'Slow pressor' hypertension from low-dose chronic angiotensin II infusion.

Abstract:

:1. Angiotensin (Ang) II causes growth-related effects on vascular smooth muscle cells in vitro and in vivo. 2. Chronic infusions of AngII systemically, at doses that are initially subpressor, result in slowly progressive increases in arterial pressure ('slow-pressor' hypertension). It has been suggested that the hypertension is due to induced growth in systemic resistance vessel walls by the AngII infusions. 3. We report the results of several studies investigating whether there are also induced structural changes in renal resistance vessels during chronic AngII infusions. We have developed models in Sprague-Dawley rats in which low-dose AngII infusions, either into the renal artery (thus restricting the effects to the kidney) or systemically, result in hypertension. 5. In both models, we have evidence suggesting that chronic AngII infusions have resulted in apparent structurally induced reductions in renal vasculature lumen upstream to the glomerulus. 6. The role of these renal changes in the development of the hypertension remain to be determined.

authors

Edgley A,Kett M,Anderson W

doi

10.1046/j.1440-1681.2001.03590.x

keywords:

subject

Has Abstract

pub_date

2001-12-01 00:00:00

pages

1035-9

issue

12

eissn

0305-1870

issn

1440-1681

pii

3590

journal_volume

28

pub_type

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