Abstract:
BACKGROUND:Distal diminutive colorectal polyps are common and accurate endoscopic prediction of hyperplastic or adenomatous polyp histology could reduce procedural time, costs and potential risks associated with the resection. Within this study we assessed whether digital chromoendoscopy can accurately predict the histology of distal diminutive colorectal polyps according to the ASGE PIVI statement. METHODS:In this prospective cohort study, 224 consecutive patients undergoing screening or surveillance colonoscopy were included. Real time histology of 121 diminutive distal colorectal polyps was evaluated using high-definition endoscopy with digital chromoendoscopy and the accuracy of predicting histology with digital chromoendoscopy was assessed. RESULTS:The overall accuracy of digital chromoendoscopy for prediction of adenomatous polyp histology was 90.1 %. Sensitivity, specificity, positive and negative predictive values were 93.3, 88.7, 88.7, and 93.2 %, respectively. In high-confidence predictions, the accuracy increased to 96.3 % while sensitivity, specificity, positive and negative predictive values were calculated as 98.1, 94.4, 94.5, and 98.1 %, respectively. Surveillance intervals with digital chromoendoscopy were correctly predicted with >90 % accuracy. CONCLUSIONS:High-definition endoscopy in combination with digital chromoendoscopy allowed real-time in vivo prediction of distal colorectal polyp histology and is accurate enough to leave distal colorectal polyps in place without resection or to resect and discard them without pathologic assessment. This approach has the potential to reduce costs and risks associated with the redundant removal of diminutive colorectal polyps. TRIAL REGISTRATION:ClinicalTrials NCT02217449.
journal_name
BMC Gastroenteroljournal_title
BMC gastroenterologyauthors
Rath T,Tontini GE,Nägel A,Vieth M,Zopf S,Günther C,Hoffman A,Neurath MF,Neumann Hdoi
10.1186/s12876-015-0374-3subject
Has Abstractpub_date
2015-10-22 00:00:00pages
145issn
1471-230Xpii
10.1186/s12876-015-0374-3journal_volume
15pub_type
杂志文章abstract:BACKGROUND:Little is known about the prognostic impact of cirrhosis on long-term survival of patients with combined hepatocellular-cholangiocarcinoma (cHCC-CC) after hepatic resection. The aim of this study was to elucidate the long-term outcome of hepatectomy in cHCC-CC patients with cirrhosis. METHODS:A total of 144...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-017-0584-y
更新日期:2017-02-10 00:00:00
abstract:BACKGROUND:We examined the intrinsic hepatic innervation after partial hepatectomy (PH) in rats and the presence and pattern of neural sprouting in regenerating liver. METHODS:Male Wistar rats (age 9-13 weeks-w, weight 204-356 g), were submitted to two-thirds PH. Rats were sacrificed at postoperative days (d) 1, 3, 5,...
journal_title:BMC gastroenterology
pub_type: 杂志文章
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abstract:BACKGROUND:The aims of this study were to assess the prevalence of hepatitis C virus (HCV) infection in Japanese patients with oral lichen planus and identify the impact of amino acid (aa) substitutions in the HCV core region and IFN-sensitivity-determining region (ISDR) of nonstructural protein 5A (NS5A) associated wi...
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journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:BMC gastroenterology
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pub_type: 杂志文章,meta分析
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journal_title:BMC gastroenterology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2013-08-22 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:BMC gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
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