Abstract:
BACKGROUND:Recent evidence suggests that estrogens exert effects in different tissues throughout the body, and that the estrogen receptor beta (ERbeta) may be important for the action of estrogen (17-beta-estradiol) on the skeleton. The cellular localization of ERbeta in the human intervertebral disc, however, has not yet been explored. METHODS:Human disc tissue and cultured human disc cells were used for immunocytochemical localization of ERbeta. mRNA was isolated from cultured human disc cells, and RT-PCR amplification of ERbeta was employed to document molecular expression of this receptor. Cultured human disc cells were tested to determine if 17-beta-estradiol stimulated cell proliferation. RESULTS:In this report data are presented which provide evidence for ERbeta gene expression in human intervertebral disc cells in vivo and in vitro. Culture of annulus cells in the presence of 10-7 M 17-beta-estradiol significantly increased cell proliferation. CONCLUSIONS:These data provide new insight into the biology of cells in the annulus of the intervertebral disc.
journal_name
BMC Musculoskelet Disordjournal_title
BMC musculoskeletal disordersauthors
Gruber HE,Yamaguchi D,Ingram J,Leslie K,Huang W,Miller TA,Hanley EN Jrdoi
10.1186/1471-2474-3-4keywords:
subject
Has Abstractpub_date
2002-01-01 00:00:00pages
4issn
1471-2474journal_volume
3pub_type
杂志文章abstract:BACKGROUND:Hyperbaric oxygenation was shown to increase bone healing in a rabbit model. However, little is known about the regulatory factors and molecular mechanism involved.We hypothesized that the effect of hyperbaric oxygen (HBO) on bone formation is mediated via increases in the osteogenic differentiation of mesen...
journal_title:BMC musculoskeletal disorders
pub_type: 杂志文章
doi:10.1186/1471-2474-15-56
更新日期:2014-02-25 00:00:00
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journal_title:BMC musculoskeletal disorders
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2474-15-90
更新日期:2014-03-19 00:00:00
abstract:BACKGROUND:Aseptic loosening is a significant impediment to joint implant longevity. Prosthetic wear particles are postulated to play a central role in the onset and progression of periprosthetic osteolysis, leading to aseptic loosening of the prosthesis. METHODS:We investigated the inhibitory effects of a lentivirus-...
journal_title:BMC musculoskeletal disorders
pub_type: 杂志文章
doi:10.1186/s12891-016-1290-6
更新日期:2016-10-18 00:00:00
abstract:BACKGROUND:A chronic pain condition may result in altered autonomic nervous system regulation in various patient populations. We evaluated whether autonomic regulation differs between sciatica patients referred to spine surgery and age-matched healthy controls analyzed with heart rate variability techniques (HRV). MET...
journal_title:BMC musculoskeletal disorders
pub_type: 杂志文章
doi:10.1186/1471-2474-14-149
更新日期:2013-04-26 00:00:00
abstract:BACKGROUND:Anterior cruciate ligament (ACL) reconstruction is today's surgical gold standard for ACL rupture. Although it provides satisfactory results, not all patients return to their previous activity level and moreover, early posttraumatic osteoarthritis is not prevented. As such, a renewed interest has emerged in ...
journal_title:BMC musculoskeletal disorders
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12891-018-2028-4
更新日期:2018-04-20 00:00:00
abstract:BACKGROUND:Vertebral fractures in patients with cystic fibrosis (CF) may contribute to an accelerated decline in lung function and can be a contraindication to lung transplantation. In this study, we examined longitudinal change in bone mineral density (BMD) and the prevalence of vertebral fractures in adult CF patient...
journal_title:BMC musculoskeletal disorders
pub_type: 杂志文章
doi:10.1186/1471-2474-9-125
更新日期:2008-09-19 00:00:00
abstract:BACKGROUND:The aim of this systematic review was to identify principles of exercise interventions associated with improved physical function, weight management or musculoskeletal pain relief among young and middle-aged adults with obesity and propose an evidence-based exercise prescription that could assist in secondar...
journal_title:BMC musculoskeletal disorders
pub_type: 杂志文章
doi:10.1186/s12891-019-3004-3
更新日期:2019-12-20 00:00:00
abstract:BACKGROUND:Functional Capacity (FC) is a multidimensional construct within the activity domain of the International Classification of Functioning, Disability and Health framework (ICF). Functional capacity evaluations (FCEs) are assessments of work-related FC. The extent to which these work-related FC tests are associa...
journal_title:BMC musculoskeletal disorders
pub_type: 杂志文章
doi:10.1186/1471-2474-14-180
更新日期:2013-06-08 00:00:00
abstract:BACKGROUND:The aim of the present study was to evaluate the accuracy of two approaches using magnetic resonance imaging (MRI) or combined ultrasonography (US) and anti-cyclic citrullinated peptide antibody (ACPA) for diagnosis and classification of individuals with established rheumatoid arthritis (RA). METHODS:In 53 ...
journal_title:BMC musculoskeletal disorders
pub_type: 杂志文章
doi:10.1186/1471-2474-15-268
更新日期:2014-08-07 00:00:00
abstract:BACKGROUND:One in three women and one in five men are expected to experience a minimal-trauma-fracture after the age of 50-years, which increases the risk of subsequent fracture. Importantly, timely diagnosis and optimal treatment in the form of a fracture liaison service (FLS), has been shown to reduce this risk of a ...
journal_title:BMC musculoskeletal disorders
pub_type: 杂志文章,多中心研究
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更新日期:2020-02-28 00:00:00
abstract:BACKGROUND:When reconstructing a hip with developmental dysplasia and high dislocation, sub-trochanteric shortening osteotomy is typically needed for placing the acetabular component in the appropriate anatomical position. However, the procedure can result in complications such as non-union of the osteotomy. We evaluat...
journal_title:BMC musculoskeletal disorders
pub_type: 杂志文章
doi:10.1186/s12891-020-03248-8
更新日期:2020-04-06 00:00:00
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journal_title:BMC musculoskeletal disorders
pub_type: 杂志文章
doi:10.1186/s12891-020-3046-6
更新日期:2020-01-18 00:00:00
abstract:BACKGROUND:Our preliminary RNA-Seq data revealed altered expression of small nucleolar RNA host gene 9 (SNHG9) in osteoarthritis (OA) and its reverse correlation with miR-34a, which can regulate chondrocyte apoptosis in rat OA model. This study was therefore carried out to investigate the potential interaction between ...
journal_title:BMC musculoskeletal disorders
pub_type: 杂志文章
doi:10.1186/s12891-020-03497-7
更新日期:2020-08-01 00:00:00
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journal_title:BMC musculoskeletal disorders
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更新日期:2019-05-01 00:00:00
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journal_title:BMC musculoskeletal disorders
pub_type: 杂志文章
doi:10.1186/s12891-016-1365-4
更新日期:2017-01-10 00:00:00
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journal_title:BMC musculoskeletal disorders
pub_type: 杂志文章
doi:10.1186/1471-2474-7-17
更新日期:2006-02-23 00:00:00
abstract:BACKGROUND:This study assessed the incidence and excess mortality of hip fractures among inpatients aged 20-40 years in a nationwide population database in Taiwan. METHODS:Subjects were selected from Taiwan's National Health Insurance Research Database for the period 2001-2008 and were followed up until the end of 201...
journal_title:BMC musculoskeletal disorders
pub_type: 杂志文章
doi:10.1186/s12891-016-1166-9
更新日期:2016-08-05 00:00:00
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journal_title:BMC musculoskeletal disorders
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2474-13-46
更新日期:2012-03-27 00:00:00
abstract:BACKGROUND:Upright head and neck position has been frequently applied as baseline for diagnosis of neck problems. However, the variance of the position after cervical motions has never been demonstrated. Thus, it is unclear if the baseline position varies evenly across the cervical joints. The purpose was to assess rep...
journal_title:BMC musculoskeletal disorders
pub_type: 杂志文章
doi:10.1186/s12891-017-1454-z
更新日期:2017-03-13 00:00:00
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journal_title:BMC musculoskeletal disorders
pub_type: 杂志文章
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journal_title:BMC musculoskeletal disorders
pub_type: 杂志文章
doi:10.1186/1471-2474-14-231
更新日期:2013-08-08 00:00:00
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journal_title:BMC musculoskeletal disorders
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2474-15-66
更新日期:2014-03-05 00:00:00
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journal_title:BMC musculoskeletal disorders
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2011-07-07 00:00:00
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journal_title:BMC musculoskeletal disorders
pub_type: 杂志文章
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更新日期:2018-09-25 00:00:00
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journal_title:BMC musculoskeletal disorders
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2474-14-291
更新日期:2013-10-12 00:00:00
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journal_title:BMC musculoskeletal disorders
pub_type: 杂志文章,评审
doi:10.1186/1471-2474-8-105
更新日期:2007-11-01 00:00:00
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journal_title:BMC musculoskeletal disorders
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2474-8-119
更新日期:2007-11-30 00:00:00
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journal_title:BMC musculoskeletal disorders
pub_type: 杂志文章
doi:10.1186/1471-2474-6-33
更新日期:2005-06-21 00:00:00
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journal_title:BMC musculoskeletal disorders
pub_type: 杂志文章
doi:10.1186/s12891-020-03759-4
更新日期:2020-11-12 00:00:00
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journal_title:BMC musculoskeletal disorders
pub_type: 杂志文章
doi:10.1186/s12891-020-03831-z
更新日期:2021-01-04 00:00:00