Blunted renal vasoconstriction in patients with subclinical contrast-induced renal injury.

abstract：:1. Oxidative stress (OS) is a biological entity indicated as being responsible for several pathologies, including diabetes. Diabetes can also be associated with human cirrhosis. Portal hypertension (PH), a major syndrome in cirrhosis, produces hyperdynamic splanchnic circulation and hyperaemia. The present study was d...

journal_title：Clinical and experimental pharmacology & physiology

authors： Evelson P,Llesuy S,Filinger E,Rodriguez RR,Lemberg A,Scorticati C,Susemihl M,Villareal I,Polo JM,Peredo H,Perazzo JC

更新日期：2004-03-01 00:00:00

abstract：:1. To understand the roles of a putative hypertension gene in the chromosome 1 quantitative trait locus (QTL) region, the response to restraint stress was studied in strains congenic for this QTL. 2. To establish congenic strains, the QTL region was introgressed from stroke-prone spontaneously hypertensive rats (SHRSP...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cui ZH,Ikeda K,Kawakami K,Gonda T,Nabika T,Masuda J

更新日期：2003-07-01 00:00:00

abstract：:Vancomycin is an antibiotic used in the treatment of infections caused by multidrug-resistant Gram-positive bacteria, especially methicillin-resistant Staphylococcus aureus. In the last decades, vancomycin has been widely used in hospital environments due to the increasing incidence of sepsis and septic shock. Sepsis ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zamoner W,Prado IRS,Balbi AL,Ponce D

更新日期：2019-04-01 00:00:00

abstract：:1. The role of calcium-activated potassium (KCa) channels in bronchodilation produced by a direct adenylyl cyclase activator, forskolin, was investigated. The involvement of intracellular cyclic AMP (cAMP) in the process was also examined. 2. The isometric tension records from guinea-pig tracheal smooth muscles indica...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hiramatsu T,Kume H,Kotlikoff MI,Takagi K

更新日期：1994-05-01 00:00:00

abstract：:1. The aim of this study was to assess the vagal and sympathetic nerve contribution to the relationship between mean arterial pressure (MAP) and heart rate (HR) at 6, 9, 14 and 20 weeks of age in conscious Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) with methoxamine- and nitroprusside-induced steady-s...

journal_title：Clinical and experimental pharmacology & physiology

authors： Head GA,Adams MA

更新日期：1988-04-01 00:00:00

abstract：:trans-Resveratrol (resveratrol) has been shown to have beneficial effects on the cardiovascular system in a number of studies. It is, however, unclear whether this naturally occurring compound can protect against cardiac hypertrophy. The aim of the present study was to investigate the effects of resveratrol on cardiac...

journal_title：Clinical and experimental pharmacology & physiology

authors： Liu Z,Song Y,Zhang X,Liu Z,Zhang W,Mao W,Wang W,Cui W,Zhang X,Jia X,Li N,Han C,Liu C

更新日期：2005-12-01 00:00:00

abstract：:1. The administration of aldosterone to adrenalectomized rats produces an increase in K+ and decrease in Na+ excretion in the urine. The relationship of the post-aldosterone to the pre-aldosterone urinary sodium and potassium excretion is termed the renal response to aldosterone. 2. The administration of L-dopa enhanc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Adam WR

更新日期：1979-01-01 00:00:00

abstract：:1. Poor perfusion of the kidneys and gut, and associated functional impairment, are major problems in the first days of life in very preterm infants. These complications can be associated with a substantial mortality and further problems such as reduced kidney growth and chronic renal problems in later childhood. 2. T...

journal_title：Clinical and experimental pharmacology & physiology

authors： Bennet L,Booth L,Malpas SC,Quaedackers JS,Jensen E,Dean J,Gunn AJ

更新日期：2006-04-01 00:00:00

abstract：:1. We investigated the effect of exercise on plasma adrenomedullin, atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) concentrations and studied the relationship between these peptides and haemodynamic parameters in nine patients with old myocardial infarction (MI) and in eight normal subjects. 2. T...

journal_title：Clinical and experimental pharmacology & physiology

authors： Morimoto A,Nishikimi T,Takaki H,Okano Y,Matsuoka H,Takishita S,Kitamura K,Miyata A,Kangawa K,Matsuo H

更新日期：1997-05-01 00:00:00

abstract：:1. The effects of 14 lignocaine homologues on the maximum upstroke velocity (Vmax) of the action potentials (AP) were studied in guinea-pig papillary muscles. These drugs possess one, two or three methyl groups in different positions: an ortho-chloro, -carbomethoxy or -ethyl group instead of an ortho-methyl group; or ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hamamoto T,Ichiyama M,Takahashi Y,Ban T

更新日期：1992-06-01 00:00:00

abstract：:Acute kidney injury (AKI) is a rapid loss of kidney function resulting in accumulation of end metabolic products and associated abnormalities in fluid, electrolyte and acid-base homeostasis. The pathophysiology of AKI is complex and multifactorial involving numerous vascular, tubular and inflammatory pathways. Neurohu...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hering D,Winklewski PJ

更新日期：2017-02-01 00:00:00

abstract：:1. Hyperhomocysteinaemia (HHcy) is associated with endothelial dysfunction and has been recognized as a risk factor of cardiovascular disease. The present study aimed to investigate the effect of homocysteine (Hcy) on endothelial function in vivo and in vitro, and the underlying signalling pathways. 2. The HHcy animal...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yan TT,Li Q,Zhang XH,Wu WK,Sun J,Li L,Zhang Q,Tan HM

更新日期：2010-11-01 00:00:00

abstract：:1. Ambulatory monitoring provides a unique opportunity for studying the temporal relationships between lifestyle factors and blood pressure (BP). These include physical activity, mental activity, environmental stressors, substances ingested for pleasure such as smoking, alcohol and caffeine, and nutrition. 2. Changes ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Pickering TG,Schwartz JE,James GD

更新日期：1995-03-01 00:00:00

abstract：:1. Conscious experimental hypertensive rats injected intraventricularly with 5,6-dihydroxytryptamine (50 microgram) responded with a rapid and long-lasting (4 days) fall in blood pressure and this was accompanied by a bradycardia of similar duration. 2. The acute actions of 5,6-dihydroxytryptamine on the cardiovascula...

journal_title：Clinical and experimental pharmacology & physiology

authors： Finch L

更新日期：1975-11-01 00:00:00

abstract：:The amino acid sequence of human renin was identified for the first time. This was determined from the nucleotide sequence of exons in the human renin gene identified in a genomic library by recombinant DNA techniques. Examination of amino acid residues involved in the enzymatic hydrolysis by human renin of the unique...

journal_title：Clinical and experimental pharmacology & physiology

authors： Morris BJ,Catanzaro DF,Hardman J,Mesterovic N,Tellam J,Hort Y,Bennetts BH,Shine J

更新日期：1984-07-01 00:00:00

abstract：:1. Rapid ventricular rate (VR) and rhythm irregularity during atrial fibrillation (AF) impair cardiac performance. Although digoxin has been widely used in patients with AF, its efficacy for the control of VR and rhythm irregularity is unsatisfactory. Whether low-dose amiodarone is more effective remains unclear. 2. W...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tse HF,Lam YM,Lau CP,Cheung BM,Kumana CR

更新日期：2001-05-01 00:00:00

abstract：:1. After a severe burn, a marked decrease in myocardial blood flow results in ischaemic and hypoxic injury, which subsequently leads to apoptosis or necrosis. Phosphatidylinositol 3-kinase (PI3-K)/Akt is an important intracellular signal transduction molecule that regulates cell proliferation, differentiation, glucose...

journal_title：Clinical and experimental pharmacology & physiology

authors： Song HP,Zhang L,Dang YM,Yan H,Chu ZG,Huang YS

更新日期：2010-05-01 00:00:00

abstract：:1. The endogenous production of and/or the bioavailability of nitric oxide (NO) is decreased in pulmonary hypertensive diseases. L-arginine (L-arg) is the substrate for NO synthase (NOS). L-arg is transported into cells via the cationic amino acid transporters (CAT), of which there are two isoforms in endothelial cell...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cui H,Chen B,Chicoine LG,Nelin LD

更新日期：2011-12-01 00:00:00

abstract：:1. The angiotensin type 1 (AT1) receptor antagonist, losartan (10 mg/kg) was infused intravenously into nine chronically catheterized fetal sheep (125-132 days gestation). Losartan reduced the fetal systolic (P <0.01) and diastolic (P <0.01) pressor response to 5 microg angiotensin II (AngII) i.v. from 27.4 +/- 1.5 to...

journal_title：Clinical and experimental pharmacology & physiology

authors： Stevenson KM,Gibson KJ,Lumbers ER

更新日期：1996-02-01 00:00:00

abstract：:1. Phytoncides are volatile substances released mainly from trees. We studied whether phytoncides can reduce stress responses in stroke-prone spontaneously hypertensive rats (SHRSP). 2. Under the restraint stress, SHRSP exposed to phytoncides showed lower blood pressure than those without the exposure (186.8 +/- 3.9 v...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kawakami K,Kawamoto M,Nomura M,Otani H,Nabika T,Gonda T

更新日期：2004-12-01 00:00:00

abstract：:Central administration of choline increases blood pressure in normotensive and hypotensive states by increasing plasma concentrations of vasopressin and catecholamines. We hypothesized that choline could also modulate the renin-angiotensin pathway, the third main pressor system in the body. Plasma renin activity (PRA)...

journal_title：Clinical and experimental pharmacology & physiology

authors： Isbil-Buyukcoskun N,Ilcol YO,Cansev M,Hamurtekin E,Ozluk K,Ulus IH

更新日期：2008-09-01 00:00:00

abstract：:This study investigated if the protective effect of taurine against high fat diet-induced hepatic steatosis involves modulating the hepatic activity of 5' AMP-activated protein kinase (AMPK) and levels/activity of the sterol regulatory element-binding proteins-1/2 (SREBP1/2). Rats were divided into four groups (n = 12...

journal_title：Clinical and experimental pharmacology & physiology

authors： Morsy MD,Aboonq MS,ALsleem MA,Abusham AA

更新日期：2020-07-21 00:00:00

abstract：:1. Twelve treated hypertensive patients (ages 58-71 years) who had also been treated for joint disease participated in a randomized double-blind crossover placebo-controlled study to investigate the effects of indomethacin (25 mg three times daily) on blood pressure and biochemical parameters over a 6-week period. 2. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wing LM,Bune AJ,Chalmers JP,Graham JR,West MJ

更新日期：1981-09-01 00:00:00

abstract：:1. Calcium regulation has been reported to be associated with the development of diabetic nephropathy. Thus, changes in Ca2+ uptake induced by ATP, an important regulator of Ca2+ uptake, in the diabetic condition and related signal pathways were examined in primary cultures of rabbit renal proximal tubule cells (PTC)....

journal_title：Clinical and experimental pharmacology & physiology

authors： Han HJ,Park SH,Lee YJ,Lee JC,Lee JH

更新日期：2003-09-01 00:00:00

abstract：:1. Infusion of increasing doses of angiotensin II (AII) in normal subjects sequentially increased blood pressure, aldosterone and atrial natriuretic peptide (ANP) levels. 2. The slope of ANP response to AII was positively correlated with basal ANP and with the slope of blood pressure response to AII (pressor slope) bu...

journal_title：Clinical and experimental pharmacology & physiology

authors： Finn WL,Tunny TJ,Klemm SA,Ryan SJ,Gordon RD

更新日期：1993-05-01 00:00:00

abstract：:1. The recognition of the role of insulin resistance in disease states and the recent development of new drugs that modify insulin-dependent metabolism has led to increased use of the euglycaemic hyperinsulinaemic clamp to measure in vivo insulin sensitivity, but several key aspects of the technique are poorly documen...

journal_title：Clinical and experimental pharmacology & physiology

authors： Morris AD,Ueda S,Petrie JR,Connell JM,Elliott HL,Donnelly R

更新日期：1997-07-01 00:00:00

abstract：:1. Alpha-terpineol is a monoterpene found in the essential oils of several aromatic plant species. In the present study, we investigated the mechanisms underlying the cardiovascular changes induced by alpha-terpineol in rats. 2. In normotensive rats, administration of alpha-terpineol (1, 5, 10, 20 and 30 mg/kg, i.v.) ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ribeiro TP,Porto DL,Menezes CP,Antunes AA,Silva DF,De Sousa DP,Nakao LS,Braga VA,Medeiros IA

更新日期：2010-08-01 00:00:00

abstract：:Asymmetric dimethylarginine (ADMA) is an endogenously produced nitric oxide synthase (NOS) inhibitor. L-Arginine can be metabolised by NOS and arginase, and arginase is the first step in polyamine production necessary for cellular proliferation. We tested the hypothesis that ADMA would inhibit NOS but not arginase act...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chen B,Strauch K,Jin Y,Cui H,Nelin LD,Chicoine LG

更新日期：2014-07-01 00:00:00

abstract：:1. We wished to determine whether, during pregnancy, there is reduced renal response to atrial distension, whether secretion of atrial natriuretic factor (ANF) is suppressed and whether neural input from the atrial volume receptors to the central nervous system is altered. 2. Conscious, chronically instrumented female...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kaufman S

更新日期：1995-02-01 00:00:00

abstract：:1. mu-Opioid receptor agonists mediate their central analgesic effects by actions on neurons within brain regions such as the mid-brain periaqueductal grey (PAG). Within the PAG, mu-opioid receptor-mediated analgesia results from inhibition of GABAergic influences on output projection neurons. We have established that...

journal_title：Clinical and experimental pharmacology & physiology

authors： Christie MJ,Connor M,Vaughan CW,Ingram SL,Bagley EE

更新日期：2000-07-01 00:00:00