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Impact of age on plasma vaspin concentration in a group of normal Chinese people.

Abstract：

PURPOSE:Visceral adipose tissue-derived serine protease inhibitor (vaspin) is an adipocytokine with insulin-sensitizing effects. Accumulating data implied that vaspin represents a compensatory mechanism but it is unknown how vaspin change during ageing. This study was designed to examine the correlation between plasma vaspin and age in a group of normal Chinese people. METHODS:A total of 191 Chinese volunteers aged 19-80 years were enrolled into four groups based upon age quartiles (19-35, 36-50, 51-65 and 66-80 years). Demographic, anthropometric, metabolic covariates, vaspin and adiponectin were measured. The influence of age on plasma vaspin was analysed using SPSS 13.0. RESULTS:Vaspin increased with ageing, with mean vaspin levels (ng/mL) of 1.01 ± 2.25, 1.67 ± 2.95, 2.05 ± 3.46 and 2.40 ± 3.06 for those between quartile ages 19-35, 36-50, 51-65 and 66-80 years. When divided into subgroups, vaspin increased with increasing age for both sexes, both insulin resistance and non-insulin resistance subjects and both obese and lean subjects. In univariate analyses, vaspin plasma level positively associated with age (r = 0.215, p = 0.003), adiponectin, insulin, homoeostasis model of assessment for insulin resistance index and waist-hip ratio in the whole population. The correlation between ageing and increasing vaspin remained significant after multivariate adjustments for factors such as sex, body mass index, waist-hip ratio, indices of glucose metabolism, white blood cell, lipid profile and adiponectin. Stepwise multiple regression analysis showed that age contributed 7.6 % on plasma vaspin level. CONCLUSION:Vaspin level increased with ageing, independent of sex, indices of glucose metabolism, lipid profile and other markers of adiposity.

journal_name

J Endocrinol Invest

journal_title

Journal of endocrinological investigation

authors

Xu X,Wen J,Lu Y,Ji H,Zhuang J,Su Y,Liu B,Li H,Xu Y

doi

10.1007/s40618-016-0533-6

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

143-151

issue

2

eissn

0391-4097

issn

1720-8386

pii

10.1007/s40618-016-0533-6

journal_volume

40

pub_type

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