Expression and localization of estrogen receptor-beta in annulus cells of the human intervertebral disc and the mitogenic effect of 17-beta-estradiol in vitro.


BACKGROUND:Recent evidence suggests that estrogens exert effects in different tissues throughout the body, and that the estrogen receptor beta (ERbeta) may be important for the action of estrogen (17-beta-estradiol) on the skeleton. The cellular localization of ERbeta in the human intervertebral disc, however, has not yet been explored. METHODS:Human disc tissue and cultured human disc cells were used for immunocytochemical localization of ERbeta. mRNA was isolated from cultured human disc cells, and RT-PCR amplification of ERbeta was employed to document molecular expression of this receptor. Cultured human disc cells were tested to determine if 17-beta-estradiol stimulated cell proliferation. RESULTS:In this report data are presented which provide evidence for ERbeta gene expression in human intervertebral disc cells in vivo and in vitro. Culture of annulus cells in the presence of 10-7 M 17-beta-estradiol significantly increased cell proliferation. CONCLUSIONS:These data provide new insight into the biology of cells in the annulus of the intervertebral disc.


Gruber HE,Yamaguchi D,Ingram J,Leslie K,Huang W,Miller TA,Hanley EN Jr





Has Abstract


2002-01-01 00:00:00








  • Hyaluronic acid affects the in vitro induction effects of synthetic PAMPS and PDMAAm hydrogels on chondrogenic differentiation of ATDC5 cells, depending on the level of concentration.

    abstract:BACKGROUND:It has been a common belief that articular cartilage tissue cannot regenerate in vivo. Recently, however, we have found that spontaneous hyaline cartilage regeneration can be induced in vivo by implanting a synthetic double-network (DN) hydrogel, which is composed of poly-(2-acrylamido-2-methylpropanesulfoni...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Yoshikawa K,Kitamura N,Kurokawa T,Gong JP,Nohara Y,Yasuda K

    更新日期:2013-02-05 00:00:00

  • Efficacy of manual therapy treatments for people with cervicogenic dizziness and pain: protocol of a randomised controlled trial.

    abstract:BACKGROUND:Cervicogenic dizziness is a disabling condition characterised by postural unsteadiness that is aggravated by cervical spine movements and associated with a painful and/or stiff neck. Two manual therapy treatments (Mulligan's Sustained Natural Apophyseal Glides (SNAGs) and Maitland's passive joint mobilisatio...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章,随机对照试验


    authors: Reid SA,Rivett DA,Katekar MG,Callister R

    更新日期:2012-10-18 00:00:00

  • Measuring the morphological characteristics of thoracolumbar fascia in ultrasound images: an inter-rater reliability study.

    abstract:BACKGROUND:Chronic lower back pain is still regarded as a poorly understood multifactorial condition. Recently, the thoracolumbar fascia complex has been found to be a contributing factor. Ultrasound imaging has shown that people with chronic lower back pain demonstrate both a significant decrease in shear strain, and ...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: De Coninck K,Hambly K,Dickinson JW,Passfield L

    更新日期:2018-06-01 00:00:00

  • Age-related changes in serum growth hormone, insulin-like growth factor-1 and somatostatin in system lupus erythematosus.

    abstract:BACKGROUND:Systemic lupus erythematosus is an age- and gender-associated autoimmune disorder. Previous studies suggested that defects in the hypothalamic/pituitary axis contributed to systemic lupus erythematosus disease progression which could also involve growth hormone, insulin-like growth factor-1 and somatostatin ...

    journal_title:BMC musculoskeletal disorders

    pub_type: 临床试验,杂志文章


    authors: Denko CW,Malemud CJ

    更新日期:2004-10-20 00:00:00

  • Comparing the MRI-based Goutallier Classification to an experimental quantitative MR spectroscopic fat measurement of the supraspinatus muscle.

    abstract:BACKGROUND:The Goutallier Classification is a semi quantitative classification system to determine the amount of fatty degeneration in rotator cuff muscles. Although initially proposed for axial computer tomography scans it is currently applied to magnet-resonance-imaging-scans. The role for its clinical use is controv...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Gilbert F,Böhm D,Eden L,Schmalzl J,Meffert RH,Köstler H,Weng AM,Ziegler D

    更新日期:2016-08-22 00:00:00

  • Inter-examiner reliability of the diagnosis of cervical pillar hyperplasia (CPH) and the correlation between CPH and spinal degenerative joint disease (DJD).

    abstract:BACKGROUND:Cervical pillar hyperplasia (CPH) is a recently described phenomenon of unknown aetiology. Its clinical importance is poorly understood at the present time; therefore, the objective of this study was to determine (1) the inter-examiner reliability of detecting CPH and (2) if there is a clinically important c...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Stupar M,Mauron D,Peterson CK

    更新日期:2003-12-17 00:00:00

  • Unusual localization and presentation of osteoid osteoma mimicking juvenile spondyloarthritis: a case report.

    abstract:BACKGROUND:Osteoid osteoma is a painful benign skeletal tumour of unknown aetiology. Most often it occurs in the long bones of extremities and responds well to nonsteroidal anti-inflammatory medications. However, unusual localization and atypical presentation of this tumour might present a diagnostic challenge, especia...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Vlaic J,Lamot L,Simunic S,Harjacek M,Bojic D

    更新日期:2019-01-08 00:00:00

  • Anatomical variation of the Psoas Valley: a scoping review.

    abstract:BACKGROUND:This scoping review aimed to investigate the literature on the anatomy of the psoas valley, an anterior depression on the acetabular rim, and propose a unified definition of the anatomical structure, describe its dimensions, anatomical variations and clinical implications. METHODS:A systematic computer sear...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章,评审


    authors: Kuroda Y,Rai A,Saito M,Khanduja V

    更新日期:2020-04-10 00:00:00

  • Inter-examiner reproducibility of tests for lumbar motor control.

    abstract:BACKGROUND:Many studies show a relation between reduced lumbar motor control (LMC) and low back pain (LBP). However, test circumstances vary and during test performance, subjects may change position. In other words, the reliability--i.e. reproducibility and validity--of tests for LMC should be based on quantitative dat...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章,随机对照试验


    authors: Enoch F,Kjaer P,Elkjaer A,Remvig L,Juul-Kristensen B

    更新日期:2011-05-25 00:00:00

  • Trabecular bone scores in young HIV-infected men: a matched case-control study.

    abstract:BACKGROUND:Screening for osteoporosis with dual-energy X-ray absorptiometry (DXA) is recommended for male HIV-infected patients only above the age of 50. Recently, trabecular bone score (TBS) has been introduced as a novel tool to assess bone microarchitecture using DXA of the lumbar spine. Few studies have reported TB...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Kim YJ,Kang KY,Shin J,Jun Y,Kim SI,Kim YR

    更新日期:2020-02-10 00:00:00

  • A new finger-preserving procedure as an alternative to amputation in recurrent severe Dupuytren contracture of the small finger.

    abstract:BACKGROUND:Recurrent severe Dupuytren contracture of the small finger's proximal interphalangeal (PIP) joint is a difficult problem. Further surgery carries high risk of complications and poor outcome. Patients are often offered finger amputation. We have devised a novel surgical procedure consisting of middle phalanx ...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Eiriksdottir A,Atroshi I

    更新日期:2019-07-09 00:00:00

  • Endostatin inhibits VEGF-A induced osteoclastic bone resorption in vitro.

    abstract:BACKGROUND:Endostatin is a C-terminal fragment of collagen XVIII which is a component of basement membranes with the structural properties of both collagens and proteoglycans. Endostatin has a major role in angiogenesis which is intimately associated with bone development and remodeling. Signaling between the endotheli...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Sipola A,Nelo K,Hautala T,Ilvesaro J,Tuukkanen J

    更新日期:2006-07-13 00:00:00

  • Test-retest reliability of knee kinesthesia in healthy adults.

    abstract:BACKGROUND:Sensory information from mechanoreceptors in the skin, muscles, tendons, and joint structures plays an important role in joint stability. A joint injury can lead to disruption of the sensory system, which can be measured by proprioceptive acuity. When evaluating proprioception, assessment tools need to be re...

    journal_title:BMC musculoskeletal disorders

    pub_type: 临床试验,杂志文章


    authors: Ageberg E,Flenhagen J,Ljung J

    更新日期:2007-07-03 00:00:00

  • A controlled before-after study to evaluate the effect of a clinician led policy to reduce knee arthroscopy in NSW.

    abstract:BACKGROUND:Clinical evidence shows knee arthroscopy has little benefit for degenerative conditions and considerable variation in the incidence of knee arthroscopy in Australia has been identified. This study aimed to evaluate a clinician-led evidence-based policy which was implemented in one local health district in Ne...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Chen HY,Harris IA,Sutherland K,Levesque JF

    更新日期:2018-05-16 00:00:00

  • Pain, pain intensity and pain disability in high school students are differently associated with physical activity, screening hours and sleep.

    abstract:BACKGROUND:Studies exploring the association between physical activity, screen time and sleep and pain usually focus on a limited number of painful body sites. Nevertheless, pain at different body sites is likely to be of different nature. Therefore, this study aims to explore and compare the association between time s...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Silva AG,Sa-Couto P,Queirós A,Neto M,Rocha NP

    更新日期:2017-05-16 00:00:00

  • Three combinations of manual therapy techniques within naprapathy in the treatment of neck and/or back pain: a randomized controlled trial.

    abstract:BACKGROUND:Manual therapy as spinal manipulation, spinal mobilization, stretching and massage are common treatment methods for neck and back pain. The objective was to compare the treatment effect on pain intensity, pain related disability and perceived recovery from a) naprapathic manual therapy (spinal manipulation, ...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章,随机对照试验


    authors: Paanalahti K,Holm LW,Nordin M,Höijer J,Lyander J,Asker M,Skillgate E

    更新日期:2016-04-23 00:00:00

  • In vitro gentamicin release from commercially available calcium-phosphate bone substitutes influence of carrier type on duration of the release profile.

    abstract:BACKGROUND:Polymethyl-methacrylate (PMMA) beads releasing antibiotics are used extensively to treat osteomyelitis, but require surgical removal afterwards because they do not degrade. METHODS:As an alternative option, this report compares the in vitro gentamicin release profile from clinically used, biodegradable carr...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Stallmann HP,Faber C,Bronckers AL,Nieuw Amerongen AV,Wuisman PI

    更新日期:2006-02-26 00:00:00

  • Do we need to suture the pronator quadratus muscle when we do open reduction and internal fixation for fracture of the distal radius.

    abstract:BACKGROUND:Open reduction and internal fixation is often used for the treatment of distal radius fracture. Opening the pronator quadratus muscle during the process of open reduction and internal fixation is necessary to achieve sufficient exposure. Therefore, knowledge on how to suture the pronator quadratus muscle wil...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Fang K,Lin X,Liu X,Ke Q,Shi S,Dai Z

    更新日期:2020-07-11 00:00:00

  • Analysis of the correlative factors in the selection of interbody fusion cage height in transforaminal lumbar interbody fusion.

    abstract:BACKGROUND:Selecting an interbody cage with appropriate height is one of the key steps in lumbar interbody fusion, and has an important impact on clinical efficacy. How to choose the appropriate height of the cage becomes one of the core problems of lumbar interbody fusion for spine surgeons. However, studies about obj...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Wang H,Chen W,Jiang J,Lu F,Ma X,Xia X

    更新日期:2016-01-12 00:00:00

  • Studying the association between musculoskeletal disorders, quality of life and mental health. A primary care pilot study in rural Crete, Greece.

    abstract:BACKGROUND:The burden of musculoskeletal disorders (MSD) on the general health and well-being of the population has been documented in various studies. The objective of this study was to explore the association between MSD and the quality of life and mental health of patients and to discuss issues concerning care seeki...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Antonopoulou MD,Alegakis AK,Hadjipavlou AG,Lionis CD

    更新日期:2009-11-20 00:00:00

  • Gel-type autologous chondrocyte (Chondron) implantation for treatment of articular cartilage defects of the knee.

    abstract:BACKGROUND:Gel-type autologous chondrocyte (Chondron) implantations have been used for several years without using periosteum or membrane. This study involves evaluations of the clinical results of Chondron at many clinical centers at various time points during the postoperative patient follow-up. METHODS:Data from 98...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Choi NY,Kim BW,Yeo WJ,Kim HB,Suh DS,Kim JS,Kim YS,Seo YH,Cho JY,Chun CW,Park HS,Shetty AA,Kim SJ

    更新日期:2010-05-28 00:00:00

  • Incidence and characteristics of distal radius fractures in a southern Swedish region.

    abstract:BACKGROUND:The incidence of distal radius fracture has increased substantially during the last 50 years according to several studies that estimated the overall incidence in various general populations. The incidence of fracture classified according to severity has not been well documented. The aim of this population-ba...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Brogren E,Petranek M,Atroshi I

    更新日期:2007-05-31 00:00:00

  • Minimal important improvement thresholds for the six-minute walk test in a knee arthroplasty cohort: triangulation of anchor- and distribution-based methods.

    abstract:BACKGROUND:The 6-minute walk test (6MWT) is a commonly used metric for measuring change in mobility after knee arthroplasty, however, what is considered an improvement after surgery has not been defined. The determination of important change in an outcome assessment tool is controversial and may require more than one a...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章,随机对照试验


    authors: Naylor JM,Mills K,Buhagiar M,Fortunato R,Wright R

    更新日期:2016-09-13 00:00:00

  • Intermittent parathyroid hormone improve bone microarchitecture of the mandible and femoral head in ovariectomized rats.

    abstract:BACKGROUND:Intermittent parathyroid hormone (PTH) can be used to treat osteoporosis of the spine and hip. However, whether it can be used to treat osteoporosis of the mandible is unclear. The purpose of this study was to explore the influence of applying intermittent PTH to ovariectomized rats on the trabecular bone mi...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Chen YJ,Wang SP,Cheng FC,Hsu PY,Li YF,Wu J,Huang HL,Tsai MT,Hsu JT

    更新日期:2017-04-24 00:00:00

  • Work outcome in persons with musculoskeletal diseases: comparison with other chronic diseases & the role of musculoskeletal diseases in multimorbidity.

    abstract:BACKGROUND:Chronic diseases and multimorbidity are increasingly common among persons in working age. This study explores the impact of type, number and combinations of chronic diseases with focus on the role of MSKD on (1) adverse work status (i.e. work disability (WD), economic unemployment (UE) or receiving a living ...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: van der Zee-Neuen A,Putrik P,Ramiro S,Keszei A,de Bie R,Chorus A,Boonen A

    更新日期:2017-01-10 00:00:00

  • Cyclo-oxygenase-2 selective inhibitors and nonsteroidal anti-inflammatory drugs: balancing gastrointestinal and cardiovascular risk.

    abstract:BACKGROUND:Differences between gastrointestinal and cardiovascular effects of traditional NSAID or cyclooxygenase-2 selective inhibitor (coxib) are affected by drug, dose, duration, outcome definition, and patient gastrointestinal and cardiovascular risk factors. We calculated the absolute risk for each effect. METHOD...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Moore RA,Derry S,McQuay HJ

    更新日期:2007-08-03 00:00:00

  • Outcome after protected full weightbearing treatment in an orthopedic device in diabetic neuropathic arthropathy (Charcot arthropathy): a comparison of unilaterally and bilaterally affected patients.

    abstract:BACKGROUND:Charcot neuropathic arthropathy (CN) is a chronic, progressive, destructive, non-infectious process that most frequently affects the bone architecture of the foot in patients with sensory neuropathy. We evaluated the outcome of protected weightbearing treatment of CN in unilaterally and bilaterally affected ...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Renner N,Wirth SH,Osterhoff G,Böni T,Berli M

    更新日期:2016-12-29 00:00:00

  • Alterations in articular cartilage T2 star relaxation time following mechanical disorders: in vivo canine supraspinatus tendon resection models.

    abstract:BACKGROUND:The role of altered joint mechanics on cartilage degeneration in in vivo models has not been studied successfully due to a lack of pre-injury information. We aimed 1) to develop an accurate in vivo canine model to measure the changes in joint loading and T2 star (T2*) relaxation time before and after unilate...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Lee D,Hong KT,Lim TS,Lee E,Lee YH,Park JS,Kim W,Oh JH,Choi JA,Song Y

    更新日期:2020-07-02 00:00:00

  • Migration analysis of a metaphyseal-anchored short femoral stem in cementless THA and factors affecting the stem subsidence.

    abstract:BACKGROUND:Early femoral stem subsidence following a cementless THA is correlated with aseptic loosening of the femoral component. The short femoral stems allow bone sparing and implantation through a minimally invasive approach; however, due to their metaphyseal anchoring, they might demonstrate different subsidence p...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Schaer MO,Finsterwald M,Holweg I,Dimitriou D,Antoniadis A,Helmy N

    更新日期:2019-12-12 00:00:00

  • Risk factors for failure of revision total hip arthroplasty using a Kerboull-type acetabular reinforcement device.

    abstract:BACKGROUND:The present study aimed to identify the risk factors associated with revision total hip arthroplasty (THA) failure using a Kerboull-type (KT) plate. METHODS:We analyzed 77 revision THAs using cemented acetabular components with a KT plate for aseptic loosening between May 2000 and March 2012. We examined th...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Hayashi S,Nishiyama T,Hashimoto S,Matsumoto T,Takayama K,Ishida K,Nishida K,Kuroda R

    更新日期:2017-09-02 00:00:00