Abstract:
BACKGROUND:Preexposure prophylaxis (PrEP) is available as a daily pill for preventing infection with the human immunodeficiency virus (HIV). Innovative methods of administering PrEP systemically or topically are being discussed and developed. OBJECTIVE:The objective of our study was to assess attitudes toward different experimental modalities of PrEP administration. METHODS:From April to July 2015, we recruited 1106 HIV-negative men who have sex with men through online social media advertisements and surveyed them about their likelihood of using different PrEP modalities. Participants responded to 5-point Likert-scale items indicating how likely they were to use each of the following PrEP modalities: a daily oral pill, on-demand pills, periodic injection, penile gel (either before or after intercourse), rectal gel (before/after), and rectal suppository (before/after). We used Wilcoxon signed rank tests to determine whether the stated likelihood of using any modality differed from daily oral PrEP. Related items were combined to assess differences in likelihood of use based on tissue or time of administration. Participants also ranked their interest in using each modality, and we used the modified Borda count method to determine consensual rankings. RESULTS:Most participants indicated they would be somewhat likely or very likely to use PrEP as an on-demand pill (685/1105, 61.99%), daily oral pill (528/1036, 50.97%), injection (575/1091, 52.70%), or penile gel (438/755, 58.01% before intercourse; 408/751, 54.33% after). The stated likelihoods of using on-demand pills (median score 4) and of using a penile gel before intercourse (median 4) were both higher than that of using a daily oral pill (median 4, P<.001 and P=.001, respectively). Compared with a daily oral pill, participants reported a significantly lower likelihood of using any of the 4 rectal modalities (Wilcoxon signed rank test, all P<.001). On 10-point Likert scales created by combining application methods, the reported likelihood of using a penile gel (median 7) was higher than that of using a rectal gel (median 6, P<.001), which was higher than the likelihood of using a rectal suppository (median 6, P<.001). The modified Borda count ranked on-demand pills as the most preferred modality. There was no difference in likelihood of use of PrEP (gel or suppository) before or after intercourse. CONCLUSIONS:Participants typically prefer systemic PrEP and are less likely to use a modality that is administered rectally. Although most of these modalities are seen as favorable or neutral, attitudes may change as information about efficacy and application becomes available. Further data on modality preference across risk groups will better inform PrEP development.
journal_name
J Med Internet Resjournal_title
Journal of medical Internet researchauthors
Hall EW,Heneine W,Sanchez T,Sineath RC,Sullivan Pdoi
10.2196/jmir.5713subject
Has Abstractpub_date
2016-05-19 00:00:00pages
e111issue
5eissn
1439-4456issn
1438-8871pii
v18i5e111journal_volume
18pub_type
杂志文章abstract:BACKGROUND:Personal health records (PHRs) remain a relatively new technology and concept in practice even though they have been discussed in the literature for more than 50 years. There is no consensus on the definition of a PHR or PHR system even within the professional societies of health information technology. OBJ...
journal_title:Journal of medical Internet research
pub_type: 杂志文章
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abstract:BACKGROUND:The massive scale of social media platforms requires an automatic solution for detecting hate speech. These automatic solutions will help reduce the need for manual analysis of content. Most previous literature has cast the hate speech detection problem as a supervised text classification task using classica...
journal_title:Journal of medical Internet research
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abstract:BACKGROUND:We describe our experiences with identifying and recruiting Ontario parents through the Internet, primarily, as well as other modes, for participation in focus groups about adding the influenza vaccine to school-based immunization programs. OBJECTIVE:Our objectives were to assess participation rates with an...
journal_title:Journal of medical Internet research
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journal_title:Journal of medical Internet research
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journal_title:Journal of medical Internet research
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journal_title:Journal of medical Internet research
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journal_title:Journal of medical Internet research
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更新日期:2018-04-23 00:00:00
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更新日期:2018-06-22 00:00:00
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