Abstract:
BACKGROUND:The mechanism for hip pain has been unclear because of a lack of experimental animal models. We aimed to establish an intra-articular injection technique to the rat hip and to document the effect of intra-articular mono-iodoacetate (MIA) injection to the rat hip with radiography and histology. METHODS:Using 60 6-week-old male Sprague Dawley rats, 25 μl of sterile saline (control group; n = 30) and 25 μl of sterile saline with 2 mg of MIA (MIA group; n = 30) was injected into the right hip joints via posterior approach using a 27G needle. The animals were examined with X-ray and histology 7, 14, 28, 42, and 56 days later (MIA group [n = 6] and control group [n = 6], respectively). RESULTS:The MIA group showed progressive radiographic changes to the hip joint during the experimental period, whereas the control group maintained a normal appearance. The microanatomic appearance was consistent with X-ray images of progressive destruction in the MIA group and normal tissue in the control group. Osteoarthritic (OA) changes became apparent at 42 and 56 days in the MIA group. CONCLUSIONS:We established an intra-articular injection technique to the rat hip, creating a hip OA model in the rat by intra-articular injection of MIA.
journal_name
BMC Musculoskelet Disordjournal_title
BMC musculoskeletal disordersauthors
Miyamoto S,Nakamura J,Ohtori S,Orita S,Omae T,Nakajima T,Suzuki T,Takahashi Kdoi
10.1186/s12891-016-0985-zsubject
Has Abstractpub_date
2016-03-18 00:00:00pages
132issn
1471-2474pii
10.1186/s12891-016-0985-zjournal_volume
17pub_type
杂志文章abstract:BACKGROUND:In Japan, the majority of hip osteoarthritis (OA) was caused by acetabular dysplasia, and about 90 % of patients were female. The present study focused on Japanese female patients with hip OA due to acetabular dysplasia, and examined the associated factors with OA staging at diagnosis, in special reference t...
journal_title:BMC musculoskeletal disorders
pub_type: 杂志文章
doi:10.1186/s12891-016-1179-4
更新日期:2016-08-02 00:00:00
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pub_type: 杂志文章
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更新日期:2013-01-16 00:00:00
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更新日期:2014-03-07 00:00:00
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journal_title:BMC musculoskeletal disorders
pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2020-11-18 00:00:00
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pub_type: 杂志文章
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更新日期:2002-01-01 00:00:00
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更新日期:2020-05-25 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2474-9-56
更新日期:2008-04-22 00:00:00
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更新日期:2018-10-10 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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更新日期:2020-08-02 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2015-06-05 00:00:00
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更新日期:2019-02-07 00:00:00