Abstract:
:Severe critical illness is often complicated by intensive care unit-acquired weakness (ICU-AW), which is associated with increased ICU and post-ICU mortality, delayed weaning from mechanical ventilation and long-term functional disability. Several mechanisms have been implicated in the pathophysiology of ICU-AW, but muscle regeneration has not been investigated to any extent in this context, even though its involvement is suggested by the protracted functional consequences of ICU-AW. Recent data suggest that muscle regeneration could be impaired after sepsis, and that mesenchymal stem cell treatment could improve the post-injury muscle recovery.
journal_name
Crit Carejournal_title
Critical care (London, England)authors
Bouglé A,Rocheteau P,Sharshar T,Chrétien Fdoi
10.1186/s13054-016-1308-3subject
Has Abstractpub_date
2016-05-19 00:00:00pages
131issue
1eissn
1364-8535issn
1466-609Xpii
10.1186/s13054-016-1308-3journal_volume
20pub_type
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