Recent developments concerning diet and hypertension.

abstract：:1. Oestrogen reduces vascular smooth muscle cell proliferation in mouse vascular injury models. Data on the antiproliferative effect of oestrogen in cultured vascular smooth muscle cells (VSMC) are less conclusive than those obtained in whole animal studies. 2. In the present study, we investigated the hypothesis that...

journal_title：Clinical and experimental pharmacology & physiology

authors： Odenlund M,Ekblad E,Nilsson BO

更新日期：2008-03-01 00:00:00

abstract：:Posture changes may differ between types of hypertensive disease. The aim is to evaluate the orthostatic response of impedance cardiography (ICG) measurements in uncomplicated and hypertensive pregnancies. Measurements were performed in supine and standing position in 202 women: 41 uncomplicated pregnancies (UP), 59 g...

journal_title：Clinical and experimental pharmacology & physiology

authors： Staelens AS,Vonck S,Mesens T,Tomsin K,Molenberghs G,Gyselaers W

更新日期：2015-10-01 00:00:00

abstract：:1. The physiological relevance of cardiac and vascular alpha-adrenoceptors may increase in disease states in which beta-adrenoceptors are altered. To test this, positive inotropic and vasoconstrictor responses to phenylephrine were measured in isolated tissues from rats with experimentally-induced hyperthyroidism, hyp...

journal_title：Clinical and experimental pharmacology & physiology

authors： Brown L,Amos G,Miller B

更新日期：1994-09-01 00:00:00

abstract：:The effects of the calcium antagonists verapamil and nifedipine on mean arterial blood pressure, heart rate and pressor responses to a range of alpha-adrenoceptor agonists were examined in male normotensive New Zealand white rabbits and in rabbits with perinephritis hypertension. Verapamil and nifedipine caused a grea...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hamilton CA,Jardine E,Sumner DJ,Reid JL

更新日期：1987-02-01 00:00:00

abstract：:Pressor responsiveness to angiotensin II (AII) and phenylephrine (PE) was examined before and after 5 days of ACTH (1 mg, i.m., daily) or hydrocortisone (200 mg, orally, daily) in six normotensive men. Pulse pressure was higher prior to PE than AII infusion, presumably due to feeding. Systolic blood pressure (SBP) was...

journal_title：Clinical and experimental pharmacology & physiology

authors： Whitworth JA,Connell JM,Lever AF,Fraser R

更新日期：1986-04-01 00:00:00

abstract：:1. To investigate the pharmacological effects of T-1095, this novel derivative of phlorizin was administered to GK rats for 8 weeks. T-1095 treatment significantly lowered plasma glucose and glycosylated haemoglobin (HbA1c) levels, but did not significantly affect bodyweight. 2. T-1095 treatment did not affect 3.3 mmo...

journal_title：Clinical and experimental pharmacology & physiology

authors： Nunoi K,Yasuda K,Adachi T,Okamoto Y,Shihara N,Uno M,Tamon A,Suzuki N,Oku A,Tsuda K

更新日期：2002-05-01 00:00:00

abstract：:1. Resveratrol (RSV), a polyphenol in red wine, exhibits cardioprotective effects in vitro, such as inhibition of angiotensin II- or phenylephrine-induced cardiomyocyte hypertrophy in rat neonatal myocyte cultures and suppression of cardiac fibroblast proliferation. The aim of the present study was to investigate the ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yang DL,Zhang HG,Xu YL,Gao YH,Yang XJ,Hao XQ,Li XH

更新日期：2010-02-01 00:00:00

abstract：:1. The influence of the passive force on the contraction and endothelium-dependent relaxation in aortae of normotensive Wistar Kyoto (WKY) rats and stroke-prone spontaneously hypertensive rats (SHRSP) were compared. 2. Force changes of endothelium-intact and -removed preparations were measured isometrically by a force...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sekiguchi F,Adachi T,Matsubara H,Matsuda K,Kita K,Shimamura K,Sunano S

更新日期：1996-06-01 00:00:00

abstract：:1. Endogenous polyamines play a key role in mediating cellular growth and differentiation. Hypertension is associated with structural modifications of the circulatory system, a process that may be facilitated by polyamines. In this study, we examined whether there are elevated polyamine concentrations in the cardiovas...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ibrahim J,Hughes AD,Schachter M,Sever PS

更新日期：1996-05-01 00:00:00

abstract：:1. Previous studies have demonstrated progressive ventricular hypertrophy, dilatation and contractile depression in response to chronic volume overload. Whether this decompensation was related to intrinsic myocyte dysfunction was not clear. The present study evaluated ventricular myocyte function at critical times dur...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ding YF,Brower GL,Zhong Q,Murray D,Holland M,Janicki JS,Zhong J

更新日期：2008-07-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a progressively fatal form of cancer originating from the malignant transformation of hepatic biliary cholangiocytes. The present study reports for the first time in vitro growth inhibitory activities of β-eudesmol, the bioactive sesquiterpenoid present in the rhizome of Atractylodes lancea...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mathema VB,Chaijaroenkul W,Karbwang J,Na-Bangchang K

更新日期：2017-11-01 00:00:00

abstract：:1. Using a nested case-control study of 661 non-institutionalized elderly (> or = 60 years) residents of Dubbo, New South Wales, Australia, the aim of this study is to determine whether the A1166C polymorphism of the angiotensin II type I (AT1) receptor gene is associated with hypertension in the elderly. 2. Individua...

journal_title：Clinical and experimental pharmacology & physiology

authors： Liyou N,Davis D,James K,Simons L,Friedlander Y,Simons J,McCallum J,Johnson A

更新日期：1999-07-01 00:00:00

abstract：:1. The actions of lidocaine on cardiac pacemaker rhythms were studied in anaesthetized dogs and in Purkinje fibres from hearts of the same animals. 2. In vivo, lidocaine (1 mg/kg, intravenously) slowed the sino-atrial (SA) node rhythm (-5.0%), and (during vagal stimulation) prolonged ventricular standstill by +25.1% a...

journal_title：Clinical and experimental pharmacology & physiology

authors： Abete P,Ferrara N,Rengo F,Vassalle M

更新日期：1991-03-01 00:00:00

abstract：:1. CYP2C19 is a polymorphism of cytochrome P450, which is responsible for the metabolism of many drugs. The genetic polymorphism shows interethnic variation and it has been demonstrated that the frequency of poor metabolizers (PM) and the distribution of alleles of CYP2C19 vary among Chinese ethnic nationalities. The ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang JH,Li PQ,Fu QY,Li QX,Cai WW

更新日期：2007-05-01 00:00:00

abstract：:1. The present study was designed to compare and contrast the effects of 1 year's treatment with angiotensin-converting enzyme inhibition (captopril 25-100 mg daily) and beta-blockade (atenolol 50-100 mg daily) on hypertensive cardiac structure and function as well as the other established cardiovascular risk factors ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Laufer E,Reid C,Qi XL,Jennings GL

更新日期：1998-03-01 00:00:00

abstract：:1. The angiotensin type 1 (AT1) receptor antagonist, losartan (10 mg/kg) was infused intravenously into nine chronically catheterized fetal sheep (125-132 days gestation). Losartan reduced the fetal systolic (P <0.01) and diastolic (P <0.01) pressor response to 5 microg angiotensin II (AngII) i.v. from 27.4 +/- 1.5 to...

journal_title：Clinical and experimental pharmacology & physiology

authors： Stevenson KM,Gibson KJ,Lumbers ER

更新日期：1996-02-01 00:00:00

abstract：:1. The antinociceptive effect of prostaglandins E1, E2 and F2alpha was studied in albino rats. Though all three prostaglandins produced similar degrees of sedation, only prostaglandin E1 (PGE1) produced a dose-related antinociceptive activity. 2. The antinociceptive activities of equi-analgesic doses of morphine (7.5....

journal_title：Clinical and experimental pharmacology & physiology

authors： Sanyal AK,Bhattacharya SK,Keshary PR,Srivastava DN,Debnath PK

更新日期：1977-05-01 00:00:00

abstract：:The P2X7 receptor is a ligand-gated purinergic receptor activated by extracellular ATP. The receptor is highly expressed in immune cells and in the brain, and, upon activation, the P2X7 receptor allows a cation flux, leading to the distinct activation of intracellular signalling pathways as the secretion of pro-inflam...

journal_title：Clinical and experimental pharmacology & physiology

authors： Guerra Martinez C

更新日期：2019-06-01 00:00:00

abstract：:1. Rats and mice were vaccinated with Haemophilus influenzae in different vaccination schedules whereafter blood eosinophils were counted. In rats a single vaccination resulted in a dose-dependent effect on the blood eosinophil count in a pattern comparable with that after Bordetella pertussis vaccination. In a long-t...

journal_title：Clinical and experimental pharmacology & physiology

authors： Terpstra GK,Raaijmakers JA,Kreukniet J

更新日期：1979-03-01 00:00:00

abstract：:1. Irinotecan (also known as CPT-11) is a water soluble, semi-synthetic analogue of 20(S)camptothecin (CPT) with promising activity against a range of tumour types. 2. As with all other active analogues of CPT, irinotecan causes cell toxicity by stabilizing a ternary complex between the nuclear enzyme topoisomerase I ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Rivory LP

更新日期：1996-10-01 00:00:00

abstract：:1. Hepatic sulphobromophthalein (BSP) transport was studied in guinea-pigs pretreated intraperitoneally with 0.7 ml of diethyl maleate to depress hepatic glutathione levels. 2. Diethyl maleate depressed the hepatic transport of infused conjugated BSP from hepatocytes into bile without influencing hepatic uptake. 3. Un...

journal_title：Clinical and experimental pharmacology & physiology

authors： Whelan G

更新日期：1980-11-01 00:00:00

abstract：:1. Phytoncides are volatile substances released mainly from trees. We studied whether phytoncides can reduce stress responses in stroke-prone spontaneously hypertensive rats (SHRSP). 2. Under the restraint stress, SHRSP exposed to phytoncides showed lower blood pressure than those without the exposure (186.8 +/- 3.9 v...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kawakami K,Kawamoto M,Nomura M,Otani H,Nabika T,Gonda T

更新日期：2004-12-01 00:00:00

abstract：:1. We have reported previously that instant coffee contains ligands for opiate receptors with characteristics similar to those of opiate antagonists. 2. A concentrate of receptor-active ligands from instant coffee was prepared by serial treatments involving Amberlite XAD-2, flash chromatography and gel permeation chro...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wynne KN,Familari M,Boublik JH,Drummer OH,Rae ID,Funder JW

更新日期：1987-10-01 00:00:00

abstract：:1. Following local vasoconstriction-inducing stimuli, such as the cold pressor test (CPT), significant changes occur in haemodynamics, with a rise in arterial blood pressure and heart rate (HR) due to the activation of the sympathetic nervous system. Among the compensatory mechanisms to local ischaemia, the endogenous...

journal_title：Clinical and experimental pharmacology & physiology

authors： Pasini FL,Capecchi PL,Colafati M,Randisi P,Puccetti L,Di Perri T

更新日期：1999-10-01 00:00:00

abstract：:1. Contractions and electrical activity were recorded from isolated segments of longitudinal (L) and circular (C) myometrium from rats on gestation days 16-17 and 21 before and during parturition. 2. The segments were arranged so that the activity of the two layers could be monitored simultaneously and independently. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tomiyasu BA,Chen CJ,Marshall JM

更新日期：1988-09-01 00:00:00

abstract：:Previous studies have shown that endothelin (ET)-1 stimulates thromboxane (Tx)A(2) production and so we hypothesized that inhibiting prostanoid TP receptors would prevent the pressor and intrarenal haemodynamic response to an acute infusion of ET-1. 2. Male Sprague-Dawley rats were anaesthetized with Inactin (Sigma Ch...

journal_title：Clinical and experimental pharmacology & physiology

authors： Williams JM,Pollock DM

更新日期：2006-03-01 00:00:00

abstract：:1. Initial unsuccessful attempts to evaluate ventricular function in terms of the 'heart as a pump' led to focusing on the 'heart as a muscle' and to the concept of myocardial contractility. However, no clinically ideal index exists to assess the contractile state. The aim of the present study was to develop a mathema...

journal_title：Clinical and experimental pharmacology & physiology

authors： Curiel R,Perez-Gonzalez J,Torres E,Landaeta R,Cerrolaza M

更新日期：2005-10-01 00:00:00

abstract：:1. Congenital long QT syndrome (LQTS) is a genetically heterogeneous disease. The aim of the present study was to identify the gene mutation in a Chinese family with LQTS and investigate the functional changes associated with the mutation. 2. Polymerase chain reaction and DNA sequencing were used to screen for the KCN...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yang HT,Sun CF,Cui CC,Xue XL,Zhang AF,Li HB,Wang DQ,Shu J

更新日期：2009-08-01 00:00:00

abstract：:1. We have examined the question asked in the title by studying: the carotid baroreceptor reflex in man with a variable-pressure neck chamber; the carotid baroreceptor reflex in conscious rabbits with a variable-pressure capsule around the carotid bifurcation; and the barorecptor-heart rate reflex. 2. At rest, the ass...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ludbrook J,Mancia G,Zanchetti A

更新日期：1980-09-01 00:00:00

abstract：:trans-Resveratrol (resveratrol) has been shown to have beneficial effects on the cardiovascular system in a number of studies. It is, however, unclear whether this naturally occurring compound can protect against cardiac hypertrophy. The aim of the present study was to investigate the effects of resveratrol on cardiac...

journal_title：Clinical and experimental pharmacology & physiology

authors： Liu Z,Song Y,Zhang X,Liu Z,Zhang W,Mao W,Wang W,Cui W,Zhang X,Jia X,Li N,Han C,Liu C

更新日期：2005-12-01 00:00:00