Abstract:
BACKGROUND:There is limited longitudinal data available on the natural history of meniscal tears especially in middle-aged adults with a low prevalence of osteoarthritis (OA). The aim of this study was to describe the natural history of meniscal tears over 8 years and the relationship with change in knee pain and structures. METHODS:One hundred ninety eight participants [mean age 47 (28-63); 57% female] were studied at baseline and 8 years later. Approximately half were the adult offspring of subjects who had a knee replacement performed for knee OA and the remainder were randomly selected controls. Meniscal tears/extrusion, cartilage volume/defects, bone marrow lesions (BMLs) and effusion were assessed on MRI. Knee pain was assessed using the Western Ontario and McMaster Universities Osteoarthritis Index. RESULTS:22% of the participants had at least one meniscal tear at any site at baseline. Over 8 years, 16% of the participants had an increase in severity of meniscal tears while none improved. Increase in meniscal tear score was associated with worsening knee pain (β = +2.81 (+1.40, +4.22)), with offspring having a significantly greater increase in pain severity compared to controls. BMI and presence of osteophytes at baseline, but not knee injury, predicted change in tears, whereas change in meniscal tears was independently associated with cartilage volume loss, change in BMLs and change in meniscal extrusion. CONCLUSION:Change in meniscal tears shares risk factors with knee OA and is independently associated with worsening knee pain and structural damage suggesting that meniscal tears are on the knee OA causal pathway.
journal_name
BMC Musculoskelet Disordjournal_title
BMC musculoskeletal disordersauthors
Khan HI,Aitken D,Ding C,Blizzard L,Pelletier JP,Martel-Pelletier J,Cicuttini F,Jones Gdoi
10.1186/s12891-015-0862-1subject
Has Abstractpub_date
2016-01-05 00:00:00pages
4issn
1471-2474pii
10.1186/s12891-015-0862-1journal_volume
17pub_type
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