Fixed dose of long-acting erythropoietic stimulating agents at higher frequency improves appetite, reduces inflammation and corrects anaemia in patients on haemodialysis.


:Anaemia is an important issue in patients undergoing haemodialysis. We aimed to identify a better dosing schedule of a fixed monthly dose of continuous erythropoietin receptor activator (CERA) in patients with chronic kidney disease (CKD) on haemodialysis. The CERA dosing schedule included 100 μg once monthly for 2 months, 50 μg twice monthly for 2 months and then 100 μg once monthly for two months. The effectiveness was determined by comparing haematocrit, nutritional status (serum protein and albumin) and inflammatory markers (tumour necrosis factor (TNF)-α, interleukin (IL)-1, IL-6 and Hepcidin) at the beginning of the study with those at the end of the study. Forty-seven out of 67 patients completed the trial. At the end, haematocrit was significantly higher (34.51 vs 33.22%, P=.004), levels of inflammatory markers were significantly lower (TNF-α (30.71 vs 35.67 ng/mL, P=.007), IL-6 (5.12 vs 7.95 ng/mL, P=.033), hepcidin (60.39 vs 74.39 ng/mL, P=.002)), blood glucose levels were significantly lower (112.40 vs 139.02 mg/dL, P=.003) and albumin was significantly higher (4.11 vs 3.98, P=.001). Patients with a better than average response had a lower initial number of red blood cells (3.3 vs 3.6 × 10(6) /mm(3) , P=.025) and a lower IL-1 (3.8 vs 12.9 ng/mL, P=.01). They also had significantly lower blood glucose levels at the end. (91.3 vs 124.0 mg/dL, P=.03). We demonstrate that a fixed monthly dose of CERA at a twice monthly dosing schedule improves nutrition, reduces the inflammation and corrects anaemia in patients on haemodialysis. This finding may provide a new strategy for treating CKD-related anaemia.


Liu WS,Chu DC,Chan HL,Li SY,Liu CK,Yang CY,Chen YW,Lee PC,Lai YT,Lin CC




Has Abstract


2016-10-01 00:00:00












  • Chronic exercise partially restores the transmural heterogeneity of action potential duration in left ventricular myocytes of spontaneous hypertensive rats.

    abstract::Hypertension leads to electrophysiological changes in the heart. Chronic exercise induced by a treadmill-running programme (TRP) is considered a potential non-pharmacological treatment for hypertension and may have implications in heart remodelling. However, it is not known whether the TRP is able to improve the elect...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Roman-Campos D,Carneiro-Júnior MA,Prímola-Gomes TN,Silva KA,Quintão-Júnior JF,Gondim AN,Duarte HL,Cruz JS,Natali AJ

    更新日期:2012-02-01 00:00:00

  • Effects of trans-resveratrol on hypertension-induced cardiac hypertrophy using the partially nephrectomized rat model.

    abstract::trans-Resveratrol (resveratrol) has been shown to have beneficial effects on the cardiovascular system in a number of studies. It is, however, unclear whether this naturally occurring compound can protect against cardiac hypertrophy. The aim of the present study was to investigate the effects of resveratrol on cardiac...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Liu Z,Song Y,Zhang X,Liu Z,Zhang W,Mao W,Wang W,Cui W,Zhang X,Jia X,Li N,Han C,Liu C

    更新日期:2005-12-01 00:00:00

  • Changes in renal renin gene expression in fetal sheep.

    abstract::1. Renin gene expression was investigated in kidneys from 13 foetal and four adult sheep. 2. The levels of renal renin mRNA in foetuses were greater than those in adult sheep (P < 0.001). 3. There was no significant difference in renin mRNA levels between foetuses aged 91 and 134 days (term 150 days). 4. The levels of...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Zhang DY,Lumbers ER,Simonetta G

    更新日期:1996-08-01 00:00:00

  • A novel model of constrictive pericarditis associated with myocardial fibrosis in rats.

    abstract::An efficient animal model is fundamental for studies on the underlying mechanisms of constrictive pericarditis (CP). A novel CP rat model was established by pericardial injection composing of lipopolysaccharides (LPS) and talcum powder without thoracotomy. Pathological changes were confirmed by histological staining. ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Qiao W,Xiao YJ,Wang X,Sun LJ,Chen YX,Ren WD

    更新日期:2020-12-21 00:00:00

  • Blood pressure regulation in baroreceptor-denervated rats.

    abstract::1. Arterial baroreceptor denervation produces acute hypertension, but chronically denervated animals have an average arterial pressure that is similar to that of baroreceptor intact animals. 2. Although cardiopulmonary baroreceptors and renal compensations have been suggested to mediate the restoration of a normal ave...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Sved AF,Schreihofer AM,Kost CK Jr

    更新日期:1997-01-01 00:00:00

  • Antifibrotic effect of AT-1 blocker and statin in rats with hepatic fibrosis.

    abstract::Hepatic fibrosis is an outcome of chronic liver injury. Angiotensin II (ANG II) may play a role in the pathogenesis of hepatic fibrosis. Certain drugs such as ACE inhibitors, ANG II antagonists, and even statins could interfere with the renin angiotensin system and modulate its deleterious effects. This study was carr...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: El-Ashmawy NE,El-Bahrawy HA,Shamloula MM,Ibrahim AO

    更新日期:2015-09-01 00:00:00

  • Neutrophil platelet-activating factor production and acetyltransferase activity in clinical acute myocardial infarction.

    abstract::1. Neutrophil function was studied in 10 males presenting with acute myocardial infarction (MI) within 6 h of onset and in 10 normal males. Neutrophil production of platelet-activating factor (PAF), determined by bioassay, that of leukotriene B4 by HPLC, and the activity of an enzyme involved in the synthesis of PAF, ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Strahan ME,Graham RM,Eccleston DS,Sturm MJ,Taylor RR

    更新日期:1995-02-01 00:00:00

  • The effect of spontaneous diabetes mellitus on fatty acid oxidation, beta-hydroxybutyrate dehydrogenase activity and respiratory coupling of hepatic mitochondria in the guinea-pig (Cavia porcellus).

    abstract::1. The purpose of this study was to determine whether hepatic mitochondria of guinea-pigs with spontaneous diabetes mellitus differ from those of non-diabetic guinea-pigs in the oxidation of fatty acids, the activity of beta-hydroxybutyrate dehydrogenase, or respiration-linked oxidative phosphorylation. During the cou...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Nevalainen TO,White WJ,Lang CM,Munger BL

    更新日期:1978-05-01 00:00:00

  • Operative contractility: a functional concept of the inotropic state.

    abstract::1. Initial unsuccessful attempts to evaluate ventricular function in terms of the 'heart as a pump' led to focusing on the 'heart as a muscle' and to the concept of myocardial contractility. However, no clinically ideal index exists to assess the contractile state. The aim of the present study was to develop a mathema...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Curiel R,Perez-Gonzalez J,Torres E,Landaeta R,Cerrolaza M

    更新日期:2005-10-01 00:00:00

  • Cardiovascular actions of human endothelin in conscious sheep.

    abstract::1. Synthetic human endothelin was injected intravenously over the range 1.5-50 micrograms to examine its cardiovascular actions in conscious sheep. 2. Mean arterial pressure increased by 9-21 mmHg within 30-120 s over the range 5-50 micrograms endothelin. The increase in blood pressure was associated with increased ca...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Scoggins BA,Spence CD,Parkes DG,McDonald M,Wade JD,Coghlan JP

    更新日期:1989-04-01 00:00:00

  • Glucuronidation of dihydrocodeine by human liver microsomes and the effect of inhibitors.

    abstract::1. Glucuronidation is the major route of metabolism of dihydrocodeine (DHC) and accounts for 25-30% of an oral dose in urine. The kinetics of DHC-6-glucuronide formation in liver microsomes from five human donors and the effect of a number of potential inhibitor drugs were examined using a newly developed and validate...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Kirkwood LC,Nation RL,Somogyi AA

    更新日期:1998-03-01 00:00:00

  • Role of AT1 receptors in the central control of sympathetic vasomotor function.

    abstract::1. In a number of species, high concentrations of angiotensin II (AngII) receptors have been found in the rostral ventrolateral medulla (RVLM) in the hindbrain, which is an important region involved in the modulation of sympathetic vasomotor tone. The present review describes studies in which the contribution of angio...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Head GA

    更新日期:1996-09-01 00:00:00

  • Increased expression of calcium-sensing receptors induced by ox-LDL amplifies apoptosis of cardiomyocytes during simulated ischaemia-reperfusion.

    abstract::1. Acute myocardial infarction (AMI) is strongly associated with atherosclerosis, and is responsible for significant morbidity and mortality worldwide. The pathogenic mechanisms that underlie atherosclerosis and AMI are undefined at present. The calcium-sensing receptor (CaSR) is a member of the superfamily of G-prote...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Guo J,Li HZ,Zhang WH,Wang LC,Wang LN,Zhang L,Li GW,Li HX,Yang BF,Wu L,Wang R,Xu CQ

    更新日期:2010-03-01 00:00:00

  • Extracellular fluid distribution in rats with chronic one- and two-kidney Goldblatt hypertension.

    abstract::1. The influence of the intact kidney on blood pressure, extracellular fluid volume (ECF, ferrocyanide space) and ECF volume distribution was studied in rats 60 days after constriction of the contralateral renal artery. 2. Renal artery constriction increased both blood pressure and ECF levels. The rise of both variabl...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Kunes J,Jelínek J

    更新日期:1979-09-01 00:00:00

  • Accelerated dosing frequency of a pulmonary formulation of tissue plasminogen activator is well-tolerated in mice.

    abstract::1. Tissue plasminogen activator (tPA) has both fibrinolytic and anti-inflammatory activity. These properties may be useful in treating inflammatory lung diseases, such as acute respiratory distress syndrome (ARDS). 2. We have previously demonstrated the feasibility of targeted pulmonary delivery of tPA. As part of our...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Stringer KA,Tobias M,Dunn JS,Campos J,Van Rheen Z,Mosharraf M,Nayar R

    更新日期:2008-12-01 00:00:00

  • Comparison of the activity of circular and longitudinal myometrium from pregnant rats: co-ordination between muscle layers.

    abstract::1. Contractions and electrical activity were recorded from isolated segments of longitudinal (L) and circular (C) myometrium from rats on gestation days 16-17 and 21 before and during parturition. 2. The segments were arranged so that the activity of the two layers could be monitored simultaneously and independently. ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Tomiyasu BA,Chen CJ,Marshall JM

    更新日期:1988-09-01 00:00:00

  • Nitric oxide as a metabolic regulator during exercise: effects of training in health and disease.

    abstract::1. Accumulating animal and human data suggest that nitric oxide (NO) is important for both coronary and peripheral haemodynamic control and metabolic regulation during performance of exercise. 2. While still controversial, NO of endothelial origin is thought to potentiate exercise-induced hyperaemia, both in the perip...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Kingwell BA

    更新日期:2000-04-01 00:00:00

  • A randomized, controlled, phase II clinical trial of β-D-mannuronic acid (M2000) in pre-surgical breast cancer patients at early stage (T1-T2).

    abstract::Following the potent efficacy of β-D-Mannuronic acid in a breast cancer murine model, we evaluated the efficacy of this novel non-steroidal anti-inflammatory drug in breast cancer patients in the present clinical trial. The study was an 8-week randomized, controlled, phase II clinical trial (IRCT: 2017012213739N7 (in ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,随机对照试验


    authors: Kashefi S,Omranipour R,Mahmoodzadeh H,Ahmadi H,Alikhassi A,Hosseini M,Cuzzocrea S,Rehm BHA,Matsuo H,Mirshafiey A

    更新日期:2019-06-01 00:00:00

  • Inhibition by ethacrynic acid of NO-mediated relaxations of the rat anococcygeus muscle.

    abstract::1. The effects of ethacrynic acid were studied on relaxations elicited by nitric oxide (NO), the NO-donors sodium nitroprusside (SNP) and glyceryl trinitrate (GTN), nitrergic nerve stimulation and the NO-independent agent papaverine in isolated preparations of rat anococcygeus muscles. 2. Ethacrynic acid (100 mumol/L)...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Li CG,Brosch SF,Rand MJ

    更新日期:1994-04-01 00:00:00

  • Hyperoxia confers myocardial protection in mechanically ventilated rats through the generation of free radicals and opening of mitochondrial ATP-sensitive potassium channels.

    abstract::1. One hour exposure to hyperoxia has been shown previously to limit a subsequent ischaemia-reperfusion injury in spontaneously breathing rats. We tested the cardioprotective effect of a shorter period of hyperoxia during mechanical ventilation and the possible contribution of reactive oxygen species (ROS) and mitocho...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Colantuono G,Tiravanti EA,Di Venosa N,Cazzato A,Rastaldo R,Cagiano R,D'Agostino D,Federici A,Fiore T

    更新日期:2008-01-01 00:00:00

  • Effect of labetalol on human platelet function.

    abstract::1. The effects of the alpha-beta-adrenergic antagonist labetalol on the activation of human platelets by adrenaline and other aggregating stimuli have been investigated. 2. Labetalol inhibited platelet aggregation and secretion induced by collagen and the second phase of aggregation caused by ADP, platelet activating ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Anfossi G,Trovati M,Lanzio M,Mularoni E,Massucco P,Emanuelli G

    更新日期:1988-06-01 00:00:00

  • Urinary excretion of glycosaminoglycans, hydroxyproline and hydroxylysine in rabbits after excessive ingestion of fluoride.

    abstract::Urinary levels of glycosaminoglycans (GAG) and hydroxyproline from normal and fluoride treated rabbits were estimated. The hydroxylysine content of serum and urine of rabbits after excessive ingestion of fluoride was also investigated. There was a progressive decrease in GAG content, reduction in hydroxylysine, wherea...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Jha M,Koacher J,Susheela AK

    更新日期:1983-09-01 00:00:00

  • Is Fleming's lysozyme an analgesic agent? Experiments on mice.

    abstract::1. Antinociceptive activity of hen egg white lysozyme (Fleming's lysozyme) was determined against abdominal contractions provoked by irritants injected intraperitoneally into mice. Carrageenan (2 mg) (CA) injected with arachidonic acid (15 micrograms) (AA) or prostaglandins PGE1 or PGF2 alpha (0.04 ng), brewer's yeast...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Bianchi C

    更新日期:1983-01-01 00:00:00

  • Stress-induced elevation of the ST segment in the rat electrocardiogram is normalized by an adrenoceptor blocker.

    abstract::1. Emotional stress is one of the aetiologies of cardiac accidents, but the precise mechanisms remain to be elucidated. In the present study we used the immobilization stress model in rats to investigate electrocardiographic (ECG) changes. 2. A rapid elevation of the ST segment at the II, III, aVF and precordial leads...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Ueyama T,Yoshida K,Senba E

    更新日期:2000-05-01 00:00:00

  • Role of non-selective adenosine receptor blockade and phosphodiesterase inhibition in cisplatin-induced nephrogonadal toxicity in rats.

    abstract::1. It is well documented that cisplatin (CDDP) treatment increases the expression of adenosine A(1) receptors in both kidney and testes. However, the effect of adenosine at these receptors is controversial. Adenosine A(1) receptors have been documented to be involved in either cytoprotection or aggravation of nephroto...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Saad SY,Najjar TA,Alashari M

    更新日期:2004-12-01 00:00:00

  • Comparison of digoxin versus low-dose amiodarone for ventricular rate control in patients with chronic atrial fibrillation.

    abstract::1. Rapid ventricular rate (VR) and rhythm irregularity during atrial fibrillation (AF) impair cardiac performance. Although digoxin has been widely used in patients with AF, its efficacy for the control of VR and rhythm irregularity is unsatisfactory. Whether low-dose amiodarone is more effective remains unclear. 2. W...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Tse HF,Lam YM,Lau CP,Cheung BM,Kumana CR

    更新日期:2001-05-01 00:00:00

  • Endoplasmic reticulum stress involved in heart and liver injury in iron-loaded rats.

    abstract::1. Iron overload contributes to the pathogenesis of various diseases and directly induces tissue injury. In the present study, we investigated the relationship between heart and liver injury induced by iron overload and cellular endoplasmic reticulum (ER) stress to explore the molecular mechanism of iron overload-indu...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Lou LX,Geng B,Chen Y,Yu F,Zhao J,Tang CS

    更新日期:2009-07-01 00:00:00

  • Pharmacology of a unique adenosine binding site in rat brain using a selective ligand.

    abstract::1. In order to further characterize the adenosine binding sites that we previously purified and termed P3 purinergic receptor-like protein (P3LP), a reliable binding assay method was developed using [3H]-5'-N-ethylcarboxamidoadenosine (NECA) as a radioligand and the newly developed high-affinity selective ligand 9-(6,...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Yoshioka K,Matsuda A,Nakata H

    更新日期:2001-04-01 00:00:00

  • Generation and entrainment of circadian rhythms.

    abstract::1. The present brief review examines some of the new developments in the area of circadian rhythm research. 2. The discovery of the mouse clock and m-per genes and their similarity to other clock genes like per and tim has provided new insight into the control of rhythms in vertebrates. In mice, these genes are expres...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Kennaway DJ

    更新日期:1998-10-01 00:00:00

  • Increased Ca2+ sensitivity of myofibrillar tension in ischaemic vs dilated cardiomyopathy.

    abstract::1. There is evidence that different aetiologies of heart failure, especially ischaemic vs dilated cardiomyopathy (ICM and DCM, respectively), may influence the prognosis of patients with this disease. Patients with ICM have a worse prognosis than those with DCM; the mechanisms underlying this difference have not yet b...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Lee S,Lu R,Müller-Ehmsen J,Schwinger RH,Brixius K

    更新日期:2010-12-01 00:00:00