Abstract:
:The role of autoimmunity targeting epithelial antigens in asthma has been suggested, in particular in non-atopic and severe asthma. Periplakin, a desmosomal component, is involved in epithelial cohesion and intracellular signaling. We detected anti-periplakin IgG antibodies in 47/260 (18 %) patients with asthma, with no association with severity or atopy. In addition, anti-periplakin IgE antibodies were detected in 12 of 138 tested patients (8.7 %) and were more frequently observed in patients with than without nasal polyposis. This study identifies a new autoimmune epithelial target in asthma. Whether periplakin autoimmunity (both IgG and IgE auto-antibodies) is involved in asthma pathogenesis remains to be studied during the disease course of these patients.
journal_name
Respir Resjournal_title
Respiratory researchauthors
Taillé C,Grootenboer-Mignot S,Estellat C,Roy C,Ly Ka So S,Pretolani M,Aubier M,Crestani B,Chollet-Martin Sdoi
10.1186/s12931-016-0441-5subject
Has Abstractpub_date
2016-10-07 00:00:00pages
126issue
1eissn
1465-9921issn
1465-993Xpii
10.1186/s12931-016-0441-5journal_volume
17pub_type
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