Abstract:
BACKGROUND:In Japan, the majority of hip osteoarthritis (OA) was caused by acetabular dysplasia, and about 90 % of patients were female. The present study focused on Japanese female patients with hip OA due to acetabular dysplasia, and examined the associated factors with OA staging at diagnosis, in special reference to body weight. METHODS:Study subjects were 336 Japanese women who were newly diagnosed with hip OA caused by acetabular dysplasia at 15 hospitals in 2008. The self-administered questionnaire elicited patients' body weight at age 20 and at OA diagnosis. Four ranked OA staging according to radiographic findings of the hip joint (pre-OA, initial stage, advanced stage or terminal stage) was regarded as the outcome index. Proportional odds models in logistic regression were used to calculate odds ratios (ORs) and 95 % confidence intervals (CIs) for severer stage of OA. RESULTS:At diagnosis, 45 % of patients suffered from terminal stage of OA, whereas 13 % and 14 % were categorized into pre-OA and initial stage, respectively. After adjustment for potential confounders, weight gain since age 20 revealed the increased ORs for severer OA stage at diagnosis (OR 2.02; 95 % CI, 1.07-3.80). Other significant characteristics were age (67+ vs. 20-49 years, OR 12.4), lower education (junior high school vs. junior college or higher, OR 4.00), parity (OR 2.19), lower acetabular head index (<60.0 vs. 71.1+, OR 2.36), and longer duration since symptom onset (6.0+ vs. <1.0 year, OR 2.94). CONCLUSIONS:Weight gain since age 20 might be involved in mechanisms of OA development, which is independent of age or severity of acetabular dysplasia.
journal_name
BMC Musculoskelet Disordjournal_title
BMC musculoskeletal disordersauthors
Ohfuji S,Jingushi S,Kondo K,Sofue M,Itoman M,Matsumoto T,Hamada Y,Shindo H,Takatori Y,Yamada H,Yasunaga Y,Ito H,Mori S,Owan I,Fujii G,Ohashi H,Takahashi S,Hirota Ydoi
10.1186/s12891-016-1179-4subject
Has Abstractpub_date
2016-08-02 00:00:00pages
320issn
1471-2474pii
10.1186/s12891-016-1179-4journal_volume
17pub_type
杂志文章abstract:BACKGROUND:The mechanism for hip pain has been unclear because of a lack of experimental animal models. We aimed to establish an intra-articular injection technique to the rat hip and to document the effect of intra-articular mono-iodoacetate (MIA) injection to the rat hip with radiography and histology. METHODS:Using...
journal_title:BMC musculoskeletal disorders
pub_type: 杂志文章
doi:10.1186/s12891-016-0985-z
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journal_title:BMC musculoskeletal disorders
pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,随机对照试验
doi:10.1186/s12891-017-1647-5
更新日期:2017-07-05 00:00:00
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2018-09-12 00:00:00