinclair S,Moorehead J

    更新日期:2006-09-29 00:00:00

  • Comparison of the 3D-printed operation guide template technique and the free-hand technique for S2-alar-iliac screw placement.

    abstract:BACKGROUND:To compare the safety and accuracy of the 3D-printed operation guide template technique and the free-hand technique in the placement of the S2-alar-iliac (S2AI) screw. METHODS:We conducted a retrospective analysis of 47 patients undergoing S2AI screw placement in our hospital, divided into the 3D-printed op...

    journal_title:BMC surgery

    pub_type: 杂志文章


    authors: Zhao Y,Ma Y,Liang J,Luo H,Cai X,Xu Y,Lu S

    更新日期:2020-10-29 00:00:00

  • Comparing laparoscopic cholecystectomy in patients with chronic obstructive pulmonary disease under spinal anesthesia and general anesthesia.

    abstract:BACKGROUND:Epidemiological data demonstrate that the worldwide prevalence of chronic obstructive pulmonary disease is increasing. These patients have an increased risk of mortality and morbidity and have constant limitations in airflow. Comparing laparoscopic cholecystectomy (LC) in patients with chronic obstructive pu...

    journal_title:BMC surgery

    pub_type: 杂志文章


    authors: Bayrak M,Altıntas Y

    更新日期:2018-08-20 00:00:00

  • Acute acalculous cholecystitis determining Mirizzi syndrome: case report and literature review.

    abstract:BACKGROUND:Although Mirizzi syndrome is widely reported in literature, little is known about acute acalcholous cholecystitis determinig the findings of a Mirizzi syndrome. CASE PRESENTATION:We report a case of MRCP-confirmed Mirizzi syndrome in acute acalculous cholecystitis resolved by surgery. CONCLUSION:Acute acal...

    journal_title:BMC surgery

    pub_type: 杂志文章,评审


    authors: Milone M,Musella M,Maietta P,Gaudioso D,Pisapia A,Coretti G,De Palma G,Milone F

    更新日期:2014-11-15 00:00:00

  • A bilateral neoplasm in chest: a case report and literature review.

    abstract:BACKGROUND:Myelolipoma is a rare neoplasm composed of yellowish adipose tissue and reddish-brown tissue corresponding to hematopoietic or hemorrhages. It typically occurs in adrenal glands as a solitary, well-circumscribed mass, and the thoracic location is extremely unusual. CASE PRESENTATION:We present a rare case w...

    journal_title:BMC surgery

    pub_type: 杂志文章,评审


    authors: Shen C,Han Z,Che G

    更新日期:2014-07-09 00:00:00

  • Relationship between the atlantodental interval and T1 slope after atlantoaxial fusion in patients with rheumatoid arthritis.

    abstract:BACKGROUND:Atlantoaxial fusion has been widely used for the treatment of atlantoaxial instability (AAI). However, atlantoaxial fusion sacrifices the motion of atlantoaxial articulation, and postoperative loss of cervical lordosis and aggravation of cervical kyphosis are observed. We investigated various factors under t...

    journal_title:BMC surgery

    pub_type: 杂志文章


    authors: Ha BJ,Won YD,Ryu JI,Han MH,Cheong JH,Kim JM,Chun HJ,Bak KH,Bae IS

    更新日期:2020-11-04 00:00:00

  • Acute inflammatory response in the subcutaneous versus periprosthethic space after incisional hernia repair: an original article.

    abstract:BACKGROUND:The acute inflammatory response following mesh implantation has been often evaluated in vitro and in animal models. The aim of this study was to evaluate the acute inflammatory response near the prosthesis in human by analysing some inflammatory indicators. METHODS:We used a cohort of twelve male patients a...

    journal_title:BMC surgery

    pub_type: 杂志文章


    authors: Patti R,Caruso AM,Aiello P,Angelo GL,Buscemi S,Di Vita G

    更新日期:2014-11-15 00:00:00

  • Rectosigmoid stump washout as an alternative to permanent mucous fistula in patients undergoing subtotal colectomy for ulcerative colitis in emergency settings.

    abstract:BACKGROUND:Restorative proctocolectomy with ileopouch-anal anastomosis (IPAA) is the treatment of choice for intractable or complicated ulcerative colitis(UC). Elderly patients often present with acute colitis requiring emergent subtotal colectomy(SC). Frail patients are at risk of developing septic complications relat...

    journal_title:BMC surgery

    pub_type: 杂志文章


    authors: Pellino G,Sciaudone G,Candilio G,Canonico S,Selvaggi F

    更新日期:2012-01-01 00:00:00

  • Cotton Bezoar--a rare cause of intestinal obstruction: case report.

    abstract:BACKGROUND:Bezoars usually present as a mass in the stomach. The patient often has a preceding history of some psychiatric predisposition. Presentation could be in the form of trichophagy followed by trichobezoar (swallowing of hair leading to formation of bezoar), orphytobezoar (swallowing of vegetable fibres). Rapunz...

    journal_title:BMC surgery

    pub_type: 杂志文章


    authors: Chintamani,Durkhure R,Singh JP,Singhal V

    更新日期:2003-09-04 00:00:00

  • Predictors of Poor Postoperative Outcomes in Pediatric Surgery Patients in Rural Ghana.

    abstract:BACKGROUND/PURPOSE:Perioperative complications cause significant pediatric morbidity and mortality in low- and lower middle -income countries. This study investigates factors associated with prolonged length of stay, 90-day readmission and in-hospital mortality among pediatric patients at Eastern Regional Hospital (ERH...

    journal_title:BMC surgery

    pub_type: 杂志文章


    authors: Peiffer S,Ssentongo AE,Keeney L,Amponsah-Manu F,Yeboako R,Ofosu-Akromah R,Arkorful TE,Agyemang E,Tsai A,Oh J,Ssentongo P

    更新日期:2020-09-22 00:00:00

  • Peroneal artery pseudoaneurysm--a case report and literature review.

    abstract:BACKGROUND:Aneurysms of the peroneal artery are infrequent and consist mainly of pseudoaneurysms. CASE PRESENTATION:This report describes an unusual case of peroneal pseudoaneurysm developing after thromoboembolectomy with a Fogarty catheter. It was managed successfully using an endovascular technique consisting of se...

    journal_title:BMC surgery

    pub_type: 杂志文章,评审


    authors: Sadat U,See T,Cousins C,Hayes P,Gaunt M

    更新日期:2007-03-29 00:00:00

  • Experience with a new prosthetic anal sphincter in three coloproctological centres.

    abstract:BACKGROUND:Fecal incontinence is a common and severely disabling disorder. For patients with severe fecal incontinence, surgery may prove to be the only adequate treatment option. METHODS:This study reports on 43 patients that were treated with a prosthetic sphincter system between 2005 and 2009 in three coloproctolog...

    journal_title:BMC surgery

    pub_type: 杂志文章,多中心研究


    authors: Goos M,Baumgartner U,Löhnert M,Thomusch O,Ruf G

    更新日期:2013-10-08 00:00:00

  • Endoscopic vacuum therapy for postoperative esophageal leak.

    abstract:BACKGROUND:Anastomotic leak is the most common and serious complication following esophagectomy. Endoscopic vacuum-assisted closure (EVAC) is a promising method for treating anastomotic leak. We aimed to evaluate the efficacy of EVAC and to identify factors associated with longer treatment duration for esophageal anast...

    journal_title:BMC surgery

    pub_type: 杂志文章


    authors: Min YW,Kim T,Lee H,Min BH,Kim HK,Choi YS,Lee JH,Rhee PL,Kim JJ,Zo JI,Shim YM

    更新日期:2019-04-11 00:00:00

  • Open vascular treatment of median arcuate ligament syndrome.

    abstract:BACKGROUND:Median arcuate ligament syndrome is a rare condition with abdominal symptoms. Accepted treatment options are open release of median arcuate ligament, laparoscopic release of edian arcuate ligament, robot-assisted release of median arcuate ligament and open vascular treatment. Here we aimed to evaluate the ce...

    journal_title:BMC surgery

    pub_type: 杂志文章


    authors: Duran M,Simon F,Ertas N,Schelzig H,Floros N

    更新日期:2017-08-29 00:00:00

  • Radiation-induced thoracic necrosis with a pulmonary cutaneous fistula repaired using a free omental flap: a case report.

    abstract:BACKGROUND:Chest wall necrosis can manifest as a late effect of radiation therapy for breast cancer. Only two cases of fistulas communicating with the respiratory tract as a result of radiation-induced necrosis of the lungs or bronchi have been reported. To the best of our knowledge, we report the first case of a pulmo...

    journal_title:BMC surgery

    pub_type: 杂志文章


    authors: Azuma R,Kajita M,Kubo S,Kiyosawa T

    更新日期:2019-02-02 00:00:00

  • Totally laparoscopic versus conventional ileoanal pouch procedure--design of a single-centre, expertise based randomised controlled trial to compare the laparoscopic and conventional surgical approach in patients undergoing primary elective restorative pr

    abstract:BACKGROUND:Restorative proctocolectomy is increasingly being performed minimal invasively but a totally laparoscopic technique has not yet been compared to the standard open technique in a randomized study. METHODS/DESIGN:This is a two armed, single centre, expertise based, preoperatively randomized, patient blinded s...

    journal_title:BMC surgery

    pub_type: 杂志文章


    authors: Antolovic D,Kienle P,Knaebel HP,Schmidt J,Gutt CN,Weitz J,Koch M,Büchler MW,Seiler CM

    更新日期:2006-11-24 00:00:00

  • Preliminary experience with laparoscopic common bile duct exploration.

    abstract:BACKGROUND:Herein we present our experience with laparoscopic common bile duct exploration (LCBDE) in managing common bile duct stones. METHODS:Data of 129 consecutive patients who underwent laparoscopic cholecystectomy (LC) and LCBDE done at our institutes from April 2011 through June 2016 were prospectively recorded...

    journal_title:BMC surgery

    pub_type: 杂志文章


    authors: Salama AF,Abd Ellatif ME,Abd Elaziz H,Magdy A,Rizk H,Basheer M,Jamal W,Dawoud I,El Nakeeb A

    更新日期:2017-03-31 00:00:00

  • The effect of melatonin on bacterial translocation following ischemia/reperfusion injury in a rat model of superior mesenteric artery occlusion.

    abstract:BACKGROUND:Acute mesenteric ischemia is a life-threatening vascular emergency resulting in tissue destruction due to ischemia-reperfusion injury. Melatonin, the primary hormone of the pineal gland, is a powerful scavenger of reactive oxygen species (ROS), including the hydroxyl and peroxyl radicals, as well as singlet ...

    journal_title:BMC surgery

    pub_type: 杂志文章


    authors: Ozban M,Aydin C,Cevahir N,Yenisey C,Birsen O,Gumrukcu G,Aydin B,Berber I

    更新日期:2015-03-08 00:00:00

  • Localized primary amyloidosis of the breast: a case report and review of the literature.

    abstract:BACKGROUND:Primary amyloidosis of the breast is an unusual benign disease that mostly occurs in postmenopausal elderly women. Amyloidosis is the deposition of amorphous protein within tissues. Breast biopsy is necessary to make a definite diagnosis in order to avoid unnecessary surgical methods. Localized primary amylo...

    journal_title:BMC surgery

    pub_type: 杂志文章,评审


    authors: Tsuji W,Takeuchi E,Oka S,Yamashita T,Yotsumoto F

    更新日期:2016-09-13 00:00:00

  • Reconstructed gastric conduit obstruction caused by a bezoar after esophagectomy: a case report.

    abstract:BACKGROUND:Bezoars are rare but may cause gastrointestinal obstruction and ulcers. To the best of our knowledge, only two cases of bezoars in the reconstructed gastric conduit have been reported, but there has been no report on reconstructed gastric conduit obstruction due to bezoars. CASE PRESENTATION:A 60-year-old m...

    journal_title:BMC surgery

    pub_type: 杂志文章


    authors: Hatoyama K,Taniyama Y,Sakurai T,Hikage M,Sato C,Okamoto H,Takaya K,Onodera Y,Kamei T

    更新日期:2019-06-07 00:00:00

  • Proteinuria can predict prognosis after liver transplantation.

    abstract:BACKGROUND:Proteinuria is a manifestation of renal dysfunction and it has been demonstrated to be a significant prognostic factor in various clinical situations. The study was designed to analyze prognosis of patients receiving liver transplantation as well as to determine predictive performance of perioperative protei...

    journal_title:BMC surgery

    pub_type: 杂志文章


    authors: Pan HC,Chen YJ,Lin JP,Tsai MJ,Jenq CC,Lee WC,Tsai MH,Fan PC,Chang CH,Chang MY,Tian YC,Hung CC,Fang JT,Yang CW,Chen YC

    更新日期:2016-09-15 00:00:00

  • Clinical pictures mimicking acute hernia complications: are we really daring to violate a traditional abdominal wall surgery dogma?

    abstract:BACKGROUND:Acute abdominal wall hernia complications usually require a prompt surgical treatment. The aim of this case series is to report our experience with some unusual cases of apparent acute and subacute hernia complications not requiring surgical treatment, changing the classical paradigm of immediate surgical ap...

    journal_title:BMC surgery

    pub_type: 杂志文章


    authors: Zanatta M,Brancato G,Basile G,Basile F,Donati M

    更新日期:2020-10-15 00:00:00

  • Comparison of single posterior debridement, bone grafting and instrumentation with single-stage anterior debridement, bone grafting and posterior instrumentation in the treatment of thoracic and thoracolumbar spinal tuberculosis.

    abstract:BACKGROUND:To compare the clinical efficacy of single posterior debridement, bone grafting and instrumentation with that of single-stage anterior debridement, bone grafting and posterior instrumentation for treatment of adult patients with thoracic and thoracolumbar spinal tuberculosis (TB). METHODS:We performed a ret...

    journal_title:BMC surgery

    pub_type: 杂志文章


    authors: Zhou Y,Li W,Liu J,Gong L,Luo J

    更新日期:2018-09-03 00:00:00

  • The utility of the preoperative neutrophil-to-lymphocyte ratio in predicting severe cholecystitis: a retrospective cohort study.

    abstract:BACKGROUND:To evaluate whether the neutrophil-to-lymphocyte ratio (NLR), as a prognostic indicator, in patients can differentiate between simple and severe cholecystitis. METHODS:A database of 632 patients who underwent cholecystectomy due to cholecystitis during approximately a seven-year span in a single institution...

    journal_title:BMC surgery

    pub_type: 杂志文章


    authors: Lee SK,Lee SC,Park JW,Kim SJ

    更新日期:2014-11-27 00:00:00

  • Is standardized care feasible in the emergency setting? A case matched analysis of patients undergoing laparoscopic cholecystectomy.

    abstract:BACKGROUND:Immediate laparoscopic cholecystectomy is the accepted standard for the treatment of acute cholecystitis. The aim of the present study was to evaluate the feasibility of a standardized approach with tailored care maps for pre- and postoperative care by comparing pain, nausea and patient satisfaction after el...

    journal_title:BMC surgery

    pub_type: 杂志文章


    authors: Grass F,Cachemaille M,Blanc C,Fournier N,Halkic N,Demartines N,Hübner M

    更新日期:2016-12-01 00:00:00

  • A locking compression plate as an external fixator for treating infected nonunion of the humeral diaphysis.

    abstract:BACKGROUND:Infected nonunion of the humeral diaphysis is a challenging problem for orthopedic surgeons. This study aimed to evaluate the outcome of using a locking compression plate (LCP) as a definitive external fixator in the management of infected nonunion of the humeral diaphysis after failure of internal fixation....

    journal_title:BMC surgery

    pub_type: 杂志文章


    authors: Xiao C,Tang F,Zhou Y,Zhang W,Luo Y,Duan H,Tu C

    更新日期:2016-08-05 00:00:00

  • Laparoscopic versus open wedge resection for gastrointestinal stromal tumors of the stomach: a single-center 8-year retrospective cohort study of 156 patients with long-term follow-up.

    abstract:BACKGROUND:The aim of this study was to compared laparoscopic (LWR) and open wedge resection (OWR) for the treatment of gastric gastrointestinal stromal tumors (GISTs). METHODS:The data of 156 consecutive GISTs patients underwent LWR or OWR between January 2006 and December 2013 were collected retrospectively. The sur...

    journal_title:BMC surgery

    pub_type: 杂志文章,meta分析,评审


    authors: Cai JQ,Chen K,Mou YP,Pan Y,Xu XW,Zhou YC,Huang CJ

    更新日期:2015-05-09 00:00:00